TM108_HUMAN
Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is necessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 and recruits the WAVE1 complex to facilitate actin-dependent BDNF:NTRK2 early endocytic trafficking and mediate signaling from early endosomes. [View more on UniProt]
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No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
No data found.
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in TM108_HUMAN |
---|---|---|---|---|
GO:0006996 | organelle organization | 41.6667 | 4 | yes |
GO:0071702 | organic substance transport | 41.6667 | 4 | no |
GO:0071705 | nitrogen compound transport | 41.6667 | 4 | no |
GO:0010468 | regulation of gene expression | 33.3333 | 5 | no |
GO:0043933 | protein-containing complex organization | 33.3333 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 33.3333 | 4 | no |
GO:0030030 | cell projection organization | 25.0000 | 4 | yes |
GO:0031175 | neuron projection development | 25.0000 | 6 | yes |
GO:0048522 | positive regulation of cellular process | 25.0000 | 4 | yes |
GO:0120036 | plasma membrane bounded cell projection organization | 25.0000 | 5 | yes |
GO:0008104 | protein localization | 25.0000 | 4 | no |
GO:0015031 | protein transport | 25.0000 | 4 | no |
GO:0022607 | cellular component assembly | 25.0000 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 25.0000 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 25.0000 | 4 | no |
GO:0065003 | protein-containing complex assembly | 25.0000 | 5 | no |
GO:0080090 | regulation of primary metabolic process | 25.0000 | 4 | no |
GO:0006897 | endocytosis | 16.6667 | 5 | yes |
GO:0006898 | receptor-mediated endocytosis | 16.6667 | 6 | yes |
GO:0016192 | vesicle-mediated transport | 16.6667 | 4 | yes |
GO:0070848 | response to growth factor | 16.6667 | 4 | yes |
GO:0071310 | cellular response to organic substance | 16.6667 | 4 | yes |
GO:0071363 | cellular response to growth factor stimulus | 16.6667 | 5 | yes |
GO:0097484 | dendrite extension | 16.6667 | 5 | yes |
GO:1990090 | cellular response to nerve growth factor stimulus | 16.6667 | 4 | yes |
GO:1990138 | neuron projection extension | 16.6667 | 4 | yes |
GO:1990416 | cellular response to brain-derived neurotrophic factor stimulus | 16.6667 | 5 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
EPS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ANXA7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARHG6_HUMAN | [view interactions] | High throughput | no | no |
SH3G2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KNTC1_HUMAN | [view interactions] | High throughput | no | no |
XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MTFP1_HUMAN | [view interactions] | High throughput | no | no |
RRN3_HUMAN | [view interactions] | High throughput | no | yes |
SCMC3_HUMAN | [view interactions] | High throughput | no | yes |
SFXN5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
BRAT1_HUMAN | [view interactions] | High throughput | no | yes |
ACD10_HUMAN | [view interactions] | High throughput | no | no |
TBB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MAP2_HUMAN | [view interactions] | High throughput | no | yes |
TCAF2_HUMAN | [view interactions] | High throughput | no | no |
FHL3_HUMAN | [view interactions] | High throughput | no | no |
FKBP7_HUMAN | [view interactions] | High throughput | no | yes |
SGTB_HUMAN | [view interactions] | High throughput | no | yes |
PO2F2_HUMAN | [view interactions] | High throughput | no | no |
SCMC1_HUMAN | [view interactions] | High throughput | no | no |
PDXD1_HUMAN | [view interactions] | High throughput | no | no |
TBC9B_HUMAN | [view interactions] | High throughput | no | yes |
TNPO2_HUMAN | [view interactions] | High throughput | no | yes |
CAND2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MTX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ECHD1_HUMAN | [view interactions] | High throughput | no | no |
SFXN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CSK_HUMAN | [view interactions] | High throughput | no | yes |
NOTC3_HUMAN | [view interactions] | High throughput | no | yes |