NPTX2_HUMAN
Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner . [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in NPTX2_HUMAN |
---|---|---|---|---|
GO:0046872 | metal ion binding | 37.5000 | 4 | yes |
GO:0001540 | amyloid-beta binding | 25.0000 | 4 | no |
GO:0001784 | phosphotyrosine residue binding | 25.0000 | 5 | no |
GO:0004674 | protein serine/threonine kinase activity | 25.0000 | 4 | no |
GO:0004707 | MAP kinase activity | 25.0000 | 5 | no |
GO:0004708 | MAP kinase kinase activity | 25.0000 | 5 | no |
GO:0004712 | protein serine/threonine/tyrosine kinase activity | 25.0000 | 4 | no |
GO:0005524 | ATP binding | 25.0000 | 5 | no |
GO:0016301 | kinase activity | 25.0000 | 4 | no |
GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 25.0000 | 4 | no |
GO:0017076 | purine nucleotide binding | 25.0000 | 4 | no |
GO:0019902 | phosphatase binding | 25.0000 | 4 | no |
GO:0030554 | adenyl nucleotide binding | 25.0000 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 25.0000 | 4 | no |
GO:0032559 | adenyl ribonucleotide binding | 25.0000 | 5 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 25.0000 | 4 | no |
GO:0045309 | protein phosphorylated amino acid binding | 25.0000 | 4 | no |
GO:0106310 | protein serine kinase activity | 25.0000 | 4 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in NPTX2_HUMAN |
---|---|---|---|---|
GO:0009966 | regulation of signal transduction | 62.5000 | 4 | yes |
GO:0010646 | regulation of cell communication | 62.5000 | 4 | yes |
GO:0007268 | chemical synaptic transmission | 50.0000 | 6 | yes |
GO:0050804 | modulation of chemical synaptic transmission | 50.0000 | 5 | yes |
GO:0098916 | anterograde trans-synaptic signaling | 50.0000 | 5 | yes |
GO:0099177 | regulation of trans-synaptic signaling | 50.0000 | 4 | yes |
GO:0099537 | trans-synaptic signaling | 50.0000 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | no |
GO:0031644 | regulation of nervous system process | 37.5000 | 5 | yes |
GO:0044057 | regulation of system process | 37.5000 | 4 | yes |
GO:0098962 | regulation of postsynaptic neurotransmitter receptor activity | 37.5000 | 5 | yes |
GO:0099601 | regulation of neurotransmitter receptor activity | 37.5000 | 4 | yes |
GO:0007167 | enzyme-linked receptor protein signaling pathway | 37.5000 | 4 | no |
GO:0032101 | regulation of response to external stimulus | 37.5000 | 4 | no |
GO:0032103 | positive regulation of response to external stimulus | 37.5000 | 5 | no |
GO:0032386 | regulation of intracellular transport | 37.5000 | 5 | no |
GO:0043085 | positive regulation of catalytic activity | 37.5000 | 4 | no |
GO:0048522 | positive regulation of cellular process | 37.5000 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 37.5000 | 4 | no |
GO:0051049 | regulation of transport | 37.5000 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 37.5000 | 5 | no |
GO:0060341 | regulation of cellular localization | 37.5000 | 4 | no |
GO:0080134 | regulation of response to stress | 37.5000 | 4 | no |
GO:0080135 | regulation of cellular response to stress | 37.5000 | 4 | no |
GO:0010038 | response to metal ion | 37.5000 | 4 | no |
GO:0033043 | regulation of organelle organization | 37.5000 | 5 | no |
GO:0048878 | chemical homeostasis | 37.5000 | 4 | no |
GO:0071241 | cellular response to inorganic substance | 37.5000 | 4 | no |
GO:0071248 | cellular response to metal ion | 37.5000 | 5 | no |
GO:0071310 | cellular response to organic substance | 37.5000 | 4 | no |
GO:1901701 | cellular response to oxygen-containing compound | 37.5000 | 4 | no |
GO:0010243 | response to organonitrogen compound | 37.5000 | 4 | no |
GO:0031399 | regulation of protein modification process | 37.5000 | 6 | no |
GO:0036211 | protein modification process | 37.5000 | 4 | no |
GO:0043412 | macromolecule modification | 37.5000 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 37.5000 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 37.5000 | 5 | no |
GO:0060255 | regulation of macromolecule metabolic process | 37.5000 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 37.5000 | 4 | no |
GO:0051338 | regulation of transferase activity | 25.0000 | 4 | no |
GO:0051347 | positive regulation of transferase activity | 25.0000 | 5 | no |
GO:0051403 | stress-activated MAPK cascade | 25.0000 | 5 | no |
GO:0051493 | regulation of cytoskeleton organization | 25.0000 | 6 | no |
GO:0051972 | regulation of telomerase activity | 25.0000 | 5 | no |
GO:0051973 | positive regulation of telomerase activity | 25.0000 | 6 | no |
GO:0055067 | monovalent inorganic cation homeostasis | 25.0000 | 7 | no |
GO:0055080 | cation homeostasis | 25.0000 | 6 | no |
GO:0060020 | Bergmann glial cell differentiation | 25.0000 | 6 | no |
GO:0060425 | lung morphogenesis | 25.0000 | 4 | no |
GO:0060440 | trachea formation | 25.0000 | 4 | no |
GO:0060627 | regulation of vesicle-mediated transport | 25.0000 | 4 | no |
GO:0061308 | cardiac neural crest cell development involved in heart development | 25.0000 | 6 | no |
GO:0062197 | cellular response to chemical stress | 25.0000 | 4 | no |
GO:0070302 | regulation of stress-activated protein kinase signaling cascade | 25.0000 | 5 | no |
GO:0070371 | ERK1 and ERK2 cascade | 25.0000 | 5 | no |
GO:0070663 | regulation of leukocyte proliferation | 25.0000 | 5 | no |
GO:0070665 | positive regulation of leukocyte proliferation | 25.0000 | 6 | no |
GO:0070848 | response to growth factor | 25.0000 | 4 | no |
GO:0071276 | cellular response to cadmium ion | 25.0000 | 6 | no |
GO:0071345 | cellular response to cytokine stimulus | 25.0000 | 5 | no |
GO:0071356 | cellular response to tumor necrosis factor | 25.0000 | 6 | no |
GO:0071407 | cellular response to organic cyclic compound | 25.0000 | 5 | no |
GO:0071417 | cellular response to organonitrogen compound | 25.0000 | 4 | no |
GO:0071622 | regulation of granulocyte chemotaxis | 25.0000 | 6 | no |
GO:0071675 | regulation of mononuclear cell migration | 25.0000 | 5 | no |
GO:0071867 | response to monoamine | 25.0000 | 5 | no |
GO:0071868 | cellular response to monoamine stimulus | 25.0000 | 5 | no |
GO:0071869 | response to catecholamine | 25.0000 | 4 | no |
GO:0071870 | cellular response to catecholamine stimulus | 25.0000 | 5 | no |
GO:0072584 | caveolin-mediated endocytosis | 25.0000 | 6 | no |
GO:0090170 | regulation of Golgi inheritance | 25.0000 | 7 | no |
GO:0098771 | inorganic ion homeostasis | 25.0000 | 6 | no |
GO:0120040 | regulation of macrophage proliferation | 25.0000 | 6 | no |
GO:0120041 | positive regulation of macrophage proliferation | 25.0000 | 7 | no |
GO:1901699 | cellular response to nitrogen compound | 25.0000 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 25.0000 | 5 | no |
GO:1903350 | response to dopamine | 25.0000 | 5 | no |
GO:1903351 | cellular response to dopamine | 25.0000 | 6 | no |
GO:1903358 | regulation of Golgi organization | 25.0000 | 6 | no |
GO:1903649 | regulation of cytoplasmic transport | 25.0000 | 6 | no |
GO:1904353 | regulation of telomere capping | 25.0000 | 7 | no |
GO:1904355 | positive regulation of telomere capping | 25.0000 | 8 | no |
GO:1904356 | regulation of telomere maintenance via telomere lengthening | 25.0000 | 7 | no |
GO:1904358 | positive regulation of telomere maintenance via telomere lengthening | 25.0000 | 8 | no |
GO:1905521 | regulation of macrophage migration | 25.0000 | 5 | no |
GO:1905523 | positive regulation of macrophage migration | 25.0000 | 6 | no |
GO:1990928 | response to amino acid starvation | 25.0000 | 4 | no |
GO:2000145 | regulation of cell motility | 25.0000 | 4 | no |
GO:2000147 | positive regulation of cell motility | 25.0000 | 5 | no |
GO:2000278 | regulation of DNA biosynthetic process | 25.0000 | 6 | no |
GO:2000573 | positive regulation of DNA biosynthetic process | 25.0000 | 7 | no |
GO:2000641 | regulation of early endosome to late endosome transport | 25.0000 | 5 | no |
GO:2001252 | positive regulation of chromosome organization | 25.0000 | 7 | no |
GO:0050890 | cognition | 25.0000 | 4 | yes |
GO:0006996 | organelle organization | 25.0000 | 4 | no |
GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 25.0000 | 5 | no |
GO:0007409 | axonogenesis | 25.0000 | 8 | no |
GO:0030030 | cell projection organization | 25.0000 | 4 | no |
GO:0032990 | cell part morphogenesis | 25.0000 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 25.0000 | 4 | no |
GO:0045595 | regulation of cell differentiation | 25.0000 | 4 | no |
GO:0048812 | neuron projection morphogenesis | 25.0000 | 7 | no |
GO:0048858 | cell projection morphogenesis | 25.0000 | 5 | no |
GO:0120039 | plasma membrane bounded cell projection morphogenesis | 25.0000 | 6 | no |
GO:0000165 | MAPK cascade | 25.0000 | 4 | no |
GO:0000302 | response to reactive oxygen species | 25.0000 | 4 | no |
GO:0001932 | regulation of protein phosphorylation | 25.0000 | 7 | no |
GO:0001934 | positive regulation of protein phosphorylation | 25.0000 | 8 | no |
GO:0002684 | positive regulation of immune system process | 25.0000 | 4 | no |
GO:0002685 | regulation of leukocyte migration | 25.0000 | 4 | no |
GO:0002687 | positive regulation of leukocyte migration | 25.0000 | 5 | no |
GO:0002688 | regulation of leukocyte chemotaxis | 25.0000 | 5 | no |
GO:0002690 | positive regulation of leukocyte chemotaxis | 25.0000 | 6 | no |
GO:0006468 | protein phosphorylation | 25.0000 | 5 | no |
GO:0006796 | phosphate-containing compound metabolic process | 25.0000 | 4 | no |
GO:0006873 | cellular ion homeostasis | 25.0000 | 4 | no |
GO:0006885 | regulation of pH | 25.0000 | 8 | no |
GO:0006897 | endocytosis | 25.0000 | 5 | no |
GO:0006915 | apoptotic process | 25.0000 | 4 | no |
GO:0006974 | cellular response to DNA damage stimulus | 25.0000 | 4 | no |
GO:0008284 | positive regulation of cell population proliferation | 25.0000 | 5 | no |
GO:0009267 | cellular response to starvation | 25.0000 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 25.0000 | 4 | no |
GO:0009891 | positive regulation of biosynthetic process | 25.0000 | 5 | no |
GO:0009893 | positive regulation of metabolic process | 25.0000 | 4 | no |
GO:0010001 | glial cell differentiation | 25.0000 | 4 | no |
GO:0010468 | regulation of gene expression | 25.0000 | 5 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 25.0000 | 5 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.0000 | 6 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 25.0000 | 6 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 25.0000 | 5 | no |
GO:0010628 | positive regulation of gene expression | 25.0000 | 6 | no |
GO:0010638 | positive regulation of organelle organization | 25.0000 | 6 | no |
GO:0010647 | positive regulation of cell communication | 25.0000 | 5 | no |
GO:0010758 | regulation of macrophage chemotaxis | 25.0000 | 6 | no |
GO:0010759 | positive regulation of macrophage chemotaxis | 25.0000 | 6 | no |
GO:0014032 | neural crest cell development | 25.0000 | 5 | no |
GO:0014070 | response to organic cyclic compound | 25.0000 | 4 | no |
GO:0016192 | vesicle-mediated transport | 25.0000 | 4 | no |
GO:0016310 | phosphorylation | 25.0000 | 5 | no |
GO:0018193 | peptidyl-amino acid modification | 25.0000 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 25.0000 | 6 | no |
GO:0023056 | positive regulation of signaling | 25.0000 | 4 | no |
GO:0030003 | cellular cation homeostasis | 25.0000 | 5 | no |
GO:0030004 | cellular monovalent inorganic cation homeostasis | 25.0000 | 6 | no |
GO:0030278 | regulation of ossification | 25.0000 | 4 | no |
GO:0030334 | regulation of cell migration | 25.0000 | 5 | no |
GO:0030335 | positive regulation of cell migration | 25.0000 | 6 | no |
GO:0030641 | regulation of cellular pH | 25.0000 | 7 | no |
GO:0030878 | thyroid gland development | 25.0000 | 5 | no |
GO:0031098 | stress-activated protein kinase signaling cascade | 25.0000 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 25.0000 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 25.0000 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 25.0000 | 5 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 25.0000 | 6 | no |
GO:0031401 | positive regulation of protein modification process | 25.0000 | 7 | no |
GO:0031663 | lipopolysaccharide-mediated signaling pathway | 25.0000 | 4 | no |
GO:0031667 | response to nutrient levels | 25.0000 | 4 | no |
GO:0031669 | cellular response to nutrient levels | 25.0000 | 4 | no |
GO:0032204 | regulation of telomere maintenance | 25.0000 | 6 | no |
GO:0032206 | positive regulation of telomere maintenance | 25.0000 | 7 | no |
GO:0032210 | regulation of telomere maintenance via telomerase | 25.0000 | 7 | no |
GO:0032212 | positive regulation of telomere maintenance via telomerase | 25.0000 | 8 | no |
GO:0032872 | regulation of stress-activated MAPK cascade | 25.0000 | 6 | no |
GO:0033044 | regulation of chromosome organization | 25.0000 | 6 | no |
GO:0034097 | response to cytokine | 25.0000 | 4 | no |
GO:0034198 | cellular response to amino acid starvation | 25.0000 | 5 | no |
GO:0034599 | cellular response to oxidative stress | 25.0000 | 4 | no |
GO:0034612 | response to tumor necrosis factor | 25.0000 | 5 | no |
GO:0034614 | cellular response to reactive oxygen species | 25.0000 | 5 | no |
GO:0040017 | positive regulation of locomotion | 25.0000 | 4 | no |
GO:0042127 | regulation of cell population proliferation | 25.0000 | 4 | no |
GO:0042325 | regulation of phosphorylation | 25.0000 | 7 | no |
GO:0042327 | positive regulation of phosphorylation | 25.0000 | 8 | no |
GO:0042473 | outer ear morphogenesis | 25.0000 | 4 | no |
GO:0043330 | response to exogenous dsRNA | 25.0000 | 5 | no |
GO:0043331 | response to dsRNA | 25.0000 | 4 | no |
GO:0043408 | regulation of MAPK cascade | 25.0000 | 6 | no |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 25.0000 | 6 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 25.0000 | 7 | no |
GO:0046686 | response to cadmium ion | 25.0000 | 5 | no |
GO:0048534 | hematopoietic or lymphoid organ development | 25.0000 | 4 | no |
GO:0048538 | thymus development | 25.0000 | 5 | no |
GO:0048708 | astrocyte differentiation | 25.0000 | 5 | no |
GO:0048732 | gland development | 25.0000 | 4 | no |
GO:0048864 | stem cell development | 25.0000 | 4 | no |
GO:0050801 | ion homeostasis | 25.0000 | 5 | no |
GO:0050920 | regulation of chemotaxis | 25.0000 | 4 | no |
GO:0050921 | positive regulation of chemotaxis | 25.0000 | 5 | no |
GO:0051052 | regulation of DNA metabolic process | 25.0000 | 5 | no |
GO:0051054 | positive regulation of DNA metabolic process | 25.0000 | 6 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
GO:0051174 | regulation of phosphorus metabolic process | 25.0000 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | no |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
FZD6_HUMAN | [view interactions] | Low throughput | no | yes |
GRIA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NPTX1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
BATF3_HUMAN | [view interactions] | High throughput | no | no |
NEUFC_HUMAN | [view interactions] | High throughput | no | yes |
HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
LYPD4_HUMAN | [view interactions] | High throughput | no | no |
RGPD5_HUMAN | [view interactions] | High throughput | no | no |
NDE1_HUMAN | [view interactions] | High throughput | no | yes |
NDEL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NPTXR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FBX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IGFL1_HUMAN | [view interactions] | High throughput | no | no |
OS9_HUMAN | [view interactions] | High throughput | no | yes |
CLC4F_HUMAN | [view interactions] | High throughput | no | no |
LACTB_HUMAN | [view interactions] | High throughput | no | yes |
UBS3B_HUMAN | [view interactions] | High throughput | no | yes |
MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MGME1_HUMAN | [view interactions] | High throughput | no | yes |
NEU2_HUMAN | [view interactions] | Computational | no | no |