Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CAD10_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CAD10_HUMAN
GO:0043169 cation binding 42.8571 4 yes
GO:0046872 metal ion binding 42.8571 5 yes
GO:0019900 kinase binding 42.8571 4 no
GO:0045296 cadherin binding 35.7143 4 yes
GO:0019901 protein kinase binding 35.7143 5 no
GO:0000166 nucleotide binding 28.5714 4 no
GO:0005524 ATP binding 28.5714 5 no
GO:0017076 purine nucleotide binding 28.5714 5 no
GO:0030554 adenyl nucleotide binding 28.5714 6 no
GO:0032555 purine ribonucleotide binding 28.5714 4 no
GO:0032559 adenyl ribonucleotide binding 28.5714 5 no
GO:0035639 purine ribonucleoside triphosphate binding 28.5714 4 no
GO:0043168 anion binding 28.5714 4 no
GO:0019902 phosphatase binding 28.5714 4 no
GO:0019903 protein phosphatase binding 28.5714 5 no
GO:0005509 calcium ion binding 21.4286 6 yes
GO:0004674 protein serine/threonine kinase activity 21.4286 4 no
GO:0016301 kinase activity 21.4286 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 21.4286 4 no
GO:0106310 protein serine kinase activity 21.4286 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in CAD10_HUMAN
GO:0048522 positive regulation of cellular process 78.5714 4 no
GO:0051128 regulation of cellular component organization 71.4286 4 no
GO:0008104 protein localization 64.2857 4 no
GO:0010646 regulation of cell communication 64.2857 4 no
GO:0060255 regulation of macromolecule metabolic process 57.1429 4 no
GO:0080090 regulation of primary metabolic process 57.1429 4 no
GO:0022607 cellular component assembly 57.1429 4 yes
GO:0072657 protein localization to membrane 57.1429 4 no
GO:0009893 positive regulation of metabolic process 57.1429 4 no
GO:0010604 positive regulation of macromolecule metabolic process 57.1429 5 no
GO:0031344 regulation of cell projection organization 50.0000 5 no
GO:0009966 regulation of signal transduction 50.0000 4 no
GO:0022603 regulation of anatomical structure morphogenesis 50.0000 4 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 50.0000 5 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0048584 positive regulation of response to stimulus 50.0000 4 no
GO:0051246 regulation of protein metabolic process 50.0000 5 no
GO:0010975 regulation of neuron projection development 42.8571 7 no
GO:0030030 cell projection organization 42.8571 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 42.8571 6 no
GO:0120036 plasma membrane bounded cell projection organization 42.8571 5 no
GO:1990778 protein localization to cell periphery 42.8571 5 no
GO:0034330 cell junction organization 42.8571 4 yes
GO:0009967 positive regulation of signal transduction 42.8571 5 no
GO:0010647 positive regulation of cell communication 42.8571 5 no
GO:0023056 positive regulation of signaling 42.8571 4 no
GO:0051049 regulation of transport 42.8571 4 no
GO:0051247 positive regulation of protein metabolic process 42.8571 6 no
GO:0072659 protein localization to plasma membrane 35.7143 5 no
GO:0031175 neuron projection development 35.7143 6 no
GO:0007043 cell-cell junction assembly 35.7143 6 yes
GO:0034329 cell junction assembly 35.7143 5 yes
GO:0045216 cell-cell junction organization 35.7143 5 yes
GO:0043113 receptor clustering 35.7143 5 no
GO:0031399 regulation of protein modification process 35.7143 6 no
GO:0060341 regulation of cellular localization 28.5714 4 no
GO:1902531 regulation of intracellular signal transduction 28.5714 5 no
GO:2000026 regulation of multicellular organismal development 28.5714 4 no
GO:0001932 regulation of protein phosphorylation 28.5714 7 no
GO:0001934 positive regulation of protein phosphorylation 28.5714 8 no
GO:0010562 positive regulation of phosphorus metabolic process 28.5714 6 no
GO:0019220 regulation of phosphate metabolic process 28.5714 6 no
GO:0031401 positive regulation of protein modification process 28.5714 7 no
GO:0042325 regulation of phosphorylation 28.5714 7 no
GO:0042327 positive regulation of phosphorylation 28.5714 8 no
GO:0045937 positive regulation of phosphate metabolic process 28.5714 7 no
GO:0051174 regulation of phosphorus metabolic process 28.5714 5 no
GO:0030334 regulation of cell migration 28.5714 5 no
GO:0050804 modulation of chemical synaptic transmission 28.5714 5 no
GO:0099177 regulation of trans-synaptic signaling 28.5714 4 no
GO:2000145 regulation of cell motility 28.5714 4 no
GO:0034332 adherens junction organization 28.5714 6 yes
GO:0006796 phosphate-containing compound metabolic process 28.5714 4 no
GO:0050808 synapse organization 28.5714 5 no
GO:0010243 response to organonitrogen compound 28.5714 4 no
GO:0032880 regulation of protein localization 28.5714 5 no
GO:0042127 regulation of cell population proliferation 28.5714 4 no
GO:0051094 positive regulation of developmental process 28.5714 4 no
GO:0051130 positive regulation of cellular component organization 28.5714 5 no
GO:0051241 negative regulation of multicellular organismal process 28.5714 4 no
GO:0051960 regulation of nervous system development 21.4286 5 no
GO:0051961 negative regulation of nervous system development 21.4286 5 no
GO:0060284 regulation of cell development 21.4286 5 no
GO:0060828 regulation of canonical Wnt signaling pathway 21.4286 6 no
GO:0071310 cellular response to organic substance 21.4286 4 no
GO:0071407 cellular response to organic cyclic compound 21.4286 5 no
GO:0071417 cellular response to organonitrogen compound 21.4286 4 no
GO:0071680 response to indole-3-methanol 21.4286 5 no
GO:0071681 cellular response to indole-3-methanol 21.4286 5 no
GO:0097305 response to alcohol 21.4286 4 no
GO:0097306 cellular response to alcohol 21.4286 5 no
GO:0141124 intracellular signaling cassette 21.4286 4 no
GO:1901699 cellular response to nitrogen compound 21.4286 4 no
GO:1901701 cellular response to oxygen-containing compound 21.4286 4 no
GO:1902533 positive regulation of intracellular signal transduction 21.4286 6 no
GO:1902680 positive regulation of RNA biosynthetic process 21.4286 7 no
GO:2000177 regulation of neural precursor cell proliferation 21.4286 5 no
GO:2001141 regulation of RNA biosynthetic process 21.4286 6 no
GO:0006996 organelle organization 21.4286 4 no
GO:0016310 phosphorylation 21.4286 5 no
GO:0048812 neuron projection morphogenesis 21.4286 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 21.4286 4 no
GO:0051050 positive regulation of transport 21.4286 4 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 21.4286 8 no
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 21.4286 9 no
GO:0043085 positive regulation of catalytic activity 21.4286 4 no
GO:0007399 nervous system development 21.4286 4 no
GO:0031346 positive regulation of cell projection organization 21.4286 6 no
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 21.4286 5 yes
GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules 21.4286 5 yes
GO:0044331 cell-cell adhesion mediated by cadherin 21.4286 4 yes
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 21.4286 4 yes
GO:0010038 response to metal ion 21.4286 4 no
GO:0006355 regulation of DNA-templated transcription 21.4286 7 no
GO:0007167 enzyme-linked receptor protein signaling pathway 21.4286 4 no
GO:0009889 regulation of biosynthetic process 21.4286 4 no
GO:0009891 positive regulation of biosynthetic process 21.4286 5 no
GO:0010468 regulation of gene expression 21.4286 6 no
GO:0010556 regulation of macromolecule biosynthetic process 21.4286 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 21.4286 6 no
GO:0010721 negative regulation of cell development 21.4286 6 no
GO:0014070 response to organic cyclic compound 21.4286 4 no
GO:0016055 Wnt signaling pathway 21.4286 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.4286 5 no
GO:0030111 regulation of Wnt signaling pathway 21.4286 5 no
GO:0031326 regulation of cellular biosynthetic process 21.4286 5 no
GO:0031328 positive regulation of cellular biosynthetic process 21.4286 6 no
GO:0033043 regulation of organelle organization 21.4286 5 no
GO:0036211 protein modification process 21.4286 4 no
GO:0043408 regulation of MAPK cascade 21.4286 6 no
GO:0043410 positive regulation of MAPK cascade 21.4286 7 no
GO:0043412 macromolecule modification 21.4286 4 no
GO:0045595 regulation of cell differentiation 21.4286 4 no
GO:0045596 negative regulation of cell differentiation 21.4286 5 no
GO:0045893 positive regulation of DNA-templated transcription 21.4286 8 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 21.4286 5 no
GO:0050767 regulation of neurogenesis 21.4286 6 no
GO:0050768 negative regulation of neurogenesis 21.4286 6 no
GO:0050807 regulation of synapse organization 21.4286 5 no
GO:0050982 detection of mechanical stimulus 21.4286 4 no
GO:0051093 negative regulation of developmental process 21.4286 4 no
GO:0051240 positive regulation of multicellular organismal process 21.4286 4 no
GO:0051252 regulation of RNA metabolic process 21.4286 5 no
GO:0051254 positive regulation of RNA metabolic process 21.4286 6 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
LRRC7_HUMAN [view entry] [view interactions] Low throughput yes no
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
CADH2_HUMAN [view entry] [view interactions] Low throughput yes no
GEPH_HUMAN [view entry] [view interactions] Low throughput yes yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
CTNA3_HUMAN [view interactions] High throughput no no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CYFP2_HUMAN [view entry] [view interactions] High throughput yes yes
MYOME_HUMAN [view interactions] High throughput no no
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
CSN6_HUMAN [view interactions] High throughput no yes
PTN_HUMAN [view entry] [view interactions] High throughput yes yes
PLAK_HUMAN [view entry] [view interactions] High throughput yes yes
KALRN_HUMAN [view entry] [view interactions] High throughput yes yes
ACK1_HUMAN [view entry] [view interactions] High throughput yes yes