Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SYT7_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory and synaptic vesicles through Ca(2+) and phospholipid binding to the C2 domain . Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis . SYT7 binds Ca(2+) with high affinity and slow kinetics compared to other synaptotagmins . Involved in Ca(2+)-triggered lysosomal exocytosis, a major component of the plasma membrane repair (PubMed). Ca(2+)-regulated delivery of lysosomal membranes to the cell surface is also involved in the phagocytic uptake of particles by macrophages . Ca(2+)-triggered lysosomal exocytosis also plays a role in bone remodeling by regulating secretory pathways in osteoclasts and osteoblasts . In case of infection, involved in participates cell invasion by Trypanosoma cruzi via Ca(2+)-triggered lysosomal exocytosis (PubMed, PubMed). Involved in cholesterol transport from lysosome to peroxisome by promoting membrane contacts between lysosomes and peroxisomes: probably acts by promoting vesicle fusion by binding phosphatidylinositol-4,5-bisphosphate on peroxisomal membranes . Acts as a key mediator of synaptic facilitation, a process also named short-term synaptic potentiation: synaptic facilitation takes place at synapses with a low initial release probability and is caused by influx of Ca(2+) into the axon terminal after spike generation, increasing the release probability of neurotransmitters . Probably mediates synaptic facilitation by directly increasing the probability of release . May also contribute to synaptic facilitation by regulating synaptic vesicle replenishment, a process required to ensure that synaptic vesicles are ready for the arrival of the next action potential: SYT7 is required for synaptic vesicle replenishment by acting as a sensor for Ca(2+) and by forming a complex with calmodulin . Also acts as a regulator of Ca(2+)-dependent insulin and glucagon secretion in beta-cells . Triggers exocytosis by promoting fusion pore opening and fusion pore expansion in chromaffin cells . Also regulates the secretion of some non-synaptic secretory granules of specialized cells . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SYT7_HUMAN
GO:0019900 kinase binding 42.8571 4 no
GO:0043168 anion binding 35.7143 4 yes
GO:0043169 cation binding 28.5714 4 yes
GO:0046872 metal ion binding 28.5714 5 yes
GO:0019901 protein kinase binding 28.5714 5 no
GO:0005509 calcium ion binding 21.4286 6 yes
GO:0000166 nucleotide binding 21.4286 4 no
GO:0017076 purine nucleotide binding 21.4286 5 no
GO:0032555 purine ribonucleotide binding 21.4286 4 no
GO:0003924 GTPase activity 21.4286 7 no
GO:0016462 pyrophosphatase activity 21.4286 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 21.4286 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 21.4286 6 no
GO:0005544 calcium-dependent phospholipid binding 14.2857 4 yes
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 14.2857 5 yes
GO:0019905 syntaxin binding 14.2857 4 yes
GO:0035091 phosphatidylinositol binding 14.2857 4 yes
GO:1901981 phosphatidylinositol phosphate binding 14.2857 5 yes
GO:1902936 phosphatidylinositol bisphosphate binding 14.2857 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SYT7_HUMAN
GO:0048522 positive regulation of cellular process 85.7143 4 yes
GO:0010646 regulation of cell communication 71.4286 4 yes
GO:0060255 regulation of macromolecule metabolic process 64.2857 4 no
GO:0080090 regulation of primary metabolic process 64.2857 4 no
GO:0031323 regulation of cellular metabolic process 64.2857 4 no
GO:0048523 negative regulation of cellular process 57.1429 4 no
GO:0051246 regulation of protein metabolic process 57.1429 5 no
GO:0051128 regulation of cellular component organization 57.1429 4 yes
GO:0009966 regulation of signal transduction 50.0000 4 no
GO:0032880 regulation of protein localization 50.0000 5 yes
GO:0050804 modulation of chemical synaptic transmission 50.0000 5 yes
GO:0060341 regulation of cellular localization 50.0000 4 yes
GO:0099177 regulation of trans-synaptic signaling 50.0000 4 yes
GO:0009889 regulation of biosynthetic process 50.0000 4 no
GO:0010556 regulation of macromolecule biosynthetic process 50.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 no
GO:0019220 regulation of phosphate metabolic process 42.8571 6 no
GO:0031399 regulation of protein modification process 42.8571 6 no
GO:0051174 regulation of phosphorus metabolic process 42.8571 5 no
GO:0006996 organelle organization 42.8571 4 yes
GO:0051049 regulation of transport 42.8571 4 yes
GO:0098657 import into cell 42.8571 4 yes
GO:0008104 protein localization 42.8571 4 no
GO:0009891 positive regulation of biosynthetic process 42.8571 5 no
GO:0009893 positive regulation of metabolic process 42.8571 4 no
GO:0010468 regulation of gene expression 42.8571 6 no
GO:0010557 positive regulation of macromolecule biosynthetic process 42.8571 6 no
GO:0010604 positive regulation of macromolecule metabolic process 42.8571 5 no
GO:0031325 positive regulation of cellular metabolic process 42.8571 5 no
GO:0031328 positive regulation of cellular biosynthetic process 42.8571 6 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 35.7143 5 no
GO:0051252 regulation of RNA metabolic process 35.7143 5 no
GO:0001932 regulation of protein phosphorylation 35.7143 7 no
GO:0009892 negative regulation of metabolic process 35.7143 4 no
GO:0010605 negative regulation of macromolecule metabolic process 35.7143 5 no
GO:0010628 positive regulation of gene expression 35.7143 7 no
GO:0031324 negative regulation of cellular metabolic process 35.7143 5 no
GO:0042127 regulation of cell population proliferation 35.7143 4 no
GO:0042325 regulation of phosphorylation 35.7143 7 no
GO:0051247 positive regulation of protein metabolic process 35.7143 6 no
GO:0010647 positive regulation of cell communication 35.7143 5 no
GO:0023056 positive regulation of signaling 35.7143 4 no
GO:0051050 positive regulation of transport 35.7143 4 yes
GO:0070201 regulation of establishment of protein localization 35.7143 6 yes
GO:0071702 organic substance transport 35.7143 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 35.7143 5 no
GO:0051254 positive regulation of RNA metabolic process 28.5714 6 no
GO:0060284 regulation of cell development 28.5714 5 no
GO:0071310 cellular response to organic substance 28.5714 4 no
GO:1902680 positive regulation of RNA biosynthetic process 28.5714 7 no
GO:1903829 positive regulation of protein localization 28.5714 5 no
GO:2000026 regulation of multicellular organismal development 28.5714 4 no
GO:2001141 regulation of RNA biosynthetic process 28.5714 6 no
GO:0008284 positive regulation of cell population proliferation 28.5714 5 no
GO:0009890 negative regulation of biosynthetic process 28.5714 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 28.5714 6 no
GO:0031327 negative regulation of cellular biosynthetic process 28.5714 6 no
GO:0031401 positive regulation of protein modification process 28.5714 7 no
GO:1902531 regulation of intracellular signal transduction 28.5714 5 no
GO:0009967 positive regulation of signal transduction 28.5714 5 no
GO:0048584 positive regulation of response to stimulus 28.5714 4 no
GO:0051240 positive regulation of multicellular organismal process 28.5714 4 no
GO:0051223 regulation of protein transport 28.5714 5 yes
GO:0060627 regulation of vesicle-mediated transport 28.5714 4 yes
GO:0141124 intracellular signaling cassette 28.5714 4 no
GO:0006355 regulation of DNA-templated transcription 28.5714 7 no
GO:0009894 regulation of catabolic process 28.5714 4 no
GO:0022607 cellular component assembly 28.5714 4 no
GO:0045595 regulation of cell differentiation 28.5714 4 no
GO:0045893 positive regulation of DNA-templated transcription 28.5714 8 no
GO:0050767 regulation of neurogenesis 21.4286 6 no
GO:0051960 regulation of nervous system development 21.4286 5 no
GO:0071407 cellular response to organic cyclic compound 21.4286 5 no
GO:0071417 cellular response to organonitrogen compound 21.4286 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 21.4286 6 no
GO:1901699 cellular response to nitrogen compound 21.4286 4 no
GO:1901701 cellular response to oxygen-containing compound 21.4286 4 no
GO:0006357 regulation of transcription by RNA polymerase II 21.4286 8 no
GO:0006886 intracellular protein transport 21.4286 4 no
GO:0009416 response to light stimulus 21.4286 4 no
GO:0010629 negative regulation of gene expression 21.4286 7 no
GO:0015031 protein transport 21.4286 4 no
GO:0042981 regulation of apoptotic process 21.4286 5 no
GO:0043066 negative regulation of apoptotic process 21.4286 6 no
GO:0043067 regulation of programmed cell death 21.4286 4 no
GO:0043069 negative regulation of programmed cell death 21.4286 5 no
GO:0043086 negative regulation of catalytic activity 21.4286 4 no
GO:0043549 regulation of kinase activity 21.4286 5 no
GO:0043933 protein-containing complex organization 21.4286 4 no
GO:0044087 regulation of cellular component biogenesis 21.4286 4 no
GO:0045859 regulation of protein kinase activity 21.4286 6 no
GO:0045944 positive regulation of transcription by RNA polymerase II 21.4286 9 no
GO:0051248 negative regulation of protein metabolic process 21.4286 6 no
GO:0051338 regulation of transferase activity 21.4286 4 no
GO:0051726 regulation of cell cycle 21.4286 4 no
GO:0071705 nitrogen compound transport 21.4286 4 no
GO:0080134 regulation of response to stress 21.4286 4 no
GO:0090304 nucleic acid metabolic process 21.4286 4 no
GO:0010562 positive regulation of phosphorus metabolic process 21.4286 6 no
GO:0045597 positive regulation of cell differentiation 21.4286 5 no
GO:0045937 positive regulation of phosphate metabolic process 21.4286 7 no
GO:0051094 positive regulation of developmental process 21.4286 4 no
GO:0007612 learning 21.4286 4 no
GO:0050890 cognition 21.4286 4 no
GO:0002791 regulation of peptide secretion 21.4286 6 yes
GO:0006906 vesicle fusion 21.4286 6 yes
GO:0010038 response to metal ion 21.4286 4 yes
GO:0016050 vesicle organization 21.4286 5 yes
GO:0016079 synaptic vesicle exocytosis 21.4286 4 yes
GO:0016482 cytosolic transport 21.4286 4 yes
GO:0017156 calcium-ion regulated exocytosis 21.4286 5 yes
GO:0017157 regulation of exocytosis 21.4286 5 yes
GO:0017158 regulation of calcium ion-dependent exocytosis 21.4286 7 yes
GO:0023061 signal release 21.4286 4 yes
GO:0030100 regulation of endocytosis 21.4286 5 yes
GO:0045055 regulated exocytosis 21.4286 4 yes
GO:0045921 positive regulation of exocytosis 21.4286 6 yes
GO:0045956 positive regulation of calcium ion-dependent exocytosis 21.4286 8 yes
GO:0046883 regulation of hormone secretion 21.4286 4 yes
GO:0046903 secretion 21.4286 4 yes
GO:0048284 organelle fusion 21.4286 5 yes
GO:0050433 regulation of catecholamine secretion 21.4286 5 yes
GO:0050708 regulation of protein secretion 21.4286 5 yes
GO:0050796 regulation of insulin secretion 21.4286 6 yes
GO:0051046 regulation of secretion 21.4286 5 yes
GO:0051047 positive regulation of secretion 21.4286 5 yes
GO:0051952 regulation of amine transport 21.4286 5 yes
GO:0061024 membrane organization 21.4286 4 yes
GO:0061025 membrane fusion 21.4286 5 yes
GO:0071241 cellular response to inorganic substance 21.4286 4 yes
GO:0071248 cellular response to metal ion 21.4286 5 yes
GO:0090087 regulation of peptide transport 21.4286 5 yes
GO:0090174 organelle membrane fusion 21.4286 6 yes
GO:0090276 regulation of peptide hormone secretion 21.4286 5 yes
GO:0099643 signal release from synapse 21.4286 5 yes
GO:1903305 regulation of regulated secretory pathway 21.4286 6 yes
GO:1903307 positive regulation of regulated secretory pathway 21.4286 7 yes
GO:1903530 regulation of secretion by cell 21.4286 4 yes
GO:1903532 positive regulation of secretion by cell 21.4286 5 yes
GO:0001558 regulation of cell growth 21.4286 4 no
GO:0010243 response to organonitrogen compound 21.4286 4 no
GO:0014070 response to organic cyclic compound 21.4286 4 no
GO:0031344 regulation of cell projection organization 21.4286 5 no
GO:0001778 plasma membrane repair 14.2857 6 yes
GO:0006869 lipid transport 14.2857 5 yes
GO:0006909 phagocytosis 14.2857 4 yes
GO:0007009 plasma membrane organization 14.2857 5 yes
GO:0014059 regulation of dopamine secretion 14.2857 6 yes
GO:0015850 organic hydroxy compound transport 14.2857 5 yes
GO:0015918 sterol transport 14.2857 6 yes
GO:0030301 cholesterol transport 14.2857 7 yes
GO:0032365 intracellular lipid transport 14.2857 4 yes
GO:0032366 intracellular sterol transport 14.2857 5 yes
GO:0032367 intracellular cholesterol transport 14.2857 6 yes
GO:0034103 regulation of tissue remodeling 14.2857 4 yes
GO:0036465 synaptic vesicle recycling 14.2857 4 yes
GO:0046850 regulation of bone remodeling 14.2857 5 yes
GO:0048791 calcium ion-regulated exocytosis of neurotransmitter 14.2857 5 yes
GO:0050764 regulation of phagocytosis 14.2857 6 yes
GO:0051592 response to calcium ion 14.2857 5 yes
GO:0070092 regulation of glucagon secretion 14.2857 6 yes
GO:0071277 cellular response to calcium ion 14.2857 6 yes
GO:0090385 phagosome-lysosome fusion 14.2857 7 yes
GO:1900242 regulation of synaptic vesicle endocytosis 14.2857 6 yes
GO:1903421 regulation of synaptic vesicle recycling 14.2857 5 yes
GO:1990926 short-term synaptic potentiation 14.2857 4 yes
GO:1990927 calcium ion regulated lysosome exocytosis 14.2857 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
STX1A_HUMAN [view entry] [view interactions] Low throughput yes yes
HNRPQ_HUMAN [view entry] [view interactions] Low throughput yes yes
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
SIAH1_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
FERM2_HUMAN [view interactions] High throughput no yes
SYT7_HUMAN [view entry] [view interactions] High throughput yes yes
MOV10_HUMAN [view interactions] High throughput no no
ARNT_HUMAN [view entry] [view interactions] High throughput yes yes
SENP2_HUMAN [view interactions] High throughput no yes
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
SMCA2_HUMAN [view interactions] High throughput no yes
INS_HUMAN [view interactions] High throughput no no
CUL1_HUMAN [view interactions] High throughput no yes
SKP2_HUMAN [view interactions] High throughput no yes
AP2A1_HUMAN [view entry] [view interactions] High throughput yes yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
SSR3_HUMAN [view interactions] High throughput no yes