Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ACSL6_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed, PubMed). Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ACSL6_HUMAN
GO:0005524 ATP binding 50.0000 5 yes
GO:0017076 purine nucleotide binding 50.0000 4 yes
GO:0030554 adenyl nucleotide binding 50.0000 5 yes
GO:0032555 purine ribonucleotide binding 50.0000 4 yes
GO:0032559 adenyl ribonucleotide binding 50.0000 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 50.0000 4 yes
GO:0042803 protein homodimerization activity 50.0000 4 yes
GO:0016405 CoA-ligase activity 33.3333 4 yes
GO:0016878 acid-thiol ligase activity 33.3333 4 yes
GO:0047676 arachidonate-CoA ligase activity 33.3333 4 yes
GO:0046872 metal ion binding 33.3333 4 no
GO:0008324 cation transmembrane transporter activity 33.3333 4 no
GO:0022853 active ion transmembrane transporter activity 33.3333 4 no
GO:0022890 inorganic cation transmembrane transporter activity 33.3333 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in ACSL6_HUMAN
GO:0001676 long-chain fatty acid metabolic process 50.0000 5 yes
GO:0006163 purine nucleotide metabolic process 50.0000 5 yes
GO:0006631 fatty acid metabolic process 50.0000 4 yes
GO:0006637 acyl-CoA metabolic process 50.0000 4 yes
GO:0006753 nucleoside phosphate metabolic process 50.0000 4 yes
GO:0006796 phosphate-containing compound metabolic process 50.0000 4 yes
GO:0008610 lipid biosynthetic process 50.0000 4 yes
GO:0009117 nucleotide metabolic process 50.0000 5 yes
GO:0009150 purine ribonucleotide metabolic process 50.0000 6 yes
GO:0009259 ribonucleotide metabolic process 50.0000 5 yes
GO:0019693 ribose phosphate metabolic process 50.0000 4 yes
GO:0019752 carboxylic acid metabolic process 50.0000 5 yes
GO:0032787 monocarboxylic acid metabolic process 50.0000 6 yes
GO:0033865 nucleoside bisphosphate metabolic process 50.0000 5 yes
GO:0033875 ribonucleoside bisphosphate metabolic process 50.0000 6 yes
GO:0034032 purine nucleoside bisphosphate metabolic process 50.0000 5 yes
GO:0043436 oxoacid metabolic process 50.0000 4 yes
GO:0043603 cellular amide metabolic process 50.0000 4 yes
GO:0072521 purine-containing compound metabolic process 50.0000 4 yes
GO:1901362 organic cyclic compound biosynthetic process 50.0000 4 yes
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0000038 very long-chain fatty acid metabolic process 33.3333 5 yes
GO:0006164 purine nucleotide biosynthetic process 33.3333 6 yes
GO:0009152 purine ribonucleotide biosynthetic process 33.3333 7 yes
GO:0009165 nucleotide biosynthetic process 33.3333 6 yes
GO:0009260 ribonucleotide biosynthetic process 33.3333 6 yes
GO:0018130 heterocycle biosynthetic process 33.3333 4 yes
GO:0019438 aromatic compound biosynthetic process 33.3333 4 yes
GO:0033866 nucleoside bisphosphate biosynthetic process 33.3333 6 yes
GO:0034030 ribonucleoside bisphosphate biosynthetic process 33.3333 7 yes
GO:0034033 purine nucleoside bisphosphate biosynthetic process 33.3333 6 yes
GO:0034654 nucleobase-containing compound biosynthetic process 33.3333 4 yes
GO:0035336 long-chain fatty-acyl-CoA metabolic process 33.3333 6 yes
GO:0035337 fatty-acyl-CoA metabolic process 33.3333 5 yes
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process 33.3333 7 yes
GO:0035384 thioester biosynthetic process 33.3333 4 yes
GO:0043604 amide biosynthetic process 33.3333 5 yes
GO:0044271 cellular nitrogen compound biosynthetic process 33.3333 4 yes
GO:0044272 sulfur compound biosynthetic process 33.3333 4 yes
GO:0046390 ribose phosphate biosynthetic process 33.3333 5 yes
GO:0046949 fatty-acyl-CoA biosynthetic process 33.3333 6 yes
GO:0071616 acyl-CoA biosynthetic process 33.3333 5 yes
GO:0072522 purine-containing compound biosynthetic process 33.3333 5 yes
GO:0090407 organophosphate biosynthetic process 33.3333 4 yes
GO:1901137 carbohydrate derivative biosynthetic process 33.3333 4 yes
GO:1901293 nucleoside phosphate biosynthetic process 33.3333 5 yes
GO:1901566 organonitrogen compound biosynthetic process 33.3333 4 yes
GO:1901568 fatty acid derivative metabolic process 33.3333 4 yes
GO:1901570 fatty acid derivative biosynthetic process 33.3333 5 yes
GO:0008202 steroid metabolic process 33.3333 4 no
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0010243 response to organonitrogen compound 33.3333 4 no
GO:0010468 regulation of gene expression 33.3333 5 no
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 no
GO:0010646 regulation of cell communication 33.3333 4 no
GO:0014070 response to organic cyclic compound 33.3333 4 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0031667 response to nutrient levels 33.3333 4 no
GO:0032355 response to estradiol 33.3333 4 no
GO:0033993 response to lipid 33.3333 4 no
GO:0036293 response to decreased oxygen levels 33.3333 4 no
GO:0036296 response to increased oxygen levels 33.3333 4 no
GO:0048522 positive regulation of cellular process 33.3333 4 no
GO:0051171 regulation of nitrogen compound metabolic process 33.3333 4 no
GO:0071310 cellular response to organic substance 33.3333 4 no
GO:0080090 regulation of primary metabolic process 33.3333 4 no
GO:0006811 ion transport 33.3333 4 no
GO:0006812 cation transport 33.3333 5 no
GO:0098655 cation transmembrane transport 33.3333 4 no
GO:0098660 inorganic ion transmembrane transport 33.3333 4 no
GO:0098662 inorganic cation transmembrane transport 33.3333 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ACSL6_HUMAN [view entry] [view interactions] Low throughput yes yes
PAHX_HUMAN [view interactions] Low throughput no yes
ZNF16_HUMAN [view interactions] High throughput no no
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
ZN655_HUMAN [view interactions] High throughput no yes
PCMD2_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
CUL4A_HUMAN [view interactions] High throughput no no
PRPH2_HUMAN [view interactions] High throughput no no
ACOX1_HUMAN [view interactions] High throughput no yes
ACOT8_HUMAN [view entry] [view interactions] High throughput yes yes
CATA_HUMAN [view entry] [view interactions] High throughput yes no
ACSL1_HUMAN [view interactions] High throughput no no