Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GBRR1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GBRR1_HUMAN
GO:0017076 purine nucleotide binding 50.0000 4 no
GO:0032555 purine ribonucleotide binding 50.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 50.0000 4 no
GO:0004890 GABA-A receptor activity 40.0000 5 yes
GO:0005216 ion channel activity 40.0000 4 yes
GO:0005230 extracellular ligand-gated ion channel activity 40.0000 6 yes
GO:0005253 anion channel activity 40.0000 5 yes
GO:0005254 chloride channel activity 40.0000 6 yes
GO:0008509 anion transmembrane transporter activity 40.0000 4 yes
GO:0015103 inorganic anion transmembrane transporter activity 40.0000 4 yes
GO:0015108 chloride transmembrane transporter activity 40.0000 5 yes
GO:0015267 channel activity 40.0000 4 yes
GO:0015276 ligand-gated ion channel activity 40.0000 5 yes
GO:0016917 GABA receptor activity 40.0000 4 yes
GO:0022834 ligand-gated channel activity 40.0000 6 yes
GO:0022836 gated channel activity 40.0000 5 yes
GO:0004674 protein serine/threonine kinase activity 40.0000 4 no
GO:0004712 protein serine/threonine/tyrosine kinase activity 40.0000 4 no
GO:0005524 ATP binding 40.0000 5 no
GO:0016301 kinase activity 40.0000 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 40.0000 4 no
GO:0030554 adenyl nucleotide binding 40.0000 5 no
GO:0032559 adenyl ribonucleotide binding 40.0000 5 no
GO:0106310 protein serine kinase activity 40.0000 4 no
GO:0022824 transmitter-gated ion channel activity 30.0000 5 yes
GO:0022835 transmitter-gated channel activity 30.0000 4 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 30.0000 4 yes
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 30.0000 5 yes
GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential 30.0000 6 yes
GO:0099507 ligand-gated ion channel activity involved in regulation of presynaptic membrane potential 20.0000 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GBRR1_HUMAN
GO:0031323 regulation of cellular metabolic process 60.0000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 60.0000 4 no
GO:0006811 ion transport 50.0000 4 yes
GO:0007268 chemical synaptic transmission 50.0000 6 yes
GO:0098916 anterograde trans-synaptic signaling 50.0000 5 yes
GO:0099537 trans-synaptic signaling 50.0000 4 yes
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0032101 regulation of response to external stimulus 50.0000 4 no
GO:0048584 positive regulation of response to stimulus 50.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0006820 anion transport 40.0000 5 yes
GO:0006821 chloride transport 40.0000 7 yes
GO:0015698 inorganic anion transport 40.0000 6 yes
GO:0098656 anion transmembrane transport 40.0000 4 yes
GO:0098660 inorganic ion transmembrane transport 40.0000 4 yes
GO:0098661 inorganic anion transmembrane transport 40.0000 5 yes
GO:1902476 chloride transmembrane transport 40.0000 6 yes
GO:0006468 protein phosphorylation 40.0000 5 no
GO:0006796 phosphate-containing compound metabolic process 40.0000 4 no
GO:0009892 negative regulation of metabolic process 40.0000 4 no
GO:0009894 regulation of catabolic process 40.0000 4 no
GO:0010647 positive regulation of cell communication 40.0000 5 no
GO:0016310 phosphorylation 40.0000 5 no
GO:0023056 positive regulation of signaling 40.0000 4 no
GO:0036211 protein modification process 40.0000 4 no
GO:0043412 macromolecule modification 40.0000 4 no
GO:0048522 positive regulation of cellular process 40.0000 4 no
GO:0048523 negative regulation of cellular process 40.0000 4 no
GO:0051049 regulation of transport 40.0000 4 no
GO:0051246 regulation of protein metabolic process 40.0000 5 no
GO:0080134 regulation of response to stress 40.0000 4 no
GO:0009966 regulation of signal transduction 40.0000 4 no
GO:0009893 positive regulation of metabolic process 30.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 30.0000 5 no
GO:0010605 negative regulation of macromolecule metabolic process 30.0000 5 no
GO:0010941 regulation of cell death 30.0000 4 no
GO:0018193 peptidyl-amino acid modification 30.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.0000 5 no
GO:0031399 regulation of protein modification process 30.0000 6 no
GO:0042981 regulation of apoptotic process 30.0000 6 no
GO:0043067 regulation of programmed cell death 30.0000 5 no
GO:0051046 regulation of secretion 30.0000 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 30.0000 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 30.0000 5 no
GO:0051248 negative regulation of protein metabolic process 30.0000 6 no
GO:0060627 regulation of vesicle-mediated transport 30.0000 4 no
GO:1903530 regulation of secretion by cell 30.0000 4 no
GO:0009967 positive regulation of signal transduction 30.0000 5 no
GO:0031324 negative regulation of cellular metabolic process 30.0000 5 no
GO:0031329 regulation of cellular catabolic process 30.0000 5 no
GO:0051128 regulation of cellular component organization 30.0000 4 no
GO:0002685 regulation of leukocyte migration 30.0000 4 no
GO:0019220 regulation of phosphate metabolic process 30.0000 6 no
GO:0030334 regulation of cell migration 30.0000 5 no
GO:0031347 regulation of defense response 30.0000 5 no
GO:0032103 positive regulation of response to external stimulus 30.0000 5 no
GO:0051174 regulation of phosphorus metabolic process 30.0000 5 no
GO:0051338 regulation of transferase activity 30.0000 4 no
GO:1902531 regulation of intracellular signal transduction 30.0000 5 no
GO:2000145 regulation of cell motility 30.0000 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TAXB1_HUMAN [view interactions] Low throughput no yes
GBRR1_HUMAN [view entry] [view interactions] Low throughput yes no
BCR_HUMAN [view entry] [view interactions] Low throughput yes yes
DNM1L_HUMAN [view entry] [view interactions] Low throughput yes yes
IP6K2_HUMAN [view interactions] Low throughput no yes
FEZF1_HUMAN [view interactions] Low throughput no yes
KPCG_HUMAN [view entry] [view interactions] Low throughput yes yes
CK2N1_HUMAN [view entry] [view interactions] Low throughput yes yes
CSK21_HUMAN [view entry] [view interactions] Low throughput yes yes
MK03_HUMAN [view entry] [view interactions] Low throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes
GBRR3_HUMAN [view entry] [view interactions] Computational yes no
GBRR2_HUMAN [view entry] [view interactions] Computational yes no