Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SYT11_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Synaptotagmin family member involved in vesicular and membrane trafficking which does not bind Ca(2+). Inhibits clathrin-mediated and bulk endocytosis, functions to ensure precision in vesicle retrieval. Plays an important role in dopamine transmission by regulating endocytosis and the vesicle-recycling process. Essential component of a neuronal vesicular trafficking pathway that differs from the synaptic vesicle trafficking pathway but is crucial for development and synaptic plasticity. In macrophages and microglia, inhibits the conventional cytokine secretion, of at least IL6 and TNF, and phagocytosis. In astrocytes, regulates lysosome exocytosis, mechanism required for the repair of injured astrocyte cell membrane . Required for the ATP13A2-mediated regulation of the autophagy-lysosome pathway (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SYT11_HUMAN
GO:0046872 metal ion binding 36.0000 4 yes
GO:0003723 RNA binding 36.0000 4 no
GO:0019900 kinase binding 28.0000 4 no
GO:0019901 protein kinase binding 28.0000 5 no
GO:0015631 tubulin binding 20.0000 4 yes
GO:0005509 calcium ion binding 16.0000 5 yes
GO:0005544 calcium-dependent phospholipid binding 16.0000 4 yes
GO:0031625 ubiquitin protein ligase binding 16.0000 5 yes
GO:0044389 ubiquitin-like protein ligase binding 16.0000 4 yes
GO:0048487 beta-tubulin binding 8.0000 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SYT11_HUMAN
GO:0048522 positive regulation of cellular process 56.0000 4 yes
GO:0048523 negative regulation of cellular process 52.0000 4 yes
GO:0010646 regulation of cell communication 48.0000 4 yes
GO:0051128 regulation of cellular component organization 48.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 48.0000 4 yes
GO:0009892 negative regulation of metabolic process 44.0000 4 yes
GO:0010468 regulation of gene expression 44.0000 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 44.0000 5 yes
GO:0051049 regulation of transport 40.0000 4 yes
GO:0006996 organelle organization 36.0000 4 yes
GO:0010629 negative regulation of gene expression 36.0000 6 yes
GO:0080134 regulation of response to stress 36.0000 4 yes
GO:0010648 negative regulation of cell communication 32.0000 5 yes
GO:0016192 vesicle-mediated transport 32.0000 4 yes
GO:0023057 negative regulation of signaling 32.0000 4 yes
GO:0043269 regulation of ion transport 32.0000 5 yes
GO:0050804 modulation of chemical synaptic transmission 32.0000 5 yes
GO:0051046 regulation of secretion 32.0000 5 yes
GO:0099177 regulation of trans-synaptic signaling 32.0000 4 yes
GO:1903530 regulation of secretion by cell 32.0000 4 yes
GO:0009893 positive regulation of metabolic process 32.0000 4 no
GO:0031323 regulation of cellular metabolic process 32.0000 4 no
GO:0048585 negative regulation of response to stimulus 28.0000 4 yes
GO:0060627 regulation of vesicle-mediated transport 28.0000 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 28.0000 5 no
GO:0031324 negative regulation of cellular metabolic process 28.0000 5 no
GO:0031325 positive regulation of cellular metabolic process 28.0000 5 no
GO:0051171 regulation of nitrogen compound metabolic process 28.0000 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 28.0000 5 no
GO:0051246 regulation of protein metabolic process 28.0000 5 no
GO:0051248 negative regulation of protein metabolic process 28.0000 6 no
GO:0080090 regulation of primary metabolic process 28.0000 4 no
GO:0017157 regulation of exocytosis 24.0000 5 yes
GO:0032880 regulation of protein localization 24.0000 5 yes
GO:0033043 regulation of organelle organization 24.0000 5 yes
GO:0050890 cognition 24.0000 4 yes
GO:0060341 regulation of cellular localization 24.0000 4 yes
GO:0071241 cellular response to inorganic substance 24.0000 4 yes
GO:0022607 cellular component assembly 24.0000 4 no
GO:0043412 macromolecule modification 24.0000 4 no
GO:0001932 regulation of protein phosphorylation 24.0000 7 no
GO:0009889 regulation of biosynthetic process 24.0000 4 no
GO:0010556 regulation of macromolecule biosynthetic process 24.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 24.0000 5 no
GO:0019220 regulation of phosphate metabolic process 24.0000 6 no
GO:0022603 regulation of anatomical structure morphogenesis 24.0000 4 no
GO:0031326 regulation of cellular biosynthetic process 24.0000 5 no
GO:0031399 regulation of protein modification process 24.0000 6 no
GO:0042325 regulation of phosphorylation 24.0000 7 no
GO:0051173 positive regulation of nitrogen compound metabolic process 24.0000 5 no
GO:0051174 regulation of phosphorus metabolic process 24.0000 5 no
GO:0051247 positive regulation of protein metabolic process 24.0000 6 no
GO:0051252 regulation of RNA metabolic process 24.0000 5 no
GO:0010628 positive regulation of gene expression 24.0000 6 no
GO:0080135 regulation of cellular response to stress 24.0000 4 no
GO:0006887 exocytosis 20.0000 4 yes
GO:0010038 response to metal ion 20.0000 4 yes
GO:0014059 regulation of dopamine secretion 20.0000 6 yes
GO:0045055 regulated exocytosis 20.0000 5 yes
GO:0046903 secretion 20.0000 4 yes
GO:0046928 regulation of neurotransmitter secretion 20.0000 4 yes
GO:0050433 regulation of catecholamine secretion 20.0000 5 yes
GO:0050805 negative regulation of synaptic transmission 20.0000 5 yes
GO:0051129 negative regulation of cellular component organization 20.0000 5 yes
GO:0051241 negative regulation of multicellular organismal process 20.0000 4 yes
GO:0051588 regulation of neurotransmitter transport 20.0000 5 yes
GO:0051952 regulation of amine transport 20.0000 5 yes
GO:0071248 cellular response to metal ion 20.0000 5 yes
GO:1903305 regulation of regulated secretory pathway 20.0000 6 yes
GO:0001817 regulation of cytokine production 16.0000 4 yes
GO:0006906 vesicle fusion 16.0000 6 yes
GO:0007612 learning 16.0000 4 yes
GO:0016050 vesicle organization 16.0000 5 yes
GO:0017156 calcium-ion regulated exocytosis 16.0000 6 yes
GO:0017158 regulation of calcium ion-dependent exocytosis 16.0000 7 yes
GO:0032101 regulation of response to external stimulus 16.0000 4 yes
GO:0046929 negative regulation of neurotransmitter secretion 16.0000 5 yes
GO:0048284 organelle fusion 16.0000 5 yes
GO:0051048 negative regulation of secretion 16.0000 5 yes
GO:0051051 negative regulation of transport 16.0000 4 yes
GO:0051589 negative regulation of neurotransmitter transport 16.0000 5 yes
GO:0051592 response to calcium ion 16.0000 5 yes
GO:0061024 membrane organization 16.0000 4 yes
GO:0061025 membrane fusion 16.0000 5 yes
GO:0071277 cellular response to calcium ion 16.0000 6 yes
GO:0090174 organelle membrane fusion 16.0000 6 yes
GO:1903531 negative regulation of secretion by cell 16.0000 5 yes
GO:1903829 positive regulation of protein localization 16.0000 5 yes
GO:0001818 negative regulation of cytokine production 12.0000 5 yes
GO:0002694 regulation of leukocyte activation 12.0000 4 yes
GO:0007613 memory 12.0000 4 yes
GO:0030100 regulation of endocytosis 12.0000 5 yes
GO:0032102 negative regulation of response to external stimulus 12.0000 5 yes
GO:0043271 negative regulation of ion transport 12.0000 5 yes
GO:0050865 regulation of cell activation 12.0000 4 yes
GO:0001778 plasma membrane repair 8.0000 6 yes
GO:0002683 negative regulation of immune system process 8.0000 4 yes
GO:0002695 negative regulation of leukocyte activation 8.0000 5 yes
GO:0002831 regulation of response to biotic stimulus 8.0000 4 yes
GO:0007009 plasma membrane organization 8.0000 5 yes
GO:0031347 regulation of defense response 8.0000 5 yes
GO:0031348 negative regulation of defense response 8.0000 5 yes
GO:0032675 regulation of interleukin-6 production 8.0000 5 yes
GO:0032680 regulation of tumor necrosis factor production 8.0000 6 yes
GO:0032715 negative regulation of interleukin-6 production 8.0000 6 yes
GO:0032720 negative regulation of tumor necrosis factor production 8.0000 7 yes
GO:0033602 negative regulation of dopamine secretion 8.0000 6 yes
GO:0033604 negative regulation of catecholamine secretion 8.0000 6 yes
GO:0043030 regulation of macrophage activation 8.0000 5 yes
GO:0043031 negative regulation of macrophage activation 8.0000 6 yes
GO:0045806 negative regulation of endocytosis 8.0000 5 yes
GO:0050727 regulation of inflammatory response 8.0000 5 yes
GO:0050728 negative regulation of inflammatory response 8.0000 6 yes
GO:0050764 regulation of phagocytosis 8.0000 5 yes
GO:0050765 negative regulation of phagocytosis 8.0000 5 yes
GO:0050866 negative regulation of cell activation 8.0000 5 yes
GO:0051650 establishment of vesicle localization 8.0000 4 yes
GO:0051953 negative regulation of amine transport 8.0000 5 yes
GO:0150077 regulation of neuroinflammatory response 8.0000 6 yes
GO:0150079 negative regulation of neuroinflammatory response 8.0000 7 yes
GO:1900424 regulation of defense response to bacterium 8.0000 5 yes
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 8.0000 5 yes
GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production 8.0000 6 yes
GO:1903978 regulation of microglial cell activation 8.0000 6 yes
GO:1903979 negative regulation of microglial cell activation 8.0000 7 yes
GO:1905162 regulation of phagosome maturation 8.0000 6 yes
GO:1905169 regulation of protein localization to phagocytic vesicle 8.0000 6 yes
GO:1905171 positive regulation of protein localization to phagocytic vesicle 8.0000 6 yes
GO:1990927 calcium ion regulated lysosome exocytosis 8.0000 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
AT132_HUMAN [view interactions] Low throughput no yes
SND1_HUMAN [view entry] [view interactions] Low throughput yes yes
KC1A_HUMAN [view interactions] Low throughput no yes
PRKN_HUMAN [view entry] [view interactions] Low throughput yes yes
MYLK_HUMAN [view interactions] High throughput no no
SGTA_HUMAN [view interactions] High throughput no yes
PDLI7_HUMAN [view entry] [view interactions] High throughput yes no
TTC1_HUMAN [view interactions] High throughput no yes
AN32B_HUMAN [view interactions] High throughput no yes
EIF3A_HUMAN [view entry] [view interactions] High throughput yes yes
RS10_HUMAN [view entry] [view interactions] High throughput yes yes
TBB4B_HUMAN [view interactions] High throughput no yes
SET_HUMAN [view interactions] High throughput no yes
CBR1_HUMAN [view entry] [view interactions] High throughput yes yes
RS3A_HUMAN [view entry] [view interactions] High throughput yes yes
RS3_HUMAN [view entry] [view interactions] High throughput yes yes
NUCL_HUMAN [view interactions] High throughput no yes
EIF3B_HUMAN [view interactions] High throughput no yes
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
PDIA6_HUMAN [view entry] [view interactions] High throughput yes yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
AGO2_HUMAN [view interactions] High throughput no yes
VTI1A_HUMAN [view interactions] High throughput no yes
VTI1B_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC4_HUMAN [view interactions] High throughput no yes
MET_HUMAN [view interactions] High throughput no yes
APBP2_HUMAN [view interactions] High throughput no yes
SGTB_HUMAN [view interactions] High throughput no yes
GPR35_HUMAN [view interactions] High throughput no no
SYT11_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
UBE2O_HUMAN [view interactions] High throughput no yes
KAP1_HUMAN [view entry] [view interactions] High throughput yes yes
PDLI5_HUMAN [view entry] [view interactions] High throughput yes no
NTRK1_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
DDR1_HUMAN [view interactions] High throughput no yes
JAK1_HUMAN [view interactions] High throughput no yes
PTPRF_HUMAN [view entry] [view interactions] High throughput yes yes
S20A1_HUMAN [view interactions] High throughput no yes
LRP10_HUMAN [view interactions] High throughput no no
PTPRS_HUMAN [view entry] [view interactions] High throughput yes no
HUTI_HUMAN [view interactions] High throughput no yes
ACV1B_HUMAN [view interactions] High throughput no no
TR10B_HUMAN [view interactions] High throughput no no
ZBT20_HUMAN [view interactions] High throughput no yes
AT2B4_HUMAN [view entry] [view interactions] High throughput yes yes
IFM1_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
HNRPQ_HUMAN [view entry] [view interactions] High throughput yes yes
SYT1_HUMAN [view entry] [view interactions] Computational yes no
SYT2_HUMAN [view entry] [view interactions] Computational yes no
SNP25_HUMAN [view entry] [view interactions] Computational yes yes
STON2_HUMAN [view interactions] Computational no yes
CCD62_HUMAN [view interactions] Computational no no