Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CABP1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs)(PubMed). Inhibits agonist-induced intracellular calcium signaling (PubMed). Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels (PubMed). Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function (PubMed). Suppresses the calcium-dependent inactivation of CACNA1D . Inhibits TRPC5 channels (PubMed). Prevents NMDA receptor-induced cellular degeneration. Required for the normal transfer of light signals through the retina . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CABP1_HUMAN
GO:0046872 metal ion binding 66.6667 4 yes
GO:0005509 calcium ion binding 50.0000 5 yes
GO:0005216 ion channel activity 33.3333 4 no
GO:0005261 cation channel activity 33.3333 5 no
GO:0005262 calcium channel activity 33.3333 6 no
GO:0008324 cation transmembrane transporter activity 33.3333 4 no
GO:0015085 calcium ion transmembrane transporter activity 33.3333 6 no
GO:0015267 channel activity 33.3333 4 no
GO:0022836 gated channel activity 33.3333 5 no
GO:0022890 inorganic cation transmembrane transporter activity 33.3333 4 no
GO:0046873 metal ion transmembrane transporter activity 33.3333 5 no
GO:0019902 phosphatase binding 33.3333 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in CABP1_HUMAN
GO:0051049 regulation of transport 50.0000 4 yes
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0048522 positive regulation of cellular process 50.0000 4 no
GO:0032386 regulation of intracellular transport 33.3333 5 yes
GO:0032880 regulation of protein localization 33.3333 5 yes
GO:0033157 regulation of intracellular protein transport 33.3333 6 yes
GO:0048523 negative regulation of cellular process 33.3333 4 yes
GO:0051223 regulation of protein transport 33.3333 5 yes
GO:0060341 regulation of cellular localization 33.3333 4 yes
GO:0070201 regulation of establishment of protein localization 33.3333 6 yes
GO:0006811 ion transport 33.3333 4 no
GO:0006812 cation transport 33.3333 5 no
GO:0006816 calcium ion transport 33.3333 7 no
GO:0009966 regulation of signal transduction 33.3333 4 no
GO:0030001 metal ion transport 33.3333 6 no
GO:0051282 regulation of sequestering of calcium ion 33.3333 4 no
GO:0070588 calcium ion transmembrane transport 33.3333 6 no
GO:0097553 calcium ion transmembrane import into cytosol 33.3333 7 no
GO:0098655 cation transmembrane transport 33.3333 4 no
GO:0098660 inorganic ion transmembrane transport 33.3333 4 no
GO:0098662 inorganic cation transmembrane transport 33.3333 5 no
GO:1902531 regulation of intracellular signal transduction 33.3333 5 no
GO:0009893 positive regulation of metabolic process 33.3333 4 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0050804 modulation of chemical synaptic transmission 33.3333 5 no
GO:0051171 regulation of nitrogen compound metabolic process 33.3333 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 33.3333 5 no
GO:0060255 regulation of macromolecule metabolic process 33.3333 4 no
GO:0080090 regulation of primary metabolic process 33.3333 4 no
GO:0099177 regulation of trans-synaptic signaling 33.3333 4 no
GO:0019722 calcium-mediated signaling 33.3333 5 no
GO:0019932 second-messenger-mediated signaling 33.3333 4 no
GO:0031279 regulation of cyclase activity 33.3333 4 no
GO:0031281 positive regulation of cyclase activity 33.3333 5 no
GO:0043085 positive regulation of catalytic activity 33.3333 4 no
GO:0045761 regulation of adenylate cyclase activity 33.3333 5 no
GO:0045762 positive regulation of adenylate cyclase activity 33.3333 6 no
GO:0051339 regulation of lyase activity 33.3333 4 no
GO:0051349 positive regulation of lyase activity 33.3333 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NSMF_HUMAN [view entry] [view interactions] Low throughput yes yes
CAC1C_HUMAN [view entry] [view interactions] Low throughput yes no
CAC1A_HUMAN [view interactions] Low throughput no no
ITPR1_HUMAN [view entry] [view interactions] Low throughput yes yes
CANB1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRK5_HUMAN [view interactions] Low throughput no yes
NMT1_HUMAN [view interactions] Low throughput no yes
SP1_HUMAN [view interactions] High throughput no yes
FOS_HUMAN [view interactions] High throughput no yes
NECD_HUMAN [view interactions] High throughput no no
UBP4_HUMAN [view interactions] High throughput no no
DDX58_HUMAN [view interactions] High throughput no yes
ATPF2_HUMAN [view interactions] High throughput no yes
AKAP5_HUMAN [view entry] [view interactions] Computational yes yes