Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GBRA3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GBRA3_HUMAN
GO:0005216 monoatomic ion channel activity 64.2857 4 yes
GO:0015267 channel activity 64.2857 4 yes
GO:0015276 ligand-gated monoatomic ion channel activity 64.2857 5 yes
GO:0022834 ligand-gated channel activity 64.2857 6 yes
GO:0022836 gated channel activity 64.2857 5 yes
GO:0005230 extracellular ligand-gated monoatomic ion channel activity 57.1429 6 yes
GO:0005253 monoatomic anion channel activity 57.1429 5 yes
GO:0005254 chloride channel activity 57.1429 6 yes
GO:0008509 monoatomic anion transmembrane transporter activity 57.1429 4 yes
GO:0015103 inorganic anion transmembrane transporter activity 57.1429 4 yes
GO:0015108 chloride transmembrane transporter activity 57.1429 5 yes
GO:0022824 transmitter-gated monoatomic ion channel activity 57.1429 5 yes
GO:0022835 transmitter-gated channel activity 57.1429 4 yes
GO:0099095 ligand-gated monoatomic anion channel activity 57.1429 6 yes
GO:0004890 GABA-A receptor activity 50.0000 5 yes
GO:0005237 inhibitory extracellular ligand-gated monoatomic ion channel activity 50.0000 7 yes
GO:0016917 GABA receptor activity 50.0000 4 yes
GO:0022851 GABA-gated chloride ion channel activity 50.0000 6 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 42.8571 4 no
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 42.8571 5 no
GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 42.8571 6 no
GO:0008503 benzodiazepine receptor activity 28.5714 4 yes
GO:0043168 anion binding 21.4286 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in GBRA3_HUMAN
GO:0007268 chemical synaptic transmission 71.4286 7 yes
GO:0098916 anterograde trans-synaptic signaling 71.4286 6 yes
GO:0099536 synaptic signaling 71.4286 4 yes
GO:0099537 trans-synaptic signaling 71.4286 5 yes
GO:0006811 monoatomic ion transport 64.2857 4 yes
GO:0006820 monoatomic anion transport 57.1429 5 yes
GO:0006821 chloride transport 57.1429 5 yes
GO:0015698 inorganic anion transport 57.1429 4 yes
GO:0098656 monoatomic anion transmembrane transport 57.1429 4 yes
GO:0098661 inorganic anion transmembrane transport 57.1429 4 yes
GO:1902476 chloride transmembrane transport 57.1429 5 yes
GO:0007214 gamma-aminobutyric acid signaling pathway 50.0000 4 yes
GO:0051932 synaptic transmission, GABAergic 50.0000 8 yes
GO:0022607 cellular component assembly 50.0000 4 no
GO:0060078 regulation of postsynaptic membrane potential 42.8571 4 yes
GO:0008104 protein localization 42.8571 4 no
GO:0034330 cell junction organization 35.7143 4 no
GO:0050808 synapse organization 35.7143 5 no
GO:0007416 synapse assembly 28.5714 6 no
GO:0034329 cell junction assembly 28.5714 5 no
GO:1904862 inhibitory synapse assembly 28.5714 7 no
GO:0009966 regulation of signal transduction 28.5714 4 no
GO:0010646 regulation of cell communication 28.5714 4 no
GO:0043113 receptor clustering 21.4286 5 no
GO:0072578 neurotransmitter-gated ion channel clustering 21.4286 6 no
GO:0072657 protein localization to membrane 21.4286 4 no
GO:1902531 regulation of intracellular signal transduction 21.4286 5 no
GO:0010243 response to organonitrogen compound 21.4286 4 no
GO:0014070 response to organic cyclic compound 21.4286 4 no
GO:0048666 neuron development 21.4286 4 no
GO:0071310 cellular response to organic substance 21.4286 4 no
GO:0071407 cellular response to organic cyclic compound 21.4286 5 no
GO:0071417 cellular response to organonitrogen compound 21.4286 4 no
GO:1901699 cellular response to nitrogen compound 21.4286 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
UBQL1_HUMAN [view interactions] Low throughput no yes
GBRA1_HUMAN [view entry] [view interactions] Low throughput yes yes
GEPH_HUMAN [view entry] [view interactions] Low throughput yes yes
GBRAP_HUMAN [view entry] [view interactions] Low throughput yes no
GBRA3_HUMAN [view entry] [view interactions] Low throughput yes yes
GBRG2_HUMAN [view entry] [view interactions] Low throughput yes no
GBRB2_HUMAN [view entry] [view interactions] Low throughput yes no
P85A_HUMAN [view interactions] High throughput no yes
GPAA1_HUMAN [view interactions] High throughput no yes
HLAC_HUMAN [view interactions] High throughput no no
GBRA5_HUMAN [view entry] [view interactions] High throughput yes no
GLRB_HUMAN [view entry] [view interactions] High throughput yes no
AMGO1_HUMAN [view interactions] High throughput no yes
TM131_HUMAN [view interactions] High throughput no yes
TTC17_HUMAN [view interactions] High throughput no yes
SC11C_HUMAN [view interactions] High throughput no no
TM59L_HUMAN [view interactions] High throughput no yes
SPCS1_HUMAN [view interactions] High throughput no yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
UD2B7_HUMAN [view interactions] High throughput no no
SDCB2_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
ABCA7_HUMAN [view interactions] High throughput no yes
TUSC3_HUMAN [view interactions] High throughput no yes
EDA_HUMAN [view interactions] High throughput no no
POMT1_HUMAN [view interactions] High throughput no no
WLS_HUMAN [view entry] [view interactions] High throughput yes no
ALG9_HUMAN [view interactions] High throughput no yes
S47A1_HUMAN [view interactions] High throughput no no
POMT2_HUMAN [view interactions] High throughput no yes
TTC13_HUMAN [view interactions] High throughput no no
SIDT2_HUMAN [view interactions] High throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
SSR3_HUMAN [view interactions] High throughput no yes
GBRA2_HUMAN [view entry] [view interactions] High throughput yes no
ARHG9_HUMAN [view entry] [view interactions] High throughput yes yes