APCL_HUMAN
Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases (PubMed). May also function in Wnt signaling by promoting the rapid degradation of CTNNB1 (PubMed, PubMed, PubMed). [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in APCL_HUMAN |
---|---|---|---|---|
GO:0019900 | kinase binding | 50.0000 | 4 | no |
GO:0019901 | protein kinase binding | 50.0000 | 5 | no |
GO:0008017 | microtubule binding | 35.7143 | 5 | yes |
GO:0015631 | tubulin binding | 35.7143 | 4 | yes |
GO:0045296 | cadherin binding | 28.5714 | 4 | no |
GO:0003723 | RNA binding | 28.5714 | 4 | no |
GO:0051010 | microtubule plus-end binding | 21.4286 | 6 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in APCL_HUMAN |
---|---|---|---|---|
GO:0051128 | regulation of cellular component organization | 85.7143 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 85.7143 | 4 | no |
GO:0010646 | regulation of cell communication | 78.5714 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 78.5714 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 71.4286 | 4 | yes |
GO:0009966 | regulation of signal transduction | 71.4286 | 4 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 71.4286 | 5 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 71.4286 | 4 | yes |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 71.4286 | 5 | yes |
GO:0051246 | regulation of protein metabolic process | 71.4286 | 5 | yes |
GO:0051247 | positive regulation of protein metabolic process | 71.4286 | 6 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 71.4286 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 71.4286 | 4 | yes |
GO:0022607 | cellular component assembly | 64.2857 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 64.2857 | 4 | no |
GO:0009894 | regulation of catabolic process | 57.1429 | 4 | yes |
GO:0010648 | negative regulation of cell communication | 57.1429 | 5 | yes |
GO:0023057 | negative regulation of signaling | 57.1429 | 4 | yes |
GO:0048585 | negative regulation of response to stimulus | 57.1429 | 4 | yes |
GO:0048584 | positive regulation of response to stimulus | 57.1429 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 57.1429 | 5 | no |
GO:0031344 | regulation of cell projection organization | 50.0000 | 5 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 50.0000 | 6 | no |
GO:0009896 | positive regulation of catabolic process | 50.0000 | 5 | yes |
GO:0009968 | negative regulation of signal transduction | 50.0000 | 5 | yes |
GO:0010647 | positive regulation of cell communication | 50.0000 | 5 | no |
GO:0023056 | positive regulation of signaling | 50.0000 | 4 | no |
GO:0034330 | cell junction organization | 50.0000 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 50.0000 | 4 | no |
GO:0008104 | protein localization | 50.0000 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 50.0000 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 50.0000 | 4 | no |
GO:0010468 | regulation of gene expression | 50.0000 | 5 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 50.0000 | 5 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 50.0000 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 50.0000 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 50.0000 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 50.0000 | 5 | no |
GO:0031399 | regulation of protein modification process | 50.0000 | 6 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 50.0000 | 5 | no |
GO:0060341 | regulation of cellular localization | 42.8571 | 4 | no |
GO:0019220 | regulation of phosphate metabolic process | 42.8571 | 6 | no |
GO:0031329 | regulation of cellular catabolic process | 42.8571 | 5 | no |
GO:0051174 | regulation of phosphorus metabolic process | 42.8571 | 5 | no |
GO:0030030 | cell projection organization | 42.8571 | 4 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 42.8571 | 5 | no |
GO:0006996 | organelle organization | 42.8571 | 4 | yes |
GO:0016055 | Wnt signaling pathway | 42.8571 | 5 | yes |
GO:0030111 | regulation of Wnt signaling pathway | 42.8571 | 5 | yes |
GO:0033043 | regulation of organelle organization | 42.8571 | 5 | yes |
GO:0042176 | regulation of protein catabolic process | 42.8571 | 5 | yes |
GO:0045595 | regulation of cell differentiation | 42.8571 | 4 | yes |
GO:0045732 | positive regulation of protein catabolic process | 42.8571 | 6 | yes |
GO:1905114 | cell surface receptor signaling pathway involved in cell-cell signaling | 42.8571 | 4 | yes |
GO:0009967 | positive regulation of signal transduction | 42.8571 | 5 | no |
GO:0051049 | regulation of transport | 42.8571 | 4 | no |
GO:0051094 | positive regulation of developmental process | 42.8571 | 4 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 42.8571 | 5 | no |
GO:0051248 | negative regulation of protein metabolic process | 42.8571 | 6 | no |
GO:0051252 | regulation of RNA metabolic process | 42.8571 | 5 | no |
GO:0001932 | regulation of protein phosphorylation | 35.7143 | 7 | no |
GO:0042325 | regulation of phosphorylation | 35.7143 | 7 | no |
GO:0031346 | positive regulation of cell projection organization | 35.7143 | 6 | no |
GO:0033365 | protein localization to organelle | 35.7143 | 5 | no |
GO:0043393 | regulation of protein binding | 35.7143 | 4 | no |
GO:0007010 | cytoskeleton organization | 35.7143 | 5 | yes |
GO:0030178 | negative regulation of Wnt signaling pathway | 35.7143 | 6 | yes |
GO:0032886 | regulation of microtubule-based process | 35.7143 | 4 | yes |
GO:0051493 | regulation of cytoskeleton organization | 35.7143 | 6 | yes |
GO:0060828 | regulation of canonical Wnt signaling pathway | 35.7143 | 6 | yes |
GO:0070507 | regulation of microtubule cytoskeleton organization | 35.7143 | 5 | yes |
GO:0090090 | negative regulation of canonical Wnt signaling pathway | 35.7143 | 7 | yes |
GO:0034329 | cell junction assembly | 35.7143 | 5 | no |
GO:0044089 | positive regulation of cellular component biogenesis | 35.7143 | 5 | no |
GO:0050804 | modulation of chemical synaptic transmission | 35.7143 | 5 | no |
GO:0099177 | regulation of trans-synaptic signaling | 35.7143 | 4 | no |
GO:0009890 | negative regulation of biosynthetic process | 35.7143 | 5 | no |
GO:0009891 | positive regulation of biosynthetic process | 35.7143 | 5 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 35.7143 | 6 | no |
GO:0010558 | negative regulation of macromolecule biosynthetic process | 35.7143 | 6 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 35.7143 | 4 | no |
GO:0031327 | negative regulation of cellular biosynthetic process | 35.7143 | 6 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 35.7143 | 6 | no |
GO:0031401 | positive regulation of protein modification process | 35.7143 | 7 | no |
GO:0032880 | regulation of protein localization | 35.7143 | 5 | no |
GO:0051099 | positive regulation of binding | 35.7143 | 4 | no |
GO:0051338 | regulation of transferase activity | 35.7143 | 4 | no |
GO:0060284 | regulation of cell development | 28.5714 | 5 | no |
GO:0080134 | regulation of response to stress | 28.5714 | 4 | no |
GO:0080135 | regulation of cellular response to stress | 28.5714 | 4 | no |
GO:1901699 | cellular response to nitrogen compound | 28.5714 | 4 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 28.5714 | 7 | no |
GO:2000112 | regulation of cellular macromolecule biosynthetic process | 28.5714 | 6 | no |
GO:2001141 | regulation of RNA biosynthetic process | 28.5714 | 6 | no |
GO:0001934 | positive regulation of protein phosphorylation | 28.5714 | 8 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 28.5714 | 6 | no |
GO:0042327 | positive regulation of phosphorylation | 28.5714 | 8 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 28.5714 | 7 | no |
GO:0060491 | regulation of cell projection assembly | 28.5714 | 5 | no |
GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 28.5714 | 6 | no |
GO:0030162 | regulation of proteolysis | 28.5714 | 6 | no |
GO:0045862 | positive regulation of proteolysis | 28.5714 | 7 | no |
GO:1903050 | regulation of proteolysis involved in protein catabolic process | 28.5714 | 7 | no |
GO:1903052 | positive regulation of proteolysis involved in protein catabolic process | 28.5714 | 8 | no |
GO:0010975 | regulation of neuron projection development | 28.5714 | 7 | no |
GO:0031175 | neuron projection development | 28.5714 | 6 | no |
GO:0044380 | protein localization to cytoskeleton | 28.5714 | 6 | no |
GO:0072698 | protein localization to microtubule cytoskeleton | 28.5714 | 7 | no |
GO:0031110 | regulation of microtubule polymerization or depolymerization | 28.5714 | 6 | yes |
GO:0043085 | positive regulation of catalytic activity | 28.5714 | 4 | yes |
GO:0051129 | negative regulation of cellular component organization | 28.5714 | 5 | yes |
GO:1902903 | regulation of supramolecular fiber organization | 28.5714 | 5 | yes |
GO:0043269 | regulation of ion transport | 28.5714 | 5 | no |
GO:0050808 | synapse organization | 28.5714 | 5 | no |
GO:0051050 | positive regulation of transport | 28.5714 | 4 | no |
GO:0051240 | positive regulation of multicellular organismal process | 28.5714 | 4 | no |
GO:0051960 | regulation of nervous system development | 28.5714 | 5 | no |
GO:2000026 | regulation of multicellular organismal development | 28.5714 | 4 | no |
GO:0007043 | cell-cell junction assembly | 28.5714 | 6 | no |
GO:0045216 | cell-cell junction organization | 28.5714 | 5 | no |
GO:0006355 | regulation of DNA-templated transcription | 28.5714 | 6 | no |
GO:0010628 | positive regulation of gene expression | 28.5714 | 6 | no |
GO:0010629 | negative regulation of gene expression | 28.5714 | 6 | no |
GO:0010941 | regulation of cell death | 28.5714 | 4 | no |
GO:0010942 | positive regulation of cell death | 28.5714 | 5 | no |
GO:0031400 | negative regulation of protein modification process | 28.5714 | 7 | no |
GO:0042127 | regulation of cell population proliferation | 28.5714 | 4 | no |
GO:0042981 | regulation of apoptotic process | 28.5714 | 6 | no |
GO:0043067 | regulation of programmed cell death | 28.5714 | 5 | no |
GO:0060070 | canonical Wnt signaling pathway | 21.4286 | 6 | no |
GO:0060548 | negative regulation of cell death | 21.4286 | 5 | no |
GO:0071310 | cellular response to organic substance | 21.4286 | 4 | no |
GO:0071417 | cellular response to organonitrogen compound | 21.4286 | 4 | no |
GO:1901701 | cellular response to oxygen-containing compound | 21.4286 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 21.4286 | 5 | no |
GO:1902680 | positive regulation of RNA biosynthetic process | 21.4286 | 7 | no |
GO:1902692 | regulation of neuroblast proliferation | 21.4286 | 6 | no |
GO:1903508 | positive regulation of nucleic acid-templated transcription | 21.4286 | 8 | no |
GO:2000177 | regulation of neural precursor cell proliferation | 21.4286 | 5 | no |
GO:2001233 | regulation of apoptotic signaling pathway | 21.4286 | 5 | no |
GO:2001234 | negative regulation of apoptotic signaling pathway | 21.4286 | 6 | no |
GO:2000113 | negative regulation of cellular macromolecule biosynthetic process | 21.4286 | 7 | no |
GO:0006974 | cellular response to DNA damage stimulus | 21.4286 | 4 | no |
GO:0017157 | regulation of exocytosis | 21.4286 | 5 | no |
GO:0046928 | regulation of neurotransmitter secretion | 21.4286 | 4 | no |
GO:0051046 | regulation of secretion | 21.4286 | 5 | no |
GO:0051588 | regulation of neurotransmitter transport | 21.4286 | 5 | no |
GO:0060627 | regulation of vesicle-mediated transport | 21.4286 | 4 | no |
GO:0061136 | regulation of proteasomal protein catabolic process | 21.4286 | 6 | no |
GO:0120034 | positive regulation of plasma membrane bounded cell projection assembly | 21.4286 | 6 | no |
GO:1901800 | positive regulation of proteasomal protein catabolic process | 21.4286 | 7 | no |
GO:1903305 | regulation of regulated secretory pathway | 21.4286 | 6 | no |
GO:1903530 | regulation of secretion by cell | 21.4286 | 4 | no |
GO:2000300 | regulation of synaptic vesicle exocytosis | 21.4286 | 5 | no |
GO:0097435 | supramolecular fiber organization | 21.4286 | 4 | no |
GO:0031331 | positive regulation of cellular catabolic process | 21.4286 | 6 | no |
GO:0032091 | negative regulation of protein binding | 21.4286 | 5 | no |
GO:0051100 | negative regulation of binding | 21.4286 | 4 | no |
GO:0070925 | organelle assembly | 21.4286 | 5 | no |
GO:2000058 | regulation of ubiquitin-dependent protein catabolic process | 21.4286 | 6 | no |
GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process | 21.4286 | 7 | no |
GO:0010563 | negative regulation of phosphorus metabolic process | 21.4286 | 6 | no |
GO:0043086 | negative regulation of catalytic activity | 21.4286 | 4 | no |
GO:0043549 | regulation of kinase activity | 21.4286 | 5 | no |
GO:0043933 | protein-containing complex organization | 21.4286 | 4 | no |
GO:0045859 | regulation of protein kinase activity | 21.4286 | 6 | no |
GO:0045936 | negative regulation of phosphate metabolic process | 21.4286 | 7 | no |
GO:0051348 | negative regulation of transferase activity | 21.4286 | 5 | no |
GO:1903829 | positive regulation of protein localization | 21.4286 | 5 | no |
GO:0032092 | positive regulation of protein binding | 21.4286 | 5 | no |
GO:0035372 | protein localization to microtubule | 21.4286 | 8 | no |
GO:0043254 | regulation of protein-containing complex assembly | 21.4286 | 5 | no |
GO:0007399 | nervous system development | 21.4286 | 4 | yes |
GO:0010639 | negative regulation of organelle organization | 21.4286 | 6 | yes |
GO:0031111 | negative regulation of microtubule polymerization or depolymerization | 21.4286 | 7 | yes |
GO:0051494 | negative regulation of cytoskeleton organization | 21.4286 | 7 | yes |
GO:1902904 | negative regulation of supramolecular fiber organization | 21.4286 | 6 | yes |
GO:0022898 | regulation of transmembrane transporter activity | 21.4286 | 4 | no |
GO:0031644 | regulation of nervous system process | 21.4286 | 5 | no |
GO:0032412 | regulation of ion transmembrane transporter activity | 21.4286 | 5 | no |
GO:0034762 | regulation of transmembrane transport | 21.4286 | 4 | no |
GO:0034765 | regulation of ion transmembrane transport | 21.4286 | 5 | no |
GO:0044057 | regulation of system process | 21.4286 | 4 | no |
GO:0050807 | regulation of synapse organization | 21.4286 | 5 | no |
GO:0051962 | positive regulation of nervous system development | 21.4286 | 5 | no |
GO:1904062 | regulation of cation transmembrane transport | 21.4286 | 6 | no |
GO:1990138 | neuron projection extension | 21.4286 | 4 | no |
GO:0006357 | regulation of transcription by RNA polymerase II | 21.4286 | 7 | no |
GO:0008285 | negative regulation of cell population proliferation | 21.4286 | 5 | no |
GO:0010243 | response to organonitrogen compound | 21.4286 | 4 | no |
GO:0010638 | positive regulation of organelle organization | 21.4286 | 6 | no |
GO:0010721 | negative regulation of cell development | 21.4286 | 6 | no |
GO:0010959 | regulation of metal ion transport | 21.4286 | 6 | no |
GO:0036211 | protein modification process | 21.4286 | 4 | no |
GO:0043065 | positive regulation of apoptotic process | 21.4286 | 7 | no |
GO:0043066 | negative regulation of apoptotic process | 21.4286 | 7 | no |
GO:0043068 | positive regulation of programmed cell death | 21.4286 | 6 | no |
GO:0043069 | negative regulation of programmed cell death | 21.4286 | 6 | no |
GO:0043412 | macromolecule modification | 21.4286 | 4 | no |
GO:0045596 | negative regulation of cell differentiation | 21.4286 | 5 | no |
GO:0045597 | positive regulation of cell differentiation | 21.4286 | 5 | no |
GO:0045893 | positive regulation of DNA-templated transcription | 21.4286 | 7 | no |
GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 21.4286 | 6 | no |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 21.4286 | 6 | no |
GO:0050767 | regulation of neurogenesis | 21.4286 | 6 | no |
GO:0051093 | negative regulation of developmental process | 21.4286 | 4 | no |
GO:0051241 | negative regulation of multicellular organismal process | 21.4286 | 4 | no |
GO:0051253 | negative regulation of RNA metabolic process | 21.4286 | 6 | no |
GO:0051254 | positive regulation of RNA metabolic process | 21.4286 | 6 | no |
GO:0051726 | regulation of cell cycle | 21.4286 | 4 | no |
GO:0007026 | negative regulation of microtubule depolymerization | 14.2857 | 7 | yes |
GO:0031114 | regulation of microtubule depolymerization | 14.2857 | 6 | yes |
GO:0043087 | regulation of GTPase activity | 14.2857 | 5 | yes |
GO:0043242 | negative regulation of protein-containing complex disassembly | 14.2857 | 6 | yes |
GO:0043244 | regulation of protein-containing complex disassembly | 14.2857 | 5 | yes |
GO:0043547 | positive regulation of GTPase activity | 14.2857 | 6 | yes |
GO:0051336 | regulation of hydrolase activity | 14.2857 | 4 | yes |
GO:0051345 | positive regulation of hydrolase activity | 14.2857 | 5 | yes |
GO:1901879 | regulation of protein depolymerization | 14.2857 | 6 | yes |
GO:1901880 | negative regulation of protein depolymerization | 14.2857 | 7 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
ASPP2_HUMAN | [view interactions] | Low throughput | no | yes |
MARE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MARE3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AXIN2_HUMAN | [view interactions] | Low throughput | no | yes |
CTNB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AXIN1_HUMAN | [view interactions] | Low throughput | no | yes |
ACTS_HUMAN | [view interactions] | Low throughput | no | no |
NEDD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
YAP1_HUMAN | [view interactions] | High throughput | no | yes |
NEK4_HUMAN | [view interactions] | High throughput | no | yes |
TIMP2_HUMAN | [view interactions] | High throughput | no | no |
FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NLGN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SMCA2_HUMAN | [view interactions] | High throughput | no | yes |
YBOX1_HUMAN | [view interactions] | High throughput | no | yes |
DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NFX1_HUMAN | [view interactions] | High throughput | no | yes |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
KI20A_HUMAN | [view interactions] | High throughput | no | yes |
GSK3B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SKP1_HUMAN | [view interactions] | Computational | no | yes |
SPT13_HUMAN | [view interactions] | Computational | no | yes |
DVL2_HUMAN | [view interactions] | Computational | no | yes |
TCF7_HUMAN | [view interactions] | Computational | no | no |
DVL3_HUMAN | [view interactions] | Computational | no | yes |
TBL1R_HUMAN | [view interactions] | Computational | no | yes |
ARHG4_HUMAN | [view interactions] | Computational | no | yes |
CTND1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
APC_HUMAN | [view entry] [view interactions] | Computational | yes | no |
DVL1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CTNA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |