Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

VGLU1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in VGLU1_HUMAN
GO:0019900 kinase binding 23.5294 4 no
GO:0019902 phosphatase binding 23.5294 4 no
GO:0019903 protein phosphatase binding 23.5294 5 no
GO:0005216 monoatomic ion channel activity 11.7647 4 yes
GO:0005253 monoatomic anion channel activity 11.7647 5 yes
GO:0008509 monoatomic anion transmembrane transporter activity 11.7647 4 yes
GO:0015267 channel activity 11.7647 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in VGLU1_HUMAN
GO:0051128 regulation of cellular component organization 70.5882 4 yes
GO:0048523 negative regulation of cellular process 70.5882 4 no
GO:0048522 positive regulation of cellular process 58.8235 4 no
GO:0051049 regulation of transport 52.9412 4 yes
GO:0031323 regulation of cellular metabolic process 52.9412 4 no
GO:0010646 regulation of cell communication 52.9412 4 no
GO:0043933 protein-containing complex organization 47.0588 4 no
GO:0060255 regulation of macromolecule metabolic process 47.0588 4 no
GO:0080090 regulation of primary metabolic process 47.0588 4 no
GO:0009966 regulation of signal transduction 47.0588 4 no
GO:0019220 regulation of phosphate metabolic process 41.1765 6 no
GO:0031399 regulation of protein modification process 41.1765 6 no
GO:0042325 regulation of phosphorylation 41.1765 7 no
GO:0051174 regulation of phosphorus metabolic process 41.1765 5 no
GO:0051246 regulation of protein metabolic process 41.1765 5 no
GO:0009893 positive regulation of metabolic process 41.1765 4 no
GO:0031325 positive regulation of cellular metabolic process 41.1765 5 no
GO:0050804 modulation of chemical synaptic transmission 41.1765 5 no
GO:0051130 positive regulation of cellular component organization 41.1765 5 no
GO:0099177 regulation of trans-synaptic signaling 41.1765 4 no
GO:0007268 chemical synaptic transmission 35.2941 7 yes
GO:0098916 anterograde trans-synaptic signaling 35.2941 6 yes
GO:0099536 synaptic signaling 35.2941 4 yes
GO:0099537 trans-synaptic signaling 35.2941 5 yes
GO:0001932 regulation of protein phosphorylation 35.2941 7 no
GO:0009889 regulation of biosynthetic process 35.2941 4 no
GO:0009892 negative regulation of metabolic process 35.2941 4 no
GO:0010468 regulation of gene expression 35.2941 6 no
GO:0010556 regulation of macromolecule biosynthetic process 35.2941 5 no
GO:0030030 cell projection organization 35.2941 4 no
GO:0031324 negative regulation of cellular metabolic process 35.2941 5 no
GO:0031326 regulation of cellular biosynthetic process 35.2941 5 no
GO:0010604 positive regulation of macromolecule metabolic process 35.2941 5 no
GO:0022607 cellular component assembly 35.2941 4 no
GO:0048584 positive regulation of response to stimulus 35.2941 4 no
GO:0050890 cognition 35.2941 4 no
GO:0060627 regulation of vesicle-mediated transport 29.4118 4 yes
GO:0009890 negative regulation of biosynthetic process 29.4118 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 29.4118 6 no
GO:0010605 negative regulation of macromolecule metabolic process 29.4118 5 no
GO:0031175 neuron projection development 29.4118 6 no
GO:0031327 negative regulation of cellular biosynthetic process 29.4118 6 no
GO:0120036 plasma membrane bounded cell projection organization 29.4118 5 no
GO:0006996 organelle organization 29.4118 4 no
GO:0007612 learning 29.4118 4 no
GO:0010562 positive regulation of phosphorus metabolic process 29.4118 6 no
GO:0010647 positive regulation of cell communication 29.4118 5 no
GO:0023056 positive regulation of signaling 29.4118 4 no
GO:0034762 regulation of transmembrane transport 29.4118 4 no
GO:0042327 positive regulation of phosphorylation 29.4118 8 no
GO:0045937 positive regulation of phosphate metabolic process 29.4118 7 no
GO:0051051 negative regulation of transport 29.4118 4 no
GO:0051094 positive regulation of developmental process 29.4118 4 no
GO:0051129 negative regulation of cellular component organization 29.4118 5 no
GO:0051247 positive regulation of protein metabolic process 29.4118 6 no
GO:0032880 regulation of protein localization 29.4118 5 no
GO:0044087 regulation of cellular component biogenesis 29.4118 4 no
GO:0060341 regulation of cellular localization 29.4118 4 no
GO:1903829 positive regulation of protein localization 29.4118 5 no
GO:0006915 apoptotic process 29.4118 4 no
GO:0030100 regulation of endocytosis 23.5294 5 yes
GO:0007417 central nervous system development 23.5294 4 no
GO:0022411 cellular component disassembly 23.5294 4 no
GO:0032984 protein-containing complex disassembly 23.5294 5 no
GO:0051261 protein depolymerization 23.5294 6 no
GO:0001934 positive regulation of protein phosphorylation 23.5294 8 no
GO:0009967 positive regulation of signal transduction 23.5294 5 no
GO:0022898 regulation of transmembrane transporter activity 23.5294 4 no
GO:0031401 positive regulation of protein modification process 23.5294 7 no
GO:0043549 regulation of kinase activity 23.5294 5 no
GO:0048168 regulation of neuronal synaptic plasticity 23.5294 4 no
GO:0048169 regulation of long-term neuronal synaptic plasticity 23.5294 5 no
GO:0050806 positive regulation of synaptic transmission 23.5294 5 no
GO:0050905 neuromuscular process 23.5294 4 no
GO:0051338 regulation of transferase activity 23.5294 4 no
GO:0036211 protein modification process 23.5294 4 no
GO:0043412 macromolecule modification 23.5294 4 no
GO:0009894 regulation of catabolic process 23.5294 4 no
GO:0031329 regulation of cellular catabolic process 23.5294 5 no
GO:0033043 regulation of organelle organization 23.5294 5 no
GO:0034330 cell junction organization 23.5294 4 no
GO:0045595 regulation of cell differentiation 23.5294 4 no
GO:0050808 synapse organization 23.5294 5 no
GO:0051240 positive regulation of multicellular organismal process 23.5294 4 no
GO:0080134 regulation of response to stress 23.5294 4 no
GO:0097435 supramolecular fiber organization 23.5294 4 no
GO:0009891 positive regulation of biosynthetic process 23.5294 5 no
GO:0031328 positive regulation of cellular biosynthetic process 23.5294 6 no
GO:0042981 regulation of apoptotic process 23.5294 5 no
GO:0043067 regulation of programmed cell death 23.5294 4 no
GO:0042127 regulation of cell population proliferation 23.5294 4 no
GO:0050807 regulation of synapse organization 23.5294 5 no
GO:0006811 monoatomic ion transport 11.7647 4 yes
GO:0006820 monoatomic anion transport 11.7647 5 yes
GO:0006836 neurotransmitter transport 11.7647 4 yes
GO:0071702 organic substance transport 11.7647 4 yes
GO:0071705 nitrogen compound transport 11.7647 4 yes
GO:1903421 regulation of synaptic vesicle recycling 11.7647 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SH3G3_HUMAN [view entry] [view interactions] Low throughput yes no
SH3G2_HUMAN [view entry] [view interactions] Low throughput yes yes
SH3G1_HUMAN [view entry] [view interactions] Low throughput yes no
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
DNJC5_HUMAN [view interactions] Low throughput no yes
SYUA_HUMAN [view entry] [view interactions] Low throughput yes no
APBB1_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
PTPRT_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
TIA1_HUMAN [view interactions] High throughput no no
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
PRRT2_HUMAN [view entry] [view interactions] High throughput yes no
UBP48_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
SPPL3_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
NLGN2_HUMAN [view entry] [view interactions] High throughput yes yes
VGLU2_HUMAN [view interactions] High throughput no no
DCE1_HUMAN [view entry] [view interactions] High throughput yes yes
DCE2_HUMAN [view interactions] High throughput no yes
PDE1B_HUMAN [view interactions] High throughput no yes
VDAC1_HUMAN [view entry] [view interactions] High throughput yes yes
CERS2_HUMAN [view interactions] High throughput no no
EST1_HUMAN [view interactions] High throughput no no
CNGA3_HUMAN [view interactions] High throughput no no
CP2U1_HUMAN [view interactions] High throughput no yes
CNGA1_HUMAN [view interactions] High throughput no no
GUC2D_HUMAN [view interactions] High throughput no no
S22A1_HUMAN [view interactions] High throughput no yes