SYT7_HUMAN
Evidence for PS localization
Functions
Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory and synaptic vesicles through Ca(2+) and phospholipid binding to the C2 domain . Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis . SYT7 binds Ca(2+) with high affinity and slow kinetics compared to other synaptotagmins . Involved in Ca(2+)-triggered lysosomal exocytosis, a major component of the plasma membrane repair (PubMed). Ca(2+)-regulated delivery of lysosomal membranes to the cell surface is also involved in the phagocytic uptake of particles by macrophages . Ca(2+)-triggered lysosomal exocytosis also plays a role in bone remodeling by regulating secretory pathways in osteoclasts and osteoblasts . In case of infection, involved in participates cell invasion by Trypanosoma cruzi via Ca(2+)-triggered lysosomal exocytosis (PubMed, PubMed). Involved in cholesterol transport from lysosome to peroxisome by promoting membrane contacts between lysosomes and peroxisomes: probably acts by promoting vesicle fusion by binding phosphatidylinositol-4,5-bisphosphate on peroxisomal membranes . Acts as a key mediator of synaptic facilitation, a process also named short-term synaptic potentiation: synaptic facilitation takes place at synapses with a low initial release probability and is caused by influx of Ca(2+) into the axon terminal after spike generation, increasing the release probability of neurotransmitters . Probably mediates synaptic facilitation by directly increasing the probability of release . May also contribute to synaptic facilitation by regulating synaptic vesicle replenishment, a process required to ensure that synaptic vesicles are ready for the arrival of the next action potential: SYT7 is required for synaptic vesicle replenishment by acting as a sensor for Ca(2+) and by forming a complex with calmodulin . Also acts as a regulator of Ca(2+)-dependent insulin and glucagon secretion in beta-cells . Triggers exocytosis by promoting fusion pore opening and fusion pore expansion in chromaffin cells . Also regulates the secretion of some non-synaptic secretory granules of specialized cells . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SYT7_HUMAN |
|---|---|---|---|---|
| GO:0019905 | syntaxin binding | 33.3333 | 4 | yes |
| GO:0019900 | kinase binding | 33.3333 | 4 | no |
| GO:0005509 | calcium ion binding | 20.0000 | 5 | yes |
| GO:0046872 | metal ion binding | 20.0000 | 4 | yes |
| GO:0005544 | calcium-dependent phospholipid binding | 13.3333 | 4 | yes |
| GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | 13.3333 | 4 | yes |
| GO:0035091 | phosphatidylinositol binding | 13.3333 | 4 | yes |
| GO:1901981 | phosphatidylinositol phosphate binding | 13.3333 | 5 | yes |
| GO:1902936 | phosphatidylinositol bisphosphate binding | 13.3333 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SYT7_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 80.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 73.3333 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 66.6667 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 66.6667 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 60.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 60.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 60.0000 | 4 | no |
| GO:0006996 | organelle organization | 53.3333 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 53.3333 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 53.3333 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 53.3333 | 5 | no |
| GO:0032880 | regulation of protein localization | 46.6667 | 5 | yes |
| GO:0051049 | regulation of transport | 46.6667 | 4 | yes |
| GO:0060341 | regulation of cellular localization | 46.6667 | 4 | yes |
| GO:0071702 | organic substance transport | 46.6667 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 46.6667 | 4 | no |
| GO:0010468 | regulation of gene expression | 46.6667 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 46.6667 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 46.6667 | 4 | no |
| GO:0008104 | protein localization | 46.6667 | 4 | no |
| GO:0006887 | exocytosis | 40.0000 | 4 | yes |
| GO:0023061 | signal release | 40.0000 | 4 | yes |
| GO:0046903 | secretion | 40.0000 | 4 | yes |
| GO:0051223 | regulation of protein transport | 40.0000 | 5 | yes |
| GO:0070201 | regulation of establishment of protein localization | 40.0000 | 6 | yes |
| GO:0009892 | negative regulation of metabolic process | 40.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 40.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.0000 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 40.0000 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 40.0000 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 40.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 40.0000 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 40.0000 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 40.0000 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 40.0000 | 6 | no |
| GO:0022607 | cellular component assembly | 40.0000 | 4 | no |
| GO:0031399 | regulation of protein modification process | 40.0000 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 40.0000 | 7 | no |
| GO:0051128 | regulation of cellular component organization | 40.0000 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 40.0000 | 5 | no |
| GO:0009966 | regulation of signal transduction | 40.0000 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 40.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 40.0000 | 4 | no |
| GO:0006906 | vesicle fusion | 33.3333 | 6 | yes |
| GO:0016050 | vesicle organization | 33.3333 | 5 | yes |
| GO:0016079 | synaptic vesicle exocytosis | 33.3333 | 4 | yes |
| GO:0045055 | regulated exocytosis | 33.3333 | 5 | yes |
| GO:0048284 | organelle fusion | 33.3333 | 5 | yes |
| GO:0051046 | regulation of secretion | 33.3333 | 5 | yes |
| GO:0051050 | positive regulation of transport | 33.3333 | 4 | yes |
| GO:0061024 | membrane organization | 33.3333 | 4 | yes |
| GO:0061025 | membrane fusion | 33.3333 | 5 | yes |
| GO:0090174 | organelle membrane fusion | 33.3333 | 6 | yes |
| GO:0099003 | vesicle-mediated transport in synapse | 33.3333 | 5 | yes |
| GO:0099643 | signal release from synapse | 33.3333 | 5 | yes |
| GO:1903530 | regulation of secretion by cell | 33.3333 | 4 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 33.3333 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 33.3333 | 6 | no |
| GO:0010628 | positive regulation of gene expression | 33.3333 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 33.3333 | 6 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 33.3333 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 33.3333 | 6 | no |
| GO:0001932 | regulation of protein phosphorylation | 33.3333 | 7 | no |
| GO:0006355 | regulation of DNA-templated transcription | 33.3333 | 6 | no |
| GO:0015031 | protein transport | 33.3333 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 33.3333 | 4 | no |
| GO:0043933 | protein-containing complex organization | 33.3333 | 4 | no |
| GO:0071705 | nitrogen compound transport | 33.3333 | 4 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 33.3333 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 33.3333 | 6 | no |
| GO:0002791 | regulation of peptide secretion | 26.6667 | 6 | yes |
| GO:0017157 | regulation of exocytosis | 26.6667 | 5 | yes |
| GO:0046883 | regulation of hormone secretion | 26.6667 | 4 | yes |
| GO:0050708 | regulation of protein secretion | 26.6667 | 5 | yes |
| GO:0050796 | regulation of insulin secretion | 26.6667 | 6 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 26.6667 | 4 | yes |
| GO:0090087 | regulation of peptide transport | 26.6667 | 5 | yes |
| GO:0090276 | regulation of peptide hormone secretion | 26.6667 | 5 | yes |
| GO:0009894 | regulation of catabolic process | 26.6667 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.6667 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 26.6667 | 6 | no |
| GO:0008284 | positive regulation of cell population proliferation | 26.6667 | 5 | no |
| GO:0043086 | negative regulation of catalytic activity | 26.6667 | 4 | no |
| GO:0045893 | positive regulation of DNA-templated transcription | 26.6667 | 7 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 26.6667 | 6 | no |
| GO:0051254 | positive regulation of RNA metabolic process | 26.6667 | 6 | no |
| GO:0051336 | regulation of hydrolase activity | 26.6667 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 26.6667 | 5 | no |
| GO:1902680 | positive regulation of RNA biosynthetic process | 26.6667 | 7 | no |
| GO:1903508 | positive regulation of nucleic acid-templated transcription | 26.6667 | 8 | no |
| GO:0009967 | positive regulation of signal transduction | 26.6667 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 26.6667 | 4 | no |
| GO:0006897 | endocytosis | 26.6667 | 5 | no |
| GO:0007612 | learning | 26.6667 | 4 | no |
| GO:0050890 | cognition | 26.6667 | 4 | no |
| GO:0010038 | response to metal ion | 20.0000 | 4 | yes |
| GO:0016482 | cytosolic transport | 20.0000 | 4 | yes |
| GO:0017156 | calcium-ion regulated exocytosis | 20.0000 | 6 | yes |
| GO:0017158 | regulation of calcium ion-dependent exocytosis | 20.0000 | 7 | yes |
| GO:0043269 | regulation of ion transport | 20.0000 | 5 | yes |
| GO:0045921 | positive regulation of exocytosis | 20.0000 | 6 | yes |
| GO:0045956 | positive regulation of calcium ion-dependent exocytosis | 20.0000 | 8 | yes |
| GO:0050433 | regulation of catecholamine secretion | 20.0000 | 5 | yes |
| GO:0051047 | positive regulation of secretion | 20.0000 | 5 | yes |
| GO:0051952 | regulation of amine transport | 20.0000 | 5 | yes |
| GO:0071241 | cellular response to inorganic substance | 20.0000 | 4 | yes |
| GO:0071248 | cellular response to metal ion | 20.0000 | 5 | yes |
| GO:1903305 | regulation of regulated secretory pathway | 20.0000 | 6 | yes |
| GO:1903307 | positive regulation of regulated secretory pathway | 20.0000 | 7 | yes |
| GO:1903532 | positive regulation of secretion by cell | 20.0000 | 5 | yes |
| GO:0001778 | plasma membrane repair | 13.3333 | 6 | yes |
| GO:0006869 | lipid transport | 13.3333 | 5 | yes |
| GO:0006909 | phagocytosis | 13.3333 | 5 | yes |
| GO:0007009 | plasma membrane organization | 13.3333 | 5 | yes |
| GO:0014059 | regulation of dopamine secretion | 13.3333 | 6 | yes |
| GO:0015850 | organic hydroxy compound transport | 13.3333 | 5 | yes |
| GO:0015918 | sterol transport | 13.3333 | 6 | yes |
| GO:0030301 | cholesterol transport | 13.3333 | 7 | yes |
| GO:0032365 | intracellular lipid transport | 13.3333 | 4 | yes |
| GO:0032366 | intracellular sterol transport | 13.3333 | 5 | yes |
| GO:0032367 | intracellular cholesterol transport | 13.3333 | 6 | yes |
| GO:0034103 | regulation of tissue remodeling | 13.3333 | 4 | yes |
| GO:0036465 | synaptic vesicle recycling | 13.3333 | 4 | yes |
| GO:0046850 | regulation of bone remodeling | 13.3333 | 5 | yes |
| GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter | 13.3333 | 5 | yes |
| GO:0050764 | regulation of phagocytosis | 13.3333 | 5 | yes |
| GO:0051592 | response to calcium ion | 13.3333 | 5 | yes |
| GO:0070092 | regulation of glucagon secretion | 13.3333 | 6 | yes |
| GO:0071277 | cellular response to calcium ion | 13.3333 | 6 | yes |
| GO:0090119 | vesicle-mediated cholesterol transport | 13.3333 | 5 | yes |
| GO:0090385 | phagosome-lysosome fusion | 13.3333 | 7 | yes |
| GO:1990926 | short-term synaptic potentiation | 13.3333 | 4 | yes |
| GO:1990927 | calcium ion regulated lysosome exocytosis | 13.3333 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| HNRPQ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STX1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| ARNT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SENP2_HUMAN | [view interactions] | High throughput | no | yes |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMCA2_HUMAN | [view interactions] | High throughput | no | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| CUL1_HUMAN | [view interactions] | High throughput | no | yes |
| SKP2_HUMAN | [view interactions] | High throughput | no | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| SIAH1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| FERM2_HUMAN | [view interactions] | High throughput | no | yes |
| SYT7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNP23_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| SNP25_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CPLX1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VAMP7_HUMAN | [view interactions] | Computational | no | yes |
| SUMO1_HUMAN | [view interactions] | Computational | no | yes |