Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GBRR1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GBRR1_HUMAN
GO:0000166 nucleotide binding 62.5000 4 no
GO:0017076 purine nucleotide binding 62.5000 5 no
GO:0032555 purine ribonucleotide binding 62.5000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 62.5000 4 no
GO:0043168 anion binding 62.5000 4 no
GO:0004674 protein serine/threonine kinase activity 50.0000 4 no
GO:0005524 ATP binding 50.0000 5 no
GO:0016301 kinase activity 50.0000 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 50.0000 4 no
GO:0030554 adenyl nucleotide binding 50.0000 6 no
GO:0032559 adenyl ribonucleotide binding 50.0000 5 no
GO:0106310 protein serine kinase activity 50.0000 4 no
GO:0004890 GABA-A receptor activity 25.0000 5 yes
GO:0005216 monoatomic ion channel activity 25.0000 4 yes
GO:0005230 extracellular ligand-gated monoatomic ion channel activity 25.0000 6 yes
GO:0005253 monoatomic anion channel activity 25.0000 5 yes
GO:0005254 chloride channel activity 25.0000 6 yes
GO:0008509 monoatomic anion transmembrane transporter activity 25.0000 4 yes
GO:0015103 inorganic anion transmembrane transporter activity 25.0000 4 yes
GO:0015108 chloride transmembrane transporter activity 25.0000 5 yes
GO:0015267 channel activity 25.0000 4 yes
GO:0015276 ligand-gated monoatomic ion channel activity 25.0000 5 yes
GO:0016917 GABA receptor activity 25.0000 4 yes
GO:0022834 ligand-gated channel activity 25.0000 6 yes
GO:0022836 gated channel activity 25.0000 5 yes
GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 25.0000 6 yes
GO:0005096 GTPase activator activity 25.0000 4 no
GO:0030695 GTPase regulator activity 25.0000 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in GBRR1_HUMAN
GO:0010646 regulation of cell communication 87.5000 4 yes
GO:0050804 modulation of chemical synaptic transmission 62.5000 5 yes
GO:0099177 regulation of trans-synaptic signaling 62.5000 4 yes
GO:0048522 positive regulation of cellular process 62.5000 4 no
GO:0048584 positive regulation of response to stimulus 62.5000 4 no
GO:0051128 regulation of cellular component organization 62.5000 4 no
GO:0006468 protein phosphorylation 50.0000 5 no
GO:0006796 phosphate-containing compound metabolic process 50.0000 4 no
GO:0009894 regulation of catabolic process 50.0000 4 no
GO:0009966 regulation of signal transduction 50.0000 4 no
GO:0010647 positive regulation of cell communication 50.0000 5 no
GO:0016310 phosphorylation 50.0000 5 no
GO:0023056 positive regulation of signaling 50.0000 4 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0036211 protein modification process 50.0000 4 no
GO:0043412 macromolecule modification 50.0000 4 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0032101 regulation of response to external stimulus 50.0000 4 no
GO:0051049 regulation of transport 50.0000 4 no
GO:0080134 regulation of response to stress 50.0000 4 no
GO:0006811 monoatomic ion transport 37.5000 4 yes
GO:0007268 chemical synaptic transmission 37.5000 7 yes
GO:0098916 anterograde trans-synaptic signaling 37.5000 6 yes
GO:0099536 synaptic signaling 37.5000 4 yes
GO:0099537 trans-synaptic signaling 37.5000 5 yes
GO:0009889 regulation of biosynthetic process 37.5000 4 no
GO:0009892 negative regulation of metabolic process 37.5000 4 no
GO:0009893 positive regulation of metabolic process 37.5000 4 no
GO:0009967 positive regulation of signal transduction 37.5000 5 no
GO:0010468 regulation of gene expression 37.5000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 37.5000 5 no
GO:0010604 positive regulation of macromolecule metabolic process 37.5000 5 no
GO:0031326 regulation of cellular biosynthetic process 37.5000 5 no
GO:0042981 regulation of apoptotic process 37.5000 5 no
GO:0043067 regulation of programmed cell death 37.5000 4 no
GO:0048585 negative regulation of response to stimulus 37.5000 4 no
GO:0002685 regulation of leukocyte migration 37.5000 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 37.5000 5 no
GO:0030334 regulation of cell migration 37.5000 5 no
GO:0032103 positive regulation of response to external stimulus 37.5000 5 no
GO:0051046 regulation of secretion 37.5000 5 no
GO:0051130 positive regulation of cellular component organization 37.5000 5 no
GO:0098657 import into cell 37.5000 4 no
GO:1902531 regulation of intracellular signal transduction 37.5000 5 no
GO:1903530 regulation of secretion by cell 37.5000 4 no
GO:2000145 regulation of cell motility 37.5000 4 no
GO:0031347 regulation of defense response 37.5000 5 no
GO:0060627 regulation of vesicle-mediated transport 37.5000 4 no
GO:0006820 monoatomic anion transport 25.0000 5 yes
GO:0006821 chloride transport 25.0000 5 yes
GO:0007214 gamma-aminobutyric acid signaling pathway 25.0000 4 yes
GO:0015698 inorganic anion transport 25.0000 4 yes
GO:0098656 monoatomic anion transmembrane transport 25.0000 4 yes
GO:0098661 inorganic anion transmembrane transport 25.0000 4 yes
GO:1902476 chloride transmembrane transport 25.0000 5 yes
GO:0006915 apoptotic process 25.0000 4 no
GO:0006974 DNA damage response 25.0000 4 no
GO:0008284 positive regulation of cell population proliferation 25.0000 5 no
GO:0009895 negative regulation of catabolic process 25.0000 5 no
GO:0009896 positive regulation of catabolic process 25.0000 5 no
GO:0009968 negative regulation of signal transduction 25.0000 5 no
GO:0010605 negative regulation of macromolecule metabolic process 25.0000 5 no
GO:0010648 negative regulation of cell communication 25.0000 5 no
GO:0018193 peptidyl-amino acid modification 25.0000 5 no
GO:0023057 negative regulation of signaling 25.0000 4 no
GO:0030162 regulation of proteolysis 25.0000 6 no
GO:0031324 negative regulation of cellular metabolic process 25.0000 5 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:0042176 regulation of protein catabolic process 25.0000 5 no
GO:0043066 negative regulation of apoptotic process 25.0000 6 no
GO:0043069 negative regulation of programmed cell death 25.0000 5 no
GO:0045861 negative regulation of proteolysis 25.0000 7 no
GO:0051246 regulation of protein metabolic process 25.0000 5 no
GO:0051248 negative regulation of protein metabolic process 25.0000 6 no
GO:0051336 regulation of hydrolase activity 25.0000 4 no
GO:0051726 regulation of cell cycle 25.0000 4 no
GO:0090304 nucleic acid metabolic process 25.0000 4 no
GO:1903050 regulation of proteolysis involved in protein catabolic process 25.0000 7 no
GO:1903051 negative regulation of proteolysis involved in protein catabolic process 25.0000 8 no
GO:2001233 regulation of apoptotic signaling pathway 25.0000 5 no
GO:0002684 positive regulation of immune system process 25.0000 4 no
GO:0002687 positive regulation of leukocyte migration 25.0000 5 no
GO:0002688 regulation of leukocyte chemotaxis 25.0000 5 no
GO:0002690 positive regulation of leukocyte chemotaxis 25.0000 6 no
GO:0006996 organelle organization 25.0000 4 no
GO:0008104 protein localization 25.0000 4 no
GO:0010506 regulation of autophagy 25.0000 6 no
GO:0010638 positive regulation of organelle organization 25.0000 6 no
GO:0022603 regulation of anatomical structure morphogenesis 25.0000 4 no
GO:0022607 cellular component assembly 25.0000 4 no
GO:0030335 positive regulation of cell migration 25.0000 6 no
GO:0031329 regulation of cellular catabolic process 25.0000 5 no
GO:0033043 regulation of organelle organization 25.0000 5 no
GO:0040017 positive regulation of locomotion 25.0000 4 no
GO:0050920 regulation of chemotaxis 25.0000 4 no
GO:0050921 positive regulation of chemotaxis 25.0000 5 no
GO:0051050 positive regulation of transport 25.0000 4 no
GO:0060341 regulation of cellular localization 25.0000 4 no
GO:0071622 regulation of granulocyte chemotaxis 25.0000 6 no
GO:1902533 positive regulation of intracellular signal transduction 25.0000 6 no
GO:2000147 positive regulation of cell motility 25.0000 5 no
GO:0017157 regulation of exocytosis 25.0000 5 no
GO:0030100 regulation of endocytosis 25.0000 5 no
GO:0043085 positive regulation of catalytic activity 25.0000 4 no
GO:0050727 regulation of inflammatory response 25.0000 5 no
GO:0050764 regulation of phagocytosis 25.0000 6 no
GO:0071310 cellular response to organic substance 25.0000 4 no
GO:0071675 regulation of mononuclear cell migration 25.0000 5 no
GO:0141124 intracellular signaling cassette 25.0000 4 no
GO:1901701 cellular response to oxygen-containing compound 25.0000 4 no
GO:1903305 regulation of regulated secretory pathway 25.0000 6 no
GO:1905521 regulation of macrophage migration 25.0000 6 no
GO:0014070 response to organic cyclic compound 25.0000 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0050890 cognition 25.0000 4 no
GO:0051052 regulation of DNA metabolic process 25.0000 5 no
GO:0051054 positive regulation of DNA metabolic process 25.0000 6 no
GO:0080135 regulation of cellular response to stress 25.0000 4 no
GO:0031349 positive regulation of defense response 25.0000 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TAXB1_HUMAN [view interactions] Low throughput no yes
GBRR1_HUMAN [view entry] [view interactions] Low throughput yes no
BCR_HUMAN [view entry] [view interactions] Low throughput yes yes
DNM1L_HUMAN [view entry] [view interactions] Low throughput yes yes
IP6K2_HUMAN [view interactions] Low throughput no yes
FEZF1_HUMAN [view interactions] Low throughput no yes
KPCG_HUMAN [view entry] [view interactions] Low throughput yes yes
CK2N1_HUMAN [view entry] [view interactions] Low throughput yes yes
CSK21_HUMAN [view entry] [view interactions] Low throughput yes yes
MK03_HUMAN [view entry] [view interactions] Low throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes