Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CPLX2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CPLX2_HUMAN
GO:0019905 syntaxin binding 38.4615 4 yes
GO:0017075 syntaxin-1 binding 30.7692 5 yes
GO:0043169 cation binding 23.0769 4 no
GO:0046872 metal ion binding 23.0769 5 no
GO:0000166 nucleotide binding 23.0769 4 no
GO:0017076 purine nucleotide binding 23.0769 5 no
GO:0032555 purine ribonucleotide binding 23.0769 4 no
GO:0035639 purine ribonucleoside triphosphate binding 23.0769 4 no
GO:0043168 anion binding 23.0769 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in CPLX2_HUMAN
GO:0010646 regulation of cell communication 84.6154 4 yes
GO:0050804 modulation of chemical synaptic transmission 76.9231 5 yes
GO:0051049 regulation of transport 76.9231 4 yes
GO:0099177 regulation of trans-synaptic signaling 76.9231 4 yes
GO:0051128 regulation of cellular component organization 69.2308 4 yes
GO:0023061 signal release 53.8462 4 yes
GO:0046903 secretion 53.8462 4 yes
GO:0051046 regulation of secretion 53.8462 5 yes
GO:0060627 regulation of vesicle-mediated transport 53.8462 4 yes
GO:0099643 signal release from synapse 53.8462 5 yes
GO:1903530 regulation of secretion by cell 53.8462 4 yes
GO:0016079 synaptic vesicle exocytosis 46.1538 4 yes
GO:0017157 regulation of exocytosis 46.1538 5 yes
GO:0045055 regulated exocytosis 46.1538 4 yes
GO:0032880 regulation of protein localization 46.1538 5 no
GO:0048522 positive regulation of cellular process 46.1538 4 no
GO:0060341 regulation of cellular localization 46.1538 4 no
GO:0044087 regulation of cellular component biogenesis 38.4615 4 no
GO:0046928 regulation of neurotransmitter secretion 38.4615 5 yes
GO:0051588 regulation of neurotransmitter transport 38.4615 5 yes
GO:0010647 positive regulation of cell communication 38.4615 5 no
GO:0022607 cellular component assembly 38.4615 4 no
GO:0023056 positive regulation of signaling 38.4615 4 no
GO:0070201 regulation of establishment of protein localization 38.4615 6 no
GO:0009966 regulation of signal transduction 38.4615 4 no
GO:0048523 negative regulation of cellular process 38.4615 4 no
GO:0033043 regulation of organelle organization 30.7692 5 yes
GO:0006906 vesicle fusion 30.7692 6 no
GO:0006996 organelle organization 30.7692 4 no
GO:0008104 protein localization 30.7692 4 no
GO:0010243 response to organonitrogen compound 30.7692 4 no
GO:0016050 vesicle organization 30.7692 5 no
GO:0043933 protein-containing complex organization 30.7692 4 no
GO:0048284 organelle fusion 30.7692 5 no
GO:0050806 positive regulation of synaptic transmission 30.7692 5 no
GO:0051223 regulation of protein transport 30.7692 5 no
GO:0061024 membrane organization 30.7692 4 no
GO:0061025 membrane fusion 30.7692 5 no
GO:0065003 protein-containing complex assembly 30.7692 5 no
GO:0071310 cellular response to organic substance 30.7692 4 no
GO:0071417 cellular response to organonitrogen compound 30.7692 4 no
GO:0090174 organelle membrane fusion 30.7692 6 no
GO:0098657 import into cell 30.7692 4 no
GO:1901699 cellular response to nitrogen compound 30.7692 4 no
GO:1901701 cellular response to oxygen-containing compound 30.7692 4 no
GO:0001932 regulation of protein phosphorylation 30.7692 7 no
GO:0019220 regulation of phosphate metabolic process 30.7692 6 no
GO:0031323 regulation of cellular metabolic process 30.7692 4 no
GO:0031399 regulation of protein modification process 30.7692 6 no
GO:0042325 regulation of phosphorylation 30.7692 7 no
GO:0043549 regulation of kinase activity 30.7692 5 no
GO:0045859 regulation of protein kinase activity 30.7692 6 no
GO:0051174 regulation of phosphorus metabolic process 30.7692 5 no
GO:0051246 regulation of protein metabolic process 30.7692 5 no
GO:0051338 regulation of transferase activity 30.7692 4 no
GO:0060255 regulation of macromolecule metabolic process 30.7692 4 no
GO:0080090 regulation of primary metabolic process 30.7692 4 no
GO:0048499 synaptic vesicle membrane organization 23.0769 5 no
GO:0009967 positive regulation of signal transduction 23.0769 5 no
GO:0048584 positive regulation of response to stimulus 23.0769 4 no
GO:1901888 regulation of cell junction assembly 23.0769 5 no
GO:1903305 regulation of regulated secretory pathway 23.0769 6 no
GO:0007268 chemical synaptic transmission 23.0769 7 no
GO:0098916 anterograde trans-synaptic signaling 23.0769 6 no
GO:0099536 synaptic signaling 23.0769 4 no
GO:0099537 trans-synaptic signaling 23.0769 5 no
GO:0031338 regulation of vesicle fusion 23.0769 5 yes
GO:0031630 regulation of synaptic vesicle fusion to presynaptic active zone membrane 23.0769 6 yes
GO:0048278 vesicle docking 23.0769 4 yes
GO:1901632 regulation of synaptic vesicle membrane organization 23.0769 5 yes
GO:0015031 protein transport 23.0769 4 no
GO:0017156 calcium-ion regulated exocytosis 23.0769 5 no
GO:0034762 regulation of transmembrane transport 23.0769 4 no
GO:0051050 positive regulation of transport 23.0769 4 no
GO:0071702 organic substance transport 23.0769 4 no
GO:0071705 nitrogen compound transport 23.0769 4 no
GO:1903829 positive regulation of protein localization 23.0769 5 no
GO:1904951 positive regulation of establishment of protein localization 23.0769 6 no
GO:0001934 positive regulation of protein phosphorylation 23.0769 8 no
GO:0009892 negative regulation of metabolic process 23.0769 4 no
GO:0009893 positive regulation of metabolic process 23.0769 4 no
GO:0010562 positive regulation of phosphorus metabolic process 23.0769 6 no
GO:0010604 positive regulation of macromolecule metabolic process 23.0769 5 no
GO:0010605 negative regulation of macromolecule metabolic process 23.0769 5 no
GO:0030030 cell projection organization 23.0769 4 no
GO:0031324 negative regulation of cellular metabolic process 23.0769 5 no
GO:0031325 positive regulation of cellular metabolic process 23.0769 5 no
GO:0031344 regulation of cell projection organization 23.0769 5 no
GO:0031401 positive regulation of protein modification process 23.0769 7 no
GO:0042327 positive regulation of phosphorylation 23.0769 8 no
GO:0043085 positive regulation of catalytic activity 23.0769 4 no
GO:0045937 positive regulation of phosphate metabolic process 23.0769 7 no
GO:0050807 regulation of synapse organization 23.0769 5 no
GO:0050890 cognition 23.0769 4 no
GO:0051247 positive regulation of protein metabolic process 23.0769 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 23.0769 6 no
GO:1902531 regulation of intracellular signal transduction 23.0769 5 no
GO:1904375 regulation of protein localization to cell periphery 23.0769 6 no
GO:1905475 regulation of protein localization to membrane 23.0769 6 no
GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane 23.0769 4 no
GO:0007399 nervous system development 15.3846 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SNP25_HUMAN [view entry] [view interactions] Low throughput yes yes
VAMP2_HUMAN [view entry] [view interactions] Low throughput yes no
STX1A_HUMAN [view entry] [view interactions] Low throughput yes yes
DEGS1_HUMAN [view interactions] High throughput no no
RAP1A_HUMAN [view entry] [view interactions] High throughput yes no
WAC2A_HUMAN [view interactions] High throughput no yes
AN13C_HUMAN [view interactions] High throughput no no
SCPDL_HUMAN [view entry] [view interactions] High throughput yes yes
CPLX1_HUMAN [view entry] [view interactions] High throughput yes yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
MYG1_HUMAN [view interactions] High throughput no yes
EFTS_HUMAN [view interactions] High throughput no no
ETS1_HUMAN [view interactions] High throughput no no
PHS_HUMAN [view interactions] High throughput no yes
NDRG4_HUMAN [view interactions] High throughput no no
PBX3_HUMAN [view interactions] High throughput no yes
STB5L_HUMAN [view interactions] High throughput no no
PHF6_HUMAN [view interactions] High throughput no yes
INF2_HUMAN [view entry] [view interactions] High throughput yes yes
SRP54_HUMAN [view interactions] High throughput no yes
ZGPAT_HUMAN [view interactions] High throughput no no
LIPB1_HUMAN [view interactions] High throughput no yes
DHX16_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
PRRT2_HUMAN [view entry] [view interactions] High throughput yes no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
SYN1_HUMAN [view entry] [view interactions] High throughput yes no
GNAQ_HUMAN [view entry] [view interactions] High throughput yes yes