Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CABP1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs)(PubMed). Inhibits agonist-induced intracellular calcium signaling (PubMed). Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels (PubMed). Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function (PubMed). Suppresses the calcium-dependent inactivation of CACNA1D . Inhibits TRPC5 channels (PubMed). Prevents NMDA receptor-induced cellular degeneration. Required for the normal transfer of light signals through the retina . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CABP1_HUMAN
GO:0043169 cation binding 88.8889 4 yes
GO:0046872 metal ion binding 88.8889 5 yes
GO:0005509 calcium ion binding 66.6667 6 yes
GO:0005246 calcium channel regulator activity 44.4444 5 yes
GO:0099106 ion channel regulator activity 44.4444 4 yes
GO:0019888 protein phosphatase regulator activity 44.4444 4 no
GO:0005216 monoatomic ion channel activity 33.3333 4 no
GO:0005261 monoatomic cation channel activity 33.3333 5 no
GO:0005262 calcium channel activity 33.3333 6 no
GO:0008324 monoatomic cation transmembrane transporter activity 33.3333 4 no
GO:0015085 calcium ion transmembrane transporter activity 33.3333 6 no
GO:0015267 channel activity 33.3333 4 no
GO:0022836 gated channel activity 33.3333 5 no
GO:0022890 inorganic cation transmembrane transporter activity 33.3333 4 no
GO:0046873 metal ion transmembrane transporter activity 33.3333 5 no
GO:0008200 ion channel inhibitor activity 33.3333 5 no
GO:0010853 cyclase activator activity 33.3333 4 no
GO:0010854 adenylate cyclase regulator activity 33.3333 4 no
GO:0010856 adenylate cyclase activator activity 33.3333 5 no
GO:0016248 channel inhibitor activity 33.3333 4 no
GO:0019209 kinase activator activity 33.3333 4 no
GO:0019211 phosphatase activator activity 33.3333 4 no
GO:0019855 calcium channel inhibitor activity 33.3333 6 no
GO:0019887 protein kinase regulator activity 33.3333 4 no
GO:0019900 kinase binding 33.3333 4 no
GO:0019901 protein kinase binding 33.3333 5 no
GO:0030295 protein kinase activator activity 33.3333 5 no
GO:0031432 titin binding 33.3333 4 no
GO:0043539 protein serine/threonine kinase activator activity 33.3333 6 no
GO:0072542 protein phosphatase activator activity 33.3333 5 no
GO:0005244 voltage-gated monoatomic ion channel activity 22.2222 5 no
GO:0005245 voltage-gated calcium channel activity 22.2222 7 no
GO:0008331 high voltage-gated calcium channel activity 22.2222 8 no
GO:0022832 voltage-gated channel activity 22.2222 6 no
GO:0022843 voltage-gated monoatomic cation channel activity 22.2222 6 no
GO:0008179 adenylate cyclase binding 22.2222 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in CABP1_HUMAN
GO:0051049 regulation of transport 77.7778 4 yes
GO:0010646 regulation of cell communication 77.7778 4 no
GO:0048523 negative regulation of cellular process 66.6667 4 yes
GO:0031323 regulation of cellular metabolic process 66.6667 4 no
GO:0048522 positive regulation of cellular process 66.6667 4 no
GO:0060255 regulation of macromolecule metabolic process 55.5556 4 no
GO:0080090 regulation of primary metabolic process 55.5556 4 no
GO:1902531 regulation of intracellular signal transduction 55.5556 5 no
GO:0051051 negative regulation of transport 55.5556 4 yes
GO:0010959 regulation of metal ion transport 55.5556 6 no
GO:0019722 calcium-mediated signaling 55.5556 5 no
GO:0034762 regulation of transmembrane transport 55.5556 4 no
GO:0034765 regulation of monoatomic ion transmembrane transport 55.5556 5 no
GO:0043269 regulation of monoatomic ion transport 55.5556 5 no
GO:0051282 regulation of sequestering of calcium ion 55.5556 4 no
GO:0051924 regulation of calcium ion transport 55.5556 7 no
GO:0141124 intracellular signaling cassette 55.5556 4 no
GO:1903169 regulation of calcium ion transmembrane transport 55.5556 7 no
GO:1904062 regulation of monoatomic cation transmembrane transport 55.5556 6 no
GO:0009893 positive regulation of metabolic process 55.5556 4 no
GO:0009966 regulation of signal transduction 55.5556 4 no
GO:0010604 positive regulation of macromolecule metabolic process 55.5556 5 no
GO:0031325 positive regulation of cellular metabolic process 55.5556 5 no
GO:0050848 regulation of calcium-mediated signaling 55.5556 6 no
GO:0051050 positive regulation of transport 55.5556 4 no
GO:0051928 positive regulation of calcium ion transport 44.4444 6 no
GO:1903170 negative regulation of calcium ion transmembrane transport 44.4444 7 no
GO:1904063 negative regulation of cation transmembrane transport 44.4444 7 no
GO:1904064 positive regulation of cation transmembrane transport 44.4444 7 no
GO:1904427 positive regulation of calcium ion transmembrane transport 44.4444 7 no
GO:0010562 positive regulation of phosphorus metabolic process 44.4444 6 no
GO:0019220 regulation of phosphate metabolic process 44.4444 6 no
GO:0031399 regulation of protein modification process 44.4444 6 no
GO:0031401 positive regulation of protein modification process 44.4444 7 no
GO:0035303 regulation of dephosphorylation 44.4444 7 no
GO:0035304 regulation of protein dephosphorylation 44.4444 7 no
GO:0035306 positive regulation of dephosphorylation 44.4444 8 no
GO:0035307 positive regulation of protein dephosphorylation 44.4444 8 no
GO:0045937 positive regulation of phosphate metabolic process 44.4444 7 no
GO:0051174 regulation of phosphorus metabolic process 44.4444 5 no
GO:0051246 regulation of protein metabolic process 44.4444 5 no
GO:0051247 positive regulation of protein metabolic process 44.4444 6 no
GO:0006937 regulation of muscle contraction 44.4444 6 no
GO:0006942 regulation of striated muscle contraction 44.4444 7 no
GO:0008016 regulation of heart contraction 44.4444 6 no
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 44.4444 6 no
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 44.4444 7 no
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling 44.4444 6 no
GO:0043085 positive regulation of catalytic activity 44.4444 4 no
GO:0044057 regulation of system process 44.4444 4 no
GO:0051279 regulation of release of sequestered calcium ion into cytosol 44.4444 5 no
GO:0055117 regulation of cardiac muscle contraction 44.4444 7 no
GO:0090257 regulation of muscle system process 44.4444 5 no
GO:1903522 regulation of blood circulation 44.4444 5 no
GO:0034763 negative regulation of transmembrane transport 44.4444 5 no
GO:0034764 positive regulation of transmembrane transport 44.4444 5 no
GO:0034766 negative regulation of monoatomic ion transmembrane transport 44.4444 6 no
GO:0034767 positive regulation of monoatomic ion transmembrane transport 44.4444 6 no
GO:0043270 positive regulation of monoatomic ion transport 44.4444 5 no
GO:0043271 negative regulation of monoatomic ion transport 44.4444 5 no
GO:0051926 negative regulation of calcium ion transport 44.4444 6 no
GO:0000086 G2/M transition of mitotic cell cycle 33.3333 5 no
GO:0001932 regulation of protein phosphorylation 33.3333 7 no
GO:0001933 negative regulation of protein phosphorylation 33.3333 8 no
GO:0001934 positive regulation of protein phosphorylation 33.3333 8 no
GO:0005513 detection of calcium ion 33.3333 4 no
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0010038 response to metal ion 33.3333 4 no
GO:0010563 negative regulation of phosphorus metabolic process 33.3333 6 no
GO:0010564 regulation of cell cycle process 33.3333 5 no
GO:0010605 negative regulation of macromolecule metabolic process 33.3333 5 no
GO:0010649 regulation of cell communication by electrical coupling 33.3333 5 no
GO:0010799 regulation of peptidyl-threonine phosphorylation 33.3333 8 no
GO:0010800 positive regulation of peptidyl-threonine phosphorylation 33.3333 9 no
GO:0010801 negative regulation of peptidyl-threonine phosphorylation 33.3333 9 no
GO:0010921 regulation of phosphatase activity 33.3333 5 no
GO:0010922 positive regulation of phosphatase activity 33.3333 6 no
GO:0021762 substantia nigra development 33.3333 4 no
GO:0022898 regulation of transmembrane transporter activity 33.3333 4 no
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 no
GO:0031400 negative regulation of protein modification process 33.3333 7 no
GO:0031952 regulation of protein autophosphorylation 33.3333 8 no
GO:0031954 positive regulation of protein autophosphorylation 33.3333 9 no
GO:0032410 negative regulation of transporter activity 33.3333 4 no
GO:0032411 positive regulation of transporter activity 33.3333 4 no
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 33.3333 5 no
GO:0032413 negative regulation of ion transmembrane transporter activity 33.3333 5 no
GO:0032414 positive regulation of ion transmembrane transporter activity 33.3333 5 no
GO:0032465 regulation of cytokinesis 33.3333 5 no
GO:0032516 positive regulation of phosphoprotein phosphatase activity 33.3333 7 no
GO:0033674 positive regulation of kinase activity 33.3333 6 no
GO:0042325 regulation of phosphorylation 33.3333 7 no
GO:0042326 negative regulation of phosphorylation 33.3333 8 no
GO:0042327 positive regulation of phosphorylation 33.3333 8 no
GO:0043549 regulation of kinase activity 33.3333 5 no
GO:0043666 regulation of phosphoprotein phosphatase activity 33.3333 6 no
GO:0044772 mitotic cell cycle phase transition 33.3333 4 no
GO:0044839 cell cycle G2/M phase transition 33.3333 4 no
GO:0045859 regulation of protein kinase activity 33.3333 6 no
GO:0045860 positive regulation of protein kinase activity 33.3333 7 no
GO:0045936 negative regulation of phosphate metabolic process 33.3333 7 no
GO:0051248 negative regulation of protein metabolic process 33.3333 6 no
GO:0051280 negative regulation of release of sequestered calcium ion into cytosol 33.3333 6 no
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 33.3333 6 no
GO:0051284 positive regulation of sequestering of calcium ion 33.3333 5 no
GO:0051302 regulation of cell division 33.3333 4 no
GO:0051336 regulation of hydrolase activity 33.3333 4 no
GO:0051338 regulation of transferase activity 33.3333 4 no
GO:0051342 regulation of cyclic-nucleotide phosphodiesterase activity 33.3333 5 no
GO:0051343 positive regulation of cyclic-nucleotide phosphodiesterase activity 33.3333 6 no
GO:0051345 positive regulation of hydrolase activity 33.3333 5 no
GO:0051347 positive regulation of transferase activity 33.3333 5 no
GO:0051592 response to calcium ion 33.3333 5 no
GO:0051726 regulation of cell cycle 33.3333 4 no
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity 33.3333 6 no
GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity 33.3333 7 no
GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity 33.3333 7 no
GO:0071900 regulation of protein serine/threonine kinase activity 33.3333 7 no
GO:0071902 positive regulation of protein serine/threonine kinase activity 33.3333 8 no
GO:1901019 regulation of calcium ion transmembrane transporter activity 33.3333 6 no
GO:1901020 negative regulation of calcium ion transmembrane transporter activity 33.3333 6 no
GO:1901021 positive regulation of calcium ion transmembrane transporter activity 33.3333 6 no
GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction 33.3333 6 no
GO:1905912 regulation of calcium ion export across plasma membrane 33.3333 8 no
GO:1905913 negative regulation of calcium ion export across plasma membrane 33.3333 8 no
GO:2001257 regulation of cation channel activity 33.3333 6 no
GO:2001258 negative regulation of cation channel activity 33.3333 6 no
GO:2001259 positive regulation of cation channel activity 33.3333 6 no
GO:0006811 monoatomic ion transport 33.3333 4 no
GO:0006812 monoatomic cation transport 33.3333 5 no
GO:0006816 calcium ion transport 33.3333 7 no
GO:0030001 metal ion transport 33.3333 6 no
GO:0070588 calcium ion transmembrane transport 33.3333 5 no
GO:0097553 calcium ion transmembrane import into cytosol 33.3333 6 no
GO:0098655 monoatomic cation transmembrane transport 33.3333 4 no
GO:0098662 inorganic cation transmembrane transport 33.3333 4 no
GO:0098901 regulation of cardiac muscle cell action potential 33.3333 4 no
GO:0050804 modulation of chemical synaptic transmission 33.3333 5 no
GO:0071310 cellular response to organic substance 33.3333 4 no
GO:0099177 regulation of trans-synaptic signaling 33.3333 4 no
GO:0010647 positive regulation of cell communication 33.3333 5 no
GO:0023056 positive regulation of signaling 33.3333 4 no
GO:1901385 regulation of voltage-gated calcium channel activity 22.2222 7 no
GO:1901386 negative regulation of voltage-gated calcium channel activity 22.2222 7 no
GO:1901841 regulation of high voltage-gated calcium channel activity 22.2222 8 no
GO:1901842 negative regulation of high voltage-gated calcium channel activity 22.2222 8 no
GO:0032880 regulation of protein localization 22.2222 5 yes
GO:0051223 regulation of protein transport 22.2222 5 yes
GO:0060341 regulation of cellular localization 22.2222 4 yes
GO:0070201 regulation of establishment of protein localization 22.2222 6 yes
GO:0007507 heart development 22.2222 4 no
GO:0070509 calcium ion import 22.2222 8 no
GO:0098657 import into cell 22.2222 4 no
GO:0098659 inorganic cation import across plasma membrane 22.2222 5 no
GO:0098703 calcium ion import across plasma membrane 22.2222 6 no
GO:0099587 inorganic ion import across plasma membrane 22.2222 4 no
GO:1902656 calcium ion import into cytosol 22.2222 8 no
GO:0009967 positive regulation of signal transduction 22.2222 5 no
GO:0048584 positive regulation of response to stimulus 22.2222 4 no
GO:0051128 regulation of cellular component organization 22.2222 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NSMF_HUMAN [view entry] [view interactions] Low throughput yes yes
CAC1C_HUMAN [view entry] [view interactions] Low throughput yes no
CAC1A_HUMAN [view entry] [view interactions] Low throughput yes no
ITPR1_HUMAN [view entry] [view interactions] Low throughput yes yes
CANB1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRK5_HUMAN [view interactions] Low throughput no yes
NMT1_HUMAN [view interactions] Low throughput no yes
SP1_HUMAN [view interactions] High throughput no yes
FOS_HUMAN [view interactions] High throughput no yes
NECD_HUMAN [view interactions] High throughput no no
UBP4_HUMAN [view interactions] High throughput no no
RIGI_HUMAN [view interactions] High throughput no yes
ATPF2_HUMAN [view interactions] High throughput no yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes