GBRG1_HUMAN
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in GBRG1_HUMAN |
---|---|---|---|---|
GO:0004890 | GABA-A receptor activity | 100.0000 | 5 | yes |
GO:0005216 | ion channel activity | 100.0000 | 4 | yes |
GO:0005230 | extracellular ligand-gated ion channel activity | 100.0000 | 6 | yes |
GO:0005237 | inhibitory extracellular ligand-gated ion channel activity | 100.0000 | 7 | yes |
GO:0005253 | anion channel activity | 100.0000 | 5 | yes |
GO:0005254 | chloride channel activity | 100.0000 | 6 | yes |
GO:0008509 | anion transmembrane transporter activity | 100.0000 | 4 | yes |
GO:0015103 | inorganic anion transmembrane transporter activity | 100.0000 | 4 | yes |
GO:0015108 | chloride transmembrane transporter activity | 100.0000 | 5 | yes |
GO:0015267 | channel activity | 100.0000 | 4 | yes |
GO:0015276 | ligand-gated ion channel activity | 100.0000 | 5 | yes |
GO:0016917 | GABA receptor activity | 100.0000 | 4 | yes |
GO:0022824 | transmitter-gated ion channel activity | 100.0000 | 5 | yes |
GO:0022834 | ligand-gated channel activity | 100.0000 | 6 | yes |
GO:0022835 | transmitter-gated channel activity | 100.0000 | 4 | yes |
GO:0022836 | gated channel activity | 100.0000 | 5 | yes |
GO:0022851 | GABA-gated chloride ion channel activity | 100.0000 | 5 | yes |
GO:0098960 | postsynaptic neurotransmitter receptor activity | 100.0000 | 4 | yes |
GO:0099095 | ligand-gated anion channel activity | 100.0000 | 6 | yes |
GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 100.0000 | 5 | yes |
GO:1904315 | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential | 100.0000 | 6 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in GBRG1_HUMAN |
---|---|---|---|---|
GO:0006811 | ion transport | 100.0000 | 4 | yes |
GO:0006820 | anion transport | 100.0000 | 5 | yes |
GO:0006821 | chloride transport | 100.0000 | 7 | yes |
GO:0007268 | chemical synaptic transmission | 100.0000 | 6 | yes |
GO:0015698 | inorganic anion transport | 100.0000 | 6 | yes |
GO:0051932 | synaptic transmission, GABAergic | 100.0000 | 7 | yes |
GO:0060078 | regulation of postsynaptic membrane potential | 100.0000 | 4 | yes |
GO:0098656 | anion transmembrane transport | 100.0000 | 4 | yes |
GO:0098660 | inorganic ion transmembrane transport | 100.0000 | 4 | yes |
GO:0098661 | inorganic anion transmembrane transport | 100.0000 | 5 | yes |
GO:0098916 | anterograde trans-synaptic signaling | 100.0000 | 5 | yes |
GO:0099537 | trans-synaptic signaling | 100.0000 | 4 | yes |
GO:1902476 | chloride transmembrane transport | 100.0000 | 6 | yes |
GO:0007416 | synapse assembly | 66.6667 | 6 | no |
GO:0022607 | cellular component assembly | 66.6667 | 4 | no |
GO:0034329 | cell junction assembly | 66.6667 | 5 | no |
GO:0034330 | cell junction organization | 66.6667 | 4 | no |
GO:0050808 | synapse organization | 66.6667 | 5 | no |
GO:1904862 | inhibitory synapse assembly | 66.6667 | 7 | no |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
GBRAP_HUMAN | [view interactions] | Low throughput | no | no |
GBRG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
OPTN_HUMAN | [view interactions] | High throughput | no | yes |
GBRA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |