Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

FLIP1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in FLIP1_HUMAN
GO:0046872 metal ion binding 37.5000 4 no
GO:0019900 kinase binding 31.2500 4 no
GO:0019901 protein kinase binding 31.2500 5 no
GO:0019902 phosphatase binding 25.0000 4 no
GO:0019903 protein phosphatase binding 25.0000 5 no
GO:0017076 purine nucleotide binding 25.0000 4 no
GO:0032555 purine ribonucleotide binding 25.0000 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in FLIP1_HUMAN
GO:0048522 positive regulation of cellular process 62.5000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 62.5000 4 no
GO:0060255 regulation of macromolecule metabolic process 62.5000 4 no
GO:0080090 regulation of primary metabolic process 62.5000 4 no
GO:0031323 regulation of cellular metabolic process 62.5000 4 no
GO:0051246 regulation of protein metabolic process 56.2500 5 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0051174 regulation of phosphorus metabolic process 50.0000 5 no
GO:0036211 protein modification process 50.0000 4 no
GO:0043412 macromolecule modification 50.0000 4 no
GO:0019220 regulation of phosphate metabolic process 50.0000 6 no
GO:0042325 regulation of phosphorylation 50.0000 7 no
GO:0001932 regulation of protein phosphorylation 43.7500 7 no
GO:0009889 regulation of biosynthetic process 43.7500 4 no
GO:0010468 regulation of gene expression 43.7500 5 no
GO:0010556 regulation of macromolecule biosynthetic process 43.7500 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 43.7500 5 no
GO:0022607 cellular component assembly 43.7500 4 no
GO:0031326 regulation of cellular biosynthetic process 43.7500 5 no
GO:0031399 regulation of protein modification process 43.7500 6 no
GO:0043549 regulation of kinase activity 37.5000 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 37.5000 6 no
GO:0051173 positive regulation of nitrogen compound metabolic process 37.5000 5 no
GO:0051252 regulation of RNA metabolic process 37.5000 5 no
GO:0051338 regulation of transferase activity 37.5000 4 no
GO:1903506 regulation of nucleic acid-templated transcription 37.5000 7 no
GO:2001141 regulation of RNA biosynthetic process 37.5000 6 no
GO:0051049 regulation of transport 37.5000 4 no
GO:0051130 positive regulation of cellular component organization 37.5000 5 no
GO:0010646 regulation of cell communication 37.5000 4 no
GO:0006796 phosphate-containing compound metabolic process 37.5000 4 no
GO:0006355 regulation of DNA-templated transcription 37.5000 6 no
GO:0009892 negative regulation of metabolic process 37.5000 4 no
GO:0009893 positive regulation of metabolic process 37.5000 4 no
GO:0009894 regulation of catabolic process 37.5000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 37.5000 5 no
GO:0010605 negative regulation of macromolecule metabolic process 37.5000 5 no
GO:0010941 regulation of cell death 37.5000 4 no
GO:0031325 positive regulation of cellular metabolic process 37.5000 5 no
GO:0033043 regulation of organelle organization 37.5000 5 no
GO:0042981 regulation of apoptotic process 31.2500 6 no
GO:0043067 regulation of programmed cell death 31.2500 5 no
GO:0044087 regulation of cellular component biogenesis 31.2500 4 no
GO:0045859 regulation of protein kinase activity 31.2500 6 no
GO:0045893 positive regulation of DNA-templated transcription 31.2500 7 no
GO:0051172 negative regulation of nitrogen compound metabolic process 31.2500 5 no
GO:0051247 positive regulation of protein metabolic process 31.2500 6 no
GO:0051254 positive regulation of RNA metabolic process 31.2500 6 no
GO:0080134 regulation of response to stress 31.2500 4 no
GO:1902680 positive regulation of RNA biosynthetic process 31.2500 7 no
GO:1903508 positive regulation of nucleic acid-templated transcription 31.2500 8 no
GO:0030030 cell projection organization 31.2500 4 no
GO:0045595 regulation of cell differentiation 31.2500 4 no
GO:0051050 positive regulation of transport 31.2500 4 no
GO:0120036 plasma membrane bounded cell projection organization 31.2500 5 no
GO:0009966 regulation of signal transduction 31.2500 4 no
GO:0009967 positive regulation of signal transduction 31.2500 5 no
GO:0010647 positive regulation of cell communication 31.2500 5 no
GO:0023056 positive regulation of signaling 31.2500 4 no
GO:0048584 positive regulation of response to stimulus 31.2500 4 no
GO:0006468 protein phosphorylation 31.2500 5 no
GO:0010562 positive regulation of phosphorus metabolic process 31.2500 6 no
GO:0016310 phosphorylation 31.2500 5 no
GO:0042327 positive regulation of phosphorylation 31.2500 8 no
GO:0045937 positive regulation of phosphate metabolic process 31.2500 7 no
GO:0006996 organelle organization 31.2500 4 no
GO:0008104 protein localization 31.2500 4 no
GO:0009891 positive regulation of biosynthetic process 31.2500 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 31.2500 6 no
GO:0031324 negative regulation of cellular metabolic process 31.2500 5 no
GO:0031328 positive regulation of cellular biosynthetic process 31.2500 6 no
GO:0031329 regulation of cellular catabolic process 31.2500 5 no
GO:0043933 protein-containing complex organization 25.0000 4 no
GO:0045787 positive regulation of cell cycle 25.0000 5 no
GO:0051129 negative regulation of cellular component organization 25.0000 5 no
GO:0051248 negative regulation of protein metabolic process 25.0000 6 no
GO:0051493 regulation of cytoskeleton organization 25.0000 6 no
GO:0051726 regulation of cell cycle 25.0000 4 no
GO:0070925 organelle assembly 25.0000 5 no
GO:0080135 regulation of cellular response to stress 25.0000 4 no
GO:0007010 cytoskeleton organization 25.0000 5 no
GO:0031344 regulation of cell projection organization 25.0000 5 no
GO:0045597 positive regulation of cell differentiation 25.0000 5 no
GO:0051094 positive regulation of developmental process 25.0000 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 25.0000 6 no
GO:0016192 vesicle-mediated transport 25.0000 4 no
GO:0034330 cell junction organization 25.0000 4 no
GO:1902531 regulation of intracellular signal transduction 25.0000 5 no
GO:1902533 positive regulation of intracellular signal transduction 25.0000 6 no
GO:1902903 regulation of supramolecular fiber organization 25.0000 5 no
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0043393 regulation of protein binding 25.0000 4 no
GO:0060627 regulation of vesicle-mediated transport 25.0000 4 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no

Disease

Term Name % Distance from top the of the tree Annotated in FLIP1_HUMAN
DOID:114 heart disease 12.5000 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
FLNA_HUMAN [view entry] [view interactions] Low throughput yes no
HSF1_HUMAN [view interactions] Low throughput no yes
FLIP1_HUMAN [view entry] [view interactions] Low throughput yes no
RD23A_HUMAN [view interactions] Low throughput no yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
RA51D_HUMAN [view interactions] High throughput no no
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
DMD_HUMAN [view entry] [view interactions] High throughput yes no
PHOCN_HUMAN [view interactions] High throughput no yes
NEK7_HUMAN [view interactions] High throughput no yes
DAPK3_HUMAN [view interactions] High throughput no yes
PIBF1_HUMAN [view interactions] High throughput no yes
PCM1_HUMAN [view interactions] High throughput no yes
STRP1_HUMAN [view interactions] High throughput no yes
PDC10_HUMAN [view interactions] High throughput no yes
MYL4_HUMAN [view entry] [view interactions] High throughput yes no
TBK1_HUMAN [view entry] [view interactions] High throughput yes yes
KAP1_HUMAN [view entry] [view interactions] High throughput yes yes
MIB1_HUMAN [view entry] [view interactions] High throughput yes yes
STK26_HUMAN [view interactions] High throughput no no
STRN3_HUMAN [view interactions] High throughput no yes
STRP2_HUMAN [view interactions] High throughput no yes
KKCC2_HUMAN [view entry] [view interactions] High throughput yes yes
STRN4_HUMAN [view entry] [view interactions] High throughput yes yes
STRN_HUMAN [view entry] [view interactions] High throughput yes yes
SLN11_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
MARE3_HUMAN [view entry] [view interactions] High throughput yes yes