Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ARBK2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ARBK2_HUMAN
GO:0001664 G protein-coupled receptor binding 50.0000 4 yes
GO:0019900 kinase binding 25.0000 4 no
GO:0019901 protein kinase binding 25.0000 5 no
GO:0031690 adrenergic receptor binding 25.0000 5 no
GO:0004930 G protein-coupled receptor activity 25.0000 4 no
GO:0005096 GTPase activator activity 25.0000 4 no
GO:0030695 GTPase regulator activity 25.0000 4 no
GO:0004674 protein serine/threonine kinase activity 16.6667 4 yes
GO:0004703 G protein-coupled receptor kinase activity 16.6667 5 yes
GO:0005524 ATP binding 16.6667 5 yes
GO:0016301 kinase activity 16.6667 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 16.6667 4 yes
GO:0017076 purine nucleotide binding 16.6667 4 yes
GO:0030554 adenyl nucleotide binding 16.6667 5 yes
GO:0032555 purine ribonucleotide binding 16.6667 4 yes
GO:0032559 adenyl ribonucleotide binding 16.6667 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 16.6667 4 yes
GO:0047696 beta-adrenergic receptor kinase activity 16.6667 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ARBK2_HUMAN
GO:0009966 regulation of signal transduction 100.0000 4 yes
GO:0010646 regulation of cell communication 100.0000 4 yes
GO:0048523 negative regulation of cellular process 100.0000 4 yes
GO:0048585 negative regulation of response to stimulus 83.3333 4 yes
GO:0048522 positive regulation of cellular process 83.3333 4 no
GO:0009968 negative regulation of signal transduction 75.0000 5 yes
GO:0010648 negative regulation of cell communication 75.0000 5 yes
GO:0023057 negative regulation of signaling 75.0000 4 yes
GO:0031323 regulation of cellular metabolic process 75.0000 4 no
GO:0051049 regulation of transport 75.0000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 75.0000 4 no
GO:0009893 positive regulation of metabolic process 66.6667 4 no
GO:0060255 regulation of macromolecule metabolic process 66.6667 4 no
GO:0080090 regulation of primary metabolic process 66.6667 4 no
GO:0051241 negative regulation of multicellular organismal process 66.6667 4 no
GO:0010604 positive regulation of macromolecule metabolic process 58.3333 5 no
GO:0031325 positive regulation of cellular metabolic process 58.3333 5 no
GO:0048584 positive regulation of response to stimulus 58.3333 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 58.3333 5 no
GO:0009889 regulation of biosynthetic process 58.3333 4 no
GO:0010468 regulation of gene expression 58.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 58.3333 5 no
GO:1902531 regulation of intracellular signal transduction 58.3333 5 no
GO:0009892 negative regulation of metabolic process 50.0000 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 50.0000 5 no
GO:0008277 regulation of G protein-coupled receptor signaling pathway 50.0000 5 yes
GO:0008104 protein localization 50.0000 4 no
GO:0009967 positive regulation of signal transduction 50.0000 5 no
GO:0010647 positive regulation of cell communication 50.0000 5 no
GO:0019220 regulation of phosphate metabolic process 50.0000 6 no
GO:0023056 positive regulation of signaling 50.0000 4 no
GO:0042325 regulation of phosphorylation 50.0000 7 no
GO:0051094 positive regulation of developmental process 50.0000 4 no
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0051174 regulation of phosphorus metabolic process 50.0000 5 no
GO:0051246 regulation of protein metabolic process 50.0000 5 no
GO:0009891 positive regulation of biosynthetic process 50.0000 5 no
GO:0010556 regulation of macromolecule biosynthetic process 50.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 50.0000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 50.0000 6 no
GO:0043408 regulation of MAPK cascade 50.0000 6 no
GO:0051050 positive regulation of transport 50.0000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 41.6667 5 no
GO:0031324 negative regulation of cellular metabolic process 41.6667 5 no
GO:0001817 regulation of cytokine production 41.6667 4 no
GO:0032101 regulation of response to external stimulus 41.6667 4 no
GO:0080134 regulation of response to stress 41.6667 4 no
GO:0006897 endocytosis 41.6667 5 yes
GO:0006898 receptor-mediated endocytosis 41.6667 6 yes
GO:0016192 vesicle-mediated transport 41.6667 4 yes
GO:0045744 negative regulation of G protein-coupled receptor signaling pathway 41.6667 6 yes
GO:0001932 regulation of protein phosphorylation 41.6667 7 no
GO:0031399 regulation of protein modification process 41.6667 6 no
GO:0043269 regulation of ion transport 41.6667 5 no
GO:0044057 regulation of system process 41.6667 4 no
GO:0050804 modulation of chemical synaptic transmission 41.6667 5 no
GO:0051130 positive regulation of cellular component organization 41.6667 5 no
GO:0051247 positive regulation of protein metabolic process 41.6667 6 no
GO:0099177 regulation of trans-synaptic signaling 41.6667 4 no
GO:0006355 regulation of DNA-templated transcription 41.6667 6 no
GO:0010557 positive regulation of macromolecule biosynthetic process 41.6667 6 no
GO:0043410 positive regulation of MAPK cascade 41.6667 7 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 41.6667 6 no
GO:0051240 positive regulation of multicellular organismal process 41.6667 4 no
GO:0051252 regulation of RNA metabolic process 41.6667 5 no
GO:1902533 positive regulation of intracellular signal transduction 41.6667 6 no
GO:1903506 regulation of nucleic acid-templated transcription 41.6667 7 no
GO:2000026 regulation of multicellular organismal development 41.6667 4 no
GO:2001141 regulation of RNA biosynthetic process 41.6667 6 no
GO:0033993 response to lipid 33.3333 4 no
GO:0045595 regulation of cell differentiation 33.3333 4 no
GO:0010941 regulation of cell death 33.3333 4 no
GO:0032651 regulation of interleukin-1 beta production 33.3333 6 no
GO:0032652 regulation of interleukin-1 production 33.3333 5 no
GO:0042981 regulation of apoptotic process 33.3333 6 no
GO:0043066 negative regulation of apoptotic process 33.3333 7 no
GO:0043067 regulation of programmed cell death 33.3333 5 no
GO:0043069 negative regulation of programmed cell death 33.3333 6 no
GO:0060548 negative regulation of cell death 33.3333 5 no
GO:1902532 negative regulation of intracellular signal transduction 33.3333 6 no
GO:0051046 regulation of secretion 33.3333 5 no
GO:0070372 regulation of ERK1 and ERK2 cascade 33.3333 7 no
GO:0070374 positive regulation of ERK1 and ERK2 cascade 33.3333 8 no
GO:1903530 regulation of secretion by cell 33.3333 4 no
GO:0002029 desensitization of G protein-coupled receptor signaling pathway 33.3333 7 yes
GO:0022401 negative adaptation of signaling pathway 33.3333 6 yes
GO:0023058 adaptation of signaling pathway 33.3333 5 yes
GO:0031623 receptor internalization 33.3333 7 yes
GO:0036211 protein modification process 33.3333 4 yes
GO:0043412 macromolecule modification 33.3333 4 yes
GO:0001934 positive regulation of protein phosphorylation 33.3333 8 no
GO:0006996 organelle organization 33.3333 4 no
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 no
GO:0031401 positive regulation of protein modification process 33.3333 7 no
GO:0031644 regulation of nervous system process 33.3333 5 no
GO:0032880 regulation of protein localization 33.3333 5 no
GO:0034762 regulation of transmembrane transport 33.3333 4 no
GO:0034765 regulation of ion transmembrane transport 33.3333 5 no
GO:0042327 positive regulation of phosphorylation 33.3333 8 no
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 no
GO:0060341 regulation of cellular localization 33.3333 4 no
GO:0060627 regulation of vesicle-mediated transport 33.3333 4 no
GO:1904062 regulation of cation transmembrane transport 33.3333 6 no
GO:0045893 positive regulation of DNA-templated transcription 33.3333 7 no
GO:0051254 positive regulation of RNA metabolic process 33.3333 6 no
GO:0071310 cellular response to organic substance 33.3333 4 no
GO:1902680 positive regulation of RNA biosynthetic process 33.3333 7 no
GO:1903508 positive regulation of nucleic acid-templated transcription 33.3333 8 no
GO:0008285 negative regulation of cell population proliferation 25.0000 5 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:0043433 negative regulation of DNA-binding transcription factor activity 25.0000 4 no
GO:0045597 positive regulation of cell differentiation 25.0000 5 no
GO:0007167 enzyme-linked receptor protein signaling pathway 25.0000 4 no
GO:0010563 negative regulation of phosphorus metabolic process 25.0000 6 no
GO:0010628 positive regulation of gene expression 25.0000 6 no
GO:0015031 protein transport 25.0000 4 no
GO:0031400 negative regulation of protein modification process 25.0000 7 no
GO:0042326 negative regulation of phosphorylation 25.0000 8 no
GO:0045936 negative regulation of phosphate metabolic process 25.0000 7 no
GO:0051248 negative regulation of protein metabolic process 25.0000 6 no
GO:0071702 organic substance transport 25.0000 4 no
GO:0071705 nitrogen compound transport 25.0000 4 no
GO:0002237 response to molecule of bacterial origin 25.0000 4 no
GO:0032496 response to lipopolysaccharide 25.0000 4 no
GO:0001818 negative regulation of cytokine production 25.0000 5 no
GO:0010629 negative regulation of gene expression 25.0000 6 no
GO:0032675 regulation of interleukin-6 production 25.0000 5 no
GO:0046578 regulation of Ras protein signal transduction 25.0000 7 no
GO:0051056 regulation of small GTPase mediated signal transduction 25.0000 6 no
GO:0043087 regulation of GTPase activity 25.0000 5 no
GO:0043523 regulation of neuron apoptotic process 25.0000 6 no
GO:0043524 negative regulation of neuron apoptotic process 25.0000 7 no
GO:0051336 regulation of hydrolase activity 25.0000 4 no
GO:1901214 regulation of neuron death 25.0000 5 no
GO:1901215 negative regulation of neuron death 25.0000 6 no
GO:0002090 regulation of receptor internalization 25.0000 7 no
GO:0007612 learning 25.0000 4 no
GO:0022603 regulation of anatomical structure morphogenesis 25.0000 4 no
GO:0022607 cellular component assembly 25.0000 4 no
GO:0022898 regulation of transmembrane transporter activity 25.0000 4 no
GO:0030030 cell projection organization 25.0000 4 no
GO:0030100 regulation of endocytosis 25.0000 5 no
GO:0031175 neuron projection development 25.0000 6 no
GO:0032412 regulation of ion transmembrane transporter activity 25.0000 5 no
GO:0043085 positive regulation of catalytic activity 25.0000 4 no
GO:0043549 regulation of kinase activity 25.0000 5 no
GO:0045859 regulation of protein kinase activity 25.0000 6 no
GO:0048259 regulation of receptor-mediated endocytosis 25.0000 6 no
GO:0050890 cognition 25.0000 4 no
GO:0051051 negative regulation of transport 25.0000 4 no
GO:0051129 negative regulation of cellular component organization 25.0000 5 no
GO:0051338 regulation of transferase activity 25.0000 4 no
GO:0072657 protein localization to membrane 25.0000 4 no
GO:0099601 regulation of neurotransmitter receptor activity 25.0000 4 no
GO:0120036 plasma membrane bounded cell projection organization 25.0000 5 no
GO:2001257 regulation of cation channel activity 25.0000 6 no
GO:0001894 tissue homeostasis 25.0000 5 no
GO:0006357 regulation of transcription by RNA polymerase II 25.0000 7 no
GO:0006937 regulation of muscle contraction 25.0000 6 no
GO:0009894 regulation of catabolic process 25.0000 4 no
GO:0010959 regulation of metal ion transport 25.0000 6 no
GO:0033043 regulation of organelle organization 25.0000 5 no
GO:0043270 positive regulation of ion transport 25.0000 5 no
GO:0051093 negative regulation of developmental process 25.0000 4 no
GO:0060249 anatomical structure homeostasis 25.0000 4 no
GO:0090257 regulation of muscle system process 25.0000 5 no
GO:1901701 cellular response to oxygen-containing compound 25.0000 4 no
GO:0006508 proteolysis 25.0000 4 no
GO:0007420 brain development 25.0000 4 no
GO:0006468 protein phosphorylation 16.6667 5 yes
GO:0006796 phosphate-containing compound metabolic process 16.6667 4 yes
GO:0016310 phosphorylation 16.6667 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
OPN4_HUMAN [view interactions] Low throughput no no
CCR4_HUMAN [view interactions] Low throughput no yes
CXCR4_HUMAN [view interactions] Low throughput no no
GIT1_HUMAN [view entry] [view interactions] Low throughput yes yes
ADRB2_HUMAN [view entry] [view interactions] Low throughput yes no
ARBK1_HUMAN [view entry] [view interactions] High throughput yes yes
H15_HUMAN [view interactions] High throughput no no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
TX101_HUMAN [view interactions] High throughput no no
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
NTRK1_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
PTC1_HUMAN [view entry] [view interactions] High throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes
SMUF1_HUMAN [view interactions] High throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
SMO_HUMAN [view interactions] Computational no yes
SE6L1_HUMAN [view interactions] Computational no no
TA2R_HUMAN [view interactions] Computational no no
NEU2_HUMAN [view interactions] Computational no no
OPRM_HUMAN [view entry] [view interactions] Computational yes no
MY18B_HUMAN [view interactions] Computational no no
GRK5_HUMAN [view interactions] Computational no yes
PAR1_HUMAN [view entry] [view interactions] Computational yes yes
ARRB2_HUMAN [view entry] [view interactions] Computational yes no
ARRB1_HUMAN [view entry] [view interactions] Computational yes yes
GRK6_HUMAN [view interactions] Computational no yes