Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ARBK2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ARBK2_HUMAN
GO:0001664 G protein-coupled receptor binding 55.5556 4 yes
GO:0019900 kinase binding 33.3333 4 no
GO:0043169 cation binding 33.3333 4 no
GO:0000166 nucleotide binding 22.2222 4 yes
GO:0004674 protein serine/threonine kinase activity 22.2222 4 yes
GO:0004703 G protein-coupled receptor kinase activity 22.2222 5 yes
GO:0005524 ATP binding 22.2222 5 yes
GO:0016301 kinase activity 22.2222 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 22.2222 4 yes
GO:0017076 purine nucleotide binding 22.2222 5 yes
GO:0030554 adenyl nucleotide binding 22.2222 6 yes
GO:0032555 purine ribonucleotide binding 22.2222 4 yes
GO:0032559 adenyl ribonucleotide binding 22.2222 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 22.2222 4 yes
GO:0043168 anion binding 22.2222 4 yes
GO:0047696 beta-adrenergic receptor kinase activity 22.2222 4 yes
GO:0031690 adrenergic receptor binding 22.2222 5 no
GO:0015631 tubulin binding 22.2222 4 no
GO:0017124 SH3 domain binding 22.2222 4 no
GO:0019901 protein kinase binding 22.2222 5 no
GO:0030165 PDZ domain binding 22.2222 4 no
GO:0043130 ubiquitin binding 22.2222 4 no
GO:0046872 metal ion binding 22.2222 5 no
GO:0042803 protein homodimerization activity 22.2222 4 no
GO:0005096 GTPase activator activity 22.2222 4 no
GO:0030695 GTPase regulator activity 22.2222 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in ARBK2_HUMAN
GO:0009966 regulation of signal transduction 100.0000 4 yes
GO:0010646 regulation of cell communication 100.0000 4 yes
GO:0048523 negative regulation of cellular process 100.0000 4 yes
GO:0048585 negative regulation of response to stimulus 88.8889 4 yes
GO:0009968 negative regulation of signal transduction 77.7778 5 yes
GO:0010648 negative regulation of cell communication 77.7778 5 yes
GO:0023057 negative regulation of signaling 77.7778 4 yes
GO:0048522 positive regulation of cellular process 77.7778 4 no
GO:0051049 regulation of transport 66.6667 4 no
GO:0031323 regulation of cellular metabolic process 66.6667 4 no
GO:0060255 regulation of macromolecule metabolic process 66.6667 4 no
GO:0080090 regulation of primary metabolic process 66.6667 4 no
GO:0051241 negative regulation of multicellular organismal process 55.5556 4 no
GO:0008104 protein localization 55.5556 4 no
GO:0009889 regulation of biosynthetic process 55.5556 4 no
GO:0009893 positive regulation of metabolic process 55.5556 4 no
GO:0010468 regulation of gene expression 55.5556 6 no
GO:0010556 regulation of macromolecule biosynthetic process 55.5556 5 no
GO:0010604 positive regulation of macromolecule metabolic process 55.5556 5 no
GO:0031325 positive regulation of cellular metabolic process 55.5556 5 no
GO:0031326 regulation of cellular biosynthetic process 55.5556 5 no
GO:0051094 positive regulation of developmental process 55.5556 4 no
GO:0019220 regulation of phosphate metabolic process 55.5556 6 no
GO:0050804 modulation of chemical synaptic transmission 55.5556 5 no
GO:0051128 regulation of cellular component organization 55.5556 4 no
GO:0051174 regulation of phosphorus metabolic process 55.5556 5 no
GO:0099177 regulation of trans-synaptic signaling 55.5556 4 no
GO:1902531 regulation of intracellular signal transduction 55.5556 5 no
GO:0008277 regulation of G protein-coupled receptor signaling pathway 44.4444 5 yes
GO:0098657 import into cell 44.4444 4 yes
GO:0051050 positive regulation of transport 44.4444 4 no
GO:0009891 positive regulation of biosynthetic process 44.4444 5 no
GO:0009892 negative regulation of metabolic process 44.4444 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 44.4444 6 no
GO:0010605 negative regulation of macromolecule metabolic process 44.4444 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 44.4444 5 no
GO:0031324 negative regulation of cellular metabolic process 44.4444 5 no
GO:0031328 positive regulation of cellular biosynthetic process 44.4444 6 no
GO:0051093 negative regulation of developmental process 44.4444 4 no
GO:0071310 cellular response to organic substance 44.4444 4 no
GO:1901701 cellular response to oxygen-containing compound 44.4444 4 no
GO:2000026 regulation of multicellular organismal development 44.4444 4 no
GO:0001932 regulation of protein phosphorylation 44.4444 7 no
GO:0007612 learning 44.4444 4 no
GO:0009894 regulation of catabolic process 44.4444 4 no
GO:0022603 regulation of anatomical structure morphogenesis 44.4444 4 no
GO:0031399 regulation of protein modification process 44.4444 6 no
GO:0042325 regulation of phosphorylation 44.4444 7 no
GO:0043549 regulation of kinase activity 44.4444 5 no
GO:0048584 positive regulation of response to stimulus 44.4444 4 no
GO:0050890 cognition 44.4444 4 no
GO:0051130 positive regulation of cellular component organization 44.4444 5 no
GO:0051246 regulation of protein metabolic process 44.4444 5 no
GO:0051338 regulation of transferase activity 44.4444 4 no
GO:0045859 regulation of protein kinase activity 33.3333 6 no
GO:0002029 desensitization of G protein-coupled receptor signaling pathway 33.3333 7 yes
GO:0006898 receptor-mediated endocytosis 33.3333 4 yes
GO:0022401 negative adaptation of signaling pathway 33.3333 6 yes
GO:0023058 adaptation of signaling pathway 33.3333 5 yes
GO:0045744 negative regulation of G protein-coupled receptor signaling pathway 33.3333 6 yes
GO:0044057 regulation of system process 33.3333 4 no
GO:0051046 regulation of secretion 33.3333 5 no
GO:1903530 regulation of secretion by cell 33.3333 4 no
GO:0006355 regulation of DNA-templated transcription 33.3333 7 no
GO:0006357 regulation of transcription by RNA polymerase II 33.3333 8 no
GO:0009890 negative regulation of biosynthetic process 33.3333 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 33.3333 6 no
GO:0030030 cell projection organization 33.3333 4 no
GO:0031175 neuron projection development 33.3333 6 no
GO:0031327 negative regulation of cellular biosynthetic process 33.3333 6 no
GO:0045893 positive regulation of DNA-templated transcription 33.3333 8 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0048638 regulation of developmental growth 33.3333 4 no
GO:0051252 regulation of RNA metabolic process 33.3333 5 no
GO:0051254 positive regulation of RNA metabolic process 33.3333 6 no
GO:0072657 protein localization to membrane 33.3333 4 no
GO:0120036 plasma membrane bounded cell projection organization 33.3333 5 no
GO:1902680 positive regulation of RNA biosynthetic process 33.3333 7 no
GO:2001141 regulation of RNA biosynthetic process 33.3333 6 no
GO:0006996 organelle organization 33.3333 4 no
GO:0009967 positive regulation of signal transduction 33.3333 5 no
GO:0010506 regulation of autophagy 33.3333 6 no
GO:0010563 negative regulation of phosphorus metabolic process 33.3333 6 no
GO:0010638 positive regulation of organelle organization 33.3333 6 no
GO:0010647 positive regulation of cell communication 33.3333 5 no
GO:0022607 cellular component assembly 33.3333 4 no
GO:0023056 positive regulation of signaling 33.3333 4 no
GO:0031329 regulation of cellular catabolic process 33.3333 5 no
GO:0031401 positive regulation of protein modification process 33.3333 7 no
GO:0033043 regulation of organelle organization 33.3333 5 no
GO:0042981 regulation of apoptotic process 33.3333 5 no
GO:0043066 negative regulation of apoptotic process 33.3333 6 no
GO:0043067 regulation of programmed cell death 33.3333 4 no
GO:0043069 negative regulation of programmed cell death 33.3333 5 no
GO:0043408 regulation of MAPK cascade 33.3333 6 no
GO:0043933 protein-containing complex organization 33.3333 4 no
GO:0045936 negative regulation of phosphate metabolic process 33.3333 7 no
GO:0051129 negative regulation of cellular component organization 33.3333 5 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0060627 regulation of vesicle-mediated transport 33.3333 4 no
GO:0065003 protein-containing complex assembly 33.3333 5 no
GO:1902532 negative regulation of intracellular signal transduction 33.3333 6 no
GO:2001242 regulation of intrinsic apoptotic signaling pathway 22.2222 6 no
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 22.2222 7 no
GO:0001934 positive regulation of protein phosphorylation 22.2222 8 no
GO:0010562 positive regulation of phosphorus metabolic process 22.2222 6 no
GO:0022898 regulation of transmembrane transporter activity 22.2222 4 no
GO:0031344 regulation of cell projection organization 22.2222 5 no
GO:0031644 regulation of nervous system process 22.2222 5 no
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 22.2222 5 no
GO:0033674 positive regulation of kinase activity 22.2222 6 no
GO:0034762 regulation of transmembrane transport 22.2222 4 no
GO:0035418 protein localization to synapse 22.2222 6 no
GO:0042327 positive regulation of phosphorylation 22.2222 8 no
GO:0043085 positive regulation of catalytic activity 22.2222 4 no
GO:0043113 receptor clustering 22.2222 5 no
GO:0045860 positive regulation of protein kinase activity 22.2222 7 no
GO:0045937 positive regulation of phosphate metabolic process 22.2222 7 no
GO:0048168 regulation of neuronal synaptic plasticity 22.2222 4 no
GO:0048169 regulation of long-term neuronal synaptic plasticity 22.2222 5 no
GO:0048812 neuron projection morphogenesis 22.2222 5 no
GO:0051347 positive regulation of transferase activity 22.2222 5 no
GO:0098815 modulation of excitatory postsynaptic potential 22.2222 4 no
GO:0099601 regulation of neurotransmitter receptor activity 22.2222 4 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 22.2222 4 no
GO:1902414 protein localization to cell junction 22.2222 5 no
GO:2000463 positive regulation of excitatory postsynaptic potential 22.2222 5 no
GO:0001817 regulation of cytokine production 22.2222 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 22.2222 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 22.2222 5 no
GO:0032101 regulation of response to external stimulus 22.2222 4 no
GO:0032651 regulation of interleukin-1 beta production 22.2222 6 no
GO:0032652 regulation of interleukin-1 production 22.2222 5 no
GO:0051240 positive regulation of multicellular organismal process 22.2222 4 no
GO:0051056 regulation of small GTPase mediated signal transduction 22.2222 6 no
GO:0006796 phosphate-containing compound metabolic process 22.2222 4 yes
GO:0016310 phosphorylation 22.2222 5 yes
GO:0031623 receptor internalization 22.2222 5 yes
GO:0006936 muscle contraction 22.2222 4 no
GO:0006937 regulation of muscle contraction 22.2222 6 no
GO:0036211 protein modification process 22.2222 4 no
GO:0043412 macromolecule modification 22.2222 4 no
GO:0045932 negative regulation of muscle contraction 22.2222 5 no
GO:0050433 regulation of catecholamine secretion 22.2222 5 no
GO:0051952 regulation of amine transport 22.2222 5 no
GO:0090257 regulation of muscle system process 22.2222 5 no
GO:0000122 negative regulation of transcription by RNA polymerase II 22.2222 9 no
GO:0006508 proteolysis 22.2222 4 no
GO:0007420 brain development 22.2222 4 no
GO:0014070 response to organic cyclic compound 22.2222 4 no
GO:0032368 regulation of lipid transport 22.2222 5 no
GO:0032880 regulation of protein localization 22.2222 5 no
GO:0033993 response to lipid 22.2222 4 no
GO:0040014 regulation of multicellular organism growth 22.2222 4 no
GO:0040015 negative regulation of multicellular organism growth 22.2222 5 no
GO:0045595 regulation of cell differentiation 22.2222 4 no
GO:0045596 negative regulation of cell differentiation 22.2222 5 no
GO:0045892 negative regulation of DNA-templated transcription 22.2222 8 no
GO:0045926 negative regulation of growth 22.2222 4 no
GO:0048640 negative regulation of developmental growth 22.2222 5 no
GO:0051253 negative regulation of RNA metabolic process 22.2222 6 no
GO:0051302 regulation of cell division 22.2222 4 no
GO:0051726 regulation of cell cycle 22.2222 4 no
GO:0060341 regulation of cellular localization 22.2222 4 no
GO:0071396 cellular response to lipid 22.2222 5 no
GO:0071407 cellular response to organic cyclic compound 22.2222 5 no
GO:1902679 negative regulation of RNA biosynthetic process 22.2222 7 no
GO:1905952 regulation of lipid localization 22.2222 4 no
GO:1990778 protein localization to cell periphery 22.2222 5 no
GO:0001933 negative regulation of protein phosphorylation 22.2222 8 no
GO:0006109 regulation of carbohydrate metabolic process 22.2222 5 no
GO:0006986 response to unfolded protein 22.2222 4 no
GO:0007034 vacuolar transport 22.2222 4 no
GO:0007041 lysosomal transport 22.2222 5 no
GO:0007268 chemical synaptic transmission 22.2222 7 no
GO:0009896 positive regulation of catabolic process 22.2222 5 no
GO:0010038 response to metal ion 22.2222 4 no
GO:0010243 response to organonitrogen compound 22.2222 4 no
GO:0010508 positive regulation of autophagy 22.2222 7 no
GO:0010628 positive regulation of gene expression 22.2222 7 no
GO:0010629 negative regulation of gene expression 22.2222 7 no
GO:0017157 regulation of exocytosis 22.2222 5 no
GO:0022604 regulation of cell morphogenesis 22.2222 5 no
GO:0030100 regulation of endocytosis 22.2222 5 no
GO:0031331 positive regulation of cellular catabolic process 22.2222 6 no
GO:0031400 negative regulation of protein modification process 22.2222 7 no
GO:0033365 protein localization to organelle 22.2222 5 no
GO:0033673 negative regulation of kinase activity 22.2222 6 no
GO:0042326 negative regulation of phosphorylation 22.2222 8 no
GO:0043086 negative regulation of catalytic activity 22.2222 4 no
GO:0043122 regulation of canonical NF-kappaB signal transduction 22.2222 6 no
GO:0043393 regulation of protein binding 22.2222 4 no
GO:0043523 regulation of neuron apoptotic process 22.2222 6 no
GO:0043524 negative regulation of neuron apoptotic process 22.2222 7 no
GO:0044087 regulation of cellular component biogenesis 22.2222 4 no
GO:0045912 negative regulation of carbohydrate metabolic process 22.2222 5 no
GO:0045944 positive regulation of transcription by RNA polymerase II 22.2222 9 no
GO:0046928 regulation of neurotransmitter secretion 22.2222 5 no
GO:0050905 neuromuscular process 22.2222 4 no
GO:0051051 negative regulation of transport 22.2222 4 no
GO:0051248 negative regulation of protein metabolic process 22.2222 6 no
GO:0051348 negative regulation of transferase activity 22.2222 5 no
GO:0051493 regulation of cytoskeleton organization 22.2222 6 no
GO:0051588 regulation of neurotransmitter transport 22.2222 5 no
GO:0062012 regulation of small molecule metabolic process 22.2222 4 no
GO:0071241 cellular response to inorganic substance 22.2222 4 no
GO:0071248 cellular response to metal ion 22.2222 5 no
GO:0071417 cellular response to organonitrogen compound 22.2222 4 no
GO:0071702 organic substance transport 22.2222 4 no
GO:0071705 nitrogen compound transport 22.2222 4 no
GO:0080134 regulation of response to stress 22.2222 4 no
GO:0098916 anterograde trans-synaptic signaling 22.2222 6 no
GO:0099536 synaptic signaling 22.2222 4 no
GO:0099537 trans-synaptic signaling 22.2222 5 no
GO:1901699 cellular response to nitrogen compound 22.2222 4 no
GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 22.2222 7 no
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 22.2222 8 no
GO:1902533 positive regulation of intracellular signal transduction 22.2222 6 no
GO:1902903 regulation of supramolecular fiber organization 22.2222 5 no
GO:2001233 regulation of apoptotic signaling pathway 22.2222 5 no
GO:2001234 negative regulation of apoptotic signaling pathway 22.2222 6 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
OPN4_HUMAN [view interactions] Low throughput no no
CCR4_HUMAN [view interactions] Low throughput no yes
CXCR4_HUMAN [view interactions] Low throughput no no
GIT1_HUMAN [view entry] [view interactions] Low throughput yes yes
ADRB2_HUMAN [view entry] [view interactions] Low throughput yes no
ARBK1_HUMAN [view entry] [view interactions] High throughput yes yes
H15_HUMAN [view interactions] High throughput no no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
TX101_HUMAN [view interactions] High throughput no no
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
NTRK1_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
PTC1_HUMAN [view entry] [view interactions] High throughput yes yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes
SMUF1_HUMAN [view interactions] High throughput no yes
FOXO1_HUMAN [view interactions] High throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes