Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DRD5_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DRD5_HUMAN
GO:0046872 metal ion binding 71.4286 4 no
GO:0001664 G protein-coupled receptor binding 57.1429 4 no
GO:0003924 GTPase activity 57.1429 7 no
GO:0005525 GTP binding 57.1429 5 no
GO:0016462 pyrophosphatase activity 57.1429 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 57.1429 4 no
GO:0017076 purine nucleotide binding 57.1429 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 57.1429 6 no
GO:0019001 guanyl nucleotide binding 57.1429 5 no
GO:0032555 purine ribonucleotide binding 57.1429 4 no
GO:0032561 guanyl ribonucleotide binding 57.1429 5 no
GO:0035639 purine ribonucleoside triphosphate binding 57.1429 4 no
GO:0035240 dopamine binding 28.5714 4 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 28.5714 4 yes
GO:0050780 dopamine receptor binding 28.5714 5 no
GO:0008509 anion transmembrane transporter activity 28.5714 4 no
GO:0015103 inorganic anion transmembrane transporter activity 28.5714 4 no
GO:0015108 chloride transmembrane transporter activity 28.5714 5 no
GO:0030695 GTPase regulator activity 28.5714 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in DRD5_HUMAN
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 71.4286 4 yes
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 57.1429 5 yes
GO:0010243 response to organonitrogen compound 42.8571 4 yes
GO:0010646 regulation of cell communication 42.8571 4 yes
GO:0014070 response to organic cyclic compound 42.8571 4 yes
GO:0043085 positive regulation of catalytic activity 42.8571 4 yes
GO:0048523 negative regulation of cellular process 42.8571 4 yes
GO:0060191 regulation of lipase activity 28.5714 5 no
GO:0060193 positive regulation of lipase activity 28.5714 6 no
GO:0080090 regulation of primary metabolic process 28.5714 4 no
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway 28.5714 4 yes
GO:0007268 chemical synaptic transmission 28.5714 6 yes
GO:0042220 response to cocaine 28.5714 4 yes
GO:0043086 negative regulation of catalytic activity 28.5714 4 yes
GO:0043279 response to alkaloid 28.5714 5 yes
GO:0071310 cellular response to organic substance 28.5714 4 yes
GO:0071407 cellular response to organic cyclic compound 28.5714 5 yes
GO:0071417 cellular response to organonitrogen compound 28.5714 4 yes
GO:0098916 anterograde trans-synaptic signaling 28.5714 5 yes
GO:0099537 trans-synaptic signaling 28.5714 4 yes
GO:1901699 cellular response to nitrogen compound 28.5714 4 yes
GO:0007600 sensory perception 28.5714 4 no
GO:0007606 sensory perception of chemical stimulus 28.5714 5 no
GO:0051240 positive regulation of multicellular organismal process 28.5714 4 no
GO:0006811 ion transport 28.5714 4 no
GO:0098660 inorganic ion transmembrane transport 28.5714 4 no
GO:0009966 regulation of signal transduction 28.5714 4 no
GO:0010517 regulation of phospholipase activity 28.5714 6 no
GO:0010518 positive regulation of phospholipase activity 28.5714 7 no
GO:0031323 regulation of cellular metabolic process 28.5714 4 no
GO:0051171 regulation of nitrogen compound metabolic process 28.5714 4 no
GO:0051336 regulation of hydrolase activity 28.5714 4 no
GO:0051345 positive regulation of hydrolase activity 28.5714 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GNA13_HUMAN [view entry] [view interactions] Low throughput yes yes
GNA12_HUMAN [view interactions] Low throughput no no
GBRG2_HUMAN [view entry] [view interactions] Low throughput yes no
GNAZ_HUMAN [view entry] [view interactions] Low throughput yes yes
NT2NC_HUMAN [view interactions] High throughput no no
NT2NA_HUMAN [view interactions] High throughput no no
GNAS1_HUMAN [view entry] [view interactions] Computational yes yes
GNAQ_HUMAN [view entry] [view interactions] Computational yes yes
HYDIN_HUMAN [view interactions] Computational no no
SC6A3_HUMAN [view entry] [view interactions] Computational yes yes
GNAL_HUMAN [view interactions] Computational no yes