Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SRGP3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SRGP3_HUMAN
GO:0005096 GTPase activator activity 22.5806 4 yes
GO:0030695 GTPase regulator activity 22.5806 4 yes
GO:0019900 kinase binding 22.5806 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in SRGP3_HUMAN
GO:0010646 regulation of cell communication 74.1935 4 yes
GO:0009966 regulation of signal transduction 64.5161 4 yes
GO:0048523 negative regulation of cellular process 61.2903 4 yes
GO:0048522 positive regulation of cellular process 61.2903 4 no
GO:0060255 regulation of macromolecule metabolic process 61.2903 4 no
GO:0006996 organelle organization 54.8387 4 no
GO:0031323 regulation of cellular metabolic process 54.8387 4 no
GO:0051171 regulation of nitrogen compound metabolic process 54.8387 4 no
GO:0080090 regulation of primary metabolic process 54.8387 4 no
GO:0009893 positive regulation of metabolic process 51.6129 4 no
GO:0051128 regulation of cellular component organization 48.3871 4 no
GO:0051246 regulation of protein metabolic process 48.3871 5 no
GO:1902531 regulation of intracellular signal transduction 45.1613 5 yes
GO:0023056 positive regulation of signaling 45.1613 4 no
GO:0031325 positive regulation of cellular metabolic process 45.1613 5 no
GO:0010604 positive regulation of macromolecule metabolic process 45.1613 5 no
GO:0008104 protein localization 41.9355 4 no
GO:0010647 positive regulation of cell communication 41.9355 5 no
GO:0051049 regulation of transport 41.9355 4 no
GO:0022607 cellular component assembly 41.9355 4 no
GO:0016192 vesicle-mediated transport 38.7097 4 no
GO:0007010 cytoskeleton organization 38.7097 5 no
GO:0019220 regulation of phosphate metabolic process 38.7097 6 no
GO:0051174 regulation of phosphorus metabolic process 38.7097 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 38.7097 5 no
GO:0031399 regulation of protein modification process 35.4839 6 no
GO:0042325 regulation of phosphorylation 35.4839 7 no
GO:0048584 positive regulation of response to stimulus 35.4839 4 no
GO:0030030 cell projection organization 35.4839 4 no
GO:0120036 plasma membrane bounded cell projection organization 35.4839 5 no
GO:0051247 positive regulation of protein metabolic process 35.4839 6 no
GO:0001932 regulation of protein phosphorylation 32.2581 7 no
GO:0009967 positive regulation of signal transduction 32.2581 5 no
GO:0031344 regulation of cell projection organization 32.2581 5 no
GO:0051130 positive regulation of cellular component organization 32.2581 5 no
GO:0009892 negative regulation of metabolic process 32.2581 4 no
GO:0010605 negative regulation of macromolecule metabolic process 32.2581 5 no
GO:0050804 modulation of chemical synaptic transmission 29.0323 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 29.0323 5 no
GO:0099177 regulation of trans-synaptic signaling 29.0323 4 no
GO:0071702 organic substance transport 29.0323 4 no
GO:0071705 nitrogen compound transport 29.0323 4 no
GO:0043933 protein-containing complex organization 29.0323 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 29.0323 6 no
GO:0010468 regulation of gene expression 29.0323 5 no
GO:0010562 positive regulation of phosphorus metabolic process 29.0323 6 no
GO:0042327 positive regulation of phosphorylation 29.0323 8 no
GO:0045937 positive regulation of phosphate metabolic process 29.0323 7 no
GO:0060627 regulation of vesicle-mediated transport 29.0323 4 no
GO:0043085 positive regulation of catalytic activity 25.8065 4 no
GO:0009894 regulation of catabolic process 25.8065 4 no
GO:0033043 regulation of organelle organization 25.8065 5 no
GO:0043269 regulation of ion transport 25.8065 5 no
GO:0044087 regulation of cellular component biogenesis 25.8065 4 no
GO:0051050 positive regulation of transport 25.8065 4 no
GO:0001934 positive regulation of protein phosphorylation 25.8065 8 no
GO:0031401 positive regulation of protein modification process 25.8065 7 no
GO:0051248 negative regulation of protein metabolic process 22.5806 6 no
GO:0015031 protein transport 22.5806 4 no
GO:0032880 regulation of protein localization 22.5806 5 no
GO:0060341 regulation of cellular localization 22.5806 4 no
GO:0031324 negative regulation of cellular metabolic process 22.5806 5 no
GO:0051056 regulation of small GTPase mediated signal transduction 22.5806 6 yes
GO:0006897 endocytosis 22.5806 5 no
GO:0010648 negative regulation of cell communication 22.5806 5 no
GO:0010941 regulation of cell death 22.5806 4 no
GO:0023057 negative regulation of signaling 22.5806 4 no
GO:0051336 regulation of hydrolase activity 22.5806 4 no
GO:0032990 cell part morphogenesis 22.5806 4 no
GO:0048858 cell projection morphogenesis 22.5806 5 no
GO:0071310 cellular response to organic substance 22.5806 4 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 22.5806 6 no
GO:0022603 regulation of anatomical structure morphogenesis 22.5806 4 no
GO:0030031 cell projection assembly 22.5806 5 no
GO:0030100 regulation of endocytosis 22.5806 5 no
GO:0031175 neuron projection development 22.5806 6 no
GO:0120031 plasma membrane bounded cell projection assembly 22.5806 6 no
GO:0030162 regulation of proteolysis 22.5806 6 no
GO:0030334 regulation of cell migration 19.3548 5 yes
GO:2000145 regulation of cell motility 19.3548 4 yes
GO:0030336 negative regulation of cell migration 12.9032 6 yes
GO:0040013 negative regulation of locomotion 12.9032 4 yes
GO:2000146 negative regulation of cell motility 12.9032 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
SH3G2_HUMAN [view entry] [view interactions] Low throughput yes yes
AMPH_HUMAN [view entry] [view interactions] Low throughput yes yes
SH3G1_HUMAN [view entry] [view interactions] Low throughput yes no
SRGP3_HUMAN [view entry] [view interactions] Low throughput yes yes
TNFL6_HUMAN [view interactions] High throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
SUV91_HUMAN [view interactions] High throughput no no
KDM1A_HUMAN [view interactions] High throughput no yes
ANM6_HUMAN [view interactions] High throughput no yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
SMCA4_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
H12_HUMAN [view interactions] High throughput no yes
S10AA_HUMAN [view interactions] High throughput no no
CYFP2_HUMAN [view entry] [view interactions] High throughput yes yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
BMI1_HUMAN [view interactions] High throughput no yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
DTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
ENKD1_HUMAN [view interactions] High throughput no yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
SRGP2_HUMAN [view entry] [view interactions] High throughput yes no
ACAD8_HUMAN [view interactions] High throughput no yes
CLOCK_HUMAN [view interactions] High throughput no yes
SPAG5_HUMAN [view interactions] High throughput no yes
CC85C_HUMAN [view interactions] High throughput no yes
ASPP1_HUMAN [view interactions] High throughput no yes
ASPP2_HUMAN [view interactions] High throughput no yes
CCD22_HUMAN [view entry] [view interactions] High throughput yes no
PGTB1_HUMAN [view interactions] High throughput no no
TGM2_HUMAN [view interactions] High throughput no no
KIF2C_HUMAN [view entry] [view interactions] High throughput yes no
RAD18_HUMAN [view interactions] High throughput no yes
CCN1_HUMAN [view interactions] High throughput no yes
RN123_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
RHG24_HUMAN [view interactions] High throughput no yes
NKTR_HUMAN [view interactions] High throughput no no
RAPH1_HUMAN [view entry] [view interactions] High throughput yes yes
ROBO1_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
MAN1_HUMAN [view interactions] High throughput no yes
VAMP2_HUMAN [view entry] [view interactions] High throughput yes no
TGS1_HUMAN [view interactions] High throughput no yes
FACE1_HUMAN [view interactions] High throughput no yes
SMHD1_HUMAN [view interactions] High throughput no yes
VAMP3_HUMAN [view entry] [view interactions] High throughput yes no
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
CHIN_HUMAN [view interactions] High throughput no no
ABR_HUMAN [view entry] [view interactions] High throughput yes yes
RHG44_HUMAN [view entry] [view interactions] High throughput yes yes
CHIO_HUMAN [view interactions] High throughput no yes
OPHN1_HUMAN [view entry] [view interactions] High throughput yes yes
ARI1A_HUMAN [view interactions] High throughput no yes
WASF1_HUMAN [view entry] [view interactions] High throughput yes yes
SMRC2_HUMAN [view interactions] High throughput no yes
SRGP1_HUMAN [view interactions] Computational no no
ROBO2_HUMAN [view interactions] Computational no yes
GRIN2_HUMAN [view interactions] Computational no yes
HYDIN_HUMAN [view interactions] Computational no no
CDC42_HUMAN [view entry] [view interactions] Computational yes yes