Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

FLIP1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in FLIP1_HUMAN
GO:0043169 cation binding 38.8889 4 no
GO:0046872 metal ion binding 38.8889 5 no
GO:0019900 kinase binding 33.3333 4 no
GO:0019901 protein kinase binding 27.7778 5 no
GO:0019902 phosphatase binding 27.7778 4 no
GO:0019903 protein phosphatase binding 27.7778 5 no
GO:0000166 nucleotide binding 22.2222 4 no
GO:0017076 purine nucleotide binding 22.2222 5 no
GO:0032555 purine ribonucleotide binding 22.2222 4 no
GO:0043168 anion binding 22.2222 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in FLIP1_HUMAN
GO:0048522 positive regulation of cellular process 66.6667 4 no
GO:0060255 regulation of macromolecule metabolic process 61.1111 4 no
GO:0080090 regulation of primary metabolic process 61.1111 4 no
GO:0048523 negative regulation of cellular process 55.5556 4 no
GO:0031323 regulation of cellular metabolic process 55.5556 4 no
GO:0051246 regulation of protein metabolic process 50.0000 5 no
GO:0051128 regulation of cellular component organization 44.4444 4 no
GO:0009889 regulation of biosynthetic process 44.4444 4 no
GO:0009966 regulation of signal transduction 44.4444 4 no
GO:0010468 regulation of gene expression 44.4444 6 no
GO:0010556 regulation of macromolecule biosynthetic process 44.4444 5 no
GO:0010646 regulation of cell communication 44.4444 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 44.4444 5 no
GO:0031326 regulation of cellular biosynthetic process 44.4444 5 no
GO:0036211 protein modification process 38.8889 4 no
GO:0043412 macromolecule modification 38.8889 4 no
GO:0001932 regulation of protein phosphorylation 38.8889 7 no
GO:0006355 regulation of DNA-templated transcription 38.8889 7 no
GO:0009892 negative regulation of metabolic process 38.8889 4 no
GO:0009893 positive regulation of metabolic process 38.8889 4 no
GO:0010604 positive regulation of macromolecule metabolic process 38.8889 5 no
GO:0010605 negative regulation of macromolecule metabolic process 38.8889 5 no
GO:0019220 regulation of phosphate metabolic process 38.8889 6 no
GO:0022607 cellular component assembly 38.8889 4 no
GO:0031324 negative regulation of cellular metabolic process 38.8889 5 no
GO:0031399 regulation of protein modification process 38.8889 6 no
GO:0042325 regulation of phosphorylation 38.8889 7 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 38.8889 5 no
GO:0051174 regulation of phosphorus metabolic process 38.8889 5 no
GO:0051252 regulation of RNA metabolic process 38.8889 5 no
GO:2001141 regulation of RNA biosynthetic process 38.8889 6 no
GO:0034330 cell junction organization 33.3333 4 yes
GO:0051049 regulation of transport 33.3333 4 no
GO:0051130 positive regulation of cellular component organization 33.3333 5 no
GO:0009891 positive regulation of biosynthetic process 33.3333 5 no
GO:0009894 regulation of catabolic process 33.3333 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 33.3333 6 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0031328 positive regulation of cellular biosynthetic process 33.3333 6 no
GO:0045893 positive regulation of DNA-templated transcription 33.3333 8 no
GO:0051254 positive regulation of RNA metabolic process 33.3333 6 no
GO:1902680 positive regulation of RNA biosynthetic process 33.3333 7 no
GO:0009967 positive regulation of signal transduction 33.3333 5 no
GO:0010647 positive regulation of cell communication 33.3333 5 no
GO:0023056 positive regulation of signaling 33.3333 4 no
GO:0048584 positive regulation of response to stimulus 33.3333 4 no
GO:0050808 synapse organization 27.7778 5 yes
GO:0006996 organelle organization 27.7778 4 no
GO:0008104 protein localization 27.7778 4 no
GO:0009890 negative regulation of biosynthetic process 27.7778 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 27.7778 6 no
GO:0031327 negative regulation of cellular biosynthetic process 27.7778 6 no
GO:0031401 positive regulation of protein modification process 27.7778 7 no
GO:0033043 regulation of organelle organization 27.7778 5 no
GO:0042127 regulation of cell population proliferation 27.7778 4 no
GO:0043549 regulation of kinase activity 27.7778 5 no
GO:0044087 regulation of cellular component biogenesis 27.7778 4 no
GO:0045859 regulation of protein kinase activity 27.7778 6 no
GO:0051247 positive regulation of protein metabolic process 27.7778 6 no
GO:0051338 regulation of transferase activity 27.7778 4 no
GO:0080134 regulation of response to stress 27.7778 4 no
GO:1902531 regulation of intracellular signal transduction 27.7778 5 no
GO:0006796 phosphate-containing compound metabolic process 27.7778 4 no
GO:0030030 cell projection organization 27.7778 4 no
GO:0120036 plasma membrane bounded cell projection organization 27.7778 5 no
GO:0051050 positive regulation of transport 22.2222 4 no
GO:0006357 regulation of transcription by RNA polymerase II 22.2222 8 no
GO:0042981 regulation of apoptotic process 22.2222 5 no
GO:0043067 regulation of programmed cell death 22.2222 4 no
GO:0045787 positive regulation of cell cycle 22.2222 5 no
GO:0045944 positive regulation of transcription by RNA polymerase II 22.2222 9 no
GO:0051248 negative regulation of protein metabolic process 22.2222 6 no
GO:0051493 regulation of cytoskeleton organization 22.2222 6 no
GO:0051726 regulation of cell cycle 22.2222 4 no
GO:0070925 organelle assembly 22.2222 5 no
GO:0044057 regulation of system process 22.2222 4 no
GO:0141124 intracellular signaling cassette 22.2222 4 no
GO:0001934 positive regulation of protein phosphorylation 22.2222 8 no
GO:0010562 positive regulation of phosphorus metabolic process 22.2222 6 no
GO:0042327 positive regulation of phosphorylation 22.2222 8 no
GO:0045937 positive regulation of phosphate metabolic process 22.2222 7 no
GO:1902903 regulation of supramolecular fiber organization 22.2222 5 no
GO:0006468 protein phosphorylation 22.2222 5 no
GO:0016310 phosphorylation 22.2222 5 no
GO:0051240 positive regulation of multicellular organismal process 22.2222 4 no
GO:1902533 positive regulation of intracellular signal transduction 22.2222 6 no
GO:0099563 modification of synaptic structure 16.6667 6 yes
GO:0099010 modification of postsynaptic structure 11.1111 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
FLNA_HUMAN [view entry] [view interactions] Low throughput yes no
HSF1_HUMAN [view interactions] Low throughput no yes
FLIP1_HUMAN [view entry] [view interactions] Low throughput yes no
RD23A_HUMAN [view interactions] Low throughput no yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
RA51D_HUMAN [view interactions] High throughput no no
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
DMD_HUMAN [view entry] [view interactions] High throughput yes no
PHOCN_HUMAN [view entry] [view interactions] High throughput yes yes
NEK7_HUMAN [view interactions] High throughput no yes
DAPK3_HUMAN [view interactions] High throughput no yes
PIBF1_HUMAN [view interactions] High throughput no yes
PCM1_HUMAN [view interactions] High throughput no yes
STRP1_HUMAN [view interactions] High throughput no yes
PDC10_HUMAN [view interactions] High throughput no yes
MYL4_HUMAN [view entry] [view interactions] High throughput yes no
TBK1_HUMAN [view entry] [view interactions] High throughput yes yes
KAP1_HUMAN [view entry] [view interactions] High throughput yes yes
MIB1_HUMAN [view entry] [view interactions] High throughput yes yes
STK26_HUMAN [view interactions] High throughput no no
STRN3_HUMAN [view entry] [view interactions] High throughput yes yes
STRP2_HUMAN [view interactions] High throughput no yes
KKCC2_HUMAN [view entry] [view interactions] High throughput yes yes
STRN4_HUMAN [view entry] [view interactions] High throughput yes yes
STRN_HUMAN [view entry] [view interactions] High throughput yes yes
SLN11_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
MARE3_HUMAN [view entry] [view interactions] High throughput yes yes