MPP2_HUMAN
Evidence for PS localization
Functions
Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density . In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression . Seems to negatively regulate SRC function in epithelial cells (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MPP2_HUMAN |
|---|---|---|---|---|
| GO:0097016 | L27 domain binding | 23.5294 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MPP2_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 58.8235 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 58.8235 | 4 | yes |
| GO:0010646 | regulation of cell communication | 52.9412 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 47.0588 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 47.0588 | 4 | no |
| GO:0022607 | cellular component assembly | 47.0588 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 41.1765 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 41.1765 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 41.1765 | 4 | no |
| GO:0072657 | protein localization to membrane | 41.1765 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 41.1765 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 41.1765 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 35.2941 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 35.2941 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 35.2941 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 35.2941 | 5 | no |
| GO:0006996 | organelle organization | 35.2941 | 4 | no |
| GO:0015031 | protein transport | 35.2941 | 4 | no |
| GO:0071702 | organic substance transport | 35.2941 | 4 | no |
| GO:0071705 | nitrogen compound transport | 35.2941 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 35.2941 | 4 | no |
| GO:1990778 | protein localization to cell periphery | 35.2941 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 35.2941 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 35.2941 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 35.2941 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 29.4118 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 29.4118 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 29.4118 | 6 | no |
| GO:0010468 | regulation of gene expression | 29.4118 | 5 | no |
| GO:0035088 | establishment or maintenance of apical/basal cell polarity | 29.4118 | 4 | no |
| GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity | 29.4118 | 5 | no |
| GO:0007268 | chemical synaptic transmission | 29.4118 | 6 | no |
| GO:0051049 | regulation of transport | 29.4118 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 29.4118 | 5 | no |
| GO:0098916 | anterograde trans-synaptic signaling | 29.4118 | 5 | no |
| GO:0099537 | trans-synaptic signaling | 29.4118 | 4 | no |
| GO:0050806 | positive regulation of synaptic transmission | 29.4118 | 5 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 23.5294 | 8 | no |
| GO:0009967 | positive regulation of signal transduction | 23.5294 | 5 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 23.5294 | 6 | no |
| GO:0019220 | regulation of phosphate metabolic process | 23.5294 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 23.5294 | 5 | no |
| GO:0031399 | regulation of protein modification process | 23.5294 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 23.5294 | 7 | no |
| GO:0042325 | regulation of phosphorylation | 23.5294 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 23.5294 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 23.5294 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 23.5294 | 5 | no |
| GO:0010038 | response to metal ion | 23.5294 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 23.5294 | 4 | no |
| GO:0022898 | regulation of transmembrane transporter activity | 23.5294 | 4 | no |
| GO:0030030 | cell projection organization | 23.5294 | 4 | no |
| GO:0032412 | regulation of ion transmembrane transporter activity | 23.5294 | 5 | no |
| GO:0033365 | protein localization to organelle | 23.5294 | 5 | no |
| GO:0034762 | regulation of transmembrane transport | 23.5294 | 4 | no |
| GO:0034765 | regulation of ion transmembrane transport | 23.5294 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 23.5294 | 4 | no |
| GO:0043269 | regulation of ion transport | 23.5294 | 5 | no |
| GO:0044057 | regulation of system process | 23.5294 | 4 | no |
| GO:0050890 | cognition | 23.5294 | 4 | no |
| GO:0060341 | regulation of cellular localization | 23.5294 | 4 | no |
| GO:0099601 | regulation of neurotransmitter receptor activity | 23.5294 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 23.5294 | 5 | no |
| GO:1904062 | regulation of cation transmembrane transport | 23.5294 | 6 | no |
| GO:2001257 | regulation of cation channel activity | 23.5294 | 6 | no |
| GO:0043933 | protein-containing complex organization | 23.5294 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 23.5294 | 5 | yes |
| GO:0001932 | regulation of protein phosphorylation | 23.5294 | 7 | no |
| GO:0060291 | long-term synaptic potentiation | 11.7647 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| JAG1_HUMAN | [view interactions] | Low throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CNTP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARHG8_HUMAN | [view interactions] | Low throughput | no | yes |
| CCG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CADM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DLGP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLK1_HUMAN | [view interactions] | High throughput | no | yes |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRAP_HUMAN | [view interactions] | High throughput | no | no |
| LIN7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRPM7_HUMAN | [view interactions] | High throughput | no | no |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| KSR2_HUMAN | [view interactions] | High throughput | no | yes |
| PRP4B_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTHD1_HUMAN | [view interactions] | High throughput | no | no |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| CUL1_HUMAN | [view interactions] | High throughput | no | yes |
| LIN7B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIN7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEBPA_HUMAN | [view interactions] | High throughput | no | yes |
| MERL_HUMAN | [view interactions] | High throughput | no | yes |
| DLG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDD_HUMAN | [view interactions] | High throughput | no | no |
| PALS2_HUMAN | [view interactions] | High throughput | no | yes |
| S20A1_HUMAN | [view interactions] | High throughput | no | yes |
| NGB_HUMAN | [view interactions] | High throughput | no | yes |
| GID4_HUMAN | [view interactions] | High throughput | no | yes |
| ARMC8_HUMAN | [view interactions] | High throughput | no | yes |
| ISOC2_HUMAN | [view interactions] | High throughput | no | yes |
| CP2S1_HUMAN | [view interactions] | High throughput | no | no |
| TCPQM_HUMAN | [view interactions] | High throughput | no | no |
| MAGA9_HUMAN | [view interactions] | High throughput | no | no |
| THRSP_HUMAN | [view interactions] | High throughput | no | no |
| MTPN_HUMAN | [view interactions] | High throughput | no | yes |
| MMAB_HUMAN | [view interactions] | High throughput | no | yes |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARM12_HUMAN | [view interactions] | High throughput | no | no |
| TEBP_HUMAN | [view interactions] | High throughput | no | yes |
| ZER1_HUMAN | [view interactions] | High throughput | no | no |
| TBB8_HUMAN | [view interactions] | High throughput | no | no |
| ABLM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MBP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ERBIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |