Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DP13B_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed, PubMed, PubMed). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed). Plays a role in immune response by modulating phagocytosis, inflammatory and innate immune responses. In macrophages, enhances Fc-gamma receptor-mediated phagocytosis through interaction with RAB31 leading to activation of PI3K/Akt signaling. In response to LPS, modulates inflammatory responses by playing a key role on the regulation of TLR4 signaling and in the nuclear translocation of RELA/NF-kappa-B p65 and the secretion of pro- and anti-inflammatory cytokines. Also functions as a negative regulator of innate immune response via inhibition of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 . Plays a role in endosomal trafficking of TGFBR1 from the endosomes to the nucleus (PubMed). Plays a role in cell metabolism by regulating adiponecting ans insulin signaling pathways and adaptative thermogenesis (PubMed) . In muscle, negatively regulates adiponectin-simulated glucose uptake and fatty acid oxidation by inhibiting adiponectin signaling pathway through APPL1 sequestration thereby antagonizing APPL1 action . In muscles, negativeliy regulates insulin-induced plasma membrane recruitment of GLUT4 and glucose uptake through interaction with TBC1D1 (PubMed). Plays a role in cold and diet-induced adaptive thermogenesis by activating ventromedial hypothalamus (VMH) neurons throught AMPK inhibition which enhances sympathetic outflow to subcutaneous white adipose tissue (sWAT), sWAT beiging and cold tolerance . Also plays a role in other signaling pathways namely Wnt/beta-catenin, HGF and glucocorticoid receptor signaling (PubMed) . Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed). May affect adult neurogenesis in hippocampus and olfactory system via regulating the sensitivity of glucocorticoid receptor. Required for fibroblast migration through HGF cell signaling . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DP13B_HUMAN
GO:0017076 purine nucleotide binding 33.3333 4 no
GO:0032555 purine ribonucleotide binding 33.3333 4 no
GO:0035639 purine ribonucleoside triphosphate binding 33.3333 4 no
GO:0003779 actin binding 25.0000 4 no
GO:0042803 protein homodimerization activity 20.8333 4 yes
GO:0016462 pyrophosphatase activity 20.8333 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 20.8333 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 20.8333 6 no
GO:0046982 protein heterodimerization activity 20.8333 4 no
GO:0035091 phosphatidylinositol binding 16.6667 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DP13B_HUMAN
GO:0048522 positive regulation of cellular process 95.8333 4 yes
GO:0051128 regulation of cellular component organization 75.0000 4 yes
GO:0051049 regulation of transport 70.8333 4 yes
GO:0060255 regulation of macromolecule metabolic process 62.5000 4 yes
GO:0031323 regulation of cellular metabolic process 58.3333 4 yes
GO:0071702 organic substance transport 58.3333 4 yes
GO:0071705 nitrogen compound transport 58.3333 4 yes
GO:0008104 protein localization 54.1667 4 yes
GO:0010646 regulation of cell communication 54.1667 4 yes
GO:0048523 negative regulation of cellular process 54.1667 4 yes
GO:0080090 regulation of primary metabolic process 54.1667 4 yes
GO:0009893 positive regulation of metabolic process 50.0000 4 yes
GO:0006886 intracellular protein transport 45.8333 4 yes
GO:0015031 protein transport 45.8333 4 yes
GO:0051050 positive regulation of transport 45.8333 4 yes
GO:0051130 positive regulation of cellular component organization 45.8333 5 yes
GO:0060627 regulation of vesicle-mediated transport 45.8333 4 yes
GO:0009966 regulation of signal transduction 41.6667 4 yes
GO:0010468 regulation of gene expression 41.6667 5 yes
GO:0051726 regulation of cell cycle 41.6667 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 41.6667 4 no
GO:0006996 organelle organization 41.6667 4 no
GO:0071310 cellular response to organic substance 37.5000 4 yes
GO:0044087 regulation of cellular component biogenesis 37.5000 4 no
GO:0051246 regulation of protein metabolic process 37.5000 5 no
GO:0022607 cellular component assembly 33.3333 4 yes
GO:0030100 regulation of endocytosis 33.3333 5 yes
GO:0048584 positive regulation of response to stimulus 33.3333 4 yes
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0016192 vesicle-mediated transport 33.3333 4 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0033043 regulation of organelle organization 33.3333 5 no
GO:0010647 positive regulation of cell communication 29.1667 5 yes
GO:0023056 positive regulation of signaling 29.1667 4 yes
GO:0033365 protein localization to organelle 29.1667 5 yes
GO:0042127 regulation of cell population proliferation 29.1667 4 yes
GO:0019220 regulation of phosphate metabolic process 29.1667 6 no
GO:0031399 regulation of protein modification process 29.1667 6 no
GO:0051174 regulation of phosphorus metabolic process 29.1667 5 no
GO:0007346 regulation of mitotic cell cycle 25.0000 5 yes
GO:0008285 negative regulation of cell population proliferation 25.0000 5 yes
GO:0009892 negative regulation of metabolic process 25.0000 4 yes
GO:0009967 positive regulation of signal transduction 25.0000 5 yes
GO:0010564 regulation of cell cycle process 25.0000 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 25.0000 5 yes
GO:0031324 negative regulation of cellular metabolic process 25.0000 5 yes
GO:0034762 regulation of transmembrane transport 25.0000 4 yes
GO:0045595 regulation of cell differentiation 25.0000 4 yes
GO:0048585 negative regulation of response to stimulus 25.0000 4 yes
GO:0051051 negative regulation of transport 25.0000 4 yes
GO:2000145 regulation of cell motility 25.0000 4 yes
GO:0009891 positive regulation of biosynthetic process 25.0000 5 no
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 no
GO:0051046 regulation of secretion 25.0000 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 25.0000 5 no
GO:0010648 negative regulation of cell communication 25.0000 5 no
GO:0023057 negative regulation of signaling 25.0000 4 no
GO:0031344 regulation of cell projection organization 25.0000 5 no
GO:0044089 positive regulation of cellular component biogenesis 25.0000 5 no
GO:0051493 regulation of cytoskeleton organization 25.0000 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 25.0000 6 no
GO:0001932 regulation of protein phosphorylation 25.0000 7 no
GO:0042325 regulation of phosphorylation 25.0000 7 no
GO:0007167 enzyme-linked receptor protein signaling pathway 20.8333 4 yes
GO:0030334 regulation of cell migration 20.8333 5 yes
GO:0045807 positive regulation of endocytosis 20.8333 5 yes
GO:0048878 chemical homeostasis 20.8333 4 yes
GO:0050776 regulation of immune response 20.8333 4 yes
GO:0051240 positive regulation of multicellular organismal process 20.8333 4 yes
GO:0072594 establishment of protein localization to organelle 20.8333 4 yes
GO:0080134 regulation of response to stress 20.8333 4 yes
GO:1901987 regulation of cell cycle phase transition 20.8333 6 yes
GO:1901990 regulation of mitotic cell cycle phase transition 20.8333 6 yes
GO:2000026 regulation of multicellular organismal development 20.8333 4 yes
GO:0006897 endocytosis 20.8333 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 20.8333 5 no
GO:0051252 regulation of RNA metabolic process 20.8333 5 no
GO:0032956 regulation of actin cytoskeleton organization 20.8333 5 no
GO:0032970 regulation of actin filament-based process 20.8333 4 no
GO:1902903 regulation of supramolecular fiber organization 20.8333 5 no
GO:0009894 regulation of catabolic process 20.8333 4 no
GO:1902531 regulation of intracellular signal transduction 20.8333 5 no
GO:0070925 organelle assembly 20.8333 5 no
GO:0045787 positive regulation of cell cycle 20.8333 5 no
GO:0051247 positive regulation of protein metabolic process 20.8333 6 no
GO:1903530 regulation of secretion by cell 20.8333 4 no
GO:0016050 vesicle organization 20.8333 5 no
GO:0030030 cell projection organization 20.8333 4 no
GO:0002697 regulation of immune effector process 16.6667 4 yes
GO:0006913 nucleocytoplasmic transport 16.6667 5 yes
GO:0010629 negative regulation of gene expression 16.6667 6 yes
GO:0019221 cytokine-mediated signaling pathway 16.6667 4 yes
GO:0034504 protein localization to nucleus 16.6667 6 yes
GO:0034763 negative regulation of transmembrane transport 16.6667 5 yes
GO:0045596 negative regulation of cell differentiation 16.6667 5 yes
GO:0048548 regulation of pinocytosis 16.6667 6 yes
GO:0048549 positive regulation of pinocytosis 16.6667 6 yes
GO:0051093 negative regulation of developmental process 16.6667 4 yes
GO:0051169 nuclear transport 16.6667 4 yes
GO:0051241 negative regulation of multicellular organismal process 16.6667 4 yes
GO:0070848 response to growth factor 16.6667 4 yes
GO:0071363 cellular response to growth factor stimulus 16.6667 5 yes
GO:0001817 regulation of cytokine production 12.5000 4 yes
GO:0002684 positive regulation of immune system process 12.5000 4 yes
GO:0002699 positive regulation of immune effector process 12.5000 5 yes
GO:0002831 regulation of response to biotic stimulus 12.5000 4 yes
GO:0006606 protein import into nucleus 12.5000 5 yes
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 12.5000 5 yes
GO:0007179 transforming growth factor beta receptor signaling pathway 12.5000 6 yes
GO:0010762 regulation of fibroblast migration 12.5000 6 yes
GO:0010827 regulation of glucose transmembrane transport 12.5000 5 yes
GO:0019216 regulation of lipid metabolic process 12.5000 5 yes
GO:0031347 regulation of defense response 12.5000 5 yes
GO:0032101 regulation of response to external stimulus 12.5000 4 yes
GO:0033211 adiponectin-activated signaling pathway 12.5000 4 yes
GO:0034121 regulation of toll-like receptor signaling pathway 12.5000 6 yes
GO:0034143 regulation of toll-like receptor 4 signaling pathway 12.5000 7 yes
GO:0035728 response to hepatocyte growth factor 12.5000 5 yes
GO:0035729 cellular response to hepatocyte growth factor stimulus 12.5000 6 yes
GO:0045088 regulation of innate immune response 12.5000 5 yes
GO:0046324 regulation of glucose import 12.5000 6 yes
GO:0050764 regulation of phagocytosis 12.5000 5 yes
GO:0050767 regulation of neurogenesis 12.5000 6 yes
GO:0050778 positive regulation of immune response 12.5000 5 yes
GO:0051170 import into nucleus 12.5000 6 yes
GO:0051960 regulation of nervous system development 12.5000 5 yes
GO:0060284 regulation of cell development 12.5000 5 yes
GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway 12.5000 5 yes
GO:0062207 regulation of pattern recognition receptor signaling pathway 12.5000 5 yes
GO:1900015 regulation of cytokine production involved in inflammatory response 12.5000 5 yes
GO:1902806 regulation of cell cycle G1/S phase transition 12.5000 7 yes
GO:1905301 regulation of macropinocytosis 12.5000 7 yes
GO:1905303 positive regulation of macropinocytosis 12.5000 7 yes
GO:1905449 regulation of Fc-gamma receptor signaling pathway involved in phagocytosis 12.5000 5 yes
GO:2000045 regulation of G1/S transition of mitotic cell cycle 12.5000 7 yes
GO:2000177 regulation of neural precursor cell proliferation 12.5000 5 yes
GO:2000178 negative regulation of neural precursor cell proliferation 12.5000 6 yes
GO:0001818 negative regulation of cytokine production 8.3333 5 yes
GO:0009631 cold acclimation 8.3333 4 yes
GO:0010565 regulation of cellular ketone metabolic process 8.3333 5 yes
GO:0010721 negative regulation of cell development 8.3333 6 yes
GO:0010829 negative regulation of glucose transmembrane transport 8.3333 6 yes
GO:0019217 regulation of fatty acid metabolic process 8.3333 6 yes
GO:0033500 carbohydrate homeostasis 8.3333 5 yes
GO:0042593 glucose homeostasis 8.3333 6 yes
GO:0043933 protein-containing complex organization 8.3333 4 yes
GO:0045833 negative regulation of lipid metabolic process 8.3333 5 yes
GO:0045922 negative regulation of fatty acid metabolic process 8.3333 6 yes
GO:0046320 regulation of fatty acid oxidation 8.3333 7 yes
GO:0046322 negative regulation of fatty acid oxidation 8.3333 7 yes
GO:0046325 negative regulation of glucose import 8.3333 7 yes
GO:0050766 positive regulation of phagocytosis 8.3333 5 yes
GO:0050768 negative regulation of neurogenesis 8.3333 6 yes
GO:0051259 protein complex oligomerization 8.3333 6 yes
GO:0051260 protein homooligomerization 8.3333 7 yes
GO:0051262 protein tetramerization 8.3333 7 yes
GO:0051289 protein homotetramerization 8.3333 8 yes
GO:0051961 negative regulation of nervous system development 8.3333 5 yes
GO:0060099 regulation of phagocytosis, engulfment 8.3333 6 yes
GO:0060100 positive regulation of phagocytosis, engulfment 8.3333 6 yes
GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway 8.3333 6 yes
GO:0062012 regulation of small molecule metabolic process 8.3333 4 yes
GO:0062014 negative regulation of small molecule metabolic process 8.3333 5 yes
GO:0065003 protein-containing complex assembly 8.3333 5 yes
GO:0120162 positive regulation of cold-induced thermogenesis 8.3333 4 yes
GO:1900016 negative regulation of cytokine production involved in inflammatory response 8.3333 6 yes
GO:1900076 regulation of cellular response to insulin stimulus 8.3333 4 yes
GO:1900077 negative regulation of cellular response to insulin stimulus 8.3333 5 yes
GO:1905153 regulation of membrane invagination 8.3333 5 yes
GO:1905155 positive regulation of membrane invagination 8.3333 6 yes
GO:1905451 positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis 8.3333 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DP13A_HUMAN [view entry] [view interactions] Low throughput yes yes
DP13B_HUMAN [view entry] [view interactions] Low throughput yes yes
RAB5A_HUMAN [view entry] [view interactions] Low throughput yes yes
SOS1_HUMAN [view entry] [view interactions] Low throughput yes yes
ARAP2_HUMAN [view interactions] Low throughput no no
TBCD1_HUMAN [view interactions] Low throughput no no
RBBP7_HUMAN [view interactions] Low throughput no yes
MTA2_HUMAN [view interactions] Low throughput no yes
PAQR1_HUMAN [view interactions] Low throughput no no
RUVB2_HUMAN [view interactions] Low throughput no yes
FSHR_HUMAN [view interactions] Low throughput no no
SUV92_HUMAN [view interactions] High throughput no no
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
ABL2_HUMAN [view entry] [view interactions] High throughput yes yes
BMX_HUMAN [view interactions] High throughput no no
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
FGFR1_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
RET_HUMAN [view interactions] High throughput no yes
LST8_HUMAN [view interactions] High throughput no yes
KMT2C_HUMAN [view interactions] High throughput no no
MARE3_HUMAN [view entry] [view interactions] High throughput yes yes
LIX1_HUMAN [view interactions] High throughput no no
RAI2_HUMAN [view interactions] High throughput no no
LDH6B_HUMAN [view interactions] High throughput no no
PINK1_HUMAN [view interactions] High throughput no yes
RET7_HUMAN [view interactions] High throughput no yes
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
CRLF3_HUMAN [view interactions] High throughput no yes
CQ082_HUMAN [view interactions] High throughput no no
ATF3_HUMAN [view interactions] High throughput no yes
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
CRADD_HUMAN [view interactions] High throughput no yes
RB22A_HUMAN [view interactions] High throughput no yes
PRR35_HUMAN [view interactions] High throughput no no
EPMIP_HUMAN [view interactions] High throughput no no
ESR1_HUMAN [view interactions] High throughput no no
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
TINF2_HUMAN [view interactions] High throughput no no
POTE1_HUMAN [view interactions] High throughput no no
LAMP1_HUMAN [view interactions] High throughput no yes
TGON2_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
FGFR4_HUMAN [view interactions] High throughput no no
LEG9C_HUMAN [view interactions] High throughput no no
DOK3_HUMAN [view interactions] High throughput no no
CRBN_HUMAN [view interactions] High throughput no yes
CNMD_HUMAN [view interactions] High throughput no no
RBTN2_HUMAN [view interactions] High throughput no yes
KIFC3_HUMAN [view interactions] High throughput no no
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
DDX58_HUMAN [view interactions] High throughput no yes
GIPC1_HUMAN [view entry] [view interactions] High throughput yes yes
CLCN5_HUMAN [view interactions] High throughput no yes
HSP72_HUMAN [view entry] [view interactions] High throughput yes no
RHOH_HUMAN [view interactions] High throughput no yes
ICLN_HUMAN [view interactions] High throughput no yes
MYO6_HUMAN [view entry] [view interactions] High throughput yes no
RPAB1_HUMAN [view interactions] High throughput no yes
RPC2_HUMAN [view interactions] High throughput no yes
RPC6_HUMAN [view interactions] High throughput no yes
RPC8_HUMAN [view interactions] High throughput no yes
ABI2_HUMAN [view entry] [view interactions] High throughput yes yes
RIPR1_HUMAN [view interactions] High throughput no no
TPM1_HUMAN [view entry] [view interactions] High throughput yes no
ANFY1_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP2_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
TFR1_HUMAN [view interactions] High throughput no yes
IFM1_HUMAN [view interactions] High throughput no no
IFM3_HUMAN [view interactions] High throughput no yes
ACE2_HUMAN [view interactions] High throughput no no
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
RBL2B_HUMAN [view interactions] Computational no no
RBL2A_HUMAN [view interactions] Computational no no