AB17B_HUMAN
Evidence for PS localization
Functions
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed). Has depalmitoylating activity towards DLG4/PSD95 (PubMed). Has depalmitoylating activity towards GAP43 . Has depalmitoylating activity towards MAP6 . Has depalmitoylating activity towards NRAS (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AB17B_HUMAN |
|---|---|---|---|---|
| GO:0004930 | G protein-coupled receptor activity | 40.0000 | 4 | no |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 40.0000 | 4 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 40.0000 | 4 | no |
| GO:0046873 | metal ion transmembrane transporter activity | 40.0000 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AB17B_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 80.0000 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 60.0000 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 60.0000 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 60.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 40.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 40.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 40.0000 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 40.0000 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 40.0000 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 40.0000 | 4 | no |
| GO:0051960 | regulation of nervous system development | 40.0000 | 5 | no |
| GO:0051962 | positive regulation of nervous system development | 40.0000 | 5 | no |
| GO:0098657 | import into cell | 40.0000 | 4 | no |
| GO:1903426 | regulation of reactive oxygen species biosynthetic process | 40.0000 | 5 | no |
| GO:2000026 | regulation of multicellular organismal development | 40.0000 | 4 | no |
| GO:2000377 | regulation of reactive oxygen species metabolic process | 40.0000 | 5 | no |
| GO:0009890 | negative regulation of biosynthetic process | 40.0000 | 5 | no |
| GO:0032880 | regulation of protein localization | 40.0000 | 5 | yes |
| GO:0050807 | regulation of synapse organization | 40.0000 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 40.0000 | 4 | yes |
| GO:0060341 | regulation of cellular localization | 40.0000 | 4 | yes |
| GO:1903828 | negative regulation of protein localization | 40.0000 | 5 | yes |
| GO:0007268 | chemical synaptic transmission | 40.0000 | 7 | no |
| GO:0007409 | axonogenesis | 40.0000 | 6 | no |
| GO:0030030 | cell projection organization | 40.0000 | 4 | no |
| GO:0048812 | neuron projection morphogenesis | 40.0000 | 5 | no |
| GO:0098916 | anterograde trans-synaptic signaling | 40.0000 | 6 | no |
| GO:0099536 | synaptic signaling | 40.0000 | 4 | no |
| GO:0099537 | trans-synaptic signaling | 40.0000 | 5 | no |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 40.0000 | 4 | no |
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 40.0000 | 4 | no |
| GO:0008285 | negative regulation of cell population proliferation | 40.0000 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 40.0000 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| A4GAT_HUMAN | [view interactions] | High throughput | no | no |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| C5AR2_HUMAN | [view interactions] | High throughput | no | yes |
| DYT2B_HUMAN | [view interactions] | High throughput | no | no |
| SFTA2_HUMAN | [view interactions] | High throughput | no | no |
| DEF1_HUMAN | [view interactions] | High throughput | no | no |
| MAS_HUMAN | [view interactions] | High throughput | no | no |
| GTR12_HUMAN | [view interactions] | High throughput | no | yes |
| TR16L_HUMAN | [view interactions] | High throughput | no | no |
| F174A_HUMAN | [view interactions] | High throughput | no | yes |
| CD79B_HUMAN | [view interactions] | High throughput | no | no |
| APJ_HUMAN | [view interactions] | High throughput | no | yes |
| MFD4A_HUMAN | [view interactions] | High throughput | no | yes |
| TM11B_HUMAN | [view interactions] | High throughput | no | no |
| SV2C_HUMAN | [view interactions] | High throughput | no | no |
| TOIP2_HUMAN | [view interactions] | High throughput | no | no |
| OPRM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GLMP_HUMAN | [view interactions] | High throughput | no | no |
| PRG3_HUMAN | [view interactions] | High throughput | no | no |
| DYLT4_HUMAN | [view interactions] | High throughput | no | no |
| OPRX_HUMAN | [view interactions] | High throughput | no | no |
| S22A2_HUMAN | [view interactions] | High throughput | no | no |
| NPTX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GR6_HUMAN | [view interactions] | High throughput | no | no |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| SO4C1_HUMAN | [view interactions] | High throughput | no | no |
| EDN3_HUMAN | [view interactions] | High throughput | no | no |
| AQP3_HUMAN | [view interactions] | High throughput | no | no |
| CKLF8_HUMAN | [view interactions] | High throughput | no | yes |
| V2R_HUMAN | [view interactions] | High throughput | no | no |
| S22A8_HUMAN | [view interactions] | High throughput | no | no |
| TEST_HUMAN | [view interactions] | High throughput | no | no |
| S26A6_HUMAN | [view interactions] | High throughput | no | yes |
| PCAT2_HUMAN | [view interactions] | High throughput | no | yes |
| C5AR1_HUMAN | [view interactions] | High throughput | no | yes |
| UPK2_HUMAN | [view interactions] | High throughput | no | no |
| S22A4_HUMAN | [view interactions] | High throughput | no | yes |
| NRBP_HUMAN | [view interactions] | High throughput | no | yes |
| LIPK_HUMAN | [view interactions] | High throughput | no | no |
| GPR12_HUMAN | [view interactions] | High throughput | no | no |
| GPR17_HUMAN | [view interactions] | High throughput | no | no |
| SC5A6_HUMAN | [view interactions] | High throughput | no | no |
| NK3R_HUMAN | [view interactions] | High throughput | no | no |
| VMAT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CD80_HUMAN | [view interactions] | High throughput | no | no |
| CXCR4_HUMAN | [view interactions] | High throughput | no | no |
| AGRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GP150_HUMAN | [view interactions] | High throughput | no | no |
| MICB_HUMAN | [view interactions] | High throughput | no | no |
| CRLF2_HUMAN | [view interactions] | High throughput | no | no |
| FFAR1_HUMAN | [view interactions] | High throughput | no | no |
| GXLT1_HUMAN | [view interactions] | High throughput | no | no |
| S22AI_HUMAN | [view interactions] | High throughput | no | no |
| GPR55_HUMAN | [view interactions] | High throughput | no | no |
| P2RY8_HUMAN | [view interactions] | High throughput | no | no |
| GPR45_HUMAN | [view interactions] | High throughput | no | no |
| TM192_HUMAN | [view interactions] | High throughput | no | yes |