Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DRD5_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DRD5_HUMAN
GO:0043169 cation binding 75.0000 4 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 50.0000 4 yes
GO:0000166 nucleotide binding 50.0000 4 no
GO:0001664 G protein-coupled receptor binding 50.0000 4 no
GO:0003924 GTPase activity 50.0000 7 no
GO:0005525 GTP binding 50.0000 5 no
GO:0016462 pyrophosphatase activity 50.0000 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 50.0000 4 no
GO:0017076 purine nucleotide binding 50.0000 5 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 50.0000 6 no
GO:0019001 guanyl nucleotide binding 50.0000 6 no
GO:0032555 purine ribonucleotide binding 50.0000 4 no
GO:0032561 guanyl ribonucleotide binding 50.0000 5 no
GO:0035639 purine ribonucleoside triphosphate binding 50.0000 4 no
GO:0043168 anion binding 50.0000 4 no
GO:0046872 metal ion binding 50.0000 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in DRD5_HUMAN
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 75.0000 4 yes
GO:0010646 regulation of cell communication 75.0000 4 yes
GO:0048523 negative regulation of cellular process 75.0000 4 yes
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 50.0000 5 yes
GO:0007268 chemical synaptic transmission 50.0000 7 yes
GO:0010243 response to organonitrogen compound 50.0000 4 yes
GO:0010648 negative regulation of cell communication 50.0000 5 yes
GO:0014070 response to organic cyclic compound 50.0000 4 yes
GO:0023057 negative regulation of signaling 50.0000 4 yes
GO:0071310 cellular response to organic substance 50.0000 4 yes
GO:0071407 cellular response to organic cyclic compound 50.0000 5 yes
GO:0071417 cellular response to organonitrogen compound 50.0000 4 yes
GO:0098916 anterograde trans-synaptic signaling 50.0000 6 yes
GO:0099536 synaptic signaling 50.0000 4 yes
GO:0099537 trans-synaptic signaling 50.0000 5 yes
GO:1901699 cellular response to nitrogen compound 50.0000 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GNA13_HUMAN [view entry] [view interactions] Low throughput yes yes
GNA12_HUMAN [view interactions] Low throughput no no
GBRG2_HUMAN [view entry] [view interactions] Low throughput yes no
GNAZ_HUMAN [view entry] [view interactions] Low throughput yes yes
NT2NC_HUMAN [view interactions] High throughput no no
NT2NA_HUMAN [view interactions] High throughput no no