Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ACSL6_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed, PubMed). Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ACSL6_HUMAN
GO:0000166 nucleotide binding 50.0000 4 yes
GO:0017076 purine nucleotide binding 50.0000 5 yes
GO:0030554 adenyl nucleotide binding 50.0000 6 yes
GO:0042803 protein homodimerization activity 50.0000 4 yes
GO:0043168 anion binding 37.5000 4 yes
GO:0043169 cation binding 37.5000 4 no
GO:0046872 metal ion binding 37.5000 5 no
GO:0005524 ATP binding 37.5000 5 yes
GO:0032555 purine ribonucleotide binding 37.5000 4 yes
GO:0032559 adenyl ribonucleotide binding 37.5000 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 37.5000 4 yes
GO:0047676 arachidonate-CoA ligase activity 25.0000 4 yes
GO:0019900 kinase binding 25.0000 4 no
GO:0005216 monoatomic ion channel activity 25.0000 4 no
GO:0005261 monoatomic cation channel activity 25.0000 5 no
GO:0008324 monoatomic cation transmembrane transporter activity 25.0000 4 no
GO:0015267 channel activity 25.0000 4 no
GO:0022853 active monoatomic ion transmembrane transporter activity 25.0000 4 no
GO:0022890 inorganic cation transmembrane transporter activity 25.0000 4 no
GO:0016405 CoA-ligase activity 25.0000 4 yes
GO:0016878 acid-thiol ligase activity 25.0000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ACSL6_HUMAN
GO:0031323 regulation of cellular metabolic process 62.5000 4 no
GO:0048523 negative regulation of cellular process 62.5000 4 no
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0048522 positive regulation of cellular process 50.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0006796 phosphate-containing compound metabolic process 50.0000 4 yes
GO:0009966 regulation of signal transduction 37.5000 4 no
GO:0048584 positive regulation of response to stimulus 37.5000 4 no
GO:0009889 regulation of biosynthetic process 37.5000 4 no
GO:0010556 regulation of macromolecule biosynthetic process 37.5000 5 no
GO:0031326 regulation of cellular biosynthetic process 37.5000 5 no
GO:0001676 long-chain fatty acid metabolic process 37.5000 5 yes
GO:0006163 purine nucleotide metabolic process 37.5000 5 yes
GO:0006631 fatty acid metabolic process 37.5000 4 yes
GO:0006753 nucleoside phosphate metabolic process 37.5000 4 yes
GO:0008610 lipid biosynthetic process 37.5000 4 yes
GO:0009117 nucleotide metabolic process 37.5000 5 yes
GO:0009150 purine ribonucleotide metabolic process 37.5000 6 yes
GO:0009259 ribonucleotide metabolic process 37.5000 5 yes
GO:0019693 ribose phosphate metabolic process 37.5000 4 yes
GO:0019752 carboxylic acid metabolic process 37.5000 5 yes
GO:0032787 monocarboxylic acid metabolic process 37.5000 6 yes
GO:0033865 nucleoside bisphosphate metabolic process 37.5000 5 yes
GO:0033875 ribonucleoside bisphosphate metabolic process 37.5000 6 yes
GO:0034032 purine nucleoside bisphosphate metabolic process 37.5000 5 yes
GO:0043436 oxoacid metabolic process 37.5000 4 yes
GO:0072521 purine-containing compound metabolic process 37.5000 4 yes
GO:1901362 organic cyclic compound biosynthetic process 37.5000 4 yes
GO:0009893 positive regulation of metabolic process 25.0000 4 no
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0010038 response to metal ion 25.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 25.0000 5 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0022607 cellular component assembly 25.0000 4 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 25.0000 5 no
GO:0043933 protein-containing complex organization 25.0000 4 no
GO:0050804 modulation of chemical synaptic transmission 25.0000 5 no
GO:0050890 cognition 25.0000 4 no
GO:0051049 regulation of transport 25.0000 4 no
GO:0051128 regulation of cellular component organization 25.0000 4 no
GO:0051246 regulation of protein metabolic process 25.0000 5 no
GO:0065003 protein-containing complex assembly 25.0000 5 no
GO:0080090 regulation of primary metabolic process 25.0000 4 no
GO:0099173 postsynapse organization 25.0000 4 no
GO:0099177 regulation of trans-synaptic signaling 25.0000 4 no
GO:0006811 monoatomic ion transport 25.0000 4 no
GO:0006812 monoatomic cation transport 25.0000 5 no
GO:0010243 response to organonitrogen compound 25.0000 4 no
GO:0010468 regulation of gene expression 25.0000 6 no
GO:0014070 response to organic cyclic compound 25.0000 4 no
GO:0032355 response to estradiol 25.0000 4 no
GO:0033993 response to lipid 25.0000 4 no
GO:0036293 response to decreased oxygen levels 25.0000 4 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:0098655 monoatomic cation transmembrane transport 25.0000 4 no
GO:0098662 inorganic cation transmembrane transport 25.0000 4 no
GO:0008202 steroid metabolic process 25.0000 4 no
GO:0009890 negative regulation of biosynthetic process 25.0000 5 no
GO:0009892 negative regulation of metabolic process 25.0000 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0010605 negative regulation of macromolecule metabolic process 25.0000 5 no
GO:0031324 negative regulation of cellular metabolic process 25.0000 5 no
GO:0031327 negative regulation of cellular biosynthetic process 25.0000 6 no
GO:0036296 response to increased oxygen levels 25.0000 4 no
GO:0000038 very long-chain fatty acid metabolic process 25.0000 5 yes
GO:0006164 purine nucleotide biosynthetic process 25.0000 6 yes
GO:0007405 neuroblast proliferation 25.0000 4 yes
GO:0009152 purine ribonucleotide biosynthetic process 25.0000 7 yes
GO:0009165 nucleotide biosynthetic process 25.0000 6 yes
GO:0009260 ribonucleotide biosynthetic process 25.0000 6 yes
GO:0033866 nucleoside bisphosphate biosynthetic process 25.0000 6 yes
GO:0034030 ribonucleoside bisphosphate biosynthetic process 25.0000 7 yes
GO:0034033 purine nucleoside bisphosphate biosynthetic process 25.0000 6 yes
GO:0034654 nucleobase-containing compound biosynthetic process 25.0000 4 yes
GO:0035336 long-chain fatty-acyl-CoA metabolic process 25.0000 5 yes
GO:0035337 fatty-acyl-CoA metabolic process 25.0000 4 yes
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process 25.0000 6 yes
GO:0035384 thioester biosynthetic process 25.0000 4 yes
GO:0044272 sulfur compound biosynthetic process 25.0000 4 yes
GO:0046390 ribose phosphate biosynthetic process 25.0000 5 yes
GO:0046949 fatty-acyl-CoA biosynthetic process 25.0000 5 yes
GO:0071616 acyl-CoA biosynthetic process 25.0000 4 yes
GO:0072522 purine-containing compound biosynthetic process 25.0000 5 yes
GO:0090407 organophosphate biosynthetic process 25.0000 4 yes
GO:1901137 carbohydrate derivative biosynthetic process 25.0000 4 yes
GO:1901293 nucleoside phosphate biosynthetic process 25.0000 5 yes
GO:1901566 organonitrogen compound biosynthetic process 25.0000 4 yes
GO:1901568 fatty acid derivative metabolic process 25.0000 4 yes
GO:1901570 fatty acid derivative biosynthetic process 25.0000 5 yes
GO:0006996 organelle organization 25.0000 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ACSL6_HUMAN [view entry] [view interactions] Low throughput yes yes
PAHX_HUMAN [view interactions] Low throughput no yes
ZNF16_HUMAN [view interactions] High throughput no no
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
BICD1_HUMAN [view interactions] High throughput no yes
ZN655_HUMAN [view interactions] High throughput no yes
PCMD2_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
CUL4A_HUMAN [view interactions] High throughput no no
PRPH2_HUMAN [view interactions] High throughput no no
UBP48_HUMAN [view interactions] High throughput no yes
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
ACOX1_HUMAN [view interactions] High throughput no yes
ACOT8_HUMAN [view entry] [view interactions] High throughput yes yes
CATA_HUMAN [view entry] [view interactions] High throughput yes no
ACSL1_HUMAN [view interactions] High throughput no no