PLPL6_HUMAN
Evidence for PS localization
Functions
Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Catalyzes the hydrolysis of several naturally occurring membrane-associated lipids (PubMed). Hydrolyzes lysophospholipids and monoacylglycerols, preferring the 1-acyl to the 2-acyl isomer. Does not catalyze hydrolysis of di- or triacylglycerols or fatty acid amides (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PLPL6_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 31.8182 | 4 | no |
| GO:0046872 | metal ion binding | 27.2727 | 5 | no |
| GO:0043168 | anion binding | 22.7273 | 4 | no |
| GO:0004620 | phospholipase activity | 9.0909 | 5 | yes |
| GO:0016298 | lipase activity | 9.0909 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PLPL6_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 40.9091 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 40.9091 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 40.9091 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 36.3636 | 4 | no |
| GO:0010468 | regulation of gene expression | 36.3636 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 36.3636 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 36.3636 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 36.3636 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 36.3636 | 4 | no |
| GO:0022607 | cellular component assembly | 31.8182 | 4 | no |
| GO:0008104 | protein localization | 31.8182 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 31.8182 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 31.8182 | 6 | no |
| GO:0010646 | regulation of cell communication | 31.8182 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 31.8182 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 31.8182 | 5 | no |
| GO:0034330 | cell junction organization | 27.2727 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 27.2727 | 7 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 27.2727 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 27.2727 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 27.2727 | 6 | no |
| GO:0033043 | regulation of organelle organization | 27.2727 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 27.2727 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 27.2727 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 27.2727 | 5 | no |
| GO:0023056 | positive regulation of signaling | 27.2727 | 4 | no |
| GO:0071702 | organic substance transport | 22.7273 | 4 | no |
| GO:0071705 | nitrogen compound transport | 22.7273 | 4 | no |
| GO:0030030 | cell projection organization | 22.7273 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 22.7273 | 4 | no |
| GO:0045597 | positive regulation of cell differentiation | 22.7273 | 5 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 22.7273 | 8 | no |
| GO:0036211 | protein modification process | 22.7273 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 22.7273 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 22.7273 | 4 | no |
| GO:0043412 | macromolecule modification | 22.7273 | 4 | no |
| GO:0006996 | organelle organization | 22.7273 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 22.7273 | 4 | no |
| GO:0009966 | regulation of signal transduction | 22.7273 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 22.7273 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 22.7273 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.7273 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 22.7273 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 9.0909 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DQA1_HUMAN | [view interactions] | High throughput | no | yes |
| TTYH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PCDB3_HUMAN | [view interactions] | High throughput | no | no |
| VIPR1_HUMAN | [view interactions] | High throughput | no | yes |
| SDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NGN3_HUMAN | [view interactions] | High throughput | no | no |
| FSCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGRC2_HUMAN | [view interactions] | High throughput | no | yes |
| PLD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| DOT1L_HUMAN | [view interactions] | High throughput | no | yes |
| MEN1_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| CL16A_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| S13A1_HUMAN | [view interactions] | High throughput | no | no |
| CLCF1_HUMAN | [view interactions] | High throughput | no | yes |
| IFFO2_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC1_HUMAN | [view interactions] | High throughput | no | yes |
| NUP35_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| RA51D_HUMAN | [view interactions] | High throughput | no | no |
| PPIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JAK3_HUMAN | [view interactions] | High throughput | no | no |
| KCC2D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COQ8A_HUMAN | [view interactions] | High throughput | no | no |
| RPKL1_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| CTDP1_HUMAN | [view interactions] | High throughput | no | yes |
| GRK5_HUMAN | [view interactions] | High throughput | no | yes |
| GASP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| DPA1_HUMAN | [view interactions] | High throughput | no | yes |
| TX264_HUMAN | [view interactions] | High throughput | no | no |
| TSN17_HUMAN | [view interactions] | High throughput | no | yes |
| EVA1C_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| BAX_HUMAN | [view interactions] | High throughput | no | yes |
| GDIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ILK_HUMAN | [view interactions] | High throughput | no | no |
| EMC5_HUMAN | [view interactions] | High throughput | no | yes |
| KTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPP6_HUMAN | [view interactions] | High throughput | no | yes |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| MRAP2_HUMAN | [view interactions] | High throughput | no | no |
| PDCD1_HUMAN | [view interactions] | High throughput | no | yes |
| HAVR2_HUMAN | [view interactions] | High throughput | no | no |
| PCDBG_HUMAN | [view interactions] | High throughput | no | no |
| ZNRF4_HUMAN | [view interactions] | High throughput | no | no |
| KCNS3_HUMAN | [view interactions] | High throughput | no | yes |
| CADH5_HUMAN | [view interactions] | High throughput | no | yes |
| CD79B_HUMAN | [view interactions] | High throughput | no | no |
| LRRT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| UBE2A_HUMAN | [view interactions] | High throughput | no | no |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| HIF1A_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| AGRIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| ANR55_HUMAN | [view interactions] | High throughput | no | yes |
| BRD1_HUMAN | [view interactions] | High throughput | no | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| PDE3A_HUMAN | [view interactions] | High throughput | no | no |
| PCDBB_HUMAN | [view interactions] | High throughput | no | no |
| PCDGM_HUMAN | [view interactions] | High throughput | no | yes |
| INLR1_HUMAN | [view interactions] | High throughput | no | no |
| FAXC_HUMAN | [view interactions] | High throughput | no | no |
| CTLA4_HUMAN | [view interactions] | High throughput | no | no |
| CLRN2_HUMAN | [view interactions] | High throughput | no | no |
| EVA1B_HUMAN | [view interactions] | High throughput | no | yes |
| STIM1_HUMAN | [view interactions] | High throughput | no | yes |
| PCDGL_HUMAN | [view interactions] | High throughput | no | no |
| I17RA_HUMAN | [view interactions] | High throughput | no | yes |
| HFE_HUMAN | [view interactions] | High throughput | no | yes |
| NKAI1_HUMAN | [view interactions] | High throughput | no | no |
| TTMP_HUMAN | [view interactions] | High throughput | no | no |
| CXCR4_HUMAN | [view interactions] | High throughput | no | no |
| RAMP2_HUMAN | [view interactions] | High throughput | no | no |
| LRP3_HUMAN | [view interactions] | High throughput | no | no |
| HCST_HUMAN | [view interactions] | High throughput | no | no |
| PCDGH_HUMAN | [view interactions] | High throughput | no | no |
| ACHD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PLPL7_HUMAN | [view interactions] | High throughput | no | yes |
| PCDB6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EFNB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PXDC2_HUMAN | [view interactions] | High throughput | no | yes |