Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GBRA6_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GBRA6_HUMAN
GO:0004890 GABA-A receptor activity 76.9231 5 yes
GO:0005216 ion channel activity 76.9231 4 yes
GO:0005230 extracellular ligand-gated ion channel activity 76.9231 6 yes
GO:0005253 anion channel activity 76.9231 5 yes
GO:0005254 chloride channel activity 76.9231 6 yes
GO:0008509 anion transmembrane transporter activity 76.9231 4 yes
GO:0015103 inorganic anion transmembrane transporter activity 76.9231 4 yes
GO:0015108 chloride transmembrane transporter activity 76.9231 5 yes
GO:0015267 channel activity 76.9231 4 yes
GO:0015276 ligand-gated ion channel activity 76.9231 5 yes
GO:0016917 GABA receptor activity 76.9231 4 yes
GO:0022824 transmitter-gated ion channel activity 76.9231 5 yes
GO:0022834 ligand-gated channel activity 76.9231 6 yes
GO:0022835 transmitter-gated channel activity 76.9231 4 yes
GO:0022836 gated channel activity 76.9231 5 yes
GO:0022851 GABA-gated chloride ion channel activity 69.2308 5 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 69.2308 4 yes
GO:0099095 ligand-gated anion channel activity 69.2308 6 yes
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 69.2308 5 yes
GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential 69.2308 6 yes
GO:0005237 inhibitory extracellular ligand-gated ion channel activity 61.5385 7 yes
GO:0008503 benzodiazepine receptor activity 38.4615 4 yes
GO:0017076 purine nucleotide binding 23.0769 4 no
GO:0032555 purine ribonucleotide binding 23.0769 4 no
GO:0035639 purine ribonucleoside triphosphate binding 23.0769 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in GBRA6_HUMAN
GO:0006811 ion transport 84.6154 4 yes
GO:0006820 anion transport 76.9231 5 yes
GO:0006821 chloride transport 76.9231 7 yes
GO:0007268 chemical synaptic transmission 76.9231 6 yes
GO:0015698 inorganic anion transport 76.9231 6 yes
GO:0098656 anion transmembrane transport 76.9231 4 yes
GO:0098660 inorganic ion transmembrane transport 76.9231 4 yes
GO:0098661 inorganic anion transmembrane transport 76.9231 5 yes
GO:0098916 anterograde trans-synaptic signaling 76.9231 5 yes
GO:0099537 trans-synaptic signaling 76.9231 4 yes
GO:1902476 chloride transmembrane transport 76.9231 6 yes
GO:0051932 synaptic transmission, GABAergic 61.5385 7 yes
GO:0060078 regulation of postsynaptic membrane potential 53.8462 4 yes
GO:0034330 cell junction organization 46.1538 4 no
GO:0050808 synapse organization 46.1538 5 no
GO:0007416 synapse assembly 38.4615 6 no
GO:0022607 cellular component assembly 38.4615 4 no
GO:0034329 cell junction assembly 38.4615 5 no
GO:1904862 inhibitory synapse assembly 38.4615 7 no
GO:0010243 response to organonitrogen compound 23.0769 4 no
GO:0014070 response to organic cyclic compound 23.0769 4 no
GO:0034776 response to histamine 23.0769 5 no
GO:0071310 cellular response to organic substance 23.0769 4 no
GO:0071407 cellular response to organic cyclic compound 23.0769 5 no
GO:0071417 cellular response to organonitrogen compound 23.0769 4 no
GO:0071420 cellular response to histamine 23.0769 5 no
GO:1901699 cellular response to nitrogen compound 23.0769 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
UBQL1_HUMAN [view interactions] Low throughput no yes
EHD2_HUMAN [view interactions] High throughput no no
DJC18_HUMAN [view interactions] High throughput no yes
ZMY19_HUMAN [view interactions] High throughput no yes
PDZD8_HUMAN [view interactions] High throughput no yes
HLAA_HUMAN [view interactions] High throughput no no
GBRB3_HUMAN [view entry] [view interactions] High throughput yes no
AT2A3_HUMAN [view interactions] High throughput no yes
HMDH_HUMAN [view interactions] High throughput no yes
BSCL2_HUMAN [view interactions] High throughput no yes
ST7L_HUMAN [view interactions] High throughput no no
PCX3_HUMAN [view interactions] High throughput no no
GBRA5_HUMAN [view entry] [view interactions] Computational yes no
GBRA3_HUMAN [view entry] [view interactions] Computational yes yes
GBRA1_HUMAN [view entry] [view interactions] Computational yes yes
GBRB2_HUMAN [view entry] [view interactions] Computational yes no
NSF_HUMAN [view entry] [view interactions] Computational yes yes
GBRD_HUMAN [view entry] [view interactions] Computational yes yes
GBRA4_HUMAN [view entry] [view interactions] Computational yes no
GEPH_HUMAN [view entry] [view interactions] Computational yes yes
GBRG2_HUMAN [view entry] [view interactions] Computational yes no
FAT2_HUMAN [view interactions] Computational no no
DYN1_HUMAN [view entry] [view interactions] Computational yes yes
GBRAP_HUMAN [view interactions] Computational no no
GBRA2_HUMAN [view entry] [view interactions] Computational yes no