LRFN4_HUMAN
Evidence for PS localization
Functions
Promotes neurite outgrowth in hippocampal neurons. May play a role in redistributing DLG4 to the cell periphery . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in LRFN4_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 31.5789 | 4 | no |
| GO:0019900 | kinase binding | 23.6842 | 4 | no |
| GO:0019901 | protein kinase binding | 21.0526 | 5 | no |
| GO:0043168 | anion binding | 21.0526 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in LRFN4_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 57.8947 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 47.3684 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 44.7368 | 4 | no |
| GO:0010646 | regulation of cell communication | 42.1053 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 39.4737 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 39.4737 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 36.8421 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 36.8421 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 36.8421 | 5 | no |
| GO:0008104 | protein localization | 36.8421 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 34.2105 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 34.2105 | 5 | no |
| GO:0009966 | regulation of signal transduction | 31.5789 | 4 | no |
| GO:0010468 | regulation of gene expression | 31.5789 | 6 | no |
| GO:0022607 | cellular component assembly | 31.5789 | 4 | no |
| GO:0051049 | regulation of transport | 31.5789 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 28.9474 | 4 | yes |
| GO:0031399 | regulation of protein modification process | 28.9474 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 28.9474 | 5 | no |
| GO:0006996 | organelle organization | 28.9474 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 26.3158 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.3158 | 5 | no |
| GO:0033043 | regulation of organelle organization | 23.6842 | 5 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 23.6842 | 7 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 23.6842 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 23.6842 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 23.6842 | 5 | no |
| GO:0031400 | negative regulation of protein modification process | 23.6842 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 23.6842 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 23.6842 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 23.6842 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 23.6842 | 6 | no |
| GO:0009890 | negative regulation of biosynthetic process | 23.6842 | 5 | no |
| GO:0090304 | nucleic acid metabolic process | 23.6842 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 21.0526 | 5 | no |
| GO:0010563 | negative regulation of phosphorus metabolic process | 21.0526 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 21.0526 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 21.0526 | 5 | no |
| GO:0023056 | positive regulation of signaling | 21.0526 | 4 | no |
| GO:0023057 | negative regulation of signaling | 21.0526 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 21.0526 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 21.0526 | 4 | no |
| GO:0043933 | protein-containing complex organization | 21.0526 | 4 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 21.0526 | 5 | no |
| GO:0045936 | negative regulation of phosphate metabolic process | 21.0526 | 7 | no |
| GO:0048584 | positive regulation of response to stimulus | 21.0526 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 21.0526 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 21.0526 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 21.0526 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 21.0526 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 21.0526 | 6 | no |
| GO:0016070 | RNA metabolic process | 21.0526 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 21.0526 | 4 | no |
| GO:0015031 | protein transport | 21.0526 | 4 | no |
| GO:0071702 | organic substance transport | 21.0526 | 4 | no |
| GO:0071705 | nitrogen compound transport | 21.0526 | 4 | no |
| GO:0050807 | regulation of synapse organization | 13.1579 | 5 | yes |
| GO:1902115 | regulation of organelle assembly | 13.1579 | 5 | yes |
| GO:0051963 | regulation of synapse assembly | 7.8947 | 6 | yes |
| GO:0099175 | regulation of postsynapse organization | 7.8947 | 6 | yes |
| GO:1901888 | regulation of cell junction assembly | 7.8947 | 5 | yes |
| GO:0099150 | regulation of postsynaptic specialization assembly | 5.2632 | 6 | yes |
| GO:0099151 | regulation of postsynaptic density assembly | 5.2632 | 7 | yes |
| GO:0099174 | regulation of presynapse organization | 5.2632 | 6 | yes |
| GO:1904889 | regulation of excitatory synapse assembly | 5.2632 | 7 | yes |
| GO:1905606 | regulation of presynapse assembly | 5.2632 | 7 | yes |
| GO:1905874 | regulation of postsynaptic density organization | 5.2632 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NCK1_HUMAN | [view interactions] | Low throughput | no | yes |
| 1433G_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTN13_HUMAN | [view interactions] | High throughput | no | yes |
| MPDZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UTRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP2AB_HUMAN | [view interactions] | High throughput | no | yes |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PYR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PP2AA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOPC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTNL1_HUMAN | [view interactions] | High throughput | no | no |
| NCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANM1_HUMAN | [view interactions] | High throughput | no | yes |
| CAN6_HUMAN | [view interactions] | High throughput | no | no |
| RIMC1_HUMAN | [view interactions] | High throughput | no | yes |
| HIP1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SLIK5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AT5G1_HUMAN | [view interactions] | High throughput | no | no |
| LEG1_HUMAN | [view interactions] | High throughput | no | yes |
| CISD3_HUMAN | [view interactions] | High throughput | no | yes |
| DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRIP6_HUMAN | [view interactions] | High throughput | no | yes |
| S27A3_HUMAN | [view interactions] | High throughput | no | no |
| UBP30_HUMAN | [view interactions] | High throughput | no | yes |
| CHSS3_HUMAN | [view interactions] | High throughput | no | no |
| HEAT3_HUMAN | [view interactions] | High throughput | no | yes |
| CIP2A_HUMAN | [view interactions] | High throughput | no | yes |
| DYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TM39B_HUMAN | [view interactions] | High throughput | no | yes |
| GCP60_HUMAN | [view interactions] | High throughput | no | yes |
| NSUN3_HUMAN | [view interactions] | High throughput | no | no |
| LRFN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBP25_HUMAN | [view interactions] | High throughput | no | yes |
| MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
| ZSWM2_HUMAN | [view interactions] | High throughput | no | no |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NT2NA_HUMAN | [view interactions] | High throughput | no | no |
| KRA11_HUMAN | [view interactions] | High throughput | no | no |
| KR108_HUMAN | [view interactions] | High throughput | no | no |
| KRA13_HUMAN | [view interactions] | High throughput | no | no |
| CRTP1_HUMAN | [view interactions] | High throughput | no | yes |
| NT2NC_HUMAN | [view interactions] | High throughput | no | no |
| KRA62_HUMAN | [view interactions] | High throughput | no | no |
| PDIA1_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| ATL4_HUMAN | [view interactions] | High throughput | no | yes |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| CYTSA_HUMAN | [view interactions] | High throughput | no | yes |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX46_HUMAN | [view interactions] | High throughput | no | no |
| REPS1_HUMAN | [view interactions] | High throughput | no | yes |
| PATL1_HUMAN | [view interactions] | High throughput | no | yes |
| LNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIGO1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DEP1A_HUMAN | [view interactions] | High throughput | no | yes |
| 5HT3D_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BMAL1_HUMAN | [view interactions] | High throughput | no | yes |
| VINEX_HUMAN | [view interactions] | High throughput | no | no |
| LMBR1_HUMAN | [view interactions] | High throughput | no | yes |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| LRFN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR76_HUMAN | [view interactions] | High throughput | no | no |
| BRME1_HUMAN | [view interactions] | High throughput | no | yes |
| SMAG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCAM_HUMAN | [view interactions] | High throughput | no | yes |
| TKTL2_HUMAN | [view interactions] | High throughput | no | no |
| T106A_HUMAN | [view interactions] | High throughput | no | no |
| FBX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VEGFB_HUMAN | [view interactions] | High throughput | no | no |
| PALS1_HUMAN | [view interactions] | High throughput | no | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |