Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NSMF_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway. Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
480 Thr Ala Hypogonadotropichypogonadism9withorwithoutanosmia(HH9) -
196 Arg His Hypogonadotropichypogonadism9withorwithoutanosmia(HH9) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NSMF_HUMAN
GO:0005509 calcium ion binding 44.4444 5 no
GO:0019900 kinase binding 44.4444 4 no
GO:0019901 protein kinase binding 44.4444 5 no
GO:0046872 metal ion binding 44.4444 4 no
GO:0008179 adenylate cyclase binding 33.3333 4 no
GO:0010856 adenylate cyclase activator activity 33.3333 4 no
GO:0019209 kinase activator activity 33.3333 4 no
GO:0019211 phosphatase activator activity 33.3333 4 no
GO:0019887 protein kinase regulator activity 33.3333 4 no
GO:0019888 protein phosphatase regulator activity 33.3333 4 no
GO:0030295 protein kinase activator activity 33.3333 5 no
GO:0031432 titin binding 33.3333 4 no
GO:0031997 N-terminal myristoylation domain binding 33.3333 4 no
GO:0043539 protein serine/threonine kinase activator activity 33.3333 6 no
GO:0072542 protein phosphatase activator activity 33.3333 5 no
GO:0097718 disordered domain specific binding 33.3333 4 no
GO:0005048 signal sequence binding 22.2222 4 no
GO:0008139 nuclear localization sequence binding 22.2222 5 no
GO:0005246 calcium channel regulator activity 22.2222 4 no
GO:0008200 ion channel inhibitor activity 22.2222 4 no
GO:0019855 calcium channel inhibitor activity 22.2222 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in NSMF_HUMAN
GO:0031323 regulation of cellular metabolic process 77.7778 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 77.7778 4 yes
GO:0060255 regulation of macromolecule metabolic process 77.7778 4 yes
GO:0080090 regulation of primary metabolic process 77.7778 4 yes
GO:0009893 positive regulation of metabolic process 66.6667 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 66.6667 5 yes
GO:0010646 regulation of cell communication 66.6667 4 yes
GO:0031325 positive regulation of cellular metabolic process 66.6667 5 yes
GO:0031399 regulation of protein modification process 66.6667 6 yes
GO:0031401 positive regulation of protein modification process 66.6667 7 yes
GO:0048522 positive regulation of cellular process 66.6667 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 66.6667 5 yes
GO:0051246 regulation of protein metabolic process 66.6667 5 yes
GO:0051247 positive regulation of protein metabolic process 66.6667 6 yes
GO:0048523 negative regulation of cellular process 55.5556 4 no
GO:0051049 regulation of transport 55.5556 4 no
GO:0010562 positive regulation of phosphorus metabolic process 55.5556 6 yes
GO:0019220 regulation of phosphate metabolic process 55.5556 6 yes
GO:0045937 positive regulation of phosphate metabolic process 55.5556 7 yes
GO:0051174 regulation of phosphorus metabolic process 55.5556 5 yes
GO:0009966 regulation of signal transduction 55.5556 4 no
GO:0021762 substantia nigra development 44.4444 4 no
GO:0031324 negative regulation of cellular metabolic process 44.4444 5 no
GO:0042325 regulation of phosphorylation 44.4444 7 no
GO:0042327 positive regulation of phosphorylation 44.4444 8 no
GO:0043085 positive regulation of catalytic activity 44.4444 4 no
GO:0051051 negative regulation of transport 44.4444 4 no
GO:0051338 regulation of transferase activity 44.4444 4 no
GO:0051347 positive regulation of transferase activity 44.4444 5 no
GO:1902531 regulation of intracellular signal transduction 44.4444 5 no
GO:0035303 regulation of dephosphorylation 44.4444 7 yes
GO:0035304 regulation of protein dephosphorylation 44.4444 7 yes
GO:0035306 positive regulation of dephosphorylation 44.4444 8 yes
GO:0035307 positive regulation of protein dephosphorylation 44.4444 8 yes
GO:0001932 regulation of protein phosphorylation 44.4444 7 no
GO:0001934 positive regulation of protein phosphorylation 44.4444 8 no
GO:0009892 negative regulation of metabolic process 44.4444 4 no
GO:0010038 response to metal ion 44.4444 4 no
GO:0010800 positive regulation of peptidyl-threonine phosphorylation 33.3333 9 no
GO:0010801 negative regulation of peptidyl-threonine phosphorylation 33.3333 9 no
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 33.3333 6 no
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 33.3333 7 no
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling 33.3333 6 no
GO:0010921 regulation of phosphatase activity 33.3333 5 no
GO:0010922 positive regulation of phosphatase activity 33.3333 6 no
GO:0010959 regulation of metal ion transport 33.3333 6 no
GO:0019722 calcium-mediated signaling 33.3333 5 no
GO:0019932 second-messenger-mediated signaling 33.3333 4 no
GO:0022898 regulation of transmembrane transporter activity 33.3333 4 no
GO:0031400 negative regulation of protein modification process 33.3333 7 no
GO:0031952 regulation of protein autophosphorylation 33.3333 8 no
GO:0031954 positive regulation of protein autophosphorylation 33.3333 9 no
GO:0032410 negative regulation of transporter activity 33.3333 4 no
GO:0032411 positive regulation of transporter activity 33.3333 4 no
GO:0032412 regulation of ion transmembrane transporter activity 33.3333 5 no
GO:0032413 negative regulation of ion transmembrane transporter activity 33.3333 5 no
GO:0032414 positive regulation of ion transmembrane transporter activity 33.3333 5 no
GO:0032465 regulation of cytokinesis 33.3333 5 no
GO:0032516 positive regulation of phosphoprotein phosphatase activity 33.3333 7 no
GO:0033674 positive regulation of kinase activity 33.3333 6 no
GO:0034762 regulation of transmembrane transport 33.3333 4 no
GO:0034763 negative regulation of transmembrane transport 33.3333 5 no
GO:0034764 positive regulation of transmembrane transport 33.3333 5 no
GO:0034765 regulation of ion transmembrane transport 33.3333 5 no
GO:0034766 negative regulation of ion transmembrane transport 33.3333 6 no
GO:0034767 positive regulation of ion transmembrane transport 33.3333 6 no
GO:0036211 protein modification process 33.3333 4 no
GO:0042326 negative regulation of phosphorylation 33.3333 8 no
GO:0043269 regulation of ion transport 33.3333 5 no
GO:0043270 positive regulation of ion transport 33.3333 5 no
GO:0043271 negative regulation of ion transport 33.3333 5 no
GO:0043388 positive regulation of DNA binding 33.3333 5 no
GO:0043412 macromolecule modification 33.3333 4 no
GO:0043549 regulation of kinase activity 33.3333 5 no
GO:0043666 regulation of phosphoprotein phosphatase activity 33.3333 6 no
GO:0044057 regulation of system process 33.3333 4 no
GO:0044772 mitotic cell cycle phase transition 33.3333 4 no
GO:0044839 cell cycle G2/M phase transition 33.3333 4 no
GO:0045859 regulation of protein kinase activity 33.3333 6 no
GO:0045860 positive regulation of protein kinase activity 33.3333 7 no
GO:0045936 negative regulation of phosphate metabolic process 33.3333 7 no
GO:0050848 regulation of calcium-mediated signaling 33.3333 6 no
GO:0051050 positive regulation of transport 33.3333 4 no
GO:0051099 positive regulation of binding 33.3333 4 no
GO:0051101 regulation of DNA binding 33.3333 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 33.3333 5 no
GO:0051248 negative regulation of protein metabolic process 33.3333 6 no
GO:0051279 regulation of release of sequestered calcium ion into cytosol 33.3333 5 no
GO:0051280 negative regulation of release of sequestered calcium ion into cytosol 33.3333 6 no
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 33.3333 6 no
GO:0051282 regulation of sequestering of calcium ion 33.3333 4 no
GO:0051284 positive regulation of sequestering of calcium ion 33.3333 5 no
GO:0051302 regulation of cell division 33.3333 4 no
GO:0051336 regulation of hydrolase activity 33.3333 4 no
GO:0051342 regulation of cyclic-nucleotide phosphodiesterase activity 33.3333 5 no
GO:0051343 positive regulation of cyclic-nucleotide phosphodiesterase activity 33.3333 6 no
GO:0051345 positive regulation of hydrolase activity 33.3333 5 no
GO:0051592 response to calcium ion 33.3333 5 no
GO:0051726 regulation of cell cycle 33.3333 4 no
GO:0051924 regulation of calcium ion transport 33.3333 7 no
GO:0051926 negative regulation of calcium ion transport 33.3333 6 no
GO:0051928 positive regulation of calcium ion transport 33.3333 6 no
GO:0055117 regulation of cardiac muscle contraction 33.3333 7 no
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity 33.3333 6 no
GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity 33.3333 7 no
GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity 33.3333 7 no
GO:0071900 regulation of protein serine/threonine kinase activity 33.3333 7 no
GO:0071902 positive regulation of protein serine/threonine kinase activity 33.3333 8 no
GO:0090257 regulation of muscle system process 33.3333 5 no
GO:1901019 regulation of calcium ion transmembrane transporter activity 33.3333 6 no
GO:1901020 negative regulation of calcium ion transmembrane transporter activity 33.3333 6 no
GO:1901021 positive regulation of calcium ion transmembrane transporter activity 33.3333 6 no
GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction 33.3333 6 no
GO:1903169 regulation of calcium ion transmembrane transport 33.3333 7 no
GO:1903170 negative regulation of calcium ion transmembrane transport 33.3333 7 no
GO:1903522 regulation of blood circulation 33.3333 5 no
GO:1904062 regulation of cation transmembrane transport 33.3333 6 no
GO:1904063 negative regulation of cation transmembrane transport 33.3333 7 no
GO:1904064 positive regulation of cation transmembrane transport 33.3333 7 no
GO:1904427 positive regulation of calcium ion transmembrane transport 33.3333 7 no
GO:1905912 regulation of calcium ion export across plasma membrane 33.3333 8 no
GO:1905913 negative regulation of calcium ion export across plasma membrane 33.3333 8 no
GO:2001257 regulation of cation channel activity 33.3333 6 no
GO:2001258 negative regulation of cation channel activity 33.3333 6 no
GO:2001259 positive regulation of cation channel activity 33.3333 6 no
GO:0010243 response to organonitrogen compound 33.3333 4 yes
GO:0010941 regulation of cell death 33.3333 4 yes
GO:0042981 regulation of apoptotic process 33.3333 6 yes
GO:0043067 regulation of programmed cell death 33.3333 5 yes
GO:0051128 regulation of cellular component organization 33.3333 4 yes
GO:0071310 cellular response to organic substance 33.3333 4 yes
GO:0008104 protein localization 33.3333 4 no
GO:0000086 G2/M transition of mitotic cell cycle 33.3333 5 no
GO:0001933 negative regulation of protein phosphorylation 33.3333 8 no
GO:0005513 detection of calcium ion 33.3333 4 no
GO:0006937 regulation of muscle contraction 33.3333 6 no
GO:0006942 regulation of striated muscle contraction 33.3333 7 no
GO:0006996 organelle organization 33.3333 4 no
GO:0008016 regulation of heart contraction 33.3333 6 no
GO:0010563 negative regulation of phosphorus metabolic process 33.3333 6 no
GO:0010564 regulation of cell cycle process 33.3333 5 no
GO:0010605 negative regulation of macromolecule metabolic process 33.3333 5 no
GO:0010649 regulation of cell communication by electrical coupling 33.3333 5 no
GO:0010799 regulation of peptidyl-threonine phosphorylation 33.3333 8 no
GO:0014070 response to organic cyclic compound 22.2222 4 no
GO:0016310 phosphorylation 22.2222 5 no
GO:0031279 regulation of cyclase activity 22.2222 4 no
GO:0031281 positive regulation of cyclase activity 22.2222 5 no
GO:0046777 protein autophosphorylation 22.2222 6 no
GO:0060627 regulation of vesicle-mediated transport 22.2222 4 no
GO:0098901 regulation of cardiac muscle cell action potential 22.2222 4 no
GO:1901385 regulation of voltage-gated calcium channel activity 22.2222 7 no
GO:1901386 negative regulation of voltage-gated calcium channel activity 22.2222 7 no
GO:1901841 regulation of high voltage-gated calcium channel activity 22.2222 8 no
GO:1901842 negative regulation of high voltage-gated calcium channel activity 22.2222 8 no
GO:0007010 cytoskeleton organization 22.2222 5 no
GO:0034097 response to cytokine 22.2222 4 no
GO:0071345 cellular response to cytokine stimulus 22.2222 5 no
GO:0007600 sensory perception 22.2222 4 no
GO:0032386 regulation of intracellular transport 22.2222 5 no
GO:0060341 regulation of cellular localization 22.2222 4 no
GO:0009889 regulation of biosynthetic process 22.2222 4 no
GO:0009891 positive regulation of biosynthetic process 22.2222 5 no
GO:0009894 regulation of catabolic process 22.2222 4 no
GO:0010506 regulation of autophagy 22.2222 6 no
GO:0010556 regulation of macromolecule biosynthetic process 22.2222 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 22.2222 6 no
GO:0016192 vesicle-mediated transport 22.2222 4 no
GO:0031326 regulation of cellular biosynthetic process 22.2222 5 no
GO:0031328 positive regulation of cellular biosynthetic process 22.2222 6 no
GO:0031329 regulation of cellular catabolic process 22.2222 5 no
GO:0032091 negative regulation of protein binding 22.2222 5 no
GO:0043393 regulation of protein binding 22.2222 4 no
GO:0051100 negative regulation of binding 22.2222 4 no
GO:0030334 regulation of cell migration 22.2222 5 yes
GO:0030335 positive regulation of cell migration 22.2222 6 yes
GO:0040017 positive regulation of locomotion 22.2222 4 yes
GO:0050804 modulation of chemical synaptic transmission 22.2222 5 yes
GO:0071417 cellular response to organonitrogen compound 22.2222 4 yes
GO:0099177 regulation of trans-synaptic signaling 22.2222 4 yes
GO:1901699 cellular response to nitrogen compound 22.2222 4 yes
GO:1901701 cellular response to oxygen-containing compound 22.2222 4 yes
GO:2000145 regulation of cell motility 22.2222 4 yes
GO:2000147 positive regulation of cell motility 22.2222 5 yes
GO:0015031 protein transport 22.2222 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 22.2222 5 no
GO:0033365 protein localization to organelle 22.2222 5 no
GO:0051052 regulation of DNA metabolic process 22.2222 5 no
GO:0071702 organic substance transport 22.2222 4 no
GO:0071705 nitrogen compound transport 22.2222 4 no
GO:0072594 establishment of protein localization to organelle 22.2222 4 no
GO:0002831 regulation of response to biotic stimulus 22.2222 4 no
GO:0006468 protein phosphorylation 22.2222 5 no
GO:0006796 phosphate-containing compound metabolic process 22.2222 4 no

Disease

Term Name % Distance from top the of the tree Annotated in NSMF_HUMAN
DOID:0050700 cardiomyopathy 22.2222 4 no
DOID:0060036 intrinsic cardiomyopathy 22.2222 5 no
DOID:114 heart disease 22.2222 3 no
DOID:2843 long QT syndrome 22.2222 6 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
AINX_HUMAN [view entry] [view interactions] Low throughput yes yes
CABP1_HUMAN [view entry] [view interactions] Low throughput yes yes
MK03_HUMAN [view entry] [view interactions] Low throughput yes yes
IMA5_HUMAN [view entry] [view interactions] Low throughput yes yes
SPT5H_HUMAN [view interactions] Low throughput no yes
RPB1_HUMAN [view interactions] Low throughput no no
INT11_HUMAN [view interactions] Low throughput no yes
GFI1B_HUMAN [view interactions] High throughput no no
MTR1A_HUMAN [view interactions] High throughput no no
MTR1B_HUMAN [view interactions] High throughput no yes
ITM2B_HUMAN [view interactions] High throughput no yes
HSPB3_HUMAN [view interactions] High throughput no no
PTN21_HUMAN [view interactions] High throughput no yes
LXN_HUMAN [view interactions] High throughput no yes
TRIM1_HUMAN [view interactions] High throughput no no
TRIP6_HUMAN [view interactions] High throughput no yes
TFP11_HUMAN [view interactions] High throughput no no
ML12B_HUMAN [view interactions] High throughput no no
RBTN2_HUMAN [view interactions] High throughput no yes
KIFC3_HUMAN [view interactions] High throughput no no
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
UBS3A_HUMAN [view interactions] High throughput no no
HSF2B_HUMAN [view interactions] High throughput no yes
CCDB1_HUMAN [view interactions] High throughput no yes
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
PNMA1_HUMAN [view interactions] High throughput no yes
CC125_HUMAN [view interactions] High throughput no yes
GG6L9_HUMAN [view interactions] High throughput no no
SOCS7_HUMAN [view interactions] High throughput no yes
KCD15_HUMAN [view interactions] High throughput no no
SUH_HUMAN [view interactions] High throughput no yes
RN123_HUMAN [view interactions] High throughput no yes
NDUF5_HUMAN [view interactions] High throughput no yes
CUL7_HUMAN [view interactions] High throughput no yes
IL1A_HUMAN [view interactions] High throughput no no
IL1B_HUMAN [view interactions] High throughput no no