Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

BC11A_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Transcription factor (PubMed, PubMed). Associated with the BAF SWI/SNF chromatin remodeling complex (PubMed). Binds to the 5-TGACCA-3 sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene (PubMed). Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level (PubMed, PubMed). Involved in brain development (PubMed). May play a role in hematopoiesis . Essential factor in lymphopoiesis required for B-cell formation in fetal liver . May function as a modulator of the transcriptional repression activity of NR2F2 . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in BC11A_HUMAN
GO:0019900 kinase binding 41.1765 4 yes
GO:0019901 protein kinase binding 41.1765 5 yes
GO:0003677 DNA binding 29.4118 4 yes
GO:0042803 protein homodimerization activity 29.4118 4 yes
GO:0043169 cation binding 29.4118 4 yes
GO:0046872 metal ion binding 29.4118 5 yes
GO:0003723 RNA binding 29.4118 4 no
GO:0046982 protein heterodimerization activity 23.5294 4 yes
GO:0140297 DNA-binding transcription factor binding 23.5294 4 yes
GO:0000166 nucleotide binding 23.5294 4 no
GO:0017076 purine nucleotide binding 23.5294 5 no
GO:0030554 adenyl nucleotide binding 23.5294 6 no
GO:0000976 transcription cis-regulatory region binding 17.6471 5 yes
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding 17.6471 6 yes
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding 17.6471 7 yes
GO:0000987 cis-regulatory region sequence-specific DNA binding 17.6471 6 yes
GO:0001067 transcription regulatory region nucleic acid binding 17.6471 4 yes
GO:0003690 double-stranded DNA binding 17.6471 5 yes
GO:0043565 sequence-specific DNA binding 17.6471 5 yes
GO:1990837 sequence-specific double-stranded DNA binding 17.6471 6 yes
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 11.7647 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in BC11A_HUMAN
GO:0009889 regulation of biosynthetic process 94.1176 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 94.1176 5 yes
GO:0031323 regulation of cellular metabolic process 94.1176 4 yes
GO:0031326 regulation of cellular biosynthetic process 94.1176 5 yes
GO:0060255 regulation of macromolecule metabolic process 94.1176 4 yes
GO:0080090 regulation of primary metabolic process 94.1176 4 yes
GO:0010468 regulation of gene expression 88.2353 6 yes
GO:0048522 positive regulation of cellular process 88.2353 4 yes
GO:0048523 negative regulation of cellular process 88.2353 4 yes
GO:0009892 negative regulation of metabolic process 82.3529 4 yes
GO:0009893 positive regulation of metabolic process 82.3529 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 82.3529 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 82.3529 5 yes
GO:0051252 regulation of RNA metabolic process 82.3529 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 76.4706 5 yes
GO:0031324 negative regulation of cellular metabolic process 76.4706 5 yes
GO:0006355 regulation of DNA-templated transcription 70.5882 7 yes
GO:0006357 regulation of transcription by RNA polymerase II 70.5882 8 yes
GO:0009891 positive regulation of biosynthetic process 70.5882 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 70.5882 6 yes
GO:0031325 positive regulation of cellular metabolic process 70.5882 5 yes
GO:0031328 positive regulation of cellular biosynthetic process 70.5882 6 yes
GO:0051128 regulation of cellular component organization 70.5882 4 yes
GO:2001141 regulation of RNA biosynthetic process 70.5882 6 yes
GO:0009890 negative regulation of biosynthetic process 64.7059 5 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 64.7059 6 yes
GO:0031327 negative regulation of cellular biosynthetic process 64.7059 6 yes
GO:0051246 regulation of protein metabolic process 64.7059 5 no
GO:0031399 regulation of protein modification process 58.8235 6 no
GO:0036211 protein modification process 52.9412 4 yes
GO:0043412 macromolecule modification 52.9412 4 yes
GO:0044087 regulation of cellular component biogenesis 52.9412 4 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 52.9412 5 yes
GO:0051254 positive regulation of RNA metabolic process 52.9412 6 yes
GO:0051247 positive regulation of protein metabolic process 52.9412 6 no
GO:0010646 regulation of cell communication 52.9412 4 no
GO:0045893 positive regulation of DNA-templated transcription 47.0588 8 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 47.0588 5 yes
GO:0045944 positive regulation of transcription by RNA polymerase II 47.0588 9 yes
GO:0051253 negative regulation of RNA metabolic process 47.0588 6 yes
GO:1902680 positive regulation of RNA biosynthetic process 47.0588 7 yes
GO:0009894 regulation of catabolic process 47.0588 4 no
GO:0000122 negative regulation of transcription by RNA polymerase II 41.1765 9 yes
GO:0010628 positive regulation of gene expression 41.1765 7 yes
GO:0045892 negative regulation of DNA-templated transcription 41.1765 8 yes
GO:0051130 positive regulation of cellular component organization 41.1765 5 yes
GO:1902679 negative regulation of RNA biosynthetic process 41.1765 7 yes
GO:0010629 negative regulation of gene expression 41.1765 7 no
GO:0031401 positive regulation of protein modification process 41.1765 7 no
GO:0009966 regulation of signal transduction 41.1765 4 no
GO:0019220 regulation of phosphate metabolic process 41.1765 6 no
GO:0022607 cellular component assembly 41.1765 4 no
GO:0048585 negative regulation of response to stimulus 41.1765 4 no
GO:0051174 regulation of phosphorus metabolic process 41.1765 5 no
GO:1902531 regulation of intracellular signal transduction 41.1765 5 no
GO:0010243 response to organonitrogen compound 35.2941 4 yes
GO:0043687 post-translational protein modification 35.2941 5 yes
GO:0051240 positive regulation of multicellular organismal process 35.2941 4 yes
GO:0051241 negative regulation of multicellular organismal process 35.2941 4 yes
GO:0051248 negative regulation of protein metabolic process 35.2941 6 no
GO:0009968 negative regulation of signal transduction 35.2941 5 no
GO:0010647 positive regulation of cell communication 35.2941 5 no
GO:0010648 negative regulation of cell communication 35.2941 5 no
GO:0023056 positive regulation of signaling 35.2941 4 no
GO:0023057 negative regulation of signaling 35.2941 4 no
GO:0033043 regulation of organelle organization 35.2941 5 no
GO:0006996 organelle organization 35.2941 4 no
GO:0018193 peptidyl-amino acid modification 29.4118 5 yes
GO:0031344 regulation of cell projection organization 29.4118 5 yes
GO:0032446 protein modification by small protein conjugation 29.4118 7 yes
GO:0045595 regulation of cell differentiation 29.4118 4 yes
GO:0051093 negative regulation of developmental process 29.4118 4 yes
GO:0051094 positive regulation of developmental process 29.4118 4 yes
GO:0070647 protein modification by small protein conjugation or removal 29.4118 6 yes
GO:0071310 cellular response to organic substance 29.4118 4 yes
GO:0071417 cellular response to organonitrogen compound 29.4118 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 29.4118 6 yes
GO:1901699 cellular response to nitrogen compound 29.4118 4 yes
GO:1901701 cellular response to oxygen-containing compound 29.4118 4 yes
GO:0001932 regulation of protein phosphorylation 29.4118 7 no
GO:0006417 regulation of translation 29.4118 6 no
GO:0009967 positive regulation of signal transduction 29.4118 5 no
GO:0010608 post-transcriptional regulation of gene expression 29.4118 7 no
GO:0030030 cell projection organization 29.4118 4 no
GO:0042127 regulation of cell population proliferation 29.4118 4 no
GO:0042325 regulation of phosphorylation 29.4118 7 no
GO:0043933 protein-containing complex organization 29.4118 4 no
GO:0048584 positive regulation of response to stimulus 29.4118 4 no
GO:1902532 negative regulation of intracellular signal transduction 29.4118 6 no
GO:0016925 protein sumoylation 23.5294 7 yes
GO:0018205 peptidyl-lysine modification 23.5294 6 yes
GO:0043254 regulation of protein-containing complex assembly 23.5294 5 yes
GO:0045596 negative regulation of cell differentiation 23.5294 5 yes
GO:0048638 regulation of developmental growth 23.5294 4 yes
GO:0008285 negative regulation of cell population proliferation 23.5294 5 no
GO:0080134 regulation of response to stress 23.5294 4 no
GO:0097435 supramolecular fiber organization 23.5294 4 no
GO:1902533 positive regulation of intracellular signal transduction 23.5294 6 no
GO:0008104 protein localization 23.5294 4 no
GO:0009895 negative regulation of catabolic process 23.5294 5 no
GO:0071702 organic substance transport 23.5294 4 no
GO:0001934 positive regulation of protein phosphorylation 23.5294 8 no
GO:0010562 positive regulation of phosphorus metabolic process 23.5294 6 no
GO:0042327 positive regulation of phosphorylation 23.5294 8 no
GO:0045937 positive regulation of phosphate metabolic process 23.5294 7 no
GO:0051726 regulation of cell cycle 23.5294 4 no
GO:0009896 positive regulation of catabolic process 23.5294 5 no
GO:0051049 regulation of transport 23.5294 4 no
GO:0010721 negative regulation of cell development 17.6471 6 yes
GO:0022603 regulation of anatomical structure morphogenesis 17.6471 4 yes
GO:0022604 regulation of cell morphogenesis 17.6471 5 yes
GO:0031346 positive regulation of cell projection organization 17.6471 6 yes
GO:0043200 response to amino acid 17.6471 4 yes
GO:0045597 positive regulation of cell differentiation 17.6471 5 yes
GO:0045664 regulation of neuron differentiation 17.6471 5 yes
GO:0045927 positive regulation of growth 17.6471 4 yes
GO:0048639 positive regulation of developmental growth 17.6471 5 yes
GO:0051129 negative regulation of cellular component organization 17.6471 5 yes
GO:0060284 regulation of cell development 17.6471 5 yes
GO:0071229 cellular response to acid chemical 17.6471 4 yes
GO:0071230 cellular response to amino acid stimulus 17.6471 5 yes
GO:2000026 regulation of multicellular organismal development 17.6471 4 yes
GO:0001558 regulation of cell growth 11.7647 4 yes
GO:0010720 positive regulation of cell development 11.7647 6 yes
GO:0010975 regulation of neuron projection development 11.7647 7 yes
GO:0010976 positive regulation of neuron projection development 11.7647 7 yes
GO:0010977 negative regulation of neuron projection development 11.7647 7 yes
GO:0014041 regulation of neuron maturation 11.7647 6 yes
GO:0014043 negative regulation of neuron maturation 11.7647 7 yes
GO:0030307 positive regulation of cell growth 11.7647 5 yes
GO:0030308 negative regulation of cell growth 11.7647 5 yes
GO:0030516 regulation of axon extension 11.7647 5 yes
GO:0030517 negative regulation of axon extension 11.7647 6 yes
GO:0031333 negative regulation of protein-containing complex assembly 11.7647 6 yes
GO:0031345 negative regulation of cell projection organization 11.7647 6 yes
GO:0032459 regulation of protein oligomerization 11.7647 6 yes
GO:0032460 negative regulation of protein oligomerization 11.7647 7 yes
GO:0032462 regulation of protein homooligomerization 11.7647 7 yes
GO:0032463 negative regulation of protein homooligomerization 11.7647 8 yes
GO:0045926 negative regulation of growth 11.7647 4 yes
GO:0048640 negative regulation of developmental growth 11.7647 5 yes
GO:0048670 regulation of collateral sprouting 11.7647 5 yes
GO:0048671 negative regulation of collateral sprouting 11.7647 6 yes
GO:0048672 positive regulation of collateral sprouting 11.7647 6 yes
GO:0050767 regulation of neurogenesis 11.7647 6 yes
GO:0050768 negative regulation of neurogenesis 11.7647 6 yes
GO:0050769 positive regulation of neurogenesis 11.7647 6 yes
GO:0050770 regulation of axonogenesis 11.7647 5 yes
GO:0050771 negative regulation of axonogenesis 11.7647 6 yes
GO:0050772 positive regulation of axonogenesis 11.7647 6 yes
GO:0050773 regulation of dendrite development 11.7647 4 yes
GO:0051960 regulation of nervous system development 11.7647 5 yes
GO:0051961 negative regulation of nervous system development 11.7647 5 yes
GO:0051962 positive regulation of nervous system development 11.7647 5 yes
GO:0060688 regulation of morphogenesis of a branching structure 11.7647 4 yes
GO:0061387 regulation of extent of cell growth 11.7647 5 yes
GO:1902065 response to L-glutamate 11.7647 4 yes
GO:1903429 regulation of cell maturation 11.7647 6 yes
GO:1903430 negative regulation of cell maturation 11.7647 7 yes
GO:1903859 regulation of dendrite extension 11.7647 5 yes
GO:1903860 negative regulation of dendrite extension 11.7647 6 yes
GO:1904799 regulation of neuron remodeling 11.7647 7 yes
GO:1904800 negative regulation of neuron remodeling 11.7647 8 yes
GO:1905232 cellular response to L-glutamate 11.7647 5 yes
GO:2000171 negative regulation of dendrite development 11.7647 5 yes
GO:2000172 regulation of branching morphogenesis of a nerve 11.7647 5 yes
GO:2000173 negative regulation of branching morphogenesis of a nerve 11.7647 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
BCL6_HUMAN [view interactions] Low throughput no no
MTA2_HUMAN [view interactions] Low throughput no yes
RBBP4_HUMAN [view interactions] Low throughput no yes
COT1_HUMAN [view interactions] Low throughput no no
COT2_HUMAN [view interactions] Low throughput no no
NR2E1_HUMAN [view interactions] Low throughput no yes
NR2E3_HUMAN [view interactions] Low throughput no no
CSKP_HUMAN [view entry] [view interactions] Low throughput yes yes
SIR1_HUMAN [view interactions] Low throughput no yes
BC11A_HUMAN [view entry] [view interactions] Low throughput yes yes
PIAS3_HUMAN [view entry] [view interactions] Low throughput yes yes
UBC9_HUMAN [view entry] [view interactions] Low throughput yes yes
HDAC1_HUMAN [view interactions] High throughput no no
HDAC2_HUMAN [view interactions] High throughput no yes
AIM2_HUMAN [view interactions] High throughput no no
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
CE192_HUMAN [view interactions] High throughput no yes
CDK6_HUMAN [view interactions] High throughput no yes
CDK4_HUMAN [view interactions] High throughput no no
YMEL1_HUMAN [view interactions] High throughput no yes
CDCA3_HUMAN [view interactions] High throughput no no
ACTC_HUMAN [view interactions] High throughput no no
FXR2_HUMAN [view entry] [view interactions] High throughput yes yes
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
RBBP7_HUMAN [view interactions] High throughput no yes
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
FEV_HUMAN [view interactions] High throughput no no
PAX9_HUMAN [view interactions] High throughput no no
FHI1B_HUMAN [view interactions] High throughput no yes
NR2F6_HUMAN [view interactions] High throughput no no
RBTN1_HUMAN [view interactions] High throughput no no
NCK2_HUMAN [view entry] [view interactions] High throughput yes yes
ZBT24_HUMAN [view interactions] High throughput no no
MO4L2_HUMAN [view interactions] High throughput no yes
PIN1_HUMAN [view entry] [view interactions] High throughput yes yes
NFAM1_HUMAN [view interactions] High throughput no yes
CHD4_HUMAN [view interactions] High throughput no yes
MTA1_HUMAN [view interactions] High throughput no yes
MBD3_HUMAN [view interactions] High throughput no yes
P20L1_HUMAN [view interactions] High throughput no yes
UBXN4_HUMAN [view interactions] High throughput no yes
MB3L1_HUMAN [view interactions] High throughput no no
FGFR2_HUMAN [view interactions] High throughput no yes
CHD3_HUMAN [view interactions] High throughput no yes
SP100_HUMAN [view interactions] High throughput no no
ZMYD8_HUMAN [view interactions] High throughput no yes
SAP30_HUMAN [view interactions] High throughput no yes
LIN37_HUMAN [view interactions] High throughput no yes
LIN9_HUMAN [view interactions] High throughput no yes
BPTF_HUMAN [view interactions] High throughput no yes
MBD2_HUMAN [view interactions] High throughput no yes
BAP18_HUMAN [view interactions] High throughput no yes
CDKA1_HUMAN [view interactions] High throughput no yes
MTA3_HUMAN [view interactions] High throughput no yes
BRM1L_HUMAN [view interactions] High throughput no no
P66B_HUMAN [view interactions] High throughput no yes
P66A_HUMAN [view interactions] High throughput no yes
MYBB_HUMAN [view interactions] High throughput no yes
SDS3_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
MTF2_HUMAN [view interactions] High throughput no no
HMGX4_HUMAN [view interactions] High throughput no yes
EZH2_HUMAN [view interactions] High throughput no no
Z512B_HUMAN [view interactions] High throughput no yes
SHPRH_HUMAN [view interactions] High throughput no yes
PHF1_HUMAN [view interactions] High throughput no yes
SUZ12_HUMAN [view interactions] High throughput no no
GATD1_HUMAN [view interactions] High throughput no no
PWP2A_HUMAN [view interactions] High throughput no no
ARI4B_HUMAN [view interactions] High throughput no yes
SIN3A_HUMAN [view interactions] High throughput no yes
SP130_HUMAN [view interactions] High throughput no no
SIN3B_HUMAN [view interactions] High throughput no yes
SMCA5_HUMAN [view interactions] High throughput no yes
HAT1_HUMAN [view interactions] High throughput no yes
SMCA1_HUMAN [view entry] [view interactions] High throughput yes yes
CAF1A_HUMAN [view interactions] High throughput no yes
DPY30_HUMAN [view interactions] High throughput no yes
PHF12_HUMAN [view interactions] High throughput no yes
CHD5_HUMAN [view interactions] High throughput no no
RM22_HUMAN [view interactions] High throughput no yes
ZN296_HUMAN [view interactions] High throughput no no
ZN219_HUMAN [view interactions] High throughput no yes
BC11B_HUMAN [view interactions] High throughput no yes
LIN52_HUMAN [view interactions] High throughput no no
CAF1B_HUMAN [view interactions] High throughput no no
ZBTB2_HUMAN [view interactions] High throughput no yes
MB3L2_HUMAN [view interactions] High throughput no no
M3K20_HUMAN [view interactions] High throughput no yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
CDKA2_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
FBX38_HUMAN [view interactions] High throughput no yes
SPT5H_HUMAN [view interactions] High throughput no yes
COIL_HUMAN [view interactions] High throughput no yes
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
RPA49_HUMAN [view interactions] High throughput no yes
VP33A_HUMAN [view entry] [view interactions] High throughput yes no
EGR2_HUMAN [view interactions] High throughput no no
GSC_HUMAN [view interactions] High throughput no no
KLF3_HUMAN [view interactions] High throughput no yes