SYT11_HUMAN
Evidence for PS localization
Functions
Synaptotagmin family member involved in vesicular and membrane trafficking which does not bind Ca(2+). Inhibits clathrin-mediated and bulk endocytosis, functions to ensure precision in vesicle retrieval. Plays an important role in dopamine transmission by regulating endocytosis and the vesicle-recycling process. Essential component of a neuronal vesicular trafficking pathway that differs from the synaptic vesicle trafficking pathway but is crucial for development and synaptic plasticity. In macrophages and microglia, inhibits the conventional cytokine secretion, of at least IL6 and TNF, and phagocytosis. In astrocytes, regulates lysosome exocytosis, mechanism required for the repair of injured astrocyte cell membrane . Required for the ATP13A2-mediated regulation of the autophagy-lysosome pathway (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SYT11_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 37.5000 | 4 | yes |
| GO:0046872 | metal ion binding | 37.5000 | 5 | yes |
| GO:0003723 | RNA binding | 34.3750 | 4 | no |
| GO:0015631 | tubulin binding | 15.6250 | 4 | yes |
| GO:0031625 | ubiquitin protein ligase binding | 15.6250 | 5 | yes |
| GO:0044389 | ubiquitin-like protein ligase binding | 15.6250 | 4 | yes |
| GO:0005509 | calcium ion binding | 6.2500 | 6 | yes |
| GO:0005544 | calcium-dependent phospholipid binding | 6.2500 | 4 | yes |
| GO:0048487 | beta-tubulin binding | 6.2500 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SYT11_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 53.1250 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 53.1250 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 43.7500 | 4 | yes |
| GO:0010468 | regulation of gene expression | 43.7500 | 6 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 43.7500 | 5 | yes |
| GO:0010646 | regulation of cell communication | 43.7500 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 43.7500 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 43.7500 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 40.6250 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 40.6250 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 40.6250 | 5 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 37.5000 | 5 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 37.5000 | 6 | yes |
| GO:0010629 | negative regulation of gene expression | 37.5000 | 7 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 37.5000 | 6 | yes |
| GO:0009893 | positive regulation of metabolic process | 37.5000 | 4 | no |
| GO:0006996 | organelle organization | 34.3750 | 4 | yes |
| GO:0051049 | regulation of transport | 34.3750 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 34.3750 | 5 | no |
| GO:0022607 | cellular component assembly | 34.3750 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 31.2500 | 5 | yes |
| GO:0080134 | regulation of response to stress | 31.2500 | 4 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 31.2500 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 31.2500 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 31.2500 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 31.2500 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 31.2500 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 28.1250 | 4 | yes |
| GO:0050890 | cognition | 28.1250 | 4 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 28.1250 | 6 | no |
| GO:0043412 | macromolecule modification | 25.0000 | 4 | no |
| GO:0043933 | protein-containing complex organization | 25.0000 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 25.0000 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 25.0000 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 25.0000 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.0000 | 6 | no |
| GO:0010628 | positive regulation of gene expression | 25.0000 | 7 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.0000 | 6 | no |
| GO:0033043 | regulation of organelle organization | 21.8750 | 5 | yes |
| GO:0051129 | negative regulation of cellular component organization | 21.8750 | 5 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 21.8750 | 4 | yes |
| GO:0036211 | protein modification process | 21.8750 | 4 | no |
| GO:0008104 | protein localization | 21.8750 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 21.8750 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 21.8750 | 5 | no |
| GO:0023056 | positive regulation of signaling | 21.8750 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 21.8750 | 4 | no |
| GO:0009894 | regulation of catabolic process | 21.8750 | 4 | no |
| GO:0031399 | regulation of protein modification process | 21.8750 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 21.8750 | 4 | no |
| GO:0032880 | regulation of protein localization | 18.7500 | 5 | yes |
| GO:0051046 | regulation of secretion | 18.7500 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 18.7500 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 18.7500 | 4 | yes |
| GO:1903530 | regulation of secretion by cell | 18.7500 | 4 | yes |
| GO:0001817 | regulation of cytokine production | 15.6250 | 4 | yes |
| GO:0007612 | learning | 15.6250 | 4 | yes |
| GO:0017157 | regulation of exocytosis | 15.6250 | 5 | yes |
| GO:0032101 | regulation of response to external stimulus | 15.6250 | 4 | yes |
| GO:0046928 | regulation of neurotransmitter secretion | 15.6250 | 5 | yes |
| GO:0051588 | regulation of neurotransmitter transport | 15.6250 | 5 | yes |
| GO:0061024 | membrane organization | 15.6250 | 4 | yes |
| GO:1903829 | positive regulation of protein localization | 15.6250 | 5 | yes |
| GO:0001818 | negative regulation of cytokine production | 12.5000 | 5 | yes |
| GO:0007613 | memory | 12.5000 | 4 | yes |
| GO:0016050 | vesicle organization | 12.5000 | 5 | yes |
| GO:0030100 | regulation of endocytosis | 12.5000 | 5 | yes |
| GO:0032102 | negative regulation of response to external stimulus | 12.5000 | 5 | yes |
| GO:0051048 | negative regulation of secretion | 12.5000 | 5 | yes |
| GO:0051051 | negative regulation of transport | 12.5000 | 4 | yes |
| GO:0061025 | membrane fusion | 12.5000 | 5 | yes |
| GO:1903305 | regulation of regulated secretory pathway | 12.5000 | 6 | yes |
| GO:1903531 | negative regulation of secretion by cell | 12.5000 | 5 | yes |
| GO:0002683 | negative regulation of immune system process | 9.3750 | 4 | yes |
| GO:0002694 | regulation of leukocyte activation | 9.3750 | 4 | yes |
| GO:0002831 | regulation of response to biotic stimulus | 9.3750 | 4 | yes |
| GO:0006906 | vesicle fusion | 9.3750 | 6 | yes |
| GO:0010038 | response to metal ion | 9.3750 | 4 | yes |
| GO:0014059 | regulation of dopamine secretion | 9.3750 | 6 | yes |
| GO:0016079 | synaptic vesicle exocytosis | 9.3750 | 4 | yes |
| GO:0017156 | calcium-ion regulated exocytosis | 9.3750 | 5 | yes |
| GO:0023061 | signal release | 9.3750 | 4 | yes |
| GO:0031347 | regulation of defense response | 9.3750 | 5 | yes |
| GO:0045055 | regulated exocytosis | 9.3750 | 4 | yes |
| GO:0046903 | secretion | 9.3750 | 4 | yes |
| GO:0046929 | negative regulation of neurotransmitter secretion | 9.3750 | 6 | yes |
| GO:0048284 | organelle fusion | 9.3750 | 5 | yes |
| GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter | 9.3750 | 5 | yes |
| GO:0050433 | regulation of catecholamine secretion | 9.3750 | 5 | yes |
| GO:0050865 | regulation of cell activation | 9.3750 | 4 | yes |
| GO:0051589 | negative regulation of neurotransmitter transport | 9.3750 | 5 | yes |
| GO:0051952 | regulation of amine transport | 9.3750 | 5 | yes |
| GO:0071241 | cellular response to inorganic substance | 9.3750 | 4 | yes |
| GO:0071248 | cellular response to metal ion | 9.3750 | 5 | yes |
| GO:0090174 | organelle membrane fusion | 9.3750 | 6 | yes |
| GO:0099643 | signal release from synapse | 9.3750 | 5 | yes |
| GO:1900242 | regulation of synaptic vesicle endocytosis | 9.3750 | 6 | yes |
| GO:1903421 | regulation of synaptic vesicle recycling | 9.3750 | 5 | yes |
| GO:0001778 | plasma membrane repair | 6.2500 | 6 | yes |
| GO:0002695 | negative regulation of leukocyte activation | 6.2500 | 5 | yes |
| GO:0007009 | plasma membrane organization | 6.2500 | 5 | yes |
| GO:0017158 | regulation of calcium ion-dependent exocytosis | 6.2500 | 7 | yes |
| GO:0031348 | negative regulation of defense response | 6.2500 | 5 | yes |
| GO:0032675 | regulation of interleukin-6 production | 6.2500 | 5 | yes |
| GO:0032680 | regulation of tumor necrosis factor production | 6.2500 | 6 | yes |
| GO:0032715 | negative regulation of interleukin-6 production | 6.2500 | 6 | yes |
| GO:0032720 | negative regulation of tumor necrosis factor production | 6.2500 | 7 | yes |
| GO:0033602 | negative regulation of dopamine secretion | 6.2500 | 7 | yes |
| GO:0033604 | negative regulation of catecholamine secretion | 6.2500 | 6 | yes |
| GO:0043030 | regulation of macrophage activation | 6.2500 | 5 | yes |
| GO:0043031 | negative regulation of macrophage activation | 6.2500 | 6 | yes |
| GO:0045806 | negative regulation of endocytosis | 6.2500 | 5 | yes |
| GO:0050727 | regulation of inflammatory response | 6.2500 | 5 | yes |
| GO:0050728 | negative regulation of inflammatory response | 6.2500 | 6 | yes |
| GO:0050764 | regulation of phagocytosis | 6.2500 | 6 | yes |
| GO:0050765 | negative regulation of phagocytosis | 6.2500 | 6 | yes |
| GO:0050866 | negative regulation of cell activation | 6.2500 | 5 | yes |
| GO:0051592 | response to calcium ion | 6.2500 | 5 | yes |
| GO:0051650 | establishment of vesicle localization | 6.2500 | 4 | yes |
| GO:0051953 | negative regulation of amine transport | 6.2500 | 5 | yes |
| GO:0071277 | cellular response to calcium ion | 6.2500 | 6 | yes |
| GO:0150077 | regulation of neuroinflammatory response | 6.2500 | 6 | yes |
| GO:0150079 | negative regulation of neuroinflammatory response | 6.2500 | 7 | yes |
| GO:1900424 | regulation of defense response to bacterium | 6.2500 | 5 | yes |
| GO:1903555 | regulation of tumor necrosis factor superfamily cytokine production | 6.2500 | 5 | yes |
| GO:1903556 | negative regulation of tumor necrosis factor superfamily cytokine production | 6.2500 | 6 | yes |
| GO:1903978 | regulation of microglial cell activation | 6.2500 | 6 | yes |
| GO:1903979 | negative regulation of microglial cell activation | 6.2500 | 7 | yes |
| GO:1905162 | regulation of phagosome maturation | 6.2500 | 6 | yes |
| GO:1905169 | regulation of protein localization to phagocytic vesicle | 6.2500 | 6 | yes |
| GO:1905171 | positive regulation of protein localization to phagocytic vesicle | 6.2500 | 6 | yes |
| GO:1990927 | calcium ion regulated lysosome exocytosis | 6.2500 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| AT132_HUMAN | [view interactions] | Low throughput | no | yes |
| SND1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KC1A_HUMAN | [view interactions] | Low throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MYLK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SGTA_HUMAN | [view interactions] | High throughput | no | yes |
| TTC1_HUMAN | [view interactions] | High throughput | no | yes |
| PDLI7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EIF3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDIA6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3B_HUMAN | [view interactions] | High throughput | no | yes |
| NUCL_HUMAN | [view interactions] | High throughput | no | yes |
| RS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AN32B_HUMAN | [view interactions] | High throughput | no | yes |
| SET_HUMAN | [view interactions] | High throughput | no | yes |
| TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
| RS10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VTI1A_HUMAN | [view interactions] | High throughput | no | yes |
| VTI1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIMS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCN2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| APBP2_HUMAN | [view interactions] | High throughput | no | yes |
| SGTB_HUMAN | [view interactions] | High throughput | no | yes |
| GPR35_HUMAN | [view interactions] | High throughput | no | no |
| SYT11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2O_HUMAN | [view interactions] | High throughput | no | yes |
| KAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDLI5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DDR1_HUMAN | [view interactions] | High throughput | no | yes |
| JAK1_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S20A1_HUMAN | [view interactions] | High throughput | no | yes |
| LRP10_HUMAN | [view interactions] | High throughput | no | no |
| PTPRS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HUTI_HUMAN | [view interactions] | High throughput | no | yes |
| ACV1B_HUMAN | [view interactions] | High throughput | no | no |
| TR10B_HUMAN | [view interactions] | High throughput | no | no |
| ZBT20_HUMAN | [view interactions] | High throughput | no | yes |
| AT2B4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| HNRPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| CNTP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |