Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GBRG1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GBRG1_HUMAN
GO:0004890 GABA-A receptor activity 60.0000 5 yes
GO:0005216 monoatomic ion channel activity 60.0000 4 yes
GO:0005230 extracellular ligand-gated monoatomic ion channel activity 60.0000 6 yes
GO:0005237 inhibitory extracellular ligand-gated monoatomic ion channel activity 60.0000 7 yes
GO:0005253 monoatomic anion channel activity 60.0000 5 yes
GO:0005254 chloride channel activity 60.0000 6 yes
GO:0008509 monoatomic anion transmembrane transporter activity 60.0000 4 yes
GO:0015103 inorganic anion transmembrane transporter activity 60.0000 4 yes
GO:0015108 chloride transmembrane transporter activity 60.0000 5 yes
GO:0015267 channel activity 60.0000 4 yes
GO:0015276 ligand-gated monoatomic ion channel activity 60.0000 5 yes
GO:0016917 GABA receptor activity 60.0000 4 yes
GO:0022824 transmitter-gated monoatomic ion channel activity 60.0000 5 yes
GO:0022834 ligand-gated channel activity 60.0000 6 yes
GO:0022835 transmitter-gated channel activity 60.0000 4 yes
GO:0022836 gated channel activity 60.0000 5 yes
GO:0022851 GABA-gated chloride ion channel activity 60.0000 6 yes
GO:0099095 ligand-gated monoatomic anion channel activity 60.0000 6 yes
GO:0050811 GABA receptor binding 40.0000 4 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 40.0000 4 no
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 40.0000 5 no
GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 40.0000 6 no

Biological process

Term Name % Distance from top the of the tree Annotated in GBRG1_HUMAN
GO:0007268 chemical synaptic transmission 100.0000 7 yes
GO:0098916 anterograde trans-synaptic signaling 100.0000 6 yes
GO:0099536 synaptic signaling 100.0000 4 yes
GO:0099537 trans-synaptic signaling 100.0000 5 yes
GO:0022607 cellular component assembly 80.0000 4 no
GO:0006811 monoatomic ion transport 60.0000 4 yes
GO:0006820 monoatomic anion transport 60.0000 5 yes
GO:0006821 chloride transport 60.0000 5 yes
GO:0007214 gamma-aminobutyric acid signaling pathway 60.0000 4 yes
GO:0015698 inorganic anion transport 60.0000 4 yes
GO:0051932 synaptic transmission, GABAergic 60.0000 8 yes
GO:0060078 regulation of postsynaptic membrane potential 60.0000 4 yes
GO:0098656 monoatomic anion transmembrane transport 60.0000 4 yes
GO:0098661 inorganic anion transmembrane transport 60.0000 4 yes
GO:1902476 chloride transmembrane transport 60.0000 5 yes
GO:0006996 organelle organization 40.0000 4 no
GO:0008104 protein localization 40.0000 4 no
GO:0009893 positive regulation of metabolic process 40.0000 4 no
GO:0009966 regulation of signal transduction 40.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 40.0000 5 no
GO:0010646 regulation of cell communication 40.0000 4 no
GO:0031399 regulation of protein modification process 40.0000 6 no
GO:0031401 positive regulation of protein modification process 40.0000 7 no
GO:0051246 regulation of protein metabolic process 40.0000 5 no
GO:0051247 positive regulation of protein metabolic process 40.0000 6 no
GO:0060255 regulation of macromolecule metabolic process 40.0000 4 no
GO:0080090 regulation of primary metabolic process 40.0000 4 no
GO:0007416 synapse assembly 40.0000 6 no
GO:0034329 cell junction assembly 40.0000 5 no
GO:0034330 cell junction organization 40.0000 4 no
GO:0050808 synapse organization 40.0000 5 no
GO:1904862 inhibitory synapse assembly 40.0000 7 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GBRAP_HUMAN [view entry] [view interactions] Low throughput yes no
GBRG2_HUMAN [view entry] [view interactions] High throughput yes no
OPTN_HUMAN [view interactions] High throughput no yes
GBRA1_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes