Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KGP2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Crucial regulator of intestinal secretion and bone growth . Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum . Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 . Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in KGP2_HUMAN
GO:0000166 nucleotide binding 75.0000 4 yes
GO:0017076 purine nucleotide binding 75.0000 5 yes
GO:0032555 purine ribonucleotide binding 75.0000 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 75.0000 4 yes
GO:0043168 anion binding 75.0000 4 yes
GO:0005524 ATP binding 62.5000 5 yes
GO:0030554 adenyl nucleotide binding 62.5000 6 yes
GO:0032559 adenyl ribonucleotide binding 62.5000 5 yes
GO:0019900 kinase binding 50.0000 4 yes
GO:0019901 protein kinase binding 50.0000 5 yes
GO:0004674 protein serine/threonine kinase activity 37.5000 4 yes
GO:0016301 kinase activity 37.5000 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 37.5000 4 yes
GO:0019001 guanyl nucleotide binding 37.5000 6 yes
GO:0032561 guanyl ribonucleotide binding 37.5000 5 yes
GO:0031625 ubiquitin protein ligase binding 37.5000 5 no
GO:0044389 ubiquitin-like protein ligase binding 37.5000 4 no
GO:0016462 pyrophosphatase activity 37.5000 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 37.5000 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 37.5000 6 no
GO:0106310 protein serine kinase activity 25.0000 4 yes
GO:0004842 ubiquitin-protein transferase activity 25.0000 4 no
GO:0016755 aminoacyltransferase activity 25.0000 4 no
GO:0019902 phosphatase binding 25.0000 4 no
GO:0019903 protein phosphatase binding 25.0000 5 no
GO:0043169 cation binding 25.0000 4 no
GO:0046872 metal ion binding 25.0000 5 no
GO:0061630 ubiquitin protein ligase activity 25.0000 5 no
GO:0061659 ubiquitin-like protein ligase activity 25.0000 4 no
GO:0005525 GTP binding 25.0000 5 no
GO:0045296 cadherin binding 25.0000 4 no
GO:0051020 GTPase binding 25.0000 4 no
GO:0003723 RNA binding 25.0000 4 no
GO:0016887 ATP hydrolysis activity 25.0000 7 no
GO:0023026 MHC class II protein complex binding 25.0000 4 no
GO:0030911 TPR domain binding 25.0000 4 no
GO:0042803 protein homodimerization activity 25.0000 4 no
GO:0042826 histone deacetylase binding 25.0000 4 no
GO:0048156 tau protein binding 25.0000 4 no
GO:0070182 DNA polymerase binding 25.0000 4 no
GO:0097718 disordered domain specific binding 25.0000 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in KGP2_HUMAN
GO:0048522 positive regulation of cellular process 87.5000 4 yes
GO:0036211 protein modification process 62.5000 4 yes
GO:0043412 macromolecule modification 62.5000 4 yes
GO:0051049 regulation of transport 62.5000 4 yes
GO:0060341 regulation of cellular localization 62.5000 4 yes
GO:0048584 positive regulation of response to stimulus 62.5000 4 no
GO:0008104 protein localization 50.0000 4 yes
GO:0032880 regulation of protein localization 50.0000 5 yes
GO:0043269 regulation of monoatomic ion transport 50.0000 5 yes
GO:0051240 positive regulation of multicellular organismal process 50.0000 4 yes
GO:0009889 regulation of biosynthetic process 50.0000 4 no
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0010556 regulation of macromolecule biosynthetic process 50.0000 5 no
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 no
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 50.0000 5 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 no
GO:0051246 regulation of protein metabolic process 50.0000 5 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0022607 cellular component assembly 37.5000 4 no
GO:0006468 protein phosphorylation 37.5000 5 yes
GO:0006796 phosphate-containing compound metabolic process 37.5000 4 yes
GO:0016310 phosphorylation 37.5000 5 yes
GO:0045595 regulation of cell differentiation 37.5000 4 yes
GO:0045597 positive regulation of cell differentiation 37.5000 5 yes
GO:0051094 positive regulation of developmental process 37.5000 4 yes
GO:0072657 protein localization to membrane 37.5000 4 yes
GO:1903829 positive regulation of protein localization 37.5000 5 yes
GO:0009891 positive regulation of biosynthetic process 37.5000 5 no
GO:0009966 regulation of signal transduction 37.5000 4 no
GO:0010468 regulation of gene expression 37.5000 6 no
GO:0010557 positive regulation of macromolecule biosynthetic process 37.5000 6 no
GO:0031325 positive regulation of cellular metabolic process 37.5000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 37.5000 6 no
GO:0042981 regulation of apoptotic process 37.5000 5 no
GO:0043067 regulation of programmed cell death 37.5000 4 no
GO:0080134 regulation of response to stress 37.5000 4 no
GO:0015031 protein transport 37.5000 4 no
GO:0032386 regulation of intracellular transport 37.5000 5 no
GO:0071702 organic substance transport 37.5000 4 no
GO:0071705 nitrogen compound transport 37.5000 4 no
GO:0031344 regulation of cell projection organization 37.5000 5 no
GO:0043085 positive regulation of catalytic activity 37.5000 4 no
GO:0051128 regulation of cellular component organization 37.5000 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 37.5000 6 no
GO:0009894 regulation of catabolic process 37.5000 4 no
GO:0042176 regulation of protein catabolic process 37.5000 5 no
GO:0051050 positive regulation of transport 37.5000 4 no
GO:0051247 positive regulation of protein metabolic process 37.5000 6 no
GO:0001932 regulation of protein phosphorylation 25.0000 7 no
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 no
GO:0006259 DNA metabolic process 25.0000 5 no
GO:0006278 RNA-templated DNA biosynthetic process 25.0000 6 no
GO:0006936 muscle contraction 25.0000 4 no
GO:0006986 response to unfolded protein 25.0000 4 no
GO:0006996 organelle organization 25.0000 4 no
GO:0007004 telomere maintenance via telomerase 25.0000 7 no
GO:0009059 macromolecule biosynthetic process 25.0000 4 no
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 no
GO:0010833 telomere maintenance via telomere lengthening 25.0000 7 no
GO:0019220 regulation of phosphate metabolic process 25.0000 6 no
GO:0022618 protein-RNA complex assembly 25.0000 6 no
GO:0031396 regulation of protein ubiquitination 25.0000 9 no
GO:0031399 regulation of protein modification process 25.0000 6 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0032200 telomere organization 25.0000 6 no
GO:0033674 positive regulation of kinase activity 25.0000 6 no
GO:0034605 cellular response to heat 25.0000 4 no
GO:0034654 nucleobase-containing compound biosynthetic process 25.0000 4 no
GO:0042325 regulation of phosphorylation 25.0000 7 no
GO:0042327 positive regulation of phosphorylation 25.0000 8 no
GO:0043549 regulation of kinase activity 25.0000 5 no
GO:0043933 protein-containing complex organization 25.0000 4 no
GO:0045428 regulation of nitric oxide biosynthetic process 25.0000 5 no
GO:0045429 positive regulation of nitric oxide biosynthetic process 25.0000 6 no
GO:0045859 regulation of protein kinase activity 25.0000 6 no
GO:0045860 positive regulation of protein kinase activity 25.0000 7 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 no
GO:0050821 protein stabilization 25.0000 4 no
GO:0051052 regulation of DNA metabolic process 25.0000 5 no
GO:0051054 positive regulation of DNA metabolic process 25.0000 6 no
GO:0051131 chaperone-mediated protein complex assembly 25.0000 6 no
GO:0051174 regulation of phosphorus metabolic process 25.0000 5 no
GO:0051276 chromosome organization 25.0000 5 no
GO:0051338 regulation of transferase activity 25.0000 4 no
GO:0051347 positive regulation of transferase activity 25.0000 5 no
GO:0051972 regulation of telomerase activity 25.0000 5 no
GO:0051973 positive regulation of telomerase activity 25.0000 6 no
GO:0065003 protein-containing complex assembly 25.0000 5 no
GO:0071826 protein-RNA complex organization 25.0000 5 no
GO:0071897 DNA biosynthetic process 25.0000 5 no
GO:0080164 regulation of nitric oxide metabolic process 25.0000 4 no
GO:0090304 nucleic acid metabolic process 25.0000 4 no
GO:0141187 nucleic acid biosynthetic process 25.0000 5 no
GO:1901362 organic cyclic compound biosynthetic process 25.0000 4 no
GO:1901873 regulation of post-translational protein modification 25.0000 7 no
GO:1902947 regulation of tau-protein kinase activity 25.0000 7 no
GO:1902949 positive regulation of tau-protein kinase activity 25.0000 8 no
GO:1903320 regulation of protein modification by small protein conjugation or removal 25.0000 8 no
GO:1904407 positive regulation of nitric oxide metabolic process 25.0000 5 no
GO:1905323 telomerase holoenzyme complex assembly 25.0000 7 no
GO:2000278 regulation of DNA biosynthetic process 25.0000 6 no
GO:2000573 positive regulation of DNA biosynthetic process 25.0000 7 no
GO:0043271 negative regulation of monoatomic ion transport 25.0000 5 yes
GO:0044070 regulation of monoatomic anion transport 25.0000 6 yes
GO:0051051 negative regulation of transport 25.0000 4 yes
GO:2000026 regulation of multicellular organismal development 25.0000 4 yes
GO:0000209 protein polyubiquitination 25.0000 9 no
GO:0001817 regulation of cytokine production 25.0000 4 no
GO:0001819 positive regulation of cytokine production 25.0000 5 no
GO:0002684 positive regulation of immune system process 25.0000 4 no
GO:0002831 regulation of response to biotic stimulus 25.0000 4 no
GO:0002833 positive regulation of response to biotic stimulus 25.0000 5 no
GO:0006355 regulation of DNA-templated transcription 25.0000 7 no
GO:0006915 apoptotic process 25.0000 4 no
GO:0010628 positive regulation of gene expression 25.0000 7 no
GO:0016567 protein ubiquitination 25.0000 8 no
GO:0030162 regulation of proteolysis 25.0000 6 no
GO:0031347 regulation of defense response 25.0000 5 no
GO:0031349 positive regulation of defense response 25.0000 5 no
GO:0032101 regulation of response to external stimulus 25.0000 4 no
GO:0032103 positive regulation of response to external stimulus 25.0000 5 no
GO:0032446 protein modification by small protein conjugation 25.0000 7 no
GO:0032479 regulation of type I interferon production 25.0000 5 no
GO:0032481 positive regulation of type I interferon production 25.0000 6 no
GO:0032648 regulation of interferon-beta production 25.0000 6 no
GO:0043687 post-translational protein modification 25.0000 5 no
GO:0045088 regulation of innate immune response 25.0000 5 no
GO:0045089 positive regulation of innate immune response 25.0000 6 no
GO:0050688 regulation of defense response to virus 25.0000 5 no
GO:0050776 regulation of immune response 25.0000 4 no
GO:0050778 positive regulation of immune response 25.0000 5 no
GO:0051252 regulation of RNA metabolic process 25.0000 5 no
GO:0070534 protein K63-linked ubiquitination 25.0000 10 no
GO:0070647 protein modification by small protein conjugation or removal 25.0000 6 no
GO:0140546 defense response to symbiont 25.0000 4 no
GO:1902531 regulation of intracellular signal transduction 25.0000 5 no
GO:2001141 regulation of RNA biosynthetic process 25.0000 6 no
GO:0043112 receptor metabolic process 25.0000 4 no
GO:0090150 establishment of protein localization to membrane 25.0000 4 no
GO:2000008 regulation of protein localization to cell surface 25.0000 6 no
GO:0001764 neuron migration 25.0000 4 no
GO:0010975 regulation of neuron projection development 25.0000 7 no
GO:0022603 regulation of anatomical structure morphogenesis 25.0000 4 no
GO:0031346 positive regulation of cell projection organization 25.0000 6 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0048814 regulation of dendrite morphogenesis 25.0000 5 no
GO:0050773 regulation of dendrite development 25.0000 4 no
GO:0050807 regulation of synapse organization 25.0000 5 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 no
GO:0051336 regulation of hydrolase activity 25.0000 4 no
GO:0051345 positive regulation of hydrolase activity 25.0000 5 no
GO:0060491 regulation of cell projection assembly 25.0000 5 no
GO:0120032 regulation of plasma membrane bounded cell projection assembly 25.0000 6 no
GO:0006886 intracellular protein transport 25.0000 4 no
GO:0009057 macromolecule catabolic process 25.0000 4 no
GO:0009892 negative regulation of metabolic process 25.0000 4 no
GO:0009896 positive regulation of catabolic process 25.0000 5 no
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0010605 negative regulation of macromolecule metabolic process 25.0000 5 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0010959 regulation of metal ion transport 25.0000 6 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0030030 cell projection organization 25.0000 4 no
GO:0032388 positive regulation of intracellular transport 25.0000 5 no
GO:0033365 protein localization to organelle 25.0000 5 no
GO:0045732 positive regulation of protein catabolic process 25.0000 6 no
GO:0046822 regulation of nucleocytoplasmic transport 25.0000 6 no
GO:0046824 positive regulation of nucleocytoplasmic transport 25.0000 6 no
GO:0048523 negative regulation of cellular process 25.0000 4 no
GO:0072594 establishment of protein localization to organelle 25.0000 4 no
GO:0090287 regulation of cellular response to growth factor stimulus 25.0000 4 no
GO:0120036 plasma membrane bounded cell projection organization 25.0000 5 no
GO:0000723 telomere maintenance 25.0000 6 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MEP50_HUMAN [view interactions] Low throughput no yes
MYLK_HUMAN [view entry] [view interactions] Low throughput yes no
RB11B_HUMAN [view entry] [view interactions] Low throughput yes no
U119A_HUMAN [view interactions] High throughput no no
KPYM_HUMAN [view interactions] High throughput no yes
CDKL5_HUMAN [view entry] [view interactions] High throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
PDE9A_HUMAN [view interactions] High throughput no yes
NPHP3_HUMAN [view interactions] High throughput no yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
TRAF3_HUMAN [view entry] [view interactions] High throughput yes yes
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
FBX25_HUMAN [view interactions] High throughput no no