SV2A_HUMAN
Evidence for PS localization
Functions
(Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA); glycosylation is not essential but enhances the interaction (PubMed). Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SV2A_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 26.6667 | 4 | no |
| GO:0017076 | purine nucleotide binding | 26.6667 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 26.6667 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.6667 | 4 | no |
| GO:0019900 | kinase binding | 20.0000 | 4 | yes |
| GO:0019901 | protein kinase binding | 16.6667 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SV2A_HUMAN |
|---|---|---|---|---|
| GO:0051049 | regulation of transport | 70.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 66.6667 | 4 | no |
| GO:0010646 | regulation of cell communication | 60.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 56.6667 | 4 | no |
| GO:0009966 | regulation of signal transduction | 46.6667 | 4 | no |
| GO:0051050 | positive regulation of transport | 46.6667 | 4 | no |
| GO:0022607 | cellular component assembly | 43.3333 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 43.3333 | 4 | no |
| GO:0008104 | protein localization | 43.3333 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 40.0000 | 4 | no |
| GO:0006996 | organelle organization | 40.0000 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 40.0000 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 40.0000 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 40.0000 | 4 | no |
| GO:0043269 | regulation of ion transport | 36.6667 | 5 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 36.6667 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 36.6667 | 4 | no |
| GO:0051046 | regulation of secretion | 33.3333 | 5 | yes |
| GO:0031323 | regulation of cellular metabolic process | 33.3333 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 33.3333 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 30.0000 | 5 | no |
| GO:0071310 | cellular response to organic substance | 30.0000 | 4 | no |
| GO:0006897 | endocytosis | 30.0000 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 30.0000 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 30.0000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 30.0000 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.0000 | 5 | no |
| GO:0030030 | cell projection organization | 26.6667 | 4 | no |
| GO:0033043 | regulation of organelle organization | 26.6667 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 26.6667 | 5 | no |
| GO:0016050 | vesicle organization | 26.6667 | 5 | no |
| GO:0023056 | positive regulation of signaling | 26.6667 | 4 | no |
| GO:0061024 | membrane organization | 26.6667 | 4 | no |
| GO:1903530 | regulation of secretion by cell | 26.6667 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 26.6667 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.6667 | 5 | no |
| GO:0031399 | regulation of protein modification process | 26.6667 | 6 | no |
| GO:0034762 | regulation of transmembrane transport | 26.6667 | 4 | no |
| GO:0034765 | regulation of ion transmembrane transport | 26.6667 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 26.6667 | 7 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 26.6667 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 26.6667 | 6 | no |
| GO:1904062 | regulation of cation transmembrane transport | 26.6667 | 6 | no |
| GO:0015031 | protein transport | 23.3333 | 4 | no |
| GO:0071702 | organic substance transport | 23.3333 | 4 | no |
| GO:0071705 | nitrogen compound transport | 23.3333 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 23.3333 | 4 | no |
| GO:0031175 | neuron projection development | 23.3333 | 6 | no |
| GO:0072657 | protein localization to membrane | 23.3333 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 23.3333 | 5 | no |
| GO:0017157 | regulation of exocytosis | 23.3333 | 5 | no |
| GO:0043933 | protein-containing complex organization | 23.3333 | 4 | yes |
| GO:0031344 | regulation of cell projection organization | 23.3333 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 23.3333 | 6 | no |
| GO:0001932 | regulation of protein phosphorylation | 23.3333 | 7 | no |
| GO:0009892 | negative regulation of metabolic process | 23.3333 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 23.3333 | 6 | no |
| GO:0010564 | regulation of cell cycle process | 23.3333 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 23.3333 | 5 | no |
| GO:0022898 | regulation of transmembrane transporter activity | 23.3333 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 23.3333 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 23.3333 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 23.3333 | 7 | no |
| GO:0032412 | regulation of ion transmembrane transporter activity | 23.3333 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 23.3333 | 4 | no |
| GO:0043270 | positive regulation of ion transport | 23.3333 | 5 | no |
| GO:0044057 | regulation of system process | 23.3333 | 4 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 23.3333 | 7 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 23.3333 | 5 | no |
| GO:0051336 | regulation of hydrolase activity | 23.3333 | 4 | no |
| GO:0051726 | regulation of cell cycle | 23.3333 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 20.0000 | 5 | yes |
| GO:0048878 | chemical homeostasis | 16.6667 | 4 | yes |
| GO:0050801 | ion homeostasis | 13.3333 | 5 | yes |
| GO:0006873 | cellular ion homeostasis | 10.0000 | 4 | yes |
| GO:0030003 | cellular cation homeostasis | 10.0000 | 5 | yes |
| GO:0051952 | regulation of amine transport | 10.0000 | 5 | yes |
| GO:0055080 | cation homeostasis | 10.0000 | 6 | yes |
| GO:0098771 | inorganic ion homeostasis | 10.0000 | 6 | yes |
| GO:0006874 | cellular calcium ion homeostasis | 6.6667 | 7 | yes |
| GO:0006875 | cellular metal ion homeostasis | 6.6667 | 6 | yes |
| GO:0055065 | metal ion homeostasis | 6.6667 | 7 | yes |
| GO:0055074 | calcium ion homeostasis | 6.6667 | 8 | yes |
| GO:0072503 | cellular divalent inorganic cation homeostasis | 6.6667 | 6 | yes |
| GO:0072507 | divalent inorganic cation homeostasis | 6.6667 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in SV2A_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 6.6667 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 6.6667 | 5 | no |
| DOID:114 | heart disease | 6.6667 | 3 | no |
| DOID:2843 | long QT syndrome | 6.6667 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MAGI2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| APBB1_HUMAN | [view interactions] | Low throughput | no | yes |
| SYT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RIN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HELLS_HUMAN | [view interactions] | High throughput | no | yes |
| F91A1_HUMAN | [view interactions] | High throughput | no | yes |
| NDUB3_HUMAN | [view interactions] | High throughput | no | yes |
| EXTL3_HUMAN | [view interactions] | High throughput | no | yes |
| DHB7_HUMAN | [view interactions] | High throughput | no | yes |
| MICU2_HUMAN | [view interactions] | High throughput | no | yes |
| JPH1_HUMAN | [view interactions] | High throughput | no | no |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| ELOV5_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| PEX14_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GIT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| LT4R2_HUMAN | [view interactions] | High throughput | no | no |
| CI072_HUMAN | [view interactions] | High throughput | no | no |
| FYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ETS1_HUMAN | [view interactions] | High throughput | no | no |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LEG8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| CLC2D_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BACD3_HUMAN | [view interactions] | High throughput | no | yes |
| BRD1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI66_HUMAN | [view interactions] | High throughput | no | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| PXMP2_HUMAN | [view interactions] | High throughput | no | no |
| ORML3_HUMAN | [view interactions] | High throughput | no | no |
| SPG7_HUMAN | [view interactions] | High throughput | no | no |
| TBB8_HUMAN | [view interactions] | High throughput | no | no |
| RN5A_HUMAN | [view interactions] | High throughput | no | yes |
| FADS1_HUMAN | [view interactions] | High throughput | no | yes |
| MCU_HUMAN | [view interactions] | High throughput | no | yes |
| STK39_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UPK2_HUMAN | [view interactions] | High throughput | no | no |
| ELOV4_HUMAN | [view interactions] | High throughput | no | no |
| GNL3L_HUMAN | [view interactions] | High throughput | no | yes |
| UCP5_HUMAN | [view interactions] | High throughput | no | no |
| PM34_HUMAN | [view interactions] | High throughput | no | yes |
| MTX3_HUMAN | [view interactions] | High throughput | no | yes |
| GFPT2_HUMAN | [view interactions] | High throughput | no | yes |
| SELT_HUMAN | [view interactions] | High throughput | no | yes |
| ACTA_HUMAN | [view interactions] | High throughput | no | no |
| ADCK1_HUMAN | [view interactions] | High throughput | no | no |
| S2546_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR11_HUMAN | [view interactions] | High throughput | no | yes |
| MTFP1_HUMAN | [view interactions] | High throughput | no | no |
| NOCT_HUMAN | [view interactions] | High throughput | no | no |
| KMCP1_HUMAN | [view interactions] | High throughput | no | no |
| CHK2_HUMAN | [view interactions] | High throughput | no | yes |
| COT2_HUMAN | [view interactions] | High throughput | no | no |
| B4GT7_HUMAN | [view interactions] | High throughput | no | yes |
| RAB3B_HUMAN | [view interactions] | High throughput | no | no |
| GLPK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NJMU_HUMAN | [view interactions] | High throughput | no | yes |
| HACL2_HUMAN | [view interactions] | High throughput | no | yes |
| MICU1_HUMAN | [view interactions] | High throughput | no | yes |
| SNP25_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| LAMA5_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| SYPH_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAB3A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SV2C_HUMAN | [view interactions] | Computational | no | no |
| SV2B_HUMAN | [view interactions] | Computational | no | yes |