Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MPP2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density . In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression . Seems to negatively regulate SRC function in epithelial cells (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in MPP2_HUMAN
GO:0019900 kinase binding 23.8095 4 no
GO:0043169 cation binding 23.8095 4 no
GO:0046872 metal ion binding 23.8095 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in MPP2_HUMAN
GO:0010646 regulation of cell communication 61.9048 4 yes
GO:0048522 positive regulation of cellular process 61.9048 4 yes
GO:0022607 cellular component assembly 57.1429 4 yes
GO:0009966 regulation of signal transduction 57.1429 4 no
GO:0008104 protein localization 57.1429 4 no
GO:0048523 negative regulation of cellular process 52.3810 4 no
GO:0060255 regulation of macromolecule metabolic process 52.3810 4 no
GO:0080090 regulation of primary metabolic process 52.3810 4 no
GO:0006996 organelle organization 42.8571 4 no
GO:0031323 regulation of cellular metabolic process 42.8571 4 no
GO:0051246 regulation of protein metabolic process 42.8571 5 no
GO:0010647 positive regulation of cell communication 38.0952 5 yes
GO:0023056 positive regulation of signaling 38.0952 4 yes
GO:0043933 protein-containing complex organization 38.0952 4 yes
GO:0065003 protein-containing complex assembly 38.0952 5 yes
GO:0009889 regulation of biosynthetic process 38.0952 4 no
GO:0009893 positive regulation of metabolic process 38.0952 4 no
GO:0010556 regulation of macromolecule biosynthetic process 38.0952 5 no
GO:0010604 positive regulation of macromolecule metabolic process 38.0952 5 no
GO:0031326 regulation of cellular biosynthetic process 38.0952 5 no
GO:0051049 regulation of transport 38.0952 4 no
GO:0051128 regulation of cellular component organization 38.0952 4 no
GO:0050804 modulation of chemical synaptic transmission 33.3333 5 yes
GO:0099177 regulation of trans-synaptic signaling 33.3333 4 yes
GO:0007268 chemical synaptic transmission 33.3333 7 no
GO:0098916 anterograde trans-synaptic signaling 33.3333 6 no
GO:0099536 synaptic signaling 33.3333 4 no
GO:0099537 trans-synaptic signaling 33.3333 5 no
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0010468 regulation of gene expression 33.3333 6 no
GO:0010605 negative regulation of macromolecule metabolic process 33.3333 5 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0031399 regulation of protein modification process 33.3333 6 no
GO:0048584 positive regulation of response to stimulus 33.3333 4 no
GO:0048585 negative regulation of response to stimulus 33.3333 4 no
GO:0050890 cognition 33.3333 4 no
GO:0051130 positive regulation of cellular component organization 33.3333 5 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:1902531 regulation of intracellular signal transduction 33.3333 5 no
GO:0072657 protein localization to membrane 33.3333 4 no
GO:0001932 regulation of protein phosphorylation 28.5714 7 no
GO:0009968 negative regulation of signal transduction 28.5714 5 no
GO:0010648 negative regulation of cell communication 28.5714 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 28.5714 5 no
GO:0019220 regulation of phosphate metabolic process 28.5714 6 no
GO:0023057 negative regulation of signaling 28.5714 4 no
GO:0030162 regulation of proteolysis 28.5714 6 no
GO:0031324 negative regulation of cellular metabolic process 28.5714 5 no
GO:0031401 positive regulation of protein modification process 28.5714 7 no
GO:0042325 regulation of phosphorylation 28.5714 7 no
GO:0051174 regulation of phosphorus metabolic process 28.5714 5 no
GO:0060341 regulation of cellular localization 28.5714 4 no
GO:0035088 establishment or maintenance of apical/basal cell polarity 28.5714 4 no
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 28.5714 5 no
GO:0071702 organic substance transport 28.5714 4 no
GO:0071705 nitrogen compound transport 28.5714 4 no
GO:1990778 protein localization to cell periphery 28.5714 5 no
GO:0050806 positive regulation of synaptic transmission 23.8095 5 yes
GO:0001817 regulation of cytokine production 23.8095 4 no
GO:0007010 cytoskeleton organization 23.8095 5 no
GO:0009890 negative regulation of biosynthetic process 23.8095 5 no
GO:0009891 positive regulation of biosynthetic process 23.8095 5 no
GO:0009967 positive regulation of signal transduction 23.8095 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 23.8095 6 no
GO:0010558 negative regulation of macromolecule biosynthetic process 23.8095 6 no
GO:0022603 regulation of anatomical structure morphogenesis 23.8095 4 no
GO:0031327 negative regulation of cellular biosynthetic process 23.8095 6 no
GO:0031328 positive regulation of cellular biosynthetic process 23.8095 6 no
GO:0032101 regulation of response to external stimulus 23.8095 4 no
GO:0032880 regulation of protein localization 23.8095 5 no
GO:0033043 regulation of organelle organization 23.8095 5 no
GO:0042127 regulation of cell population proliferation 23.8095 4 no
GO:0043085 positive regulation of catalytic activity 23.8095 4 no
GO:0044087 regulation of cellular component biogenesis 23.8095 4 no
GO:0050776 regulation of immune response 23.8095 4 no
GO:0051129 negative regulation of cellular component organization 23.8095 5 no
GO:0051248 negative regulation of protein metabolic process 23.8095 6 no
GO:0051338 regulation of transferase activity 23.8095 4 no
GO:0071310 cellular response to organic substance 23.8095 4 no
GO:0080134 regulation of response to stress 23.8095 4 no
GO:1903829 positive regulation of protein localization 23.8095 5 no
GO:0010038 response to metal ion 23.8095 4 no
GO:0030030 cell projection organization 23.8095 4 no
GO:0034762 regulation of transmembrane transport 23.8095 4 no
GO:0120036 plasma membrane bounded cell projection organization 23.8095 5 no
GO:0015031 protein transport 23.8095 4 no
GO:0033365 protein localization to organelle 23.8095 5 no
GO:0051259 protein complex oligomerization 9.5238 6 yes
GO:0051260 protein homooligomerization 9.5238 7 yes
GO:0060291 long-term synaptic potentiation 9.5238 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CNTP2_HUMAN [view entry] [view interactions] Low throughput yes yes
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
ARHG8_HUMAN [view interactions] Low throughput no yes
CCG2_HUMAN [view entry] [view interactions] Low throughput yes no
CADM1_HUMAN [view entry] [view interactions] Low throughput yes no
DLGP1_HUMAN [view entry] [view interactions] Low throughput yes no
JAG1_HUMAN [view interactions] Low throughput no no
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
MERL_HUMAN [view interactions] High throughput no yes
DLG1_HUMAN [view entry] [view interactions] High throughput yes yes
CDD_HUMAN [view interactions] High throughput no no
PALS2_HUMAN [view interactions] High throughput no yes
S20A1_HUMAN [view interactions] High throughput no yes
NGB_HUMAN [view interactions] High throughput no yes
GID4_HUMAN [view interactions] High throughput no yes
ARMC8_HUMAN [view interactions] High throughput no yes
ISOC2_HUMAN [view interactions] High throughput no yes
CP2S1_HUMAN [view interactions] High throughput no no
TCPQM_HUMAN [view interactions] High throughput no no
MAGA9_HUMAN [view interactions] High throughput no no
THRSP_HUMAN [view interactions] High throughput no no
MTPN_HUMAN [view interactions] High throughput no yes
MMAB_HUMAN [view interactions] High throughput no yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
ARM12_HUMAN [view interactions] High throughput no no
TEBP_HUMAN [view interactions] High throughput no yes
ZER1_HUMAN [view interactions] High throughput no no
TBB8_HUMAN [view interactions] High throughput no no
ABLM1_HUMAN [view entry] [view interactions] High throughput yes yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ACVL1_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
UBP48_HUMAN [view interactions] High throughput no yes
MET14_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
MIDN_HUMAN [view interactions] High throughput no no
MBP_HUMAN [view entry] [view interactions] High throughput yes no
ERBIN_HUMAN [view entry] [view interactions] High throughput yes yes
CSK2B_HUMAN [view entry] [view interactions] High throughput yes yes
PLK1_HUMAN [view interactions] High throughput no yes
GBRL2_HUMAN [view entry] [view interactions] High throughput yes yes
GBRAP_HUMAN [view entry] [view interactions] High throughput yes no
LIN7A_HUMAN [view entry] [view interactions] High throughput yes yes
TRPM7_HUMAN [view interactions] High throughput no no
KSR1_HUMAN [view interactions] High throughput no yes
KSR2_HUMAN [view interactions] High throughput no yes
PRP4B_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
PTHD1_HUMAN [view interactions] High throughput no no
CDC5L_HUMAN [view interactions] High throughput no yes
HSC20_HUMAN [view interactions] High throughput no yes
INSR_HUMAN [view interactions] High throughput no yes
ITM2B_HUMAN [view interactions] High throughput no yes
CUL1_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
LIN7B_HUMAN [view entry] [view interactions] High throughput yes no
LIN7C_HUMAN [view entry] [view interactions] High throughput yes yes
CEBPA_HUMAN [view interactions] High throughput no yes