Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PLCB4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
329 Asn Thr Auriculocondylarsyndrome2(ARCND2) -
621 Arg Cys Auriculocondylarsyndrome2(ARCND2) -
621 Arg His Auriculocondylarsyndrome2(ARCND2) -
623 Tyr Cys Auriculocondylarsyndrome2(ARCND2) -
650 Asn His Auriculocondylarsyndrome2(ARCND2) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PLCB4_HUMAN
GO:0043168 anion binding 76.9231 4 no
GO:0000166 nucleotide binding 69.2308 4 no
GO:0017076 purine nucleotide binding 69.2308 5 no
GO:0032555 purine ribonucleotide binding 69.2308 4 no
GO:0003924 GTPase activity 61.5385 7 no
GO:0005525 GTP binding 61.5385 5 no
GO:0016462 pyrophosphatase activity 61.5385 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 61.5385 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 61.5385 6 no
GO:0019001 guanyl nucleotide binding 61.5385 6 no
GO:0032561 guanyl ribonucleotide binding 61.5385 5 no
GO:0035639 purine ribonucleoside triphosphate binding 61.5385 4 no
GO:0019900 kinase binding 38.4615 4 no
GO:0019901 protein kinase binding 38.4615 5 no
GO:0005509 calcium ion binding 15.3846 6 yes
GO:0043169 cation binding 15.3846 4 yes
GO:0046872 metal ion binding 15.3846 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PLCB4_HUMAN
GO:0048522 positive regulation of cellular process 76.9231 4 no
GO:0022607 cellular component assembly 69.2308 4 no
GO:0051128 regulation of cellular component organization 69.2308 4 no
GO:0097435 supramolecular fiber organization 61.5385 4 no
GO:0030334 regulation of cell migration 53.8462 5 no
GO:0141124 intracellular signaling cassette 53.8462 4 no
GO:2000145 regulation of cell motility 53.8462 4 no
GO:0044087 regulation of cellular component biogenesis 53.8462 4 no
GO:0007015 actin filament organization 53.8462 5 no
GO:0007264 small GTPase-mediated signal transduction 53.8462 5 no
GO:0033043 regulation of organelle organization 46.1538 5 no
GO:0060255 regulation of macromolecule metabolic process 46.1538 4 no
GO:0080090 regulation of primary metabolic process 46.1538 4 no
GO:0030335 positive regulation of cell migration 46.1538 6 no
GO:0031344 regulation of cell projection organization 46.1538 5 no
GO:0040017 positive regulation of locomotion 46.1538 4 no
GO:0051049 regulation of transport 46.1538 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 46.1538 6 no
GO:2000147 positive regulation of cell motility 46.1538 5 no
GO:0048584 positive regulation of response to stimulus 46.1538 4 no
GO:0006996 organelle organization 46.1538 4 no
GO:0007010 cytoskeleton organization 46.1538 5 no
GO:0030030 cell projection organization 38.4615 4 no
GO:0030155 regulation of cell adhesion 38.4615 4 no
GO:0032956 regulation of actin cytoskeleton organization 38.4615 5 no
GO:0032970 regulation of actin filament-based process 38.4615 4 no
GO:0051493 regulation of cytoskeleton organization 38.4615 6 no
GO:0061024 membrane organization 38.4615 4 no
GO:0060341 regulation of cellular localization 38.4615 4 no
GO:0060491 regulation of cell projection assembly 38.4615 5 no
GO:0120032 regulation of plasma membrane bounded cell projection assembly 38.4615 6 no
GO:0009966 regulation of signal transduction 38.4615 4 no
GO:0009967 positive regulation of signal transduction 38.4615 5 no
GO:0010646 regulation of cell communication 38.4615 4 no
GO:0010647 positive regulation of cell communication 38.4615 5 no
GO:0023056 positive regulation of signaling 38.4615 4 no
GO:0044089 positive regulation of cellular component biogenesis 38.4615 5 no
GO:0051130 positive regulation of cellular component organization 38.4615 5 no
GO:0009893 positive regulation of metabolic process 38.4615 4 no
GO:0010604 positive regulation of macromolecule metabolic process 38.4615 5 no
GO:0031323 regulation of cellular metabolic process 38.4615 4 no
GO:0048523 negative regulation of cellular process 38.4615 4 yes
GO:0010810 regulation of cell-substrate adhesion 38.4615 5 no
GO:0022603 regulation of anatomical structure morphogenesis 30.7692 4 no
GO:0030031 cell projection assembly 30.7692 5 no
GO:0031175 neuron projection development 30.7692 6 no
GO:0045785 positive regulation of cell adhesion 30.7692 5 no
GO:0098916 anterograde trans-synaptic signaling 30.7692 6 no
GO:0099024 plasma membrane invagination 30.7692 6 no
GO:0099536 synaptic signaling 30.7692 4 no
GO:0099537 trans-synaptic signaling 30.7692 5 no
GO:0120036 plasma membrane bounded cell projection organization 30.7692 5 no
GO:0008104 protein localization 30.7692 4 no
GO:0010632 regulation of epithelial cell migration 30.7692 4 no
GO:0032880 regulation of protein localization 30.7692 5 no
GO:0051726 regulation of cell cycle 30.7692 4 no
GO:0060627 regulation of vesicle-mediated transport 30.7692 4 no
GO:0050807 regulation of synapse organization 30.7692 5 no
GO:0007266 Rho protein signal transduction 30.7692 6 no
GO:0009889 regulation of biosynthetic process 30.7692 4 no
GO:0010468 regulation of gene expression 30.7692 6 no
GO:0010556 regulation of macromolecule biosynthetic process 30.7692 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.7692 5 no
GO:0031325 positive regulation of cellular metabolic process 30.7692 5 no
GO:0031326 regulation of cellular biosynthetic process 30.7692 5 no
GO:0042127 regulation of cell population proliferation 30.7692 4 no
GO:2000377 regulation of reactive oxygen species metabolic process 30.7692 5 no
GO:0002685 regulation of leukocyte migration 30.7692 4 no
GO:0007268 chemical synaptic transmission 30.7692 7 no
GO:0010324 membrane invagination 30.7692 5 no
GO:0016055 Wnt signaling pathway 30.7692 4 no
GO:0022604 regulation of cell morphogenesis 23.0769 5 no
GO:0030865 cortical cytoskeleton organization 23.0769 6 no
GO:0060326 cell chemotaxis 23.0769 4 no
GO:1900024 regulation of substrate adhesion-dependent cell spreading 23.0769 6 no
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 23.0769 7 no
GO:1902622 regulation of neutrophil migration 23.0769 5 no
GO:0032101 regulation of response to external stimulus 23.0769 4 no
GO:0050920 regulation of chemotaxis 23.0769 4 no
GO:0051246 regulation of protein metabolic process 23.0769 5 no
GO:0010564 regulation of cell cycle process 23.0769 5 no
GO:0010634 positive regulation of epithelial cell migration 23.0769 5 no
GO:0032465 regulation of cytokinesis 23.0769 5 no
GO:0032535 regulation of cellular component size 23.0769 4 no
GO:0045787 positive regulation of cell cycle 23.0769 5 no
GO:0051302 regulation of cell division 23.0769 4 no
GO:0090068 positive regulation of cell cycle process 23.0769 6 no
GO:0034329 cell junction assembly 23.0769 5 no
GO:0034330 cell junction organization 23.0769 4 no
GO:0044057 regulation of system process 23.0769 4 no
GO:0051050 positive regulation of transport 23.0769 4 no
GO:0051094 positive regulation of developmental process 23.0769 4 no
GO:0051240 positive regulation of multicellular organismal process 23.0769 4 no
GO:1901888 regulation of cell junction assembly 23.0769 5 no
GO:2000026 regulation of multicellular organismal development 23.0769 4 no
GO:0002684 positive regulation of immune system process 23.0769 4 no
GO:0002687 positive regulation of leukocyte migration 23.0769 5 no
GO:0006355 regulation of DNA-templated transcription 23.0769 7 no
GO:0010594 regulation of endothelial cell migration 23.0769 5 no
GO:0010638 positive regulation of organelle organization 23.0769 6 no
GO:0030336 negative regulation of cell migration 23.0769 6 no
GO:0032231 regulation of actin filament bundle assembly 23.0769 5 no
GO:0032233 positive regulation of actin filament bundle assembly 23.0769 6 no
GO:0035567 non-canonical Wnt signaling pathway 23.0769 5 no
GO:0040013 negative regulation of locomotion 23.0769 4 no
GO:0042981 regulation of apoptotic process 23.0769 5 no
GO:0043067 regulation of programmed cell death 23.0769 4 no
GO:0043254 regulation of protein-containing complex assembly 23.0769 5 no
GO:0051252 regulation of RNA metabolic process 23.0769 5 no
GO:0051492 regulation of stress fiber assembly 23.0769 6 no
GO:0051495 positive regulation of cytoskeleton organization 23.0769 7 no
GO:0051496 positive regulation of stress fiber assembly 23.0769 7 no
GO:0060071 Wnt signaling pathway, planar cell polarity pathway 23.0769 6 no
GO:0071310 cellular response to organic substance 23.0769 4 no
GO:0099159 regulation of modification of postsynaptic structure 23.0769 7 no
GO:0110020 regulation of actomyosin structure organization 23.0769 6 no
GO:0110053 regulation of actin filament organization 23.0769 6 no
GO:1901701 cellular response to oxygen-containing compound 23.0769 4 no
GO:1902531 regulation of intracellular signal transduction 23.0769 5 no
GO:1902533 positive regulation of intracellular signal transduction 23.0769 6 no
GO:1902903 regulation of supramolecular fiber organization 23.0769 5 no
GO:1902905 positive regulation of supramolecular fiber organization 23.0769 6 no
GO:1905244 regulation of modification of synaptic structure 23.0769 6 no
GO:2000146 negative regulation of cell motility 23.0769 5 no
GO:2001141 regulation of RNA biosynthetic process 23.0769 6 no
GO:0043933 protein-containing complex organization 23.0769 4 no
GO:0065003 protein-containing complex assembly 23.0769 5 no
GO:0008284 positive regulation of cell population proliferation 23.0769 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 23.0769 5 no
GO:1903829 positive regulation of protein localization 23.0769 5 no
GO:0010591 regulation of lamellipodium assembly 23.0769 7 no
GO:0010592 positive regulation of lamellipodium assembly 23.0769 7 no
GO:0031346 positive regulation of cell projection organization 23.0769 6 no
GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 23.0769 6 no
GO:1902743 regulation of lamellipodium organization 23.0769 7 no
GO:1902745 positive regulation of lamellipodium organization 23.0769 7 no
GO:0006811 monoatomic ion transport 23.0769 4 yes
GO:0006812 monoatomic cation transport 23.0769 5 yes
GO:0030001 metal ion transport 23.0769 6 yes
GO:0098655 monoatomic cation transmembrane transport 23.0769 4 yes
GO:0098662 inorganic cation transmembrane transport 23.0769 4 yes
GO:0006911 phagocytosis, engulfment 23.0769 7 no
GO:0010811 positive regulation of cell-substrate adhesion 23.0769 6 no
GO:0016601 Rac protein signal transduction 23.0769 6 no
GO:0006816 calcium ion transport 15.3846 7 yes
GO:0070588 calcium ion transmembrane transport 15.3846 5 yes
GO:0097553 calcium ion transmembrane import into cytosol 15.3846 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NMDZ1_HUMAN [view entry] [view interactions] Low throughput yes yes
INADL_HUMAN [view interactions] Low throughput no no
KDM1A_HUMAN [view interactions] High throughput no yes
RUFY1_HUMAN [view interactions] High throughput no yes
UBP14_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
REL_HUMAN [view interactions] High throughput no yes
NLGN3_HUMAN [view entry] [view interactions] High throughput yes yes
MEOX2_HUMAN [view interactions] High throughput no no
HNRPL_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOV_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
CSK_HUMAN [view interactions] High throughput no yes
DPP4_HUMAN [view interactions] High throughput no no
MLP3B_HUMAN [view interactions] High throughput no yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB25_HUMAN [view interactions] High throughput no no