Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CPLX2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CPLX2_HUMAN
GO:0019905 syntaxin binding 33.3333 4 yes
GO:0017075 syntaxin-1 binding 22.2222 5 yes
GO:0017076 purine nucleotide binding 22.2222 4 no
GO:0032555 purine ribonucleotide binding 22.2222 4 no
GO:0035639 purine ribonucleoside triphosphate binding 22.2222 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in CPLX2_HUMAN
GO:0010646 regulation of cell communication 72.2222 4 yes
GO:0016192 vesicle-mediated transport 66.6667 4 yes
GO:0046903 secretion 66.6667 4 yes
GO:0050804 modulation of chemical synaptic transmission 66.6667 5 yes
GO:0051049 regulation of transport 66.6667 4 yes
GO:0099177 regulation of trans-synaptic signaling 66.6667 4 yes
GO:0006887 exocytosis 61.1111 4 yes
GO:0051046 regulation of secretion 55.5556 5 yes
GO:1903530 regulation of secretion by cell 55.5556 4 yes
GO:0048522 positive regulation of cellular process 55.5556 4 no
GO:0023061 signal release 50.0000 4 yes
GO:0051128 regulation of cellular component organization 50.0000 4 yes
GO:0060627 regulation of vesicle-mediated transport 50.0000 4 yes
GO:0008104 protein localization 50.0000 4 no
GO:0023056 positive regulation of signaling 50.0000 4 no
GO:0006996 organelle organization 50.0000 4 no
GO:0017157 regulation of exocytosis 44.4444 5 yes
GO:0045055 regulated exocytosis 44.4444 5 yes
GO:0099643 signal release from synapse 44.4444 5 yes
GO:0010647 positive regulation of cell communication 44.4444 5 no
GO:0032880 regulation of protein localization 44.4444 5 no
GO:0060341 regulation of cellular localization 44.4444 4 no
GO:0006906 vesicle fusion 44.4444 6 no
GO:0016050 vesicle organization 44.4444 5 no
GO:0022607 cellular component assembly 44.4444 4 no
GO:0043933 protein-containing complex organization 44.4444 4 no
GO:0048284 organelle fusion 44.4444 5 no
GO:0061024 membrane organization 44.4444 4 no
GO:0061025 membrane fusion 44.4444 5 no
GO:0065003 protein-containing complex assembly 44.4444 5 no
GO:0090174 organelle membrane fusion 44.4444 6 no
GO:0015031 protein transport 44.4444 4 no
GO:0071702 organic substance transport 44.4444 4 no
GO:0071705 nitrogen compound transport 44.4444 4 no
GO:0048278 vesicle docking 38.8889 4 yes
GO:0009966 regulation of signal transduction 38.8889 4 no
GO:0060255 regulation of macromolecule metabolic process 38.8889 4 no
GO:0050806 positive regulation of synaptic transmission 38.8889 5 no
GO:0016079 synaptic vesicle exocytosis 33.3333 4 yes
GO:0046928 regulation of neurotransmitter secretion 33.3333 4 yes
GO:0051588 regulation of neurotransmitter transport 33.3333 5 yes
GO:0099003 vesicle-mediated transport in synapse 33.3333 5 yes
GO:0048523 negative regulation of cellular process 33.3333 4 no
GO:0048584 positive regulation of response to stimulus 33.3333 4 no
GO:0071310 cellular response to organic substance 33.3333 4 no
GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane 33.3333 4 no
GO:0048499 synaptic vesicle membrane organization 33.3333 5 no
GO:0051223 regulation of protein transport 33.3333 5 no
GO:0070201 regulation of establishment of protein localization 33.3333 6 no
GO:0051050 positive regulation of transport 33.3333 4 no
GO:0009893 positive regulation of metabolic process 27.7778 4 no
GO:0010604 positive regulation of macromolecule metabolic process 27.7778 5 no
GO:0031323 regulation of cellular metabolic process 27.7778 4 no
GO:0031344 regulation of cell projection organization 27.7778 5 no
GO:0043085 positive regulation of catalytic activity 27.7778 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 27.7778 6 no
GO:1903829 positive regulation of protein localization 27.7778 5 no
GO:0017156 calcium-ion regulated exocytosis 27.7778 6 no
GO:0033043 regulation of organelle organization 22.2222 5 yes
GO:0001932 regulation of protein phosphorylation 22.2222 7 no
GO:0009967 positive regulation of signal transduction 22.2222 5 no
GO:0010243 response to organonitrogen compound 22.2222 4 no
GO:0019220 regulation of phosphate metabolic process 22.2222 6 no
GO:0031325 positive regulation of cellular metabolic process 22.2222 5 no
GO:0031399 regulation of protein modification process 22.2222 6 no
GO:0042325 regulation of phosphorylation 22.2222 7 no
GO:0043549 regulation of kinase activity 22.2222 5 no
GO:0044087 regulation of cellular component biogenesis 22.2222 4 no
GO:0045859 regulation of protein kinase activity 22.2222 6 no
GO:0051171 regulation of nitrogen compound metabolic process 22.2222 4 no
GO:0051174 regulation of phosphorus metabolic process 22.2222 5 no
GO:0051246 regulation of protein metabolic process 22.2222 5 no
GO:0051338 regulation of transferase activity 22.2222 4 no
GO:0071417 cellular response to organonitrogen compound 22.2222 4 no
GO:0072657 protein localization to membrane 22.2222 4 no
GO:0080090 regulation of primary metabolic process 22.2222 4 no
GO:1901699 cellular response to nitrogen compound 22.2222 4 no
GO:1901701 cellular response to oxygen-containing compound 22.2222 4 no
GO:1903305 regulation of regulated secretory pathway 22.2222 6 no
GO:1904375 regulation of protein localization to cell periphery 22.2222 6 no
GO:1905475 regulation of protein localization to membrane 22.2222 6 no
GO:0006836 neurotransmitter transport 22.2222 4 no
GO:0006897 endocytosis 22.2222 5 no
GO:0007268 chemical synaptic transmission 22.2222 6 no
GO:0060291 long-term synaptic potentiation 22.2222 4 no
GO:0098916 anterograde trans-synaptic signaling 22.2222 5 no
GO:0098967 exocytic insertion of neurotransmitter receptor to postsynaptic membrane 22.2222 4 no
GO:0099537 trans-synaptic signaling 22.2222 4 no
GO:0006886 intracellular protein transport 22.2222 4 no
GO:0010468 regulation of gene expression 22.2222 5 no
GO:0035493 SNARE complex assembly 22.2222 6 no
GO:0042127 regulation of cell population proliferation 22.2222 4 no
GO:0051222 positive regulation of protein transport 22.2222 5 no
GO:1904951 positive regulation of establishment of protein localization 22.2222 6 no
GO:0043269 regulation of ion transport 22.2222 5 no
GO:0002275 myeloid cell activation involved in immune response 11.1111 4 yes
GO:0007399 nervous system development 11.1111 4 yes
GO:0031338 regulation of vesicle fusion 11.1111 5 yes
GO:0031630 regulation of synaptic vesicle fusion to presynaptic active zone membrane 11.1111 6 yes
GO:1901632 regulation of synaptic vesicle membrane organization 11.1111 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in CPLX2_HUMAN
DOID:1826 epilepsy 11.1111 5 no
DOID:331 central nervous system disease 11.1111 3 no
DOID:936 brain disease 11.1111 4 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
VAMP2_HUMAN [view entry] [view interactions] Low throughput yes no
SNP25_HUMAN [view entry] [view interactions] Low throughput yes yes
STX1A_HUMAN [view entry] [view interactions] Low throughput yes yes
RAP1A_HUMAN [view entry] [view interactions] High throughput yes no
SCPDL_HUMAN [view entry] [view interactions] High throughput yes yes
AN13C_HUMAN [view interactions] High throughput no no
WAC2A_HUMAN [view interactions] High throughput no yes
DEGS1_HUMAN [view interactions] High throughput no no
CPLX1_HUMAN [view entry] [view interactions] High throughput yes yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
MYG1_HUMAN [view interactions] High throughput no yes
EFTS_HUMAN [view interactions] High throughput no no
ETS1_HUMAN [view interactions] High throughput no no
PHS_HUMAN [view interactions] High throughput no yes
NDRG4_HUMAN [view interactions] High throughput no no
PBX3_HUMAN [view interactions] High throughput no yes
STB5L_HUMAN [view interactions] High throughput no no
PHF6_HUMAN [view interactions] High throughput no yes
INF2_HUMAN [view entry] [view interactions] High throughput yes yes
SRP54_HUMAN [view interactions] High throughput no yes
ZGPAT_HUMAN [view interactions] High throughput no no
LIPB1_HUMAN [view interactions] High throughput no yes
DHX16_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
SYN1_HUMAN [view entry] [view interactions] High throughput yes no
GNAQ_HUMAN [view entry] [view interactions] High throughput yes yes
STX4_HUMAN [view entry] [view interactions] Computational yes no
SNP29_HUMAN [view interactions] Computational no yes
CPLX3_HUMAN [view interactions] Computational no no
VAMP3_HUMAN [view entry] [view interactions] Computational yes no
STX1B_HUMAN [view entry] [view interactions] Computational yes yes
VAMP1_HUMAN [view interactions] Computational no no
STX3_HUMAN [view entry] [view interactions] Computational yes no
SNP23_HUMAN [view entry] [view interactions] Computational yes no
VAMP4_HUMAN [view interactions] Computational no yes
VAMP8_HUMAN [view interactions] Computational no no
SYN2_HUMAN [view entry] [view interactions] Computational yes no
CPLX4_HUMAN [view interactions] Computational no no
NDF2_HUMAN [view interactions] Computational no no