Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KGP2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Crucial regulator of intestinal secretion and bone growth . Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum . Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 . Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in KGP2_HUMAN
GO:0046872 metal ion binding 58.6207 4 no
GO:0035639 purine ribonucleoside triphosphate binding 41.3793 4 yes
GO:0017076 purine nucleotide binding 41.3793 4 yes
GO:0032555 purine ribonucleotide binding 41.3793 4 yes
GO:0008324 cation transmembrane transporter activity 31.0345 4 no
GO:0022890 inorganic cation transmembrane transporter activity 31.0345 4 no
GO:0046873 metal ion transmembrane transporter activity 31.0345 5 no
GO:0005524 ATP binding 31.0345 5 yes
GO:0030554 adenyl nucleotide binding 31.0345 5 yes
GO:0032559 adenyl ribonucleotide binding 31.0345 5 yes
GO:0019900 kinase binding 27.5862 4 no
GO:0019901 protein kinase binding 27.5862 5 no
GO:0015085 calcium ion transmembrane transporter activity 27.5862 6 no
GO:0022853 active ion transmembrane transporter activity 24.1379 4 no
GO:0019902 phosphatase binding 20.6897 4 no
GO:0042578 phosphoric ester hydrolase activity 20.6897 4 no
GO:0019001 guanyl nucleotide binding 17.2414 5 yes
GO:0032561 guanyl ribonucleotide binding 17.2414 5 yes
GO:0106310 protein serine kinase activity 10.3448 4 yes
GO:0004674 protein serine/threonine kinase activity 10.3448 4 yes
GO:0004712 protein serine/threonine/tyrosine kinase activity 10.3448 4 yes
GO:0016301 kinase activity 10.3448 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 10.3448 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in KGP2_HUMAN
GO:0048522 positive regulation of cellular process 62.0690 4 no
GO:0060255 regulation of macromolecule metabolic process 58.6207 4 no
GO:0010468 regulation of gene expression 51.7241 5 no
GO:0031323 regulation of cellular metabolic process 51.7241 4 no
GO:0080090 regulation of primary metabolic process 51.7241 4 no
GO:0010646 regulation of cell communication 48.2759 4 no
GO:0051171 regulation of nitrogen compound metabolic process 48.2759 4 no
GO:0051246 regulation of protein metabolic process 48.2759 5 no
GO:0009966 regulation of signal transduction 44.8276 4 no
GO:0051049 regulation of transport 41.3793 4 yes
GO:0010647 positive regulation of cell communication 41.3793 5 no
GO:0023056 positive regulation of signaling 41.3793 4 no
GO:0006796 phosphate-containing compound metabolic process 37.9310 4 yes
GO:1902531 regulation of intracellular signal transduction 37.9310 5 no
GO:0036211 protein modification process 34.4828 4 yes
GO:0043412 macromolecule modification 34.4828 4 yes
GO:0009967 positive regulation of signal transduction 34.4828 5 no
GO:0048584 positive regulation of response to stimulus 34.4828 4 no
GO:0006811 ion transport 34.4828 4 no
GO:0006812 cation transport 34.4828 5 no
GO:0009889 regulation of biosynthetic process 34.4828 4 no
GO:0009893 positive regulation of metabolic process 34.4828 4 no
GO:0010556 regulation of macromolecule biosynthetic process 34.4828 5 no
GO:0010604 positive regulation of macromolecule metabolic process 34.4828 5 no
GO:0019220 regulation of phosphate metabolic process 34.4828 6 no
GO:0030001 metal ion transport 34.4828 6 no
GO:0031326 regulation of cellular biosynthetic process 34.4828 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 34.4828 5 no
GO:0051174 regulation of phosphorus metabolic process 34.4828 5 no
GO:0051247 positive regulation of protein metabolic process 34.4828 6 no
GO:1902533 positive regulation of intracellular signal transduction 31.0345 6 no
GO:0031325 positive regulation of cellular metabolic process 31.0345 5 no
GO:0031399 regulation of protein modification process 31.0345 6 no
GO:0042325 regulation of phosphorylation 31.0345 7 no
GO:0043085 positive regulation of catalytic activity 31.0345 4 no
GO:0044057 regulation of system process 31.0345 4 no
GO:0048878 chemical homeostasis 31.0345 4 no
GO:0043269 regulation of ion transport 27.5862 5 yes
GO:0060341 regulation of cellular localization 27.5862 4 no
GO:0001932 regulation of protein phosphorylation 27.5862 7 no
GO:0006816 calcium ion transport 27.5862 7 no
GO:0006873 cellular ion homeostasis 27.5862 4 no
GO:0006875 cellular metal ion homeostasis 27.5862 6 no
GO:0008016 regulation of heart contraction 27.5862 6 no
GO:0009892 negative regulation of metabolic process 27.5862 4 no
GO:0010562 positive regulation of phosphorus metabolic process 27.5862 6 no
GO:0010605 negative regulation of macromolecule metabolic process 27.5862 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 27.5862 5 no
GO:0030003 cellular cation homeostasis 27.5862 5 no
GO:0045937 positive regulation of phosphate metabolic process 27.5862 7 no
GO:0048523 negative regulation of cellular process 27.5862 4 no
GO:0050801 ion homeostasis 27.5862 5 no
GO:0055065 metal ion homeostasis 27.5862 7 no
GO:0055080 cation homeostasis 27.5862 6 no
GO:0098771 inorganic ion homeostasis 27.5862 6 no
GO:1903522 regulation of blood circulation 27.5862 5 no
GO:0010941 regulation of cell death 27.5862 4 no
GO:0042981 regulation of apoptotic process 27.5862 6 no
GO:0043067 regulation of programmed cell death 27.5862 5 no
GO:0045595 regulation of cell differentiation 24.1379 4 no
GO:0051094 positive regulation of developmental process 24.1379 4 no
GO:0051240 positive regulation of multicellular organismal process 24.1379 4 no
GO:2000026 regulation of multicellular organismal development 24.1379 4 no
GO:0006874 cellular calcium ion homeostasis 24.1379 7 no
GO:0009894 regulation of catabolic process 24.1379 4 no
GO:0031401 positive regulation of protein modification process 24.1379 7 no
GO:0042327 positive regulation of phosphorylation 24.1379 8 no
GO:0043549 regulation of kinase activity 24.1379 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 24.1379 5 no
GO:0051338 regulation of transferase activity 24.1379 4 no
GO:0055074 calcium ion homeostasis 24.1379 8 no
GO:0070588 calcium ion transmembrane transport 24.1379 6 no
GO:0072503 cellular divalent inorganic cation homeostasis 24.1379 6 no
GO:0072507 divalent inorganic cation homeostasis 24.1379 7 no
GO:0098655 cation transmembrane transport 24.1379 4 no
GO:0098660 inorganic ion transmembrane transport 24.1379 4 no
GO:0098662 inorganic cation transmembrane transport 24.1379 5 no
GO:1903779 regulation of cardiac conduction 24.1379 4 no
GO:0008104 protein localization 20.6897 4 yes
GO:0001934 positive regulation of protein phosphorylation 20.6897 8 no
GO:0006355 regulation of DNA-templated transcription 20.6897 6 no
GO:0014070 response to organic cyclic compound 20.6897 4 no
GO:0031324 negative regulation of cellular metabolic process 20.6897 5 no
GO:0031329 regulation of cellular catabolic process 20.6897 5 no
GO:0045859 regulation of protein kinase activity 20.6897 6 no
GO:0051252 regulation of RNA metabolic process 20.6897 5 no
GO:0071310 cellular response to organic substance 20.6897 4 no
GO:0080134 regulation of response to stress 20.6897 4 no
GO:0090257 regulation of muscle system process 20.6897 5 no
GO:1903506 regulation of nucleic acid-templated transcription 20.6897 7 no
GO:2001141 regulation of RNA biosynthetic process 20.6897 6 no
GO:0043933 protein-containing complex organization 20.6897 4 no
GO:0051128 regulation of cellular component organization 20.6897 4 no
GO:0006468 protein phosphorylation 13.7931 5 yes
GO:0016310 phosphorylation 13.7931 5 yes
GO:0072657 protein localization to membrane 13.7931 4 yes
GO:0019751 polyol metabolic process 6.8966 4 yes
GO:0043271 negative regulation of ion transport 6.8966 5 yes
GO:0044070 regulation of anion transport 6.8966 6 yes
GO:0046777 protein autophosphorylation 6.8966 6 yes
GO:0051051 negative regulation of transport 6.8966 4 yes
GO:0072659 protein localization to plasma membrane 6.8966 5 yes
GO:1990778 protein localization to cell periphery 6.8966 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MEP50_HUMAN [view interactions] Low throughput no yes
MYLK_HUMAN [view interactions] Low throughput no no
RB11B_HUMAN [view entry] [view interactions] Low throughput yes no
U119A_HUMAN [view interactions] High throughput no no
KPYM_HUMAN [view interactions] High throughput no yes
CDKL5_HUMAN [view entry] [view interactions] High throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
PDE9A_HUMAN [view interactions] High throughput no yes
NPHP3_HUMAN [view interactions] High throughput no yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
TRAF3_HUMAN [view entry] [view interactions] High throughput yes yes
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
FBX25_HUMAN [view interactions] High throughput no no
BAD_HUMAN [view entry] [view interactions] Computational yes yes
AT2B2_HUMAN [view entry] [view interactions] Computational yes yes
CD38_HUMAN [view interactions] Computational no no
IRAG1_HUMAN [view interactions] Computational no yes
TNNI1_HUMAN [view interactions] Computational no no
MK14_HUMAN [view interactions] Computational no yes
GCYB1_HUMAN [view interactions] Computational no yes
PP1A_HUMAN [view entry] [view interactions] Computational yes yes
PP1G_HUMAN [view entry] [view interactions] Computational yes yes
BST1_HUMAN [view interactions] Computational no no
RAF1_HUMAN [view entry] [view interactions] Computational yes no
AT2B4_HUMAN [view entry] [view interactions] Computational yes yes
CAC1D_HUMAN [view interactions] Computational no yes
CAC1C_HUMAN [view entry] [view interactions] Computational yes no
KCMA1_HUMAN [view entry] [view interactions] Computational yes no
PLIN1_HUMAN [view interactions] Computational no no
NAC2_HUMAN [view entry] [view interactions] Computational yes no
NAC1_HUMAN [view entry] [view interactions] Computational yes yes
GTF2I_HUMAN [view interactions] Computational no yes
PPR17_HUMAN [view interactions] Computational no no
GT2D1_HUMAN [view interactions] Computational no yes
PP1B_HUMAN [view entry] [view interactions] Computational yes yes
TRPC6_HUMAN [view interactions] Computational no no
PLCB1_HUMAN [view entry] [view interactions] Computational yes yes
RGF1B_HUMAN [view interactions] Computational no no
KCMB3_HUMAN [view interactions] Computational no no
MK11_HUMAN [view interactions] Computational no yes
RASK_HUMAN [view entry] [view interactions] Computational yes no
PTPS_HUMAN [view interactions] Computational no yes
KCMB4_HUMAN [view interactions] Computational no no
PPLA_HUMAN [view interactions] Computational no no
AT2B1_HUMAN [view entry] [view interactions] Computational yes yes
GCYA2_HUMAN [view entry] [view interactions] Computational yes yes
RGS2_HUMAN [view interactions] Computational no no
PLCB3_HUMAN [view entry] [view interactions] Computational yes no
PLCB2_HUMAN [view interactions] Computational no no
CAC1S_HUMAN [view interactions] Computational no no
VASP_HUMAN [view interactions] Computational no yes
NHRF2_HUMAN [view entry] [view interactions] Computational yes no
CAC1F_HUMAN [view interactions] Computational no no
MK13_HUMAN [view interactions] Computational no yes
LIPS_HUMAN [view entry] [view interactions] Computational yes no
KGP1_HUMAN [view interactions] Computational no yes
MYPT1_HUMAN [view entry] [view interactions] Computational yes yes
MK12_HUMAN [view interactions] Computational no no
PLCB4_HUMAN [view entry] [view interactions] Computational yes yes
KCMB1_HUMAN [view interactions] Computational no no
AT2B3_HUMAN [view entry] [view interactions] Computational yes yes
GCYA1_HUMAN [view interactions] Computational no yes
SPRE_HUMAN [view interactions] Computational no yes
NAC3_HUMAN [view entry] [view interactions] Computational yes no