RUFY3_HUMAN
Evidence for PS localization
Functions
Plays a role in the generation of neuronal polarity formation and axon growth . Implicated in the formation of a single axon by developing neurons . May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes . Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery (PubMed). Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones . Promotes gastric cancer cell migration and invasion in a PAK1-dependent manner (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RUFY3_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 30.7692 | 4 | no |
| GO:0046872 | metal ion binding | 30.7692 | 5 | no |
| GO:0000166 | nucleotide binding | 23.0769 | 4 | no |
| GO:0017076 | purine nucleotide binding | 23.0769 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 23.0769 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 23.0769 | 4 | no |
| GO:0043168 | anion binding | 23.0769 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RUFY3_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 65.3846 | 4 | yes |
| GO:0010646 | regulation of cell communication | 61.5385 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 53.8462 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 53.8462 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 42.3077 | 4 | no |
| GO:0006996 | organelle organization | 38.4615 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 38.4615 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 38.4615 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 34.6154 | 4 | no |
| GO:0008104 | protein localization | 34.6154 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 34.6154 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 34.6154 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 34.6154 | 5 | no |
| GO:0022607 | cellular component assembly | 34.6154 | 4 | no |
| GO:0023056 | positive regulation of signaling | 34.6154 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 30.7692 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 30.7692 | 5 | yes |
| GO:0030030 | cell projection organization | 30.7692 | 4 | no |
| GO:0050890 | cognition | 30.7692 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.7692 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 30.7692 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 30.7692 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 30.7692 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 26.9231 | 4 | yes |
| GO:0051960 | regulation of nervous system development | 26.9231 | 5 | yes |
| GO:0060284 | regulation of cell development | 26.9231 | 5 | yes |
| GO:2000026 | regulation of multicellular organismal development | 26.9231 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 26.9231 | 4 | no |
| GO:0007612 | learning | 26.9231 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 26.9231 | 5 | no |
| GO:0023057 | negative regulation of signaling | 26.9231 | 4 | no |
| GO:0034330 | cell junction organization | 26.9231 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 26.9231 | 4 | no |
| GO:0050808 | synapse organization | 26.9231 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 26.9231 | 5 | no |
| GO:0009894 | regulation of catabolic process | 26.9231 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 26.9231 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.9231 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.9231 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.9231 | 5 | no |
| GO:0032880 | regulation of protein localization | 23.0769 | 5 | yes |
| GO:0050767 | regulation of neurogenesis | 23.0769 | 6 | yes |
| GO:0051049 | regulation of transport | 23.0769 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 23.0769 | 4 | yes |
| GO:0051129 | negative regulation of cellular component organization | 23.0769 | 5 | yes |
| GO:0051962 | positive regulation of nervous system development | 23.0769 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 23.0769 | 4 | yes |
| GO:0097435 | supramolecular fiber organization | 23.0769 | 4 | yes |
| GO:0050807 | regulation of synapse organization | 23.0769 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 23.0769 | 5 | no |
| GO:0031175 | neuron projection development | 23.0769 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 23.0769 | 6 | no |
| GO:0031399 | regulation of protein modification process | 23.0769 | 6 | no |
| GO:0009889 | regulation of biosynthetic process | 23.0769 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 23.0769 | 5 | no |
| GO:0010468 | regulation of gene expression | 23.0769 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 23.0769 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 23.0769 | 6 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 23.0769 | 5 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 23.0769 | 6 | no |
| GO:0001558 | regulation of cell growth | 19.2308 | 4 | yes |
| GO:0010720 | positive regulation of cell development | 19.2308 | 6 | yes |
| GO:0010975 | regulation of neuron projection development | 19.2308 | 7 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 19.2308 | 4 | yes |
| GO:0031344 | regulation of cell projection organization | 19.2308 | 5 | yes |
| GO:0045597 | positive regulation of cell differentiation | 19.2308 | 5 | yes |
| GO:0050769 | positive regulation of neurogenesis | 19.2308 | 6 | yes |
| GO:0051093 | negative regulation of developmental process | 19.2308 | 4 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 19.2308 | 4 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 19.2308 | 6 | yes |
| GO:1903829 | positive regulation of protein localization | 19.2308 | 5 | yes |
| GO:0045596 | negative regulation of cell differentiation | 15.3846 | 5 | yes |
| GO:0048638 | regulation of developmental growth | 15.3846 | 4 | yes |
| GO:0050770 | regulation of axonogenesis | 15.3846 | 5 | yes |
| GO:0051050 | positive regulation of transport | 15.3846 | 4 | yes |
| GO:0007015 | actin filament organization | 11.5385 | 5 | yes |
| GO:0010721 | negative regulation of cell development | 11.5385 | 6 | yes |
| GO:0030307 | positive regulation of cell growth | 11.5385 | 5 | yes |
| GO:0030334 | regulation of cell migration | 11.5385 | 5 | yes |
| GO:0030516 | regulation of axon extension | 11.5385 | 5 | yes |
| GO:0031345 | negative regulation of cell projection organization | 11.5385 | 6 | yes |
| GO:0031346 | positive regulation of cell projection organization | 11.5385 | 6 | yes |
| GO:0045773 | positive regulation of axon extension | 11.5385 | 6 | yes |
| GO:0045927 | positive regulation of growth | 11.5385 | 4 | yes |
| GO:0048639 | positive regulation of developmental growth | 11.5385 | 5 | yes |
| GO:0050772 | positive regulation of axonogenesis | 11.5385 | 6 | yes |
| GO:0061387 | regulation of extent of cell growth | 11.5385 | 5 | yes |
| GO:2000145 | regulation of cell motility | 11.5385 | 4 | yes |
| GO:0010977 | negative regulation of neuron projection development | 7.6923 | 7 | yes |
| GO:0030335 | positive regulation of cell migration | 7.6923 | 6 | yes |
| GO:0040017 | positive regulation of locomotion | 7.6923 | 4 | yes |
| GO:0050768 | negative regulation of neurogenesis | 7.6923 | 6 | yes |
| GO:0050771 | negative regulation of axonogenesis | 7.6923 | 6 | yes |
| GO:0051961 | negative regulation of nervous system development | 7.6923 | 5 | yes |
| GO:0070201 | regulation of establishment of protein localization | 7.6923 | 6 | yes |
| GO:2000147 | positive regulation of cell motility | 7.6923 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RGS14_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARL8B_HUMAN | [view interactions] | Low throughput | no | yes |
| SMCA2_HUMAN | [view interactions] | High throughput | no | yes |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| MD13L_HUMAN | [view interactions] | High throughput | no | no |
| CEP63_HUMAN | [view interactions] | High throughput | no | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| RB33A_HUMAN | [view interactions] | High throughput | no | no |
| ABI3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| U119A_HUMAN | [view interactions] | High throughput | no | no |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DSCAM_HUMAN | [view interactions] | High throughput | no | yes |
| CT2NL_HUMAN | [view interactions] | High throughput | no | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| CAN3_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KTNA1_HUMAN | [view interactions] | High throughput | no | yes |
| TRM9B_HUMAN | [view interactions] | High throughput | no | yes |
| DCA15_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| RUFY1_HUMAN | [view interactions] | High throughput | no | yes |
| RUFY2_HUMAN | [view interactions] | High throughput | no | yes |
| GL1D1_HUMAN | [view interactions] | High throughput | no | no |
| ATS12_HUMAN | [view interactions] | High throughput | no | no |
| CHIA_HUMAN | [view interactions] | High throughput | no | yes |
| GANAB_HUMAN | [view interactions] | High throughput | no | yes |
| ASB8_HUMAN | [view interactions] | High throughput | no | yes |
| CBAR1_HUMAN | [view interactions] | High throughput | no | no |
| TTC23_HUMAN | [view interactions] | High throughput | no | yes |
| TEDC2_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRCA2_HUMAN | [view interactions] | High throughput | no | no |
| TRPV1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NGB_HUMAN | [view interactions] | High throughput | no | yes |
| DHX33_HUMAN | [view interactions] | High throughput | no | yes |
| INSY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRIM8_HUMAN | [view interactions] | High throughput | no | yes |
| MELK_HUMAN | [view interactions] | High throughput | no | yes |
| KT222_HUMAN | [view interactions] | High throughput | no | no |
| KRT37_HUMAN | [view interactions] | High throughput | no | no |
| KI18B_HUMAN | [view interactions] | High throughput | no | no |
| MTG2_HUMAN | [view interactions] | High throughput | no | yes |
| PRUN1_HUMAN | [view interactions] | High throughput | no | no |
| PDE7B_HUMAN | [view interactions] | High throughput | no | no |
| BACE2_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| CTTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NIPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STRN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1C19_HUMAN | [view interactions] | High throughput | no | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARL8A_HUMAN | [view interactions] | High throughput | no | no |
| CNTP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GEPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRIA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NRX1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PPP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHEB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |