Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DIXC1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DIXC1_HUMAN
GO:0003779 actin binding 44.4444 4 yes
GO:0015631 tubulin binding 27.7778 4 yes
GO:0000166 nucleotide binding 22.2222 4 no
GO:0017076 purine nucleotide binding 22.2222 5 no
GO:0030554 adenyl nucleotide binding 22.2222 6 no
GO:0045296 cadherin binding 22.2222 4 no
GO:0043015 gamma-tubulin binding 11.1111 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DIXC1_HUMAN
GO:0048522 positive regulation of cellular process 83.3333 4 yes
GO:0051128 regulation of cellular component organization 77.7778 4 yes
GO:0048523 negative regulation of cellular process 66.6667 4 yes
GO:0010646 regulation of cell communication 61.1111 4 yes
GO:0010647 positive regulation of cell communication 55.5556 5 yes
GO:0023056 positive regulation of signaling 55.5556 4 yes
GO:0048584 positive regulation of response to stimulus 55.5556 4 yes
GO:0009966 regulation of signal transduction 50.0000 4 yes
GO:0009967 positive regulation of signal transduction 50.0000 5 yes
GO:0006996 organelle organization 50.0000 4 no
GO:0008104 protein localization 50.0000 4 no
GO:0022607 cellular component assembly 50.0000 4 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0030030 cell projection organization 50.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0045595 regulation of cell differentiation 44.4444 4 yes
GO:0009889 regulation of biosynthetic process 44.4444 4 no
GO:0010468 regulation of gene expression 44.4444 6 no
GO:0010556 regulation of macromolecule biosynthetic process 44.4444 5 no
GO:0031326 regulation of cellular biosynthetic process 44.4444 5 no
GO:0051130 positive regulation of cellular component organization 38.8889 5 no
GO:0051240 positive regulation of multicellular organismal process 38.8889 4 no
GO:0033043 regulation of organelle organization 38.8889 5 yes
GO:0009893 positive regulation of metabolic process 38.8889 4 no
GO:0007010 cytoskeleton organization 38.8889 5 no
GO:0051246 regulation of protein metabolic process 38.8889 5 no
GO:0051094 positive regulation of developmental process 33.3333 4 no
GO:0051252 regulation of RNA metabolic process 33.3333 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 33.3333 6 no
GO:0097435 supramolecular fiber organization 33.3333 4 no
GO:0032970 regulation of actin filament-based process 33.3333 4 yes
GO:0051493 regulation of cytoskeleton organization 33.3333 6 yes
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0031344 regulation of cell projection organization 33.3333 5 no
GO:0031346 positive regulation of cell projection organization 33.3333 6 no
GO:0044087 regulation of cellular component biogenesis 33.3333 4 no
GO:0050804 modulation of chemical synaptic transmission 27.7778 5 no
GO:0051049 regulation of transport 27.7778 4 no
GO:0099177 regulation of trans-synaptic signaling 27.7778 4 no
GO:0007409 axonogenesis 27.7778 6 no
GO:0010975 regulation of neuron projection development 27.7778 7 no
GO:0030705 cytoskeleton-dependent intracellular transport 27.7778 4 no
GO:0048812 neuron projection morphogenesis 27.7778 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 27.7778 4 no
GO:1902531 regulation of intracellular signal transduction 27.7778 5 no
GO:0006355 regulation of DNA-templated transcription 27.7778 7 no
GO:0042127 regulation of cell population proliferation 27.7778 4 no
GO:2001141 regulation of RNA biosynthetic process 27.7778 6 no
GO:0032956 regulation of actin cytoskeleton organization 27.7778 5 yes
GO:0009894 regulation of catabolic process 27.7778 4 no
GO:0036211 protein modification process 27.7778 4 no
GO:0043412 macromolecule modification 27.7778 4 no
GO:0070925 organelle assembly 27.7778 5 no
GO:0071702 organic substance transport 27.7778 4 no
GO:0071705 nitrogen compound transport 27.7778 4 no
GO:0009891 positive regulation of biosynthetic process 27.7778 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 27.7778 6 no
GO:0031328 positive regulation of cellular biosynthetic process 27.7778 6 no
GO:0120036 plasma membrane bounded cell projection organization 27.7778 5 no
GO:0009890 negative regulation of biosynthetic process 27.7778 5 no
GO:0009892 negative regulation of metabolic process 27.7778 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 27.7778 6 no
GO:0010605 negative regulation of macromolecule metabolic process 27.7778 5 no
GO:0031324 negative regulation of cellular metabolic process 27.7778 5 no
GO:0031327 negative regulation of cellular biosynthetic process 27.7778 6 no
GO:0060998 regulation of dendritic spine development 22.2222 4 no
GO:0008088 axo-dendritic transport 22.2222 5 no
GO:0010970 transport along microtubule 22.2222 4 no
GO:0032880 regulation of protein localization 22.2222 5 no
GO:0060341 regulation of cellular localization 22.2222 4 no
GO:0099111 microtubule-based transport 22.2222 4 no
GO:0030155 regulation of cell adhesion 22.2222 4 no
GO:0045785 positive regulation of cell adhesion 22.2222 5 no
GO:1902533 positive regulation of intracellular signal transduction 22.2222 6 no
GO:0007015 actin filament organization 22.2222 5 no
GO:0010720 positive regulation of cell development 22.2222 6 no
GO:0010976 positive regulation of neuron projection development 22.2222 7 no
GO:0045597 positive regulation of cell differentiation 22.2222 5 no
GO:0050807 regulation of synapse organization 22.2222 5 no
GO:0060284 regulation of cell development 22.2222 5 no
GO:2000026 regulation of multicellular organismal development 22.2222 4 no
GO:0051129 negative regulation of cellular component organization 22.2222 5 no
GO:1902903 regulation of supramolecular fiber organization 22.2222 5 no
GO:0006357 regulation of transcription by RNA polymerase II 22.2222 8 no
GO:0051726 regulation of cell cycle 22.2222 4 no
GO:0021795 cerebral cortex cell migration 22.2222 6 yes
GO:0021799 cerebral cortex radially oriented cell migration 22.2222 7 yes
GO:0021885 forebrain cell migration 22.2222 4 yes
GO:0022029 telencephalon cell migration 22.2222 5 yes
GO:0030111 regulation of Wnt signaling pathway 22.2222 5 yes
GO:0045596 negative regulation of cell differentiation 22.2222 5 yes
GO:0051093 negative regulation of developmental process 22.2222 4 yes
GO:0009896 positive regulation of catabolic process 22.2222 5 no
GO:0015031 protein transport 22.2222 4 no
GO:0016070 RNA metabolic process 22.2222 5 no
GO:0090304 nucleic acid metabolic process 22.2222 4 no
GO:0022603 regulation of anatomical structure morphogenesis 22.2222 4 no
GO:0051247 positive regulation of protein metabolic process 22.2222 6 no
GO:0034762 regulation of transmembrane transport 22.2222 4 no
GO:0016055 Wnt signaling pathway 16.6667 4 yes
GO:0030177 positive regulation of Wnt signaling pathway 16.6667 6 yes
GO:0032886 regulation of microtubule-based process 16.6667 4 yes
GO:0045664 regulation of neuron differentiation 16.6667 5 yes
GO:0045665 negative regulation of neuron differentiation 16.6667 6 yes
GO:0060070 canonical Wnt signaling pathway 16.6667 5 yes
GO:0070507 regulation of microtubule cytoskeleton organization 16.6667 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DIXC1_HUMAN [view entry] [view interactions] Low throughput yes no
DVL2_HUMAN [view interactions] Low throughput no yes
PLK1_HUMAN [view interactions] Low throughput no yes
AXIN1_HUMAN [view interactions] Low throughput no yes
BRK1_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
NDEL1_HUMAN [view entry] [view interactions] High throughput yes yes
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
FLOT2_HUMAN [view entry] [view interactions] High throughput yes yes
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
LIS1_HUMAN [view entry] [view interactions] High throughput yes yes
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
CALL3_HUMAN [view interactions] High throughput no yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
T3HPD_HUMAN [view interactions] High throughput no yes
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
KPYM_HUMAN [view interactions] High throughput no yes
ULK2_HUMAN [view interactions] High throughput no yes
NDE1_HUMAN [view interactions] High throughput no yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
CDC5L_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
ZDH17_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
PHAG1_HUMAN [view interactions] High throughput no yes
F124A_HUMAN [view interactions] High throughput no no
FBLI1_HUMAN [view interactions] High throughput no yes