Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CBLN1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

The cerebellin peptide exerts neuromodulatory functions. Directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CBLN1_HUMAN
GO:0046872 metal ion binding 50.0000 4 no
GO:0097109 neuroligin family protein binding 50.0000 4 no
GO:0005246 calcium channel regulator activity 33.3333 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in CBLN1_HUMAN
GO:0007268 chemical synaptic transmission 83.3333 6 yes
GO:0008104 protein localization 83.3333 4 yes
GO:0034330 cell junction organization 83.3333 4 yes
GO:0050808 synapse organization 83.3333 5 yes
GO:0098916 anterograde trans-synaptic signaling 83.3333 5 yes
GO:0099537 trans-synaptic signaling 83.3333 4 yes
GO:0010646 regulation of cell communication 66.6667 4 yes
GO:0044087 regulation of cellular component biogenesis 66.6667 4 yes
GO:0044089 positive regulation of cellular component biogenesis 66.6667 5 yes
GO:0046903 secretion 66.6667 4 yes
GO:0048522 positive regulation of cellular process 66.6667 4 yes
GO:0050804 modulation of chemical synaptic transmission 66.6667 5 yes
GO:0050807 regulation of synapse organization 66.6667 5 yes
GO:0051094 positive regulation of developmental process 66.6667 4 yes
GO:0051128 regulation of cellular component organization 66.6667 4 yes
GO:0051130 positive regulation of cellular component organization 66.6667 5 yes
GO:0051240 positive regulation of multicellular organismal process 66.6667 4 yes
GO:0051960 regulation of nervous system development 66.6667 5 yes
GO:0051962 positive regulation of nervous system development 66.6667 5 yes
GO:0051963 regulation of synapse assembly 66.6667 6 yes
GO:0051965 positive regulation of synapse assembly 66.6667 6 yes
GO:0099177 regulation of trans-synaptic signaling 66.6667 4 yes
GO:1901888 regulation of cell junction assembly 66.6667 5 yes
GO:1901890 positive regulation of cell junction assembly 66.6667 6 yes
GO:2000026 regulation of multicellular organismal development 66.6667 4 yes
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 50.0000 5 yes
GO:0009966 regulation of signal transduction 50.0000 4 yes
GO:0021533 cell differentiation in hindbrain 50.0000 4 yes
GO:0021707 cerebellar granule cell differentiation 50.0000 5 yes
GO:0021953 central nervous system neuron differentiation 50.0000 5 yes
GO:0030182 neuron differentiation 50.0000 4 yes
GO:0031644 regulation of nervous system process 50.0000 5 yes
GO:0033043 regulation of organelle organization 50.0000 5 yes
GO:0044057 regulation of system process 50.0000 4 yes
GO:0048585 negative regulation of response to stimulus 50.0000 4 yes
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 50.0000 4 yes
GO:0098815 modulation of excitatory postsynaptic potential 50.0000 4 yes
GO:0099150 regulation of postsynaptic specialization assembly 50.0000 6 yes
GO:0099151 regulation of postsynaptic density assembly 50.0000 7 yes
GO:0099175 regulation of postsynapse organization 50.0000 6 yes
GO:1900452 regulation of long-term synaptic depression 50.0000 4 yes
GO:1900454 positive regulation of long-term synaptic depression 50.0000 4 yes
GO:1902115 regulation of organelle assembly 50.0000 5 yes
GO:1904889 regulation of excitatory synapse assembly 50.0000 7 yes
GO:1905874 regulation of postsynaptic density organization 50.0000 6 yes
GO:0007416 synapse assembly 50.0000 6 no
GO:0022607 cellular component assembly 50.0000 4 no
GO:0034329 cell junction assembly 50.0000 5 no
GO:0007158 neuron cell-cell adhesion 50.0000 4 no
GO:0007612 learning 50.0000 4 no
GO:0050890 cognition 50.0000 4 no
GO:0007399 nervous system development 33.3333 4 yes
GO:0009306 protein secretion 33.3333 4 yes
GO:0009968 negative regulation of signal transduction 33.3333 5 yes
GO:0010648 negative regulation of cell communication 33.3333 5 yes
GO:0015031 protein transport 33.3333 4 yes
GO:0023057 negative regulation of signaling 33.3333 4 yes
GO:0034331 cell junction maintenance 33.3333 5 yes
GO:0035592 establishment of protein localization to extracellular region 33.3333 4 yes
GO:0043954 cellular component maintenance 33.3333 4 yes
GO:0048523 negative regulation of cellular process 33.3333 4 yes
GO:0050805 negative regulation of synaptic transmission 33.3333 5 yes
GO:0051093 negative regulation of developmental process 33.3333 4 yes
GO:0051129 negative regulation of cellular component organization 33.3333 5 yes
GO:0051241 negative regulation of multicellular organismal process 33.3333 4 yes
GO:0051961 negative regulation of nervous system development 33.3333 5 yes
GO:0051964 negative regulation of synapse assembly 33.3333 6 yes
GO:0071692 protein localization to extracellular region 33.3333 5 yes
GO:0071702 organic substance transport 33.3333 4 yes
GO:0071705 nitrogen compound transport 33.3333 4 yes
GO:0090394 negative regulation of excitatory postsynaptic potential 33.3333 5 yes
GO:0099174 regulation of presynapse organization 33.3333 6 yes
GO:0099558 maintenance of synapse structure 33.3333 6 yes
GO:1901889 negative regulation of cell junction assembly 33.3333 6 yes
GO:1905606 regulation of presynapse assembly 33.3333 7 yes
GO:1905702 regulation of inhibitory synapse assembly 33.3333 7 yes
GO:1905703 negative regulation of inhibitory synapse assembly 33.3333 7 yes
GO:1905809 negative regulation of synapse organization 33.3333 6 yes
GO:0007411 axon guidance 33.3333 8 no
GO:0030030 cell projection organization 33.3333 4 no
GO:0031175 neuron projection development 33.3333 6 no
GO:0097485 neuron projection guidance 33.3333 7 no
GO:0120036 plasma membrane bounded cell projection organization 33.3333 5 no
GO:0001941 postsynaptic membrane organization 33.3333 5 no
GO:0006836 neurotransmitter transport 33.3333 4 no
GO:0007269 neurotransmitter secretion 33.3333 4 no
GO:0023061 signal release 33.3333 4 no
GO:0031223 auditory behavior 33.3333 4 no
GO:0035418 protein localization to synapse 33.3333 6 no
GO:0042297 vocal learning 33.3333 5 no
GO:0043113 receptor clustering 33.3333 5 no
GO:0061024 membrane organization 33.3333 4 no
GO:0071709 membrane assembly 33.3333 5 no
GO:0072657 protein localization to membrane 33.3333 4 no
GO:0097104 postsynaptic membrane assembly 33.3333 6 no
GO:0097116 gephyrin clustering involved in postsynaptic density assembly 33.3333 7 no
GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly 33.3333 6 no
GO:0097119 postsynaptic density protein 95 clustering 33.3333 5 no
GO:0098596 imitative learning 33.3333 6 no
GO:0098597 observational learning 33.3333 5 no
GO:0098598 learned vocalization behavior or vocal learning 33.3333 4 no
GO:0099643 signal release from synapse 33.3333 5 no
GO:1902414 protein localization to cell junction 33.3333 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GRID2_HUMAN [view entry] [view interactions] Low throughput yes no
NRX1A_HUMAN [view entry] [view interactions] Low throughput yes no
CBLN1_HUMAN [view entry] [view interactions] Low throughput yes no
FACD2_HUMAN [view interactions] High throughput no no
CBLN3_HUMAN [view interactions] High throughput no no
NRX3A_HUMAN [view entry] [view interactions] Computational yes yes
NRX2A_HUMAN [view entry] [view interactions] Computational yes no
NXN_HUMAN [view interactions] Computational no no