DRP2_HUMAN
Evidence for PS localization
Functions
Required for normal myelination and for normal organization of the cytoplasm and the formation of Cajal bands in myelinating Schwann cells. Required for normal PRX location at appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane. Possibly involved in membrane-cytoskeleton interactions of the central nervous system. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DRP2_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 50.0000 | 4 | yes |
| GO:0008270 | zinc ion binding | 40.0000 | 6 | yes |
| GO:0046914 | transition metal ion binding | 40.0000 | 5 | yes |
| GO:0003723 | RNA binding | 30.0000 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DRP2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 60.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 50.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 50.0000 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 50.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 40.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.0000 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 40.0000 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 40.0000 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 40.0000 | 5 | no |
| GO:0099537 | trans-synaptic signaling | 30.0000 | 4 | no |
| GO:0006996 | organelle organization | 30.0000 | 4 | no |
| GO:0007010 | cytoskeleton organization | 30.0000 | 5 | no |
| GO:0030030 | cell projection organization | 30.0000 | 4 | no |
| GO:0044057 | regulation of system process | 30.0000 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 30.0000 | 4 | no |
| GO:0045597 | positive regulation of cell differentiation | 30.0000 | 5 | no |
| GO:0050807 | regulation of synapse organization | 30.0000 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 30.0000 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 30.0000 | 5 | no |
| GO:0051960 | regulation of nervous system development | 30.0000 | 5 | no |
| GO:0051962 | positive regulation of nervous system development | 30.0000 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 30.0000 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.0000 | 5 | no |
| GO:2000026 | regulation of multicellular organismal development | 30.0000 | 4 | no |
| GO:0008104 | protein localization | 30.0000 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 30.0000 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 30.0000 | 5 | no |
| GO:0022607 | cellular component assembly | 30.0000 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 30.0000 | 5 | no |
| GO:0051049 | regulation of transport | 30.0000 | 4 | no |
| GO:0051050 | positive regulation of transport | 30.0000 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 30.0000 | 5 | no |
| GO:0034330 | cell junction organization | 20.0000 | 4 | yes |
| GO:0050808 | synapse organization | 20.0000 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in DRP2_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 20.0000 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 20.0000 | 5 | no |
| DOID:114 | heart disease | 20.0000 | 3 | no |
| DOID:0080000 | muscular disease | 20.0000 | 3 | no |
| DOID:423 | myopathy | 20.0000 | 5 | no |
| DOID:66 | muscle tissue disease | 20.0000 | 4 | no |
| DOID:9884 | muscular dystrophy | 20.0000 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DTNA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DAG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PRAX_HUMAN | [view interactions] | Low throughput | no | no |
| HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRIA4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNTG1_HUMAN | [view interactions] | High throughput | no | no |
| SNTG2_HUMAN | [view interactions] | High throughput | no | no |
| DMD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NLGN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |