Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PCDB6_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PCDB6_HUMAN
GO:0043169 cation binding 62.5000 4 yes
GO:0046872 metal ion binding 62.5000 5 yes
GO:0005509 calcium ion binding 37.5000 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PCDB6_HUMAN
GO:0022607 cellular component assembly 50.0000 4 yes
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 50.0000 4 yes
GO:0099536 synaptic signaling 50.0000 4 yes
GO:0099537 trans-synaptic signaling 50.0000 5 yes
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 37.5000 5 yes
GO:0007268 chemical synaptic transmission 37.5000 7 yes
GO:0007416 synapse assembly 37.5000 6 yes
GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules 37.5000 5 yes
GO:0034329 cell junction assembly 37.5000 5 yes
GO:0034330 cell junction organization 37.5000 4 yes
GO:0050808 synapse organization 37.5000 5 yes
GO:0098916 anterograde trans-synaptic signaling 37.5000 6 yes
GO:0006796 phosphate-containing compound metabolic process 37.5000 4 no
GO:0009966 regulation of signal transduction 37.5000 4 no
GO:0010646 regulation of cell communication 37.5000 4 no
GO:0033043 regulation of organelle organization 37.5000 5 no
GO:0048522 positive regulation of cellular process 37.5000 4 no
GO:0051128 regulation of cellular component organization 37.5000 4 no
GO:0009889 regulation of biosynthetic process 37.5000 4 no
GO:0009893 positive regulation of metabolic process 37.5000 4 no
GO:0010468 regulation of gene expression 37.5000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 37.5000 5 no
GO:0010604 positive regulation of macromolecule metabolic process 37.5000 5 no
GO:0031323 regulation of cellular metabolic process 37.5000 4 no
GO:0031326 regulation of cellular biosynthetic process 37.5000 5 no
GO:0031399 regulation of protein modification process 37.5000 6 no
GO:0051246 regulation of protein metabolic process 37.5000 5 no
GO:0060255 regulation of macromolecule metabolic process 37.5000 4 no
GO:0080090 regulation of primary metabolic process 37.5000 4 no
GO:0007399 nervous system development 25.0000 4 yes
GO:0010975 regulation of neuron projection development 25.0000 7 no
GO:0031344 regulation of cell projection organization 25.0000 5 no
GO:0036211 protein modification process 25.0000 4 no
GO:0043412 macromolecule modification 25.0000 4 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0048523 negative regulation of cellular process 25.0000 4 no
GO:0050776 regulation of immune response 25.0000 4 no
GO:0050807 regulation of synapse organization 25.0000 5 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 no
GO:0051963 regulation of synapse assembly 25.0000 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 25.0000 6 no
GO:1901888 regulation of cell junction assembly 25.0000 5 no
GO:0009892 negative regulation of metabolic process 25.0000 4 no
GO:0009894 regulation of catabolic process 25.0000 4 no
GO:0009895 negative regulation of catabolic process 25.0000 5 no
GO:0010605 negative regulation of macromolecule metabolic process 25.0000 5 no
GO:0031396 regulation of protein ubiquitination 25.0000 9 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0051247 positive regulation of protein metabolic process 25.0000 6 no
GO:0051248 negative regulation of protein metabolic process 25.0000 6 no
GO:1901873 regulation of post-translational protein modification 25.0000 7 no
GO:1903320 regulation of protein modification by small protein conjugation or removal 25.0000 8 no
GO:0006355 regulation of DNA-templated transcription 25.0000 7 no
GO:0009891 positive regulation of biosynthetic process 25.0000 5 no
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 25.0000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 no
GO:0048584 positive regulation of response to stimulus 25.0000 4 no
GO:0051252 regulation of RNA metabolic process 25.0000 5 no
GO:0051338 regulation of transferase activity 25.0000 4 no
GO:0071310 cellular response to organic substance 25.0000 4 no
GO:1901701 cellular response to oxygen-containing compound 25.0000 4 no
GO:1902531 regulation of intracellular signal transduction 25.0000 5 no
GO:1902533 positive regulation of intracellular signal transduction 25.0000 6 no
GO:2001141 regulation of RNA biosynthetic process 25.0000 6 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PCDB5_HUMAN [view entry] [view interactions] Low throughput yes no
PCDB6_HUMAN [view entry] [view interactions] Low throughput yes no
KLRG2_HUMAN [view interactions] High throughput no no
PLPL6_HUMAN [view entry] [view interactions] High throughput yes yes
POMT1_HUMAN [view interactions] High throughput no no
PCDGK_HUMAN [view interactions] High throughput no yes
BT2A2_HUMAN [view interactions] High throughput no no
PCDBG_HUMAN [view interactions] High throughput no no
RL23_HUMAN [view entry] [view interactions] High throughput yes yes
MACOI_HUMAN [view interactions] High throughput no no
POMT2_HUMAN [view interactions] High throughput no yes
KCNT2_HUMAN [view interactions] High throughput no no
MP2K7_HUMAN [view entry] [view interactions] High throughput yes yes
UPK3L_HUMAN [view interactions] High throughput no yes
NMU_HUMAN [view interactions] High throughput no no
MELK_HUMAN [view interactions] High throughput no yes
M3K7_HUMAN [view interactions] High throughput no yes
S27A6_HUMAN [view interactions] High throughput no yes
PTPRD_HUMAN [view entry] [view interactions] High throughput yes no
PCDB4_HUMAN [view interactions] High throughput no yes
MYCB2_HUMAN [view entry] [view interactions] High throughput yes no
ST7_HUMAN [view interactions] High throughput no yes
TM131_HUMAN [view interactions] High throughput no yes
PWP3A_HUMAN [view interactions] High throughput no yes
ST7L_HUMAN [view interactions] High throughput no no
PCDBC_HUMAN [view interactions] High throughput no no
LTBP1_HUMAN [view interactions] High throughput no no