RUFY3_HUMAN
Plays a role in the generation of neuronal polarity formation and axon growth . Implicated in the formation of a single axon by developing neurons . May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes . Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery (PubMed). Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones . Promotes gastric cancer cell migration and invasion in a PAK1-dependent manner (PubMed). [View more on UniProt]
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No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
No data found.
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in RUFY3_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 66.6667 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 60.0000 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 53.3333 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 53.3333 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 53.3333 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 53.3333 | 4 | no |
GO:0009966 | regulation of signal transduction | 46.6667 | 4 | no |
GO:0010646 | regulation of cell communication | 46.6667 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 46.6667 | 4 | no |
GO:0045595 | regulation of cell differentiation | 40.0000 | 4 | yes |
GO:0051240 | positive regulation of multicellular organismal process | 40.0000 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 40.0000 | 4 | no |
GO:0006996 | organelle organization | 40.0000 | 4 | no |
GO:0022607 | cellular component assembly | 40.0000 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 40.0000 | 5 | no |
GO:0001558 | regulation of cell growth | 33.3333 | 4 | yes |
GO:0031344 | regulation of cell projection organization | 33.3333 | 5 | yes |
GO:0032880 | regulation of protein localization | 33.3333 | 5 | yes |
GO:0045597 | positive regulation of cell differentiation | 33.3333 | 5 | yes |
GO:0051049 | regulation of transport | 33.3333 | 4 | yes |
GO:0051094 | positive regulation of developmental process | 33.3333 | 4 | yes |
GO:0051129 | negative regulation of cellular component organization | 33.3333 | 5 | yes |
GO:0060284 | regulation of cell development | 33.3333 | 5 | yes |
GO:0060341 | regulation of cellular localization | 33.3333 | 4 | yes |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 33.3333 | 6 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 33.3333 | 5 | no |
GO:0008104 | protein localization | 33.3333 | 4 | no |
GO:0071310 | cellular response to organic substance | 33.3333 | 4 | no |
GO:1901701 | cellular response to oxygen-containing compound | 33.3333 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 33.3333 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 33.3333 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 33.3333 | 5 | no |
GO:0050804 | modulation of chemical synaptic transmission | 33.3333 | 5 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 33.3333 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 33.3333 | 5 | no |
GO:0099177 | regulation of trans-synaptic signaling | 33.3333 | 4 | no |
GO:0010720 | positive regulation of cell development | 26.6667 | 6 | yes |
GO:0010975 | regulation of neuron projection development | 26.6667 | 7 | yes |
GO:0022603 | regulation of anatomical structure morphogenesis | 26.6667 | 4 | yes |
GO:0048638 | regulation of developmental growth | 26.6667 | 4 | yes |
GO:0050767 | regulation of neurogenesis | 26.6667 | 6 | yes |
GO:0050769 | positive regulation of neurogenesis | 26.6667 | 6 | yes |
GO:0051050 | positive regulation of transport | 26.6667 | 4 | yes |
GO:0051093 | negative regulation of developmental process | 26.6667 | 4 | yes |
GO:0051130 | positive regulation of cellular component organization | 26.6667 | 5 | yes |
GO:0051960 | regulation of nervous system development | 26.6667 | 5 | yes |
GO:0051962 | positive regulation of nervous system development | 26.6667 | 5 | yes |
GO:0097435 | supramolecular fiber organization | 26.6667 | 4 | yes |
GO:1903829 | positive regulation of protein localization | 26.6667 | 5 | yes |
GO:2000026 | regulation of multicellular organismal development | 26.6667 | 4 | yes |
GO:0033043 | regulation of organelle organization | 26.6667 | 5 | no |
GO:0044087 | regulation of cellular component biogenesis | 26.6667 | 4 | no |
GO:0050807 | regulation of synapse organization | 26.6667 | 5 | no |
GO:0010243 | response to organonitrogen compound | 26.6667 | 4 | no |
GO:0010647 | positive regulation of cell communication | 26.6667 | 5 | no |
GO:0016192 | vesicle-mediated transport | 26.6667 | 4 | no |
GO:0023056 | positive regulation of signaling | 26.6667 | 4 | no |
GO:0048878 | chemical homeostasis | 26.6667 | 4 | no |
GO:0071417 | cellular response to organonitrogen compound | 26.6667 | 4 | no |
GO:1901699 | cellular response to nitrogen compound | 26.6667 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 26.6667 | 5 | no |
GO:0009894 | regulation of catabolic process | 26.6667 | 4 | no |
GO:0010468 | regulation of gene expression | 26.6667 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 26.6667 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 26.6667 | 6 | no |
GO:0030030 | cell projection organization | 26.6667 | 4 | no |
GO:0031399 | regulation of protein modification process | 26.6667 | 6 | no |
GO:0042325 | regulation of phosphorylation | 26.6667 | 7 | no |
GO:0043933 | protein-containing complex organization | 26.6667 | 4 | no |
GO:0050890 | cognition | 26.6667 | 4 | no |
GO:0051174 | regulation of phosphorus metabolic process | 26.6667 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 26.6667 | 6 | no |
GO:0051336 | regulation of hydrolase activity | 26.6667 | 4 | no |
GO:0070848 | response to growth factor | 26.6667 | 4 | no |
GO:0071363 | cellular response to growth factor stimulus | 26.6667 | 5 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 26.6667 | 5 | no |
GO:0030307 | positive regulation of cell growth | 20.0000 | 5 | yes |
GO:0030334 | regulation of cell migration | 20.0000 | 5 | yes |
GO:0030516 | regulation of axon extension | 20.0000 | 5 | yes |
GO:0031345 | negative regulation of cell projection organization | 20.0000 | 6 | yes |
GO:0031346 | positive regulation of cell projection organization | 20.0000 | 6 | yes |
GO:0045596 | negative regulation of cell differentiation | 20.0000 | 5 | yes |
GO:0045773 | positive regulation of axon extension | 20.0000 | 6 | yes |
GO:0045927 | positive regulation of growth | 20.0000 | 4 | yes |
GO:0048639 | positive regulation of developmental growth | 20.0000 | 5 | yes |
GO:0050770 | regulation of axonogenesis | 20.0000 | 5 | yes |
GO:0050772 | positive regulation of axonogenesis | 20.0000 | 6 | yes |
GO:0051241 | negative regulation of multicellular organismal process | 20.0000 | 4 | yes |
GO:0061387 | regulation of extent of cell growth | 20.0000 | 5 | yes |
GO:0070201 | regulation of establishment of protein localization | 20.0000 | 6 | yes |
GO:2000145 | regulation of cell motility | 20.0000 | 4 | yes |
GO:0007015 | actin filament organization | 13.3333 | 5 | yes |
GO:0010721 | negative regulation of cell development | 13.3333 | 6 | yes |
GO:0030335 | positive regulation of cell migration | 13.3333 | 6 | yes |
GO:0040017 | positive regulation of locomotion | 13.3333 | 4 | yes |
GO:0051222 | positive regulation of protein transport | 13.3333 | 5 | yes |
GO:0051223 | regulation of protein transport | 13.3333 | 5 | yes |
GO:1904951 | positive regulation of establishment of protein localization | 13.3333 | 6 | yes |
GO:2000147 | positive regulation of cell motility | 13.3333 | 5 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
RGS14_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SMCA2_HUMAN | [view interactions] | High throughput | no | yes |
RB33A_HUMAN | [view interactions] | High throughput | no | no |
ABI3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
U119A_HUMAN | [view interactions] | High throughput | no | no |
DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CT2NL_HUMAN | [view interactions] | High throughput | no | yes |
RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
CAN3_HUMAN | [view interactions] | High throughput | no | no |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KTNA1_HUMAN | [view interactions] | High throughput | no | yes |
TRM9B_HUMAN | [view interactions] | High throughput | no | yes |
DCA15_HUMAN | [view interactions] | High throughput | no | no |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
RUFY1_HUMAN | [view interactions] | High throughput | no | yes |
RUFY2_HUMAN | [view interactions] | High throughput | no | yes |
GL1D1_HUMAN | [view interactions] | High throughput | no | no |
ATS12_HUMAN | [view interactions] | High throughput | no | no |
CHIA_HUMAN | [view interactions] | High throughput | no | yes |
GANAB_HUMAN | [view interactions] | High throughput | no | yes |
ASB8_HUMAN | [view interactions] | High throughput | no | yes |
CBAR1_HUMAN | [view interactions] | High throughput | no | no |
TTC23_HUMAN | [view interactions] | High throughput | no | yes |
TEDC2_HUMAN | [view interactions] | High throughput | no | no |
NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BRCA2_HUMAN | [view interactions] | High throughput | no | no |
TRPV1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NGB_HUMAN | [view interactions] | High throughput | no | yes |
DHX33_HUMAN | [view interactions] | High throughput | no | yes |
INSY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRIM8_HUMAN | [view interactions] | High throughput | no | yes |
MELK_HUMAN | [view interactions] | High throughput | no | yes |
KT222_HUMAN | [view interactions] | High throughput | no | no |
KRT37_HUMAN | [view interactions] | High throughput | no | no |
KI18B_HUMAN | [view interactions] | High throughput | no | no |
MTG2_HUMAN | [view interactions] | High throughput | no | yes |
PRUN1_HUMAN | [view interactions] | High throughput | no | no |
PDE7B_HUMAN | [view interactions] | High throughput | no | no |
BACE2_HUMAN | [view interactions] | High throughput | no | yes |
RHOQ_HUMAN | [view interactions] | High throughput | no | no |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
CTTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NIPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STRN3_HUMAN | [view interactions] | High throughput | no | yes |
K1C19_HUMAN | [view interactions] | High throughput | no | no |
LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
LAMP3_HUMAN | [view interactions] | High throughput | no | no |
LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IFM3_HUMAN | [view interactions] | High throughput | no | yes |
RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SHOT1_HUMAN | [view interactions] | Computational | no | no |