Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

APCL_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases (PubMed). May also function in Wnt signaling by promoting the rapid degradation of CTNNB1 (PubMed, PubMed, PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in APCL_HUMAN
GO:0008017 microtubule binding 55.5556 5 yes
GO:0015631 tubulin binding 55.5556 4 yes
GO:0019900 kinase binding 44.4444 4 no
GO:0019901 protein kinase binding 44.4444 5 no
GO:0003723 RNA binding 33.3333 4 no
GO:0051010 microtubule plus-end binding 33.3333 6 no
GO:0045296 cadherin binding 22.2222 4 no
GO:0031625 ubiquitin protein ligase binding 22.2222 5 no
GO:0044389 ubiquitin-like protein ligase binding 22.2222 4 no
GO:0003727 single-stranded RNA binding 22.2222 5 no
GO:0003729 mRNA binding 22.2222 5 no
GO:0003730 mRNA 3-UTR binding 22.2222 6 no
GO:0033592 RNA strand annealing activity 22.2222 5 no
GO:0042803 protein homodimerization activity 22.2222 4 no
GO:0046982 protein heterodimerization activity 22.2222 4 no
GO:0140666 annealing activity 22.2222 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in APCL_HUMAN
GO:0051128 regulation of cellular component organization 100.0000 4 yes
GO:0022607 cellular component assembly 88.8889 4 no
GO:0048522 positive regulation of cellular process 88.8889 4 no
GO:0051246 regulation of protein metabolic process 77.7778 5 yes
GO:0051247 positive regulation of protein metabolic process 77.7778 6 yes
GO:0060255 regulation of macromolecule metabolic process 77.7778 4 yes
GO:0080090 regulation of primary metabolic process 77.7778 4 yes
GO:0044087 regulation of cellular component biogenesis 77.7778 4 no
GO:0009893 positive regulation of metabolic process 77.7778 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 77.7778 5 yes
GO:0010646 regulation of cell communication 77.7778 4 yes
GO:0051130 positive regulation of cellular component organization 66.6667 5 no
GO:0006996 organelle organization 66.6667 4 yes
GO:0048523 negative regulation of cellular process 66.6667 4 yes
GO:0070925 organelle assembly 55.5556 5 no
GO:0031323 regulation of cellular metabolic process 55.5556 4 no
GO:0031399 regulation of protein modification process 55.5556 6 no
GO:0009894 regulation of catabolic process 55.5556 4 yes
GO:0009896 positive regulation of catabolic process 55.5556 5 yes
GO:0009966 regulation of signal transduction 55.5556 4 yes
GO:0033043 regulation of organelle organization 55.5556 5 yes
GO:0045595 regulation of cell differentiation 55.5556 4 yes
GO:0051493 regulation of cytoskeleton organization 44.4444 6 yes
GO:0051603 proteolysis involved in protein catabolic process 44.4444 5 yes
GO:0070507 regulation of microtubule cytoskeleton organization 44.4444 5 yes
GO:1902903 regulation of supramolecular fiber organization 44.4444 5 yes
GO:0008104 protein localization 44.4444 4 no
GO:0044089 positive regulation of cellular component biogenesis 44.4444 5 no
GO:0140694 non-membrane-bounded organelle assembly 44.4444 6 no
GO:0009889 regulation of biosynthetic process 44.4444 4 no
GO:0009891 positive regulation of biosynthetic process 44.4444 5 no
GO:0009892 negative regulation of metabolic process 44.4444 4 no
GO:0010468 regulation of gene expression 44.4444 6 no
GO:0010556 regulation of macromolecule biosynthetic process 44.4444 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 44.4444 6 no
GO:0010605 negative regulation of macromolecule metabolic process 44.4444 5 no
GO:0010647 positive regulation of cell communication 44.4444 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 44.4444 5 no
GO:0023056 positive regulation of signaling 44.4444 4 no
GO:0031324 negative regulation of cellular metabolic process 44.4444 5 no
GO:0031325 positive regulation of cellular metabolic process 44.4444 5 no
GO:0031326 regulation of cellular biosynthetic process 44.4444 5 no
GO:0031328 positive regulation of cellular biosynthetic process 44.4444 6 no
GO:0051094 positive regulation of developmental process 44.4444 4 no
GO:0051240 positive regulation of multicellular organismal process 44.4444 4 no
GO:0051248 negative regulation of protein metabolic process 44.4444 6 no
GO:0051252 regulation of RNA metabolic process 44.4444 5 no
GO:0051960 regulation of nervous system development 44.4444 5 no
GO:2000026 regulation of multicellular organismal development 44.4444 4 no
GO:0001932 regulation of protein phosphorylation 44.4444 7 no
GO:0019220 regulation of phosphate metabolic process 44.4444 6 no
GO:0031344 regulation of cell projection organization 44.4444 5 no
GO:0042325 regulation of phosphorylation 44.4444 7 no
GO:0051174 regulation of phosphorus metabolic process 44.4444 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 44.4444 6 no
GO:0050804 modulation of chemical synaptic transmission 44.4444 5 no
GO:0099177 regulation of trans-synaptic signaling 44.4444 4 no
GO:0006508 proteolysis 44.4444 4 yes
GO:0006511 ubiquitin-dependent protein catabolic process 44.4444 7 yes
GO:0007010 cytoskeleton organization 44.4444 5 yes
GO:0009057 macromolecule catabolic process 44.4444 4 yes
GO:0016055 Wnt signaling pathway 44.4444 4 yes
GO:0019941 modification-dependent protein catabolic process 44.4444 6 yes
GO:0030111 regulation of Wnt signaling pathway 44.4444 5 yes
GO:0031110 regulation of microtubule polymerization or depolymerization 44.4444 6 yes
GO:0032886 regulation of microtubule-based process 44.4444 4 yes
GO:0043632 modification-dependent macromolecule catabolic process 44.4444 5 yes
GO:0048585 negative regulation of response to stimulus 44.4444 4 yes
GO:0051494 negative regulation of cytoskeleton organization 33.3333 7 yes
GO:0060828 regulation of canonical Wnt signaling pathway 33.3333 6 yes
GO:0090090 negative regulation of canonical Wnt signaling pathway 33.3333 7 yes
GO:1901565 organonitrogen compound catabolic process 33.3333 4 yes
GO:1902904 negative regulation of supramolecular fiber organization 33.3333 6 yes
GO:0033365 protein localization to organelle 33.3333 5 no
GO:0043933 protein-containing complex organization 33.3333 4 no
GO:0044380 protein localization to cytoskeleton 33.3333 6 no
GO:0065003 protein-containing complex assembly 33.3333 5 no
GO:0072698 protein localization to microtubule cytoskeleton 33.3333 7 no
GO:0009890 negative regulation of biosynthetic process 33.3333 5 no
GO:0009967 positive regulation of signal transduction 33.3333 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 33.3333 6 no
GO:0010628 positive regulation of gene expression 33.3333 7 no
GO:0010629 negative regulation of gene expression 33.3333 7 no
GO:0031327 negative regulation of cellular biosynthetic process 33.3333 6 no
GO:0034329 cell junction assembly 33.3333 5 no
GO:0034330 cell junction organization 33.3333 4 no
GO:0042127 regulation of cell population proliferation 33.3333 4 no
GO:0043269 regulation of monoatomic ion transport 33.3333 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0048584 positive regulation of response to stimulus 33.3333 4 no
GO:0050767 regulation of neurogenesis 33.3333 6 no
GO:0050807 regulation of synapse organization 33.3333 5 no
GO:0051049 regulation of transport 33.3333 4 no
GO:0051254 positive regulation of RNA metabolic process 33.3333 6 no
GO:0051726 regulation of cell cycle 33.3333 4 no
GO:0051962 positive regulation of nervous system development 33.3333 5 no
GO:0060284 regulation of cell development 33.3333 5 no
GO:0031346 positive regulation of cell projection organization 33.3333 6 no
GO:0060491 regulation of cell projection assembly 33.3333 5 no
GO:0120032 regulation of plasma membrane bounded cell projection assembly 33.3333 6 no
GO:0001934 positive regulation of protein phosphorylation 33.3333 8 no
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 no
GO:0031401 positive regulation of protein modification process 33.3333 7 no
GO:0042327 positive regulation of phosphorylation 33.3333 8 no
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 no
GO:0051966 regulation of synaptic transmission, glutamatergic 33.3333 6 no
GO:0007399 nervous system development 33.3333 4 yes
GO:0009968 negative regulation of signal transduction 33.3333 5 yes
GO:0010498 proteasomal protein catabolic process 33.3333 5 yes
GO:0010639 negative regulation of organelle organization 33.3333 6 yes
GO:0010648 negative regulation of cell communication 33.3333 5 yes
GO:0023057 negative regulation of signaling 33.3333 4 yes
GO:0030163 protein catabolic process 33.3333 4 yes
GO:0030178 negative regulation of Wnt signaling pathway 33.3333 6 yes
GO:0031111 negative regulation of microtubule polymerization or depolymerization 33.3333 7 yes
GO:0042176 regulation of protein catabolic process 33.3333 5 yes
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 33.3333 6 yes
GO:0045732 positive regulation of protein catabolic process 33.3333 6 yes
GO:0051129 negative regulation of cellular component organization 33.3333 5 yes
GO:1901879 regulation of protein depolymerization 22.2222 6 yes
GO:1901880 negative regulation of protein depolymerization 22.2222 7 yes
GO:0010638 positive regulation of organelle organization 22.2222 6 no
GO:0030030 cell projection organization 22.2222 4 no
GO:0030031 cell projection assembly 22.2222 5 no
GO:0031113 regulation of microtubule polymerization 22.2222 6 no
GO:0032271 regulation of protein polymerization 22.2222 6 no
GO:0035372 protein localization to microtubule 22.2222 8 no
GO:0043254 regulation of protein-containing complex assembly 22.2222 5 no
GO:0044782 cilium organization 22.2222 5 no
GO:0051225 spindle assembly 22.2222 4 no
GO:0060271 cilium assembly 22.2222 6 no
GO:0071539 protein localization to centrosome 22.2222 9 no
GO:0120031 plasma membrane bounded cell projection assembly 22.2222 6 no
GO:0120036 plasma membrane bounded cell projection organization 22.2222 5 no
GO:1905508 protein localization to microtubule organizing center 22.2222 8 no
GO:1905515 non-motile cilium assembly 22.2222 7 no
GO:0001764 neuron migration 22.2222 4 no
GO:0002052 positive regulation of neuroblast proliferation 22.2222 7 no
GO:0006355 regulation of DNA-templated transcription 22.2222 7 no
GO:0007043 cell-cell junction assembly 22.2222 6 no
GO:0007167 enzyme-linked receptor protein signaling pathway 22.2222 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 22.2222 5 no
GO:0007268 chemical synaptic transmission 22.2222 7 no
GO:0007346 regulation of mitotic cell cycle 22.2222 5 no
GO:0008284 positive regulation of cell population proliferation 22.2222 5 no
GO:0008285 negative regulation of cell population proliferation 22.2222 5 no
GO:0010564 regulation of cell cycle process 22.2222 5 no
GO:0010720 positive regulation of cell development 22.2222 6 no
GO:0010959 regulation of metal ion transport 22.2222 6 no
GO:0016070 RNA metabolic process 22.2222 5 no
GO:0022603 regulation of anatomical structure morphogenesis 22.2222 4 no
GO:0031400 negative regulation of protein modification process 22.2222 7 no
GO:0032880 regulation of protein localization 22.2222 5 no
GO:0033044 regulation of chromosome organization 22.2222 6 no
GO:0042981 regulation of apoptotic process 22.2222 5 no
GO:0043065 positive regulation of apoptotic process 22.2222 6 no
GO:0043067 regulation of programmed cell death 22.2222 4 no
GO:0043068 positive regulation of programmed cell death 22.2222 5 no
GO:0045216 cell-cell junction organization 22.2222 5 no
GO:0045597 positive regulation of cell differentiation 22.2222 5 no
GO:0045786 negative regulation of cell cycle 22.2222 5 no
GO:0045893 positive regulation of DNA-templated transcription 22.2222 8 no
GO:0045930 negative regulation of mitotic cell cycle 22.2222 6 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 22.2222 5 no
GO:0050769 positive regulation of neurogenesis 22.2222 6 no
GO:0050808 synapse organization 22.2222 5 no
GO:0051241 negative regulation of multicellular organismal process 22.2222 4 no
GO:0051253 negative regulation of RNA metabolic process 22.2222 6 no
GO:0051924 regulation of calcium ion transport 22.2222 7 no
GO:0051963 regulation of synapse assembly 22.2222 6 no
GO:0060070 canonical Wnt signaling pathway 22.2222 5 no
GO:0060341 regulation of cellular localization 22.2222 4 no
GO:0090304 nucleic acid metabolic process 22.2222 4 no
GO:0098916 anterograde trans-synaptic signaling 22.2222 6 no
GO:0099536 synaptic signaling 22.2222 4 no
GO:0099537 trans-synaptic signaling 22.2222 5 no
GO:1901888 regulation of cell junction assembly 22.2222 5 no
GO:1902680 positive regulation of RNA biosynthetic process 22.2222 7 no
GO:1902692 regulation of neuroblast proliferation 22.2222 6 no
GO:1990138 neuron projection extension 22.2222 4 no
GO:2000177 regulation of neural precursor cell proliferation 22.2222 5 no
GO:2000179 positive regulation of neural precursor cell proliferation 22.2222 6 no
GO:2001141 regulation of RNA biosynthetic process 22.2222 6 no
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 22.2222 6 no
GO:0006974 DNA damage response 22.2222 4 no
GO:0043549 regulation of kinase activity 22.2222 5 no
GO:0045859 regulation of protein kinase activity 22.2222 6 no
GO:0051338 regulation of transferase activity 22.2222 4 no
GO:0071900 regulation of protein serine/threonine kinase activity 22.2222 7 no
GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 22.2222 6 no
GO:1904029 regulation of cyclin-dependent protein kinase activity 22.2222 5 no
GO:0022898 regulation of transmembrane transporter activity 22.2222 4 no
GO:0031644 regulation of nervous system process 22.2222 5 no
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 22.2222 5 no
GO:0034762 regulation of transmembrane transport 22.2222 4 no
GO:0034765 regulation of monoatomic ion transmembrane transport 22.2222 5 no
GO:0044057 regulation of system process 22.2222 4 no
GO:0050806 positive regulation of synaptic transmission 22.2222 5 no
GO:0051050 positive regulation of transport 22.2222 4 no
GO:0000381 regulation of alternative mRNA splicing, via spliceosome 22.2222 8 no
GO:0006417 regulation of translation 22.2222 6 no
GO:0010608 post-transcriptional regulation of gene expression 22.2222 7 no
GO:0017148 negative regulation of translation 22.2222 7 no
GO:0043484 regulation of RNA splicing 22.2222 6 no
GO:0043488 regulation of mRNA stability 22.2222 4 no
GO:0045727 positive regulation of translation 22.2222 7 no
GO:0048024 regulation of mRNA splicing, via spliceosome 22.2222 7 no
GO:0050684 regulation of mRNA processing 22.2222 7 no
GO:0051489 regulation of filopodium assembly 22.2222 7 no
GO:0060147 regulation of post-transcriptional gene silencing 22.2222 7 no
GO:0060148 positive regulation of post-transcriptional gene silencing 22.2222 4 no
GO:0060964 regulation of miRNA-mediated gene silencing 22.2222 9 no
GO:0060966 regulation of gene silencing by regulatory ncRNA 22.2222 7 no
GO:0061013 regulation of mRNA catabolic process 22.2222 5 no
GO:1900368 regulation of post-transcriptional gene silencing by regulatory ncRNA 22.2222 8 no
GO:1900370 positive regulation of post-transcriptional gene silencing by RNA 22.2222 5 no
GO:1903311 regulation of mRNA metabolic process 22.2222 6 no
GO:2000637 positive regulation of miRNA-mediated gene silencing 22.2222 6 no
GO:0030162 regulation of proteolysis 22.2222 6 no
GO:0045862 positive regulation of proteolysis 22.2222 7 no
GO:0060998 regulation of dendritic spine development 22.2222 4 no
GO:1903050 regulation of proteolysis involved in protein catabolic process 22.2222 7 no
GO:1903052 positive regulation of proteolysis involved in protein catabolic process 22.2222 8 no
GO:0007026 negative regulation of microtubule depolymerization 22.2222 7 yes
GO:0031114 regulation of microtubule depolymerization 22.2222 6 yes
GO:0043085 positive regulation of catalytic activity 22.2222 4 yes
GO:0043242 negative regulation of protein-containing complex disassembly 22.2222 6 yes
GO:0043244 regulation of protein-containing complex disassembly 22.2222 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ASPP2_HUMAN [view interactions] Low throughput no yes
MARE3_HUMAN [view entry] [view interactions] Low throughput yes yes
MARE1_HUMAN [view entry] [view interactions] Low throughput yes yes
AXIN2_HUMAN [view interactions] Low throughput no yes
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
AXIN1_HUMAN [view interactions] Low throughput no yes
ACTS_HUMAN [view interactions] Low throughput no no
YAP1_HUMAN [view interactions] High throughput no yes
NEK4_HUMAN [view interactions] High throughput no yes
TIMP2_HUMAN [view interactions] High throughput no no
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
DYR1A_HUMAN [view interactions] High throughput no yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
NLGN3_HUMAN [view entry] [view interactions] High throughput yes yes
SMCA2_HUMAN [view interactions] High throughput no yes
YBOX1_HUMAN [view interactions] High throughput no yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
DSCAM_HUMAN [view interactions] High throughput no yes
NFX1_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
KI20A_HUMAN [view interactions] High throughput no yes
APC_HUMAN [view entry] [view interactions] High throughput yes no