Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AB17B_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed). Has depalmitoylating activity towards DLG4/PSD95 (PubMed). Has depalmitoylating activity towards GAP43 . Has depalmitoylating activity towards MAP6 . Has depalmitoylating activity towards NRAS (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in AB17B_HUMAN
GO:0003924 GTPase activity 37.5000 7 no
GO:0005525 GTP binding 37.5000 5 no
GO:0016462 pyrophosphatase activity 37.5000 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 37.5000 4 no
GO:0017076 purine nucleotide binding 37.5000 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 37.5000 6 no
GO:0019001 guanyl nucleotide binding 37.5000 5 no
GO:0019003 GDP binding 37.5000 4 no
GO:0032555 purine ribonucleotide binding 37.5000 4 no
GO:0032561 guanyl ribonucleotide binding 37.5000 5 no
GO:0035639 purine ribonucleoside triphosphate binding 37.5000 4 no
GO:0004930 G protein-coupled receptor activity 25.0000 4 no
GO:0008324 cation transmembrane transporter activity 25.0000 4 no
GO:0022890 inorganic cation transmembrane transporter activity 25.0000 4 no
GO:0046873 metal ion transmembrane transporter activity 25.0000 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in AB17B_HUMAN
GO:0048522 positive regulation of cellular process 75.0000 4 yes
GO:0048523 negative regulation of cellular process 75.0000 4 yes
GO:0042127 regulation of cell population proliferation 62.5000 4 no
GO:0010646 regulation of cell communication 62.5000 4 no
GO:0031323 regulation of cellular metabolic process 62.5000 4 no
GO:0051128 regulation of cellular component organization 50.0000 4 yes
GO:0009966 regulation of signal transduction 50.0000 4 no
GO:0050804 modulation of chemical synaptic transmission 50.0000 5 no
GO:0099177 regulation of trans-synaptic signaling 50.0000 4 no
GO:0009889 regulation of biosynthetic process 50.0000 4 no
GO:0009892 negative regulation of metabolic process 50.0000 4 no
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 50.0000 5 no
GO:0051171 regulation of nitrogen compound metabolic process 50.0000 4 no
GO:0032880 regulation of protein localization 37.5000 5 yes
GO:0050807 regulation of synapse organization 37.5000 5 yes
GO:0060341 regulation of cellular localization 37.5000 4 yes
GO:0000165 MAPK cascade 37.5000 4 no
GO:0007264 small GTPase mediated signal transduction 37.5000 4 no
GO:0007265 Ras protein signal transduction 37.5000 5 no
GO:0008284 positive regulation of cell population proliferation 37.5000 5 no
GO:0044087 regulation of cellular component biogenesis 37.5000 4 no
GO:0008285 negative regulation of cell population proliferation 37.5000 5 no
GO:0009891 positive regulation of biosynthetic process 37.5000 5 no
GO:0009967 positive regulation of signal transduction 37.5000 5 no
GO:0010647 positive regulation of cell communication 37.5000 5 no
GO:0023056 positive regulation of signaling 37.5000 4 no
GO:0031399 regulation of protein modification process 37.5000 6 no
GO:0048584 positive regulation of response to stimulus 37.5000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 37.5000 5 no
GO:0051240 positive regulation of multicellular organismal process 37.5000 4 no
GO:0051246 regulation of protein metabolic process 37.5000 5 no
GO:0060255 regulation of macromolecule metabolic process 37.5000 4 no
GO:0080090 regulation of primary metabolic process 37.5000 4 no
GO:1902531 regulation of intracellular signal transduction 37.5000 5 no
GO:1902533 positive regulation of intracellular signal transduction 37.5000 6 no
GO:0031344 regulation of cell projection organization 25.0000 5 yes
GO:0099175 regulation of postsynapse organization 25.0000 6 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 25.0000 6 yes
GO:1902473 regulation of protein localization to synapse 25.0000 6 yes
GO:1903828 negative regulation of protein localization 25.0000 5 yes
GO:1903829 positive regulation of protein localization 25.0000 5 yes
GO:0050678 regulation of epithelial cell proliferation 25.0000 5 no
GO:0050679 positive regulation of epithelial cell proliferation 25.0000 6 no
GO:0006996 organelle organization 25.0000 4 no
GO:0007268 chemical synaptic transmission 25.0000 6 no
GO:0007409 axonogenesis 25.0000 8 no
GO:0030030 cell projection organization 25.0000 4 no
GO:0031644 regulation of nervous system process 25.0000 5 no
GO:0032990 cell part morphogenesis 25.0000 4 no
GO:0033043 regulation of organelle organization 25.0000 5 no
GO:0044057 regulation of system process 25.0000 4 no
GO:0048812 neuron projection morphogenesis 25.0000 7 no
GO:0048858 cell projection morphogenesis 25.0000 5 no
GO:0051963 regulation of synapse assembly 25.0000 6 no
GO:0098916 anterograde trans-synaptic signaling 25.0000 5 no
GO:0099537 trans-synaptic signaling 25.0000 4 no
GO:0099601 regulation of neurotransmitter receptor activity 25.0000 4 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 25.0000 6 no
GO:1901888 regulation of cell junction assembly 25.0000 5 no
GO:0001932 regulation of protein phosphorylation 25.0000 7 no
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 no
GO:0010468 regulation of gene expression 25.0000 5 no
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 no
GO:0010604 positive regulation of macromolecule metabolic process 25.0000 5 no
GO:0010605 negative regulation of macromolecule metabolic process 25.0000 5 no
GO:0010628 positive regulation of gene expression 25.0000 6 no
GO:0010941 regulation of cell death 25.0000 4 no
GO:0016192 vesicle-mediated transport 25.0000 4 no
GO:0019220 regulation of phosphate metabolic process 25.0000 6 no
GO:0030334 regulation of cell migration 25.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0042325 regulation of phosphorylation 25.0000 7 no
GO:0042327 positive regulation of phosphorylation 25.0000 8 no
GO:0042981 regulation of apoptotic process 25.0000 6 no
GO:0043066 negative regulation of apoptotic process 25.0000 7 no
GO:0043067 regulation of programmed cell death 25.0000 5 no
GO:0043069 negative regulation of programmed cell death 25.0000 6 no
GO:0043408 regulation of MAPK cascade 25.0000 6 no
GO:0043410 positive regulation of MAPK cascade 25.0000 7 no
GO:0043523 regulation of neuron apoptotic process 25.0000 6 no
GO:0043524 negative regulation of neuron apoptotic process 25.0000 7 no
GO:0044089 positive regulation of cellular component biogenesis 25.0000 5 no
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 no
GO:0048168 regulation of neuronal synaptic plasticity 25.0000 4 no
GO:0048169 regulation of long-term neuronal synaptic plasticity 25.0000 5 no
GO:0051049 regulation of transport 25.0000 4 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 no
GO:0051174 regulation of phosphorus metabolic process 25.0000 5 no
GO:0051223 regulation of protein transport 25.0000 5 no
GO:0051247 positive regulation of protein metabolic process 25.0000 6 no
GO:0060548 negative regulation of cell death 25.0000 5 no
GO:0070201 regulation of establishment of protein localization 25.0000 6 no
GO:0070372 regulation of ERK1 and ERK2 cascade 25.0000 7 no
GO:0070374 positive regulation of ERK1 and ERK2 cascade 25.0000 8 no
GO:0080134 regulation of response to stress 25.0000 4 no
GO:0080135 regulation of cellular response to stress 25.0000 4 no
GO:1901214 regulation of neuron death 25.0000 5 no
GO:1901215 negative regulation of neuron death 25.0000 6 no
GO:2000145 regulation of cell motility 25.0000 4 no
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 25.0000 4 no
GO:0009890 negative regulation of biosynthetic process 25.0000 5 no
GO:0010243 response to organonitrogen compound 25.0000 4 no
GO:0031324 negative regulation of cellular metabolic process 25.0000 5 no
GO:0045595 regulation of cell differentiation 25.0000 4 no
GO:0051094 positive regulation of developmental process 25.0000 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 25.0000 5 no
GO:0051960 regulation of nervous system development 25.0000 5 no
GO:0051962 positive regulation of nervous system development 25.0000 5 no
GO:2000026 regulation of multicellular organismal development 25.0000 4 no
GO:0051093 negative regulation of developmental process 25.0000 4 no
GO:1903426 regulation of reactive oxygen species biosynthetic process 25.0000 5 no
GO:2000377 regulation of reactive oxygen species metabolic process 25.0000 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
A4GAT_HUMAN [view interactions] High throughput no no
FAF2_HUMAN [view interactions] High throughput no yes
C5AR2_HUMAN [view interactions] High throughput no yes
DYT2B_HUMAN [view interactions] High throughput no no
SFTA2_HUMAN [view interactions] High throughput no no
DEF1_HUMAN [view interactions] High throughput no no
MAS_HUMAN [view interactions] High throughput no no
GTR12_HUMAN [view interactions] High throughput no yes
TR16L_HUMAN [view interactions] High throughput no no
F174A_HUMAN [view interactions] High throughput no yes
CD79B_HUMAN [view interactions] High throughput no no
APJ_HUMAN [view interactions] High throughput no yes
MFD4A_HUMAN [view interactions] High throughput no yes
TM11B_HUMAN [view interactions] High throughput no no
SV2C_HUMAN [view interactions] High throughput no no
TOIP2_HUMAN [view interactions] High throughput no no
OPRM_HUMAN [view entry] [view interactions] High throughput yes no
GLMP_HUMAN [view interactions] High throughput no no
PRG3_HUMAN [view interactions] High throughput no no
NPC1_HUMAN [view interactions] High throughput no yes
DYLT4_HUMAN [view interactions] High throughput no no
OPRX_HUMAN [view interactions] High throughput no no
S22A2_HUMAN [view interactions] High throughput no no
NPTX1_HUMAN [view entry] [view interactions] High throughput yes yes
GR6_HUMAN [view interactions] High throughput no no
GP182_HUMAN [view interactions] High throughput no no
SO4C1_HUMAN [view interactions] High throughput no no
EDN3_HUMAN [view interactions] High throughput no no
AQP3_HUMAN [view interactions] High throughput no no
CKLF8_HUMAN [view interactions] High throughput no yes
V2R_HUMAN [view interactions] High throughput no no
S22A8_HUMAN [view interactions] High throughput no no
TEST_HUMAN [view interactions] High throughput no no
S26A6_HUMAN [view interactions] High throughput no yes
PCAT2_HUMAN [view interactions] High throughput no yes
C5AR1_HUMAN [view interactions] High throughput no yes
UPK2_HUMAN [view interactions] High throughput no no
S22A4_HUMAN [view interactions] High throughput no yes
NRBP_HUMAN [view interactions] High throughput no yes
LIPK_HUMAN [view interactions] High throughput no no
GPR12_HUMAN [view interactions] High throughput no no
GPR17_HUMAN [view interactions] High throughput no no
SC5A6_HUMAN [view interactions] High throughput no no
NK3R_HUMAN [view interactions] High throughput no no
VMAT2_HUMAN [view entry] [view interactions] High throughput yes no
CD80_HUMAN [view interactions] High throughput no no
CXCR4_HUMAN [view interactions] High throughput no no
AGRB1_HUMAN [view entry] [view interactions] High throughput yes no
GP150_HUMAN [view interactions] High throughput no no
MICB_HUMAN [view interactions] High throughput no no
CRLF2_HUMAN [view interactions] High throughput no no
FFAR1_HUMAN [view interactions] High throughput no no
GXLT1_HUMAN [view interactions] High throughput no no
S22AI_HUMAN [view interactions] High throughput no no
GPR55_HUMAN [view interactions] High throughput no no
P2RY8_HUMAN [view interactions] High throughput no no
GPR45_HUMAN [view interactions] High throughput no no
TM192_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] Computational yes no
RASH_HUMAN [view entry] [view interactions] Computational yes no
RASN_HUMAN [view entry] [view interactions] Computational yes no