Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RGS8_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2 . Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed). Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RGS8_HUMAN
GO:0003924 GTPase activity 71.4286 7 yes
GO:0016462 pyrophosphatase activity 71.4286 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 71.4286 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 71.4286 6 yes
GO:0005096 GTPase activator activity 50.0000 4 yes
GO:0030695 GTPase regulator activity 50.0000 4 yes
GO:0046872 metal ion binding 35.7143 4 no
GO:0001664 G protein-coupled receptor binding 28.5714 4 no
GO:0005525 GTP binding 28.5714 5 no
GO:0017076 purine nucleotide binding 28.5714 4 no
GO:0019001 guanyl nucleotide binding 28.5714 5 no
GO:0032555 purine ribonucleotide binding 28.5714 4 no
GO:0032561 guanyl ribonucleotide binding 28.5714 5 no
GO:0035639 purine ribonucleoside triphosphate binding 28.5714 4 no
GO:0031821 G protein-coupled serotonin receptor binding 21.4286 5 no
GO:0019900 kinase binding 21.4286 4 no
GO:0019901 protein kinase binding 21.4286 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in RGS8_HUMAN
GO:0009966 regulation of signal transduction 78.5714 4 yes
GO:0010646 regulation of cell communication 78.5714 4 yes
GO:0048523 negative regulation of cellular process 78.5714 4 yes
GO:0009968 negative regulation of signal transduction 57.1429 5 yes
GO:0010648 negative regulation of cell communication 57.1429 5 yes
GO:0023057 negative regulation of signaling 57.1429 4 yes
GO:0048585 negative regulation of response to stimulus 57.1429 4 yes
GO:0043085 positive regulation of catalytic activity 50.0000 4 yes
GO:0048522 positive regulation of cellular process 50.0000 4 no
GO:0031323 regulation of cellular metabolic process 42.8571 4 no
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 42.8571 4 no
GO:0051336 regulation of hydrolase activity 35.7143 4 yes
GO:0051345 positive regulation of hydrolase activity 35.7143 5 yes
GO:0051171 regulation of nitrogen compound metabolic process 35.7143 4 no
GO:0060255 regulation of macromolecule metabolic process 35.7143 4 no
GO:0080090 regulation of primary metabolic process 35.7143 4 no
GO:0008277 regulation of G protein-coupled receptor signaling pathway 35.7143 5 no
GO:0043087 regulation of GTPase activity 28.5714 5 yes
GO:0043547 positive regulation of GTPase activity 28.5714 6 yes
GO:0006996 organelle organization 28.5714 4 no
GO:0009416 response to light stimulus 28.5714 4 no
GO:0009889 regulation of biosynthetic process 28.5714 4 no
GO:0009892 negative regulation of metabolic process 28.5714 4 no
GO:0009893 positive regulation of metabolic process 28.5714 4 no
GO:0010243 response to organonitrogen compound 28.5714 4 no
GO:0010556 regulation of macromolecule biosynthetic process 28.5714 5 no
GO:0019220 regulation of phosphate metabolic process 28.5714 6 no
GO:0031324 negative regulation of cellular metabolic process 28.5714 5 no
GO:0031325 positive regulation of cellular metabolic process 28.5714 5 no
GO:0031326 regulation of cellular biosynthetic process 28.5714 5 no
GO:0051174 regulation of phosphorus metabolic process 28.5714 5 no
GO:0051240 positive regulation of multicellular organismal process 28.5714 4 no
GO:1902531 regulation of intracellular signal transduction 28.5714 5 no
GO:0031399 regulation of protein modification process 28.5714 6 no
GO:0051246 regulation of protein metabolic process 28.5714 5 no
GO:0007213 G protein-coupled acetylcholine receptor signaling pathway 21.4286 4 yes
GO:0095500 acetylcholine receptor signaling pathway 21.4286 4 yes
GO:0006355 regulation of DNA-templated transcription 21.4286 6 no
GO:0009891 positive regulation of biosynthetic process 21.4286 5 no
GO:0010468 regulation of gene expression 21.4286 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 21.4286 6 no
GO:0010563 negative regulation of phosphorus metabolic process 21.4286 6 no
GO:0010604 positive regulation of macromolecule metabolic process 21.4286 5 no
GO:0010605 negative regulation of macromolecule metabolic process 21.4286 5 no
GO:0010647 positive regulation of cell communication 21.4286 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.4286 5 no
GO:0023056 positive regulation of signaling 21.4286 4 no
GO:0031328 positive regulation of cellular biosynthetic process 21.4286 6 no
GO:0033043 regulation of organelle organization 21.4286 5 no
GO:0036211 protein modification process 21.4286 4 no
GO:0043412 macromolecule modification 21.4286 4 no
GO:0044057 regulation of system process 21.4286 4 no
GO:0045936 negative regulation of phosphate metabolic process 21.4286 7 no
GO:0051094 positive regulation of developmental process 21.4286 4 no
GO:0051128 regulation of cellular component organization 21.4286 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 21.4286 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 21.4286 5 no
GO:0051252 regulation of RNA metabolic process 21.4286 5 no
GO:0071310 cellular response to organic substance 21.4286 4 no
GO:0090257 regulation of muscle system process 21.4286 5 no
GO:0097305 response to alcohol 21.4286 4 no
GO:1901652 response to peptide 21.4286 4 no
GO:1901701 cellular response to oxygen-containing compound 21.4286 4 no
GO:1903506 regulation of nucleic acid-templated transcription 21.4286 7 no
GO:2001141 regulation of RNA biosynthetic process 21.4286 6 no
GO:0001932 regulation of protein phosphorylation 21.4286 7 no
GO:0042325 regulation of phosphorylation 21.4286 7 no
GO:0043086 negative regulation of catalytic activity 21.4286 4 no
GO:0043549 regulation of kinase activity 21.4286 5 no
GO:0045859 regulation of protein kinase activity 21.4286 6 no
GO:0051338 regulation of transferase activity 21.4286 4 no
GO:0009894 regulation of catabolic process 21.4286 4 no
GO:0010506 regulation of autophagy 21.4286 6 no
GO:0031329 regulation of cellular catabolic process 21.4286 5 no
GO:0034762 regulation of transmembrane transport 21.4286 4 no
GO:0034765 regulation of ion transmembrane transport 21.4286 5 no
GO:0043269 regulation of ion transport 21.4286 5 no
GO:0051049 regulation of transport 21.4286 4 no
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 21.4286 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GNAO_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAI3_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAQ_HUMAN [view entry] [view interactions] Low throughput yes yes
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
HOOK2_HUMAN [view interactions] High throughput no yes
UHMK1_HUMAN [view interactions] High throughput no no
CC85B_HUMAN [view interactions] High throughput no yes
PKHF2_HUMAN [view interactions] High throughput no yes
K1C40_HUMAN [view interactions] High throughput no no
NXT2_HUMAN [view interactions] High throughput no yes
UBR2_HUMAN [view interactions] High throughput no yes
K1C17_HUMAN [view interactions] High throughput no no
CSK_HUMAN [view interactions] High throughput no yes
ADRB2_HUMAN [view entry] [view interactions] High throughput yes no
CPNE9_HUMAN [view interactions] High throughput no no
RGS1_HUMAN [view interactions] Computational no yes
RGS9_HUMAN [view entry] [view interactions] Computational yes no
RGS6_HUMAN [view entry] [view interactions] Computational yes no
GNAI1_HUMAN [view entry] [view interactions] Computational yes yes
RGS3_HUMAN [view interactions] Computational no no
RGS17_HUMAN [view entry] [view interactions] Computational yes yes
RGS19_HUMAN [view interactions] Computational no yes
RGS18_HUMAN [view interactions] Computational no yes
RGS14_HUMAN [view entry] [view interactions] Computational yes yes
RGS12_HUMAN [view interactions] Computational no no
RGS7_HUMAN [view entry] [view interactions] Computational yes yes
RGS16_HUMAN [view interactions] Computational no no
RGS11_HUMAN [view interactions] Computational no yes
RGS13_HUMAN [view interactions] Computational no no
ACM3_HUMAN [view entry] [view interactions] Computational yes yes
RGS5_HUMAN [view interactions] Computational no no
RGS10_HUMAN [view interactions] Computational no yes
RGS20_HUMAN [view interactions] Computational no no
RGS4_HUMAN [view interactions] Computational no no
RGS21_HUMAN [view interactions] Computational no no