TM108_HUMAN
Evidence for PS localization
Functions
Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is necessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 and recruits the WAVE1 complex to facilitate actin-dependent BDNF:NTRK2 early endocytic trafficking and mediate signaling from early endosomes. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in TM108_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 27.2727 | 4 | no |
| GO:0046872 | metal ion binding | 27.2727 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in TM108_HUMAN |
|---|---|---|---|---|
| GO:0006996 | organelle organization | 36.3636 | 4 | yes |
| GO:0071702 | organic substance transport | 36.3636 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 36.3636 | 4 | no |
| GO:0010468 | regulation of gene expression | 36.3636 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 36.3636 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 36.3636 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 36.3636 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 36.3636 | 4 | no |
| GO:0030030 | cell projection organization | 27.2727 | 4 | yes |
| GO:0031175 | neuron projection development | 27.2727 | 6 | yes |
| GO:0048522 | positive regulation of cellular process | 27.2727 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 27.2727 | 5 | yes |
| GO:0006839 | mitochondrial transport | 27.2727 | 4 | no |
| GO:0071705 | nitrogen compound transport | 27.2727 | 4 | no |
| GO:0043933 | protein-containing complex organization | 27.2727 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 27.2727 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 27.2727 | 4 | no |
| GO:0071363 | cellular response to growth factor stimulus | 18.1818 | 4 | yes |
| GO:0097484 | dendrite extension | 18.1818 | 5 | yes |
| GO:1990089 | response to nerve growth factor | 18.1818 | 4 | yes |
| GO:1990090 | cellular response to nerve growth factor stimulus | 18.1818 | 5 | yes |
| GO:1990138 | neuron projection extension | 18.1818 | 4 | yes |
| GO:1990416 | cellular response to brain-derived neurotrophic factor stimulus | 18.1818 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ANXA7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARHG6_HUMAN | [view interactions] | High throughput | no | no |
| SH3G2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCAF2_HUMAN | [view interactions] | High throughput | no | no |
| MAP2_HUMAN | [view interactions] | High throughput | no | yes |
| KNTC1_HUMAN | [view interactions] | High throughput | no | no |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACD10_HUMAN | [view interactions] | High throughput | no | no |
| BRAT1_HUMAN | [view interactions] | High throughput | no | yes |
| SFXN5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SCMC3_HUMAN | [view interactions] | High throughput | no | yes |
| RRN3_HUMAN | [view interactions] | High throughput | no | yes |
| MTFP1_HUMAN | [view interactions] | High throughput | no | no |
| XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FHL3_HUMAN | [view interactions] | High throughput | no | no |
| FKBP7_HUMAN | [view interactions] | High throughput | no | yes |
| SGTB_HUMAN | [view interactions] | High throughput | no | yes |
| PO2F2_HUMAN | [view interactions] | High throughput | no | no |
| SCMC1_HUMAN | [view interactions] | High throughput | no | no |
| PDXD1_HUMAN | [view interactions] | High throughput | no | no |
| TBC9B_HUMAN | [view interactions] | High throughput | no | yes |
| TNPO2_HUMAN | [view interactions] | High throughput | no | yes |
| CAND2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MTX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ECHD1_HUMAN | [view interactions] | High throughput | no | no |
| SFXN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| NOTC3_HUMAN | [view interactions] | High throughput | no | yes |