STXB3_HUMAN
Evidence for PS localization
Functions
Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in STXB3_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 46.1538 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 46.1538 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 46.1538 | 4 | no |
| GO:0019900 | kinase binding | 33.3333 | 4 | no |
| GO:0003924 | GTPase activity | 33.3333 | 7 | no |
| GO:0005525 | GTP binding | 33.3333 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 33.3333 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 33.3333 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 33.3333 | 6 | no |
| GO:0019001 | guanyl nucleotide binding | 33.3333 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 33.3333 | 5 | no |
| GO:0019901 | protein kinase binding | 30.7692 | 5 | no |
| GO:0019905 | syntaxin binding | 10.2564 | 4 | yes |
| GO:0017075 | syntaxin-1 binding | 5.1282 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in STXB3_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 56.4103 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 53.8462 | 4 | yes |
| GO:0071702 | organic substance transport | 53.8462 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 53.8462 | 4 | yes |
| GO:0006996 | organelle organization | 53.8462 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 53.8462 | 4 | no |
| GO:0015031 | protein transport | 51.2821 | 4 | yes |
| GO:0046903 | secretion | 43.5897 | 4 | yes |
| GO:0051049 | regulation of transport | 43.5897 | 4 | yes |
| GO:0010646 | regulation of cell communication | 43.5897 | 4 | no |
| GO:0022607 | cellular component assembly | 43.5897 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 43.5897 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 41.0256 | 5 | no |
| GO:0023056 | positive regulation of signaling | 41.0256 | 4 | no |
| GO:0006887 | exocytosis | 38.4615 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 38.4615 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 35.8974 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 35.8974 | 4 | no |
| GO:0061024 | membrane organization | 35.8974 | 4 | no |
| GO:0030030 | cell projection organization | 33.3333 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 33.3333 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 33.3333 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 30.7692 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 30.7692 | 4 | yes |
| GO:0071310 | cellular response to organic substance | 30.7692 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 30.7692 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 30.7692 | 4 | no |
| GO:0008284 | positive regulation of cell population proliferation | 28.2051 | 5 | no |
| GO:0051046 | regulation of secretion | 28.2051 | 5 | yes |
| GO:0007010 | cytoskeleton organization | 28.2051 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 28.2051 | 5 | no |
| GO:0030155 | regulation of cell adhesion | 28.2051 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 28.2051 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 28.2051 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 28.2051 | 5 | no |
| GO:0032880 | regulation of protein localization | 28.2051 | 5 | no |
| GO:0060341 | regulation of cellular localization | 28.2051 | 4 | no |
| GO:0006886 | intracellular protein transport | 25.6410 | 4 | yes |
| GO:0017157 | regulation of exocytosis | 25.6410 | 5 | yes |
| GO:1903530 | regulation of secretion by cell | 25.6410 | 4 | yes |
| GO:0002684 | positive regulation of immune system process | 25.6410 | 4 | no |
| GO:0030334 | regulation of cell migration | 25.6410 | 5 | no |
| GO:0040017 | positive regulation of locomotion | 25.6410 | 4 | no |
| GO:2000145 | regulation of cell motility | 25.6410 | 4 | no |
| GO:0072657 | protein localization to membrane | 25.6410 | 4 | no |
| GO:0010941 | regulation of cell death | 25.6410 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 25.6410 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 25.6410 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 25.6410 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 25.6410 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 25.6410 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 25.6410 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 25.6410 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.6410 | 4 | no |
| GO:0007264 | small GTPase mediated signal transduction | 25.6410 | 4 | no |
| GO:0010468 | regulation of gene expression | 25.6410 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 23.0769 | 6 | no |
| GO:0010243 | response to organonitrogen compound | 23.0769 | 4 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 23.0769 | 4 | no |
| GO:0033043 | regulation of organelle organization | 23.0769 | 5 | no |
| GO:0030335 | positive regulation of cell migration | 23.0769 | 6 | no |
| GO:0032101 | regulation of response to external stimulus | 23.0769 | 4 | no |
| GO:0036211 | protein modification process | 23.0769 | 4 | no |
| GO:0043412 | macromolecule modification | 23.0769 | 4 | no |
| GO:2000147 | positive regulation of cell motility | 23.0769 | 5 | no |
| GO:0048193 | Golgi vesicle transport | 23.0769 | 5 | no |
| GO:0098876 | vesicle-mediated transport to the plasma membrane | 23.0769 | 4 | no |
| GO:0051223 | regulation of protein transport | 23.0769 | 5 | no |
| GO:0070201 | regulation of establishment of protein localization | 23.0769 | 6 | no |
| GO:0007265 | Ras protein signal transduction | 23.0769 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 23.0769 | 4 | no |
| GO:0045785 | positive regulation of cell adhesion | 23.0769 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 23.0769 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 23.0769 | 5 | no |
| GO:0031175 | neuron projection development | 20.5128 | 6 | no |
| GO:1903829 | positive regulation of protein localization | 20.5128 | 5 | no |
| GO:0048278 | vesicle docking | 20.5128 | 4 | yes |
| GO:0032103 | positive regulation of response to external stimulus | 20.5128 | 5 | no |
| GO:0051050 | positive regulation of transport | 20.5128 | 4 | no |
| GO:0006892 | post-Golgi vesicle-mediated transport | 20.5128 | 6 | no |
| GO:0009894 | regulation of catabolic process | 20.5128 | 4 | no |
| GO:0030031 | cell projection assembly | 20.5128 | 5 | no |
| GO:1990778 | protein localization to cell periphery | 20.5128 | 5 | no |
| GO:0016050 | vesicle organization | 20.5128 | 5 | no |
| GO:0031399 | regulation of protein modification process | 20.5128 | 6 | no |
| GO:0061025 | membrane fusion | 20.5128 | 5 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 20.5128 | 6 | no |
| GO:0019220 | regulation of phosphate metabolic process | 20.5128 | 6 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 20.5128 | 5 | no |
| GO:0032970 | regulation of actin filament-based process | 20.5128 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 20.5128 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 20.5128 | 8 | no |
| GO:0043085 | positive regulation of catalytic activity | 20.5128 | 4 | no |
| GO:0045597 | positive regulation of cell differentiation | 20.5128 | 5 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 20.5128 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 20.5128 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 20.5128 | 6 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 20.5128 | 4 | no |
| GO:0032868 | response to insulin | 17.9487 | 5 | yes |
| GO:0034097 | response to cytokine | 17.9487 | 4 | yes |
| GO:0043434 | response to peptide hormone | 17.9487 | 4 | yes |
| GO:1901652 | response to peptide | 17.9487 | 4 | yes |
| GO:0071345 | cellular response to cytokine stimulus | 15.3846 | 5 | yes |
| GO:1903305 | regulation of regulated secretory pathway | 15.3846 | 6 | yes |
| GO:0009306 | protein secretion | 12.8205 | 4 | yes |
| GO:0023061 | signal release | 12.8205 | 4 | yes |
| GO:0035592 | establishment of protein localization to extracellular region | 12.8205 | 4 | yes |
| GO:0045055 | regulated exocytosis | 12.8205 | 5 | yes |
| GO:0071692 | protein localization to extracellular region | 12.8205 | 5 | yes |
| GO:0009914 | hormone transport | 10.2564 | 4 | yes |
| GO:0034762 | regulation of transmembrane transport | 10.2564 | 4 | yes |
| GO:0046879 | hormone secretion | 10.2564 | 5 | yes |
| GO:0034341 | response to interferon-gamma | 7.6923 | 5 | yes |
| GO:0048878 | chemical homeostasis | 7.6923 | 4 | yes |
| GO:0051051 | negative regulation of transport | 7.6923 | 4 | yes |
| GO:0071346 | cellular response to interferon-gamma | 7.6923 | 6 | yes |
| GO:0099643 | signal release from synapse | 7.6923 | 5 | yes |
| GO:0002275 | myeloid cell activation involved in immune response | 5.1282 | 4 | yes |
| GO:0002790 | peptide secretion | 5.1282 | 5 | yes |
| GO:0007420 | brain development | 5.1282 | 4 | yes |
| GO:0015833 | peptide transport | 5.1282 | 5 | yes |
| GO:0017158 | regulation of calcium ion-dependent exocytosis | 5.1282 | 7 | yes |
| GO:0030072 | peptide hormone secretion | 5.1282 | 6 | yes |
| GO:0030073 | insulin secretion | 5.1282 | 5 | yes |
| GO:0036230 | granulocyte activation | 5.1282 | 4 | yes |
| GO:0042886 | amide transport | 5.1282 | 5 | yes |
| GO:0051048 | negative regulation of secretion | 5.1282 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| STX4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MTR1A_HUMAN | [view interactions] | Low throughput | no | no |
| VAMP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| STX1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SNP23_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| STX2_HUMAN | [view interactions] | Low throughput | no | no |
| SNTG1_HUMAN | [view interactions] | Low throughput | no | no |
| IPPK_HUMAN | [view interactions] | High throughput | no | yes |
| CC50B_HUMAN | [view interactions] | High throughput | no | yes |
| SGMR2_HUMAN | [view interactions] | High throughput | no | no |
| ASPH_HUMAN | [view interactions] | High throughput | no | yes |
| ICMT_HUMAN | [view interactions] | High throughput | no | no |
| GPC5B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PLPR1_HUMAN | [view interactions] | High throughput | no | no |
| AAGAB_HUMAN | [view interactions] | High throughput | no | yes |
| GP141_HUMAN | [view interactions] | High throughput | no | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| MTMR7_HUMAN | [view interactions] | High throughput | no | no |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| SYNE2_HUMAN | [view interactions] | High throughput | no | no |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| ATG2A_HUMAN | [view interactions] | High throughput | no | yes |
| MTR1B_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| CD81_HUMAN | [view interactions] | High throughput | no | no |
| RL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBL4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEL2B_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| TBA3C_HUMAN | [view interactions] | High throughput | no | no |
| TBA3D_HUMAN | [view interactions] | High throughput | no | no |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| PSDE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBT7B_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| BACD3_HUMAN | [view interactions] | High throughput | no | yes |
| EMC4_HUMAN | [view interactions] | High throughput | no | yes |
| APR_HUMAN | [view interactions] | High throughput | no | yes |
| IL1B_HUMAN | [view interactions] | High throughput | no | no |
| STRA6_HUMAN | [view interactions] | High throughput | no | no |
| S1PR1_HUMAN | [view interactions] | High throughput | no | no |
| CERT_HUMAN | [view interactions] | High throughput | no | yes |
| LAPM5_HUMAN | [view interactions] | High throughput | no | yes |
| CXD4_HUMAN | [view interactions] | High throughput | no | yes |
| TEBP_HUMAN | [view interactions] | High throughput | no | yes |
| TM192_HUMAN | [view interactions] | High throughput | no | yes |
| MARH1_HUMAN | [view interactions] | High throughput | no | yes |
| RN149_HUMAN | [view interactions] | High throughput | no | no |
| T2R19_HUMAN | [view interactions] | High throughput | no | no |
| GPC5D_HUMAN | [view interactions] | High throughput | no | yes |
| PLPP4_HUMAN | [view interactions] | High throughput | no | yes |
| KDSR_HUMAN | [view interactions] | High throughput | no | yes |
| S35F2_HUMAN | [view interactions] | High throughput | no | yes |
| NRSN1_HUMAN | [view interactions] | High throughput | no | yes |
| SNAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| MOT1_HUMAN | [view interactions] | High throughput | no | no |
| SH3L3_HUMAN | [view interactions] | High throughput | no | no |
| RRP44_HUMAN | [view interactions] | High throughput | no | yes |
| KPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STXB2_HUMAN | [view interactions] | High throughput | no | no |
| SMD2_HUMAN | [view interactions] | High throughput | no | yes |
| SMD3_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| KS6A2_HUMAN | [view interactions] | High throughput | no | yes |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC8_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| EXOC6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| EXOC7_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| EXOC3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| KPCG_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| STX3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RAB10_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAB8A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| WNK1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| EXOC2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| KPCZ_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| EXOC5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GLUT4_HUMAN | [view interactions] | Computational | no | no |
| EXOC4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAB13_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ASPC1_HUMAN | [view interactions] | Computational | no | yes |