PLCB4_HUMAN
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction. [View more on UniProt]
Interacting region for partners were not defined.
Position | Amino acid | Mutation | Disease | Overlap with binding region |
---|---|---|---|---|
329 | Asn | Thr | Auriculocondylarsyndrome2(ARCND2) | - |
621 | Arg | Cys | Auriculocondylarsyndrome2(ARCND2) | - |
621 | Arg | His | Auriculocondylarsyndrome2(ARCND2) | - |
623 | Tyr | Cys | Auriculocondylarsyndrome2(ARCND2) | - |
650 | Asn | His | Auriculocondylarsyndrome2(ARCND2) | - |
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in PLCB4_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 77.7778 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 77.7778 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 77.7778 | 4 | no |
GO:0019001 | guanyl nucleotide binding | 66.6667 | 5 | no |
GO:0032561 | guanyl ribonucleotide binding | 66.6667 | 5 | no |
GO:0005525 | GTP binding | 61.1111 | 5 | no |
GO:0003924 | GTPase activity | 55.5556 | 7 | no |
GO:0016462 | pyrophosphatase activity | 55.5556 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 55.5556 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 55.5556 | 6 | no |
GO:0019900 | kinase binding | 38.8889 | 4 | no |
GO:0019901 | protein kinase binding | 38.8889 | 5 | no |
GO:0046872 | metal ion binding | 27.7778 | 4 | yes |
GO:0005524 | ATP binding | 22.2222 | 5 | no |
GO:0016301 | kinase activity | 22.2222 | 4 | no |
GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 22.2222 | 4 | no |
GO:0030554 | adenyl nucleotide binding | 22.2222 | 5 | no |
GO:0032559 | adenyl ribonucleotide binding | 22.2222 | 5 | no |
GO:0005509 | calcium ion binding | 11.1111 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in PLCB4_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 66.6667 | 4 | no |
GO:0006996 | organelle organization | 61.1111 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 61.1111 | 4 | no |
GO:0009966 | regulation of signal transduction | 55.5556 | 4 | no |
GO:0010646 | regulation of cell communication | 55.5556 | 4 | no |
GO:0051128 | regulation of cellular component organization | 55.5556 | 4 | no |
GO:0061024 | membrane organization | 55.5556 | 4 | no |
GO:0022607 | cellular component assembly | 50.0000 | 4 | no |
GO:0033043 | regulation of organelle organization | 50.0000 | 5 | no |
GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | no |
GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 44.4444 | 4 | no |
GO:0007010 | cytoskeleton organization | 44.4444 | 5 | no |
GO:0009893 | positive regulation of metabolic process | 44.4444 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 44.4444 | 5 | no |
GO:0044089 | positive regulation of cellular component biogenesis | 38.8889 | 5 | no |
GO:0051049 | regulation of transport | 38.8889 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 38.8889 | 5 | no |
GO:0007015 | actin filament organization | 38.8889 | 5 | no |
GO:0007264 | small GTPase mediated signal transduction | 38.8889 | 4 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 38.8889 | 4 | no |
GO:0022604 | regulation of cell morphogenesis | 38.8889 | 5 | no |
GO:0032956 | regulation of actin cytoskeleton organization | 38.8889 | 5 | no |
GO:0032970 | regulation of actin filament-based process | 38.8889 | 4 | no |
GO:0051493 | regulation of cytoskeleton organization | 38.8889 | 6 | no |
GO:0097435 | supramolecular fiber organization | 38.8889 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 38.8889 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 38.8889 | 4 | no |
GO:0006796 | phosphate-containing compound metabolic process | 38.8889 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 33.3333 | 4 | no |
GO:0051094 | positive regulation of developmental process | 33.3333 | 4 | no |
GO:0007265 | Ras protein signal transduction | 33.3333 | 5 | no |
GO:0008360 | regulation of cell shape | 33.3333 | 6 | no |
GO:0030030 | cell projection organization | 33.3333 | 4 | no |
GO:0030865 | cortical cytoskeleton organization | 33.3333 | 6 | no |
GO:0043085 | positive regulation of catalytic activity | 33.3333 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 33.3333 | 4 | no |
GO:0019220 | regulation of phosphate metabolic process | 33.3333 | 6 | no |
GO:0042325 | regulation of phosphorylation | 33.3333 | 7 | no |
GO:0051174 | regulation of phosphorus metabolic process | 33.3333 | 5 | no |
GO:0009967 | positive regulation of signal transduction | 27.7778 | 5 | no |
GO:0010647 | positive regulation of cell communication | 27.7778 | 5 | no |
GO:0016192 | vesicle-mediated transport | 27.7778 | 4 | no |
GO:0023056 | positive regulation of signaling | 27.7778 | 4 | no |
GO:0010324 | membrane invagination | 27.7778 | 5 | no |
GO:0010810 | regulation of cell-substrate adhesion | 27.7778 | 5 | no |
GO:0030031 | cell projection assembly | 27.7778 | 5 | no |
GO:0030155 | regulation of cell adhesion | 27.7778 | 4 | no |
GO:0030334 | regulation of cell migration | 27.7778 | 5 | no |
GO:0031175 | neuron projection development | 27.7778 | 6 | no |
GO:0031344 | regulation of cell projection organization | 27.7778 | 5 | no |
GO:0042127 | regulation of cell population proliferation | 27.7778 | 4 | no |
GO:0099024 | plasma membrane invagination | 27.7778 | 6 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 27.7778 | 6 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 27.7778 | 5 | no |
GO:2000145 | regulation of cell motility | 27.7778 | 4 | no |
GO:2000377 | regulation of reactive oxygen species metabolic process | 27.7778 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 27.7778 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 27.7778 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 27.7778 | 5 | no |
GO:0010638 | positive regulation of organelle organization | 27.7778 | 6 | no |
GO:0045595 | regulation of cell differentiation | 27.7778 | 4 | no |
GO:0031324 | negative regulation of cellular metabolic process | 27.7778 | 5 | no |
GO:0048585 | negative regulation of response to stimulus | 27.7778 | 4 | no |
GO:0043549 | regulation of kinase activity | 27.7778 | 5 | no |
GO:0051338 | regulation of transferase activity | 27.7778 | 4 | no |
GO:0007268 | chemical synaptic transmission | 22.2222 | 6 | no |
GO:0034329 | cell junction assembly | 22.2222 | 5 | no |
GO:0034330 | cell junction organization | 22.2222 | 4 | no |
GO:0043269 | regulation of ion transport | 22.2222 | 5 | no |
GO:0051050 | positive regulation of transport | 22.2222 | 4 | no |
GO:0098916 | anterograde trans-synaptic signaling | 22.2222 | 5 | no |
GO:0099537 | trans-synaptic signaling | 22.2222 | 4 | no |
GO:0002685 | regulation of leukocyte migration | 22.2222 | 4 | no |
GO:0006911 | phagocytosis, engulfment | 22.2222 | 7 | no |
GO:0008284 | positive regulation of cell population proliferation | 22.2222 | 5 | no |
GO:0030335 | positive regulation of cell migration | 22.2222 | 6 | no |
GO:0040017 | positive regulation of locomotion | 22.2222 | 4 | no |
GO:0060341 | regulation of cellular localization | 22.2222 | 4 | no |
GO:0060491 | regulation of cell projection assembly | 22.2222 | 5 | no |
GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 22.2222 | 6 | no |
GO:2000147 | positive regulation of cell motility | 22.2222 | 5 | no |
GO:0009889 | regulation of biosynthetic process | 22.2222 | 4 | no |
GO:0010468 | regulation of gene expression | 22.2222 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.2222 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 22.2222 | 5 | no |
GO:0051336 | regulation of hydrolase activity | 22.2222 | 4 | no |
GO:0051345 | positive regulation of hydrolase activity | 22.2222 | 5 | no |
GO:0007266 | Rho protein signal transduction | 22.2222 | 6 | no |
GO:0010941 | regulation of cell death | 22.2222 | 4 | no |
GO:0042981 | regulation of apoptotic process | 22.2222 | 6 | no |
GO:0043067 | regulation of programmed cell death | 22.2222 | 5 | no |
GO:0016055 | Wnt signaling pathway | 22.2222 | 5 | no |
GO:0045597 | positive regulation of cell differentiation | 22.2222 | 5 | no |
GO:0045785 | positive regulation of cell adhesion | 22.2222 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 22.2222 | 5 | no |
GO:1905114 | cell surface receptor signaling pathway involved in cell-cell signaling | 22.2222 | 4 | no |
GO:0009894 | regulation of catabolic process | 22.2222 | 4 | no |
GO:0031329 | regulation of cellular catabolic process | 22.2222 | 5 | no |
GO:0043086 | negative regulation of catalytic activity | 22.2222 | 4 | no |
GO:0009968 | negative regulation of signal transduction | 22.2222 | 5 | no |
GO:0010648 | negative regulation of cell communication | 22.2222 | 5 | no |
GO:0023057 | negative regulation of signaling | 22.2222 | 4 | no |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
NMDZ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
INADL_HUMAN | [view interactions] | Low throughput | no | no |
KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
RUFY1_HUMAN | [view interactions] | High throughput | no | yes |
UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
REL_HUMAN | [view interactions] | High throughput | no | yes |
NLGN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MEOX2_HUMAN | [view interactions] | High throughput | no | no |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
P53_HUMAN | [view interactions] | High throughput | no | no |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
RHOQ_HUMAN | [view interactions] | High throughput | no | no |
RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOC_HUMAN | [view interactions] | High throughput | no | no |
RHOD_HUMAN | [view interactions] | High throughput | no | no |
RHOF_HUMAN | [view interactions] | High throughput | no | no |
RHOV_HUMAN | [view interactions] | High throughput | no | no |
RHOH_HUMAN | [view interactions] | High throughput | no | yes |
CSK_HUMAN | [view interactions] | High throughput | no | yes |
DPP4_HUMAN | [view interactions] | High throughput | no | no |
MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
PI42B_HUMAN | [view entry] [view interactions] | Computational | yes | no |
PI5L1_HUMAN | [view interactions] | Computational | no | no |
KGP2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CASR_HUMAN | [view interactions] | Computational | no | no |
GNA11_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GNAI3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GNA15_HUMAN | [view interactions] | Computational | no | yes |
GNAQ_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PI51B_HUMAN | [view interactions] | Computational | no | yes |
GPC6A_HUMAN | [view interactions] | Computational | no | no |
PI42C_HUMAN | [view interactions] | Computational | no | yes |
KGP1_HUMAN | [view interactions] | Computational | no | yes |
ITPR2_HUMAN | [view interactions] | Computational | no | yes |
GNAT3_HUMAN | [view interactions] | Computational | no | no |
PI42A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PI51C_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ITPR3_HUMAN | [view interactions] | Computational | no | yes |
PI51A_HUMAN | [view interactions] | Computational | no | yes |