CA2D2_HUMAN
Evidence for PS localization
Functions
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G) (PubMed, PubMed). Overexpression induces apoptosis. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CA2D2_HUMAN |
|---|---|---|---|---|
| GO:0005216 | ion channel activity | 30.7692 | 4 | yes |
| GO:0005244 | voltage-gated ion channel activity | 30.7692 | 4 | yes |
| GO:0005261 | cation channel activity | 30.7692 | 5 | yes |
| GO:0008324 | cation transmembrane transporter activity | 30.7692 | 4 | yes |
| GO:0015267 | channel activity | 30.7692 | 4 | yes |
| GO:0022832 | voltage-gated channel activity | 30.7692 | 6 | yes |
| GO:0022836 | gated channel activity | 30.7692 | 5 | yes |
| GO:0022843 | voltage-gated cation channel activity | 30.7692 | 5 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 30.7692 | 4 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 30.7692 | 5 | yes |
| GO:0005245 | voltage-gated calcium channel activity | 26.9231 | 6 | yes |
| GO:0005262 | calcium channel activity | 26.9231 | 6 | yes |
| GO:0015085 | calcium ion transmembrane transporter activity | 26.9231 | 6 | yes |
| GO:0046872 | metal ion binding | 23.0769 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CA2D2_HUMAN |
|---|---|---|---|---|
| GO:0051049 | regulation of transport | 57.6923 | 4 | yes |
| GO:0043269 | regulation of ion transport | 46.1538 | 5 | yes |
| GO:0048522 | positive regulation of cellular process | 38.4615 | 4 | no |
| GO:0034762 | regulation of transmembrane transport | 34.6154 | 4 | yes |
| GO:0034765 | regulation of ion transmembrane transport | 34.6154 | 5 | yes |
| GO:0071310 | cellular response to organic substance | 26.9231 | 4 | no |
| GO:0007268 | chemical synaptic transmission | 26.9231 | 6 | no |
| GO:0010646 | regulation of cell communication | 26.9231 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 26.9231 | 4 | no |
| GO:0046903 | secretion | 26.9231 | 4 | no |
| GO:0051046 | regulation of secretion | 26.9231 | 5 | no |
| GO:0098916 | anterograde trans-synaptic signaling | 26.9231 | 5 | no |
| GO:0099537 | trans-synaptic signaling | 26.9231 | 4 | no |
| GO:1903530 | regulation of secretion by cell | 26.9231 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 23.0769 | 4 | no |
| GO:0006887 | exocytosis | 23.0769 | 4 | no |
| GO:0099003 | vesicle-mediated transport in synapse | 23.0769 | 5 | no |
| GO:0008104 | protein localization | 23.0769 | 4 | no |
| GO:0051050 | positive regulation of transport | 23.0769 | 4 | no |
| GO:0010959 | regulation of metal ion transport | 23.0769 | 6 | no |
| GO:1904062 | regulation of cation transmembrane transport | 23.0769 | 6 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TSP4_HUMAN | [view interactions] | Low throughput | no | no |
| CAC1C_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| UBP2_HUMAN | [view interactions] | Low throughput | no | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPT1_HUMAN | [view interactions] | High throughput | no | yes |
| IGHA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TANK_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| TAZ_HUMAN | [view interactions] | High throughput | no | yes |
| TMM25_HUMAN | [view interactions] | High throughput | no | yes |
| BTNL8_HUMAN | [view interactions] | High throughput | no | no |
| PTC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPRK_HUMAN | [view interactions] | High throughput | no | no |
| RNS13_HUMAN | [view interactions] | High throughput | no | no |
| PON2_HUMAN | [view interactions] | High throughput | no | yes |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| SG1D4_HUMAN | [view interactions] | High throughput | no | no |
| DEF1_HUMAN | [view interactions] | High throughput | no | no |
| SG1D1_HUMAN | [view interactions] | High throughput | no | no |
| LIPR1_HUMAN | [view interactions] | High throughput | no | no |
| CG069_HUMAN | [view interactions] | High throughput | no | no |
| INSL5_HUMAN | [view interactions] | High throughput | no | no |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| DB123_HUMAN | [view interactions] | High throughput | no | no |
| HYOU1_HUMAN | [view interactions] | High throughput | no | yes |
| NDP_HUMAN | [view interactions] | High throughput | no | no |
| EP3B_HUMAN | [view interactions] | High throughput | no | no |
| EP3A_HUMAN | [view interactions] | High throughput | no | no |
| BY55_HUMAN | [view interactions] | High throughput | no | no |
| LCFC1_HUMAN | [view interactions] | High throughput | no | no |
| DB110_HUMAN | [view interactions] | High throughput | no | no |
| FBX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| REL1_HUMAN | [view interactions] | High throughput | no | no |
| PGFRA_HUMAN | [view interactions] | High throughput | no | no |
| DB135_HUMAN | [view interactions] | High throughput | no | no |
| BRID5_HUMAN | [view interactions] | High throughput | no | no |
| PATE1_HUMAN | [view interactions] | High throughput | no | no |
| NMS_HUMAN | [view interactions] | High throughput | no | no |
| D107A_HUMAN | [view interactions] | High throughput | no | no |
| ALKL2_HUMAN | [view interactions] | High throughput | no | no |
| PA2G5_HUMAN | [view interactions] | High throughput | no | yes |
| PATE2_HUMAN | [view interactions] | High throughput | no | no |
| CLGN_HUMAN | [view interactions] | High throughput | no | no |
| DIK1A_HUMAN | [view interactions] | High throughput | no | yes |
| DYR2_HUMAN | [view interactions] | High throughput | no | yes |
| BTNL2_HUMAN | [view interactions] | High throughput | no | no |
| DRB1_HUMAN | [view interactions] | High throughput | no | no |
| B3GT4_HUMAN | [view interactions] | High throughput | no | yes |
| NCTR3_HUMAN | [view interactions] | High throughput | no | no |
| SDF2L_HUMAN | [view interactions] | High throughput | no | yes |
| DPB1_HUMAN | [view interactions] | High throughput | no | no |
| FIBIN_HUMAN | [view interactions] | High throughput | no | yes |
| APOM_HUMAN | [view interactions] | High throughput | no | no |
| UPK2_HUMAN | [view interactions] | High throughput | no | no |
| PSPC_HUMAN | [view interactions] | High throughput | no | no |
| FUT8_HUMAN | [view interactions] | High throughput | no | yes |
| B3GA2_HUMAN | [view interactions] | High throughput | no | no |
| CBLN4_HUMAN | [view interactions] | High throughput | no | no |
| LY86_HUMAN | [view interactions] | High throughput | no | no |
| DNSL1_HUMAN | [view interactions] | High throughput | no | yes |
| SLUR1_HUMAN | [view interactions] | High throughput | no | no |
| SIRPD_HUMAN | [view interactions] | High throughput | no | no |
| LYZL2_HUMAN | [view interactions] | High throughput | no | no |
| IFNE_HUMAN | [view interactions] | High throughput | no | no |
| ISLR_HUMAN | [view interactions] | High throughput | no | no |
| LYZL1_HUMAN | [view interactions] | High throughput | no | no |
| CATG_HUMAN | [view interactions] | High throughput | no | no |
| MFAP4_HUMAN | [view interactions] | High throughput | no | no |
| T106A_HUMAN | [view interactions] | High throughput | no | no |
| PRG2_HUMAN | [view interactions] | High throughput | no | no |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTR9_HUMAN | [view interactions] | High throughput | no | yes |
| CAC1A_HUMAN | [view interactions] | Computational | no | no |
| SESN1_HUMAN | [view interactions] | Computational | no | no |
| CAC1B_HUMAN | [view interactions] | Computational | no | yes |
| CACB2_HUMAN | [view interactions] | Computational | no | yes |
| SNP25_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GBG13_HUMAN | [view interactions] | Computational | no | no |
| CAC1E_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GBG8_HUMAN | [view interactions] | Computational | no | no |
| GBB4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SYT5_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CAC1H_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GBG3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GBG10_HUMAN | [view interactions] | Computational | no | no |
| STXB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GBB3_HUMAN | [view interactions] | Computational | no | yes |
| GBGT2_HUMAN | [view interactions] | Computational | no | no |
| GBG5_HUMAN | [view interactions] | Computational | no | no |
| CCG1_HUMAN | [view interactions] | Computational | no | no |
| CAC1G_HUMAN | [view interactions] | Computational | no | no |
| CAC1D_HUMAN | [view interactions] | Computational | no | yes |
| CAC1F_HUMAN | [view interactions] | Computational | no | no |
| GBG1_HUMAN | [view interactions] | Computational | no | no |
| CACB4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CAC1S_HUMAN | [view interactions] | Computational | no | no |
| GBG11_HUMAN | [view interactions] | Computational | no | no |
| GBG12_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GBG4_HUMAN | [view interactions] | Computational | no | no |
| SESN3_HUMAN | [view interactions] | Computational | no | no |
| CACB3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GBB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GNB5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VAMP2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GBB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GBG7_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| STX1A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| INS_HUMAN | [view interactions] | Computational | no | no |
| CACB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GBG2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |