Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GBRA3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GBRA3_HUMAN
GO:0005216 ion channel activity 61.5385 4 yes
GO:0005230 extracellular ligand-gated ion channel activity 61.5385 6 yes
GO:0005237 inhibitory extracellular ligand-gated ion channel activity 61.5385 7 yes
GO:0005253 anion channel activity 61.5385 5 yes
GO:0005254 chloride channel activity 61.5385 6 yes
GO:0008509 anion transmembrane transporter activity 61.5385 4 yes
GO:0015103 inorganic anion transmembrane transporter activity 61.5385 4 yes
GO:0015108 chloride transmembrane transporter activity 61.5385 5 yes
GO:0015267 channel activity 61.5385 4 yes
GO:0015276 ligand-gated ion channel activity 61.5385 5 yes
GO:0022824 transmitter-gated ion channel activity 61.5385 5 yes
GO:0022834 ligand-gated channel activity 61.5385 6 yes
GO:0022835 transmitter-gated channel activity 61.5385 4 yes
GO:0022836 gated channel activity 61.5385 5 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 61.5385 4 yes
GO:0099095 ligand-gated anion channel activity 61.5385 6 yes
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 61.5385 5 yes
GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential 61.5385 6 yes
GO:0004890 GABA-A receptor activity 53.8462 5 yes
GO:0016917 GABA receptor activity 53.8462 4 yes
GO:0022851 GABA-gated chloride ion channel activity 53.8462 5 yes
GO:0008503 benzodiazepine receptor activity 38.4615 4 yes
GO:0017076 purine nucleotide binding 23.0769 4 no
GO:0032555 purine ribonucleotide binding 23.0769 4 no
GO:0035639 purine ribonucleoside triphosphate binding 23.0769 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in GBRA3_HUMAN
GO:0006811 ion transport 69.2308 4 yes
GO:0006820 anion transport 61.5385 5 yes
GO:0006821 chloride transport 61.5385 7 yes
GO:0007268 chemical synaptic transmission 61.5385 6 yes
GO:0015698 inorganic anion transport 61.5385 6 yes
GO:0098656 anion transmembrane transport 61.5385 4 yes
GO:0098660 inorganic ion transmembrane transport 61.5385 4 yes
GO:0098661 inorganic anion transmembrane transport 61.5385 5 yes
GO:0098916 anterograde trans-synaptic signaling 61.5385 5 yes
GO:0099537 trans-synaptic signaling 61.5385 4 yes
GO:1902476 chloride transmembrane transport 61.5385 6 yes
GO:0051932 synaptic transmission, GABAergic 53.8462 7 yes
GO:0060078 regulation of postsynaptic membrane potential 53.8462 4 yes
GO:0008104 protein localization 30.7692 4 no
GO:0072657 protein localization to membrane 23.0769 4 no
GO:0010646 regulation of cell communication 23.0769 4 no
GO:0034330 cell junction organization 23.0769 4 no
GO:0050808 synapse organization 23.0769 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
UBQL1_HUMAN [view interactions] Low throughput no yes
GEPH_HUMAN [view entry] [view interactions] Low throughput yes yes
GBRAP_HUMAN [view interactions] Low throughput no no
GBRA3_HUMAN [view entry] [view interactions] Low throughput yes yes
P85A_HUMAN [view interactions] High throughput no yes
SPCS1_HUMAN [view interactions] High throughput no yes
TM59L_HUMAN [view interactions] High throughput no yes
SC11C_HUMAN [view interactions] High throughput no no
TTC17_HUMAN [view interactions] High throughput no yes
TM131_HUMAN [view interactions] High throughput no yes
AMGO1_HUMAN [view interactions] High throughput no yes
GLRB_HUMAN [view entry] [view interactions] High throughput yes no
HLAC_HUMAN [view interactions] High throughput no no
GPAA1_HUMAN [view interactions] High throughput no yes
GBRA5_HUMAN [view entry] [view interactions] High throughput yes no
UD2B7_HUMAN [view interactions] High throughput no no
SDCB2_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
ABCA7_HUMAN [view interactions] High throughput no yes
TUSC3_HUMAN [view interactions] High throughput no yes
EDA_HUMAN [view interactions] High throughput no no
POMT1_HUMAN [view interactions] High throughput no no
WLS_HUMAN [view entry] [view interactions] High throughput yes no
ALG9_HUMAN [view interactions] High throughput no yes
S47A1_HUMAN [view interactions] High throughput no no
GBRA1_HUMAN [view entry] [view interactions] High throughput yes yes
POMT2_HUMAN [view interactions] High throughput no yes
TTC13_HUMAN [view interactions] High throughput no no
SIDT2_HUMAN [view interactions] High throughput no yes
GBRA2_HUMAN [view entry] [view interactions] High throughput yes no
ARHG9_HUMAN [view entry] [view interactions] High throughput yes yes
DYN1_HUMAN [view entry] [view interactions] Computational yes yes
GBRA6_HUMAN [view entry] [view interactions] Computational yes no
GBRA4_HUMAN [view entry] [view interactions] Computational yes no
NSF_HUMAN [view entry] [view interactions] Computational yes yes