DCE1_HUMAN
Catalyzes the production of GABA. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in DCE1_HUMAN |
---|---|---|---|---|
GO:0046872 | metal ion binding | 48.4848 | 4 | no |
GO:0017076 | purine nucleotide binding | 27.2727 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 27.2727 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 27.2727 | 4 | no |
GO:0019900 | kinase binding | 24.2424 | 4 | no |
GO:0019901 | protein kinase binding | 24.2424 | 5 | no |
GO:0005524 | ATP binding | 24.2424 | 5 | no |
GO:0030554 | adenyl nucleotide binding | 24.2424 | 5 | no |
GO:0032559 | adenyl ribonucleotide binding | 24.2424 | 5 | no |
GO:0005509 | calcium ion binding | 21.2121 | 5 | no |
GO:0030170 | pyridoxal phosphate binding | 12.1212 | 4 | yes |
GO:0016831 | carboxy-lyase activity | 9.0909 | 4 | yes |
GO:0004351 | glutamate decarboxylase activity | 6.0606 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in DCE1_HUMAN |
---|---|---|---|---|
GO:0010646 | regulation of cell communication | 54.5455 | 4 | no |
GO:0048522 | positive regulation of cellular process | 48.4848 | 4 | no |
GO:0051049 | regulation of transport | 48.4848 | 4 | no |
GO:0051050 | positive regulation of transport | 42.4242 | 4 | no |
GO:0036211 | protein modification process | 39.3939 | 4 | yes |
GO:0043412 | macromolecule modification | 39.3939 | 4 | yes |
GO:0050804 | modulation of chemical synaptic transmission | 39.3939 | 5 | no |
GO:0099177 | regulation of trans-synaptic signaling | 39.3939 | 4 | no |
GO:0048523 | negative regulation of cellular process | 39.3939 | 4 | no |
GO:0051128 | regulation of cellular component organization | 36.3636 | 4 | no |
GO:0043269 | regulation of ion transport | 36.3636 | 5 | no |
GO:0019752 | carboxylic acid metabolic process | 33.3333 | 5 | yes |
GO:0043436 | oxoacid metabolic process | 33.3333 | 4 | yes |
GO:0009966 | regulation of signal transduction | 33.3333 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 33.3333 | 4 | no |
GO:0009063 | cellular amino acid catabolic process | 30.3030 | 4 | yes |
GO:0009064 | glutamine family amino acid metabolic process | 30.3030 | 5 | yes |
GO:0016054 | organic acid catabolic process | 30.3030 | 4 | yes |
GO:0046395 | carboxylic acid catabolic process | 30.3030 | 5 | yes |
GO:1901565 | organonitrogen compound catabolic process | 30.3030 | 4 | yes |
GO:1901605 | alpha-amino acid metabolic process | 30.3030 | 4 | yes |
GO:0034762 | regulation of transmembrane transport | 30.3030 | 4 | no |
GO:0034765 | regulation of ion transmembrane transport | 30.3030 | 5 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 30.3030 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 30.3030 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 30.3030 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 30.3030 | 5 | no |
GO:0010243 | response to organonitrogen compound | 30.3030 | 4 | no |
GO:0006536 | glutamate metabolic process | 27.2727 | 6 | yes |
GO:0009065 | glutamine family amino acid catabolic process | 27.2727 | 6 | yes |
GO:0043648 | dicarboxylic acid metabolic process | 27.2727 | 6 | yes |
GO:1901606 | alpha-amino acid catabolic process | 27.2727 | 5 | yes |
GO:0006796 | phosphate-containing compound metabolic process | 27.2727 | 4 | no |
GO:0010959 | regulation of metal ion transport | 27.2727 | 6 | no |
GO:0051924 | regulation of calcium ion transport | 27.2727 | 7 | no |
GO:0071310 | cellular response to organic substance | 27.2727 | 4 | no |
GO:1903169 | regulation of calcium ion transmembrane transport | 27.2727 | 7 | no |
GO:1904062 | regulation of cation transmembrane transport | 27.2727 | 6 | no |
GO:0009892 | negative regulation of metabolic process | 27.2727 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 27.2727 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 27.2727 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 27.2727 | 5 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 27.2727 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 27.2727 | 5 | no |
GO:0007268 | chemical synaptic transmission | 24.2424 | 6 | yes |
GO:0098916 | anterograde trans-synaptic signaling | 24.2424 | 5 | yes |
GO:0099537 | trans-synaptic signaling | 24.2424 | 4 | yes |
GO:0032880 | regulation of protein localization | 24.2424 | 5 | no |
GO:0051223 | regulation of protein transport | 24.2424 | 5 | no |
GO:0060341 | regulation of cellular localization | 24.2424 | 4 | no |
GO:0070201 | regulation of establishment of protein localization | 24.2424 | 6 | no |
GO:0001932 | regulation of protein phosphorylation | 24.2424 | 7 | no |
GO:0019220 | regulation of phosphate metabolic process | 24.2424 | 6 | no |
GO:0031324 | negative regulation of cellular metabolic process | 24.2424 | 5 | no |
GO:0031399 | regulation of protein modification process | 24.2424 | 6 | no |
GO:0031400 | negative regulation of protein modification process | 24.2424 | 7 | no |
GO:0042325 | regulation of phosphorylation | 24.2424 | 7 | no |
GO:0051174 | regulation of phosphorus metabolic process | 24.2424 | 5 | no |
GO:0051248 | negative regulation of protein metabolic process | 24.2424 | 6 | no |
GO:1901566 | organonitrogen compound biosynthetic process | 24.2424 | 4 | no |
GO:0006996 | organelle organization | 21.2121 | 4 | no |
GO:0010647 | positive regulation of cell communication | 21.2121 | 5 | no |
GO:0023056 | positive regulation of signaling | 21.2121 | 4 | no |
GO:0050890 | cognition | 21.2121 | 4 | no |
GO:0051046 | regulation of secretion | 21.2121 | 5 | no |
GO:0010941 | regulation of cell death | 21.2121 | 4 | no |
GO:0043270 | positive regulation of ion transport | 21.2121 | 5 | no |
GO:0048585 | negative regulation of response to stimulus | 21.2121 | 4 | no |
GO:0051279 | regulation of release of sequestered calcium ion into cytosol | 21.2121 | 5 | no |
GO:0051282 | regulation of sequestering of calcium ion | 21.2121 | 4 | no |
GO:0001934 | positive regulation of protein phosphorylation | 21.2121 | 8 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 21.2121 | 6 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 21.2121 | 5 | no |
GO:0031401 | positive regulation of protein modification process | 21.2121 | 7 | no |
GO:0042327 | positive regulation of phosphorylation | 21.2121 | 8 | no |
GO:0043085 | positive regulation of catalytic activity | 21.2121 | 4 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 21.2121 | 7 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 21.2121 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 21.2121 | 6 | no |
GO:0051726 | regulation of cell cycle | 21.2121 | 4 | no |
GO:0006468 | protein phosphorylation | 21.2121 | 5 | no |
GO:0014070 | response to organic cyclic compound | 21.2121 | 4 | no |
GO:0016310 | phosphorylation | 21.2121 | 5 | no |
GO:0048878 | chemical homeostasis | 21.2121 | 4 | no |
GO:0051222 | positive regulation of protein transport | 21.2121 | 5 | no |
GO:1901701 | cellular response to oxygen-containing compound | 21.2121 | 4 | no |
GO:1903829 | positive regulation of protein localization | 21.2121 | 5 | no |
GO:1904951 | positive regulation of establishment of protein localization | 21.2121 | 6 | no |
GO:0008652 | cellular amino acid biosynthetic process | 21.2121 | 4 | no |
GO:0016053 | organic acid biosynthetic process | 21.2121 | 4 | no |
GO:0046394 | carboxylic acid biosynthetic process | 21.2121 | 5 | no |
GO:1901607 | alpha-amino acid biosynthetic process | 21.2121 | 5 | no |
GO:0006538 | glutamate catabolic process | 18.1818 | 5 | yes |
GO:0043649 | dicarboxylic acid catabolic process | 18.1818 | 6 | yes |
GO:0035641 | locomotory exploration behavior | 9.0909 | 4 | yes |
GO:0006540 | glutamate decarboxylation to succinate | 6.0606 | 6 | yes |
GO:0018352 | protein-pyridoxal-5-phosphate linkage | 6.0606 | 5 | yes |
GO:0042136 | neurotransmitter biosynthetic process | 6.0606 | 4 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in DCE1_HUMAN |
---|---|---|---|---|
DOID:0050700 | cardiomyopathy | 6.0606 | 4 | no |
DOID:0060036 | intrinsic cardiomyopathy | 6.0606 | 5 | no |
DOID:114 | heart disease | 6.0606 | 3 | no |
DOID:2843 | long QT syndrome | 6.0606 | 6 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
DCE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DCE2_HUMAN | [view interactions] | Low throughput | no | yes |
UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PRIO_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CALM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CALM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
BASP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KAPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KPCE_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DNMT1_HUMAN | [view interactions] | Low throughput | no | no |
TET1_HUMAN | [view interactions] | Low throughput | no | no |
MBD2_HUMAN | [view interactions] | Low throughput | no | yes |
ABL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NCK1_HUMAN | [view interactions] | High throughput | no | yes |
CKLF5_HUMAN | [view interactions] | High throughput | no | yes |
PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
3HAO_HUMAN | [view interactions] | High throughput | no | no |
STK3_HUMAN | [view interactions] | High throughput | no | yes |
ATRAP_HUMAN | [view interactions] | High throughput | no | yes |
MAL2_HUMAN | [view interactions] | High throughput | no | no |
JUN_HUMAN | [view interactions] | High throughput | no | yes |
TRI23_HUMAN | [view interactions] | High throughput | no | yes |
K1H1_HUMAN | [view interactions] | High throughput | no | no |
TRIP6_HUMAN | [view interactions] | High throughput | no | yes |
KRA32_HUMAN | [view interactions] | High throughput | no | no |
K1C40_HUMAN | [view interactions] | High throughput | no | no |
FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AURKB_HUMAN | [view interactions] | High throughput | no | yes |
DX39A_HUMAN | [view interactions] | High throughput | no | yes |
BLK_HUMAN | [view interactions] | High throughput | no | no |
APLP1_HUMAN | [view interactions] | High throughput | no | yes |
CALB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
JMJD6_HUMAN | [view interactions] | High throughput | no | yes |
VGLU1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SNP25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PP2AB_HUMAN | [view interactions] | High throughput | no | yes |
RAB3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FCERG_HUMAN | [view interactions] | Computational | no | no |
FCERA_HUMAN | [view interactions] | Computational | no | yes |
CNDP2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CNDP1_HUMAN | [view interactions] | Computational | no | yes |
CDO1_HUMAN | [view interactions] | Computational | no | no |
SMS_HUMAN | [view entry] [view interactions] | Computational | yes | no |
ASGL1_HUMAN | [view interactions] | Computational | no | yes |
AL3B1_HUMAN | [view interactions] | Computational | no | yes |
GCSH_HUMAN | [view interactions] | Computational | no | yes |
AL3B2_HUMAN | [view interactions] | Computational | no | yes |
OPLA_HUMAN | [view interactions] | Computational | no | no |
GSH0_HUMAN | [view interactions] | Computational | no | yes |
PRVA_HUMAN | [view interactions] | Computational | no | yes |
PAQR1_HUMAN | [view interactions] | Computational | no | no |
CSAD_HUMAN | [view interactions] | Computational | no | yes |
GGT5_HUMAN | [view interactions] | Computational | no | yes |
PURA2_HUMAN | [view interactions] | Computational | no | yes |
VIAAT_HUMAN | [view interactions] | Computational | no | yes |
AL3A1_HUMAN | [view interactions] | Computational | no | no |
SYEP_HUMAN | [view interactions] | Computational | no | yes |
FTCD_HUMAN | [view interactions] | Computational | no | no |
ASSY_HUMAN | [view interactions] | Computational | no | yes |
ASNS_HUMAN | [view interactions] | Computational | no | yes |
LAT_HUMAN | [view interactions] | Computational | no | no |
P5CS_HUMAN | [view interactions] | Computational | no | yes |
AATC2_HUMAN | [view interactions] | Computational | no | no |
AATM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
FCERB_HUMAN | [view interactions] | Computational | no | no |
AL4A1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PYR1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AEDO_HUMAN | [view interactions] | Computational | no | yes |
BAAT_HUMAN | [view interactions] | Computational | no | no |
ACY2_HUMAN | [view interactions] | Computational | no | no |
BUP1_HUMAN | [view interactions] | Computational | no | no |
CALB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GABT_HUMAN | [view interactions] | Computational | no | yes |
GCSP_HUMAN | [view interactions] | Computational | no | yes |
GLSK_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SC6A1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
MECP2_HUMAN | [view interactions] | Computational | no | yes |
CRNS1_HUMAN | [view interactions] | Computational | no | no |
LCP2_HUMAN | [view interactions] | Computational | no | yes |
VGLU2_HUMAN | [view interactions] | Computational | no | no |
DHE3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
DHE4_HUMAN | [view interactions] | Computational | no | yes |
PLCG1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SYEM_HUMAN | [view interactions] | Computational | no | yes |
NAT8L_HUMAN | [view interactions] | Computational | no | no |
AATC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GCST_HUMAN | [view interactions] | Computational | no | yes |
NTAL_HUMAN | [view interactions] | Computational | no | no |
PURA1_HUMAN | [view interactions] | Computational | no | no |
OXLA_HUMAN | [view interactions] | Computational | no | no |
GLNA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GATM_HUMAN | [view interactions] | Computational | no | no |
DLDH_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GGT1_HUMAN | [view interactions] | Computational | no | no |
GLSL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GGT7_HUMAN | [view interactions] | Computational | no | yes |
GADL1_HUMAN | [view interactions] | Computational | no | no |
L2HDH_HUMAN | [view interactions] | Computational | no | yes |