Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RGS8_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2 . Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed). Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RGS8_HUMAN
GO:0043169 cation binding 71.4286 4 no
GO:0003924 GTPase activity 57.1429 7 yes
GO:0016462 pyrophosphatase activity 57.1429 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 57.1429 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 57.1429 6 yes
GO:0000166 nucleotide binding 57.1429 4 no
GO:0017076 purine nucleotide binding 57.1429 5 no
GO:0046872 metal ion binding 57.1429 5 no
GO:0001664 G protein-coupled receptor binding 42.8571 4 no
GO:0005525 GTP binding 42.8571 5 no
GO:0019001 guanyl nucleotide binding 42.8571 6 no
GO:0032555 purine ribonucleotide binding 42.8571 4 no
GO:0032561 guanyl ribonucleotide binding 42.8571 5 no
GO:0035639 purine ribonucleoside triphosphate binding 42.8571 4 no
GO:0043168 anion binding 42.8571 4 no
GO:0005096 GTPase activator activity 28.5714 4 yes
GO:0030695 GTPase regulator activity 28.5714 4 yes
GO:0019900 kinase binding 28.5714 4 no
GO:0019901 protein kinase binding 28.5714 5 no
GO:0042803 protein homodimerization activity 28.5714 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in RGS8_HUMAN
GO:0048523 negative regulation of cellular process 71.4286 4 yes
GO:0031323 regulation of cellular metabolic process 71.4286 4 no
GO:0009966 regulation of signal transduction 57.1429 4 yes
GO:0010646 regulation of cell communication 57.1429 4 yes
GO:0009893 positive regulation of metabolic process 57.1429 4 no
GO:0031325 positive regulation of cellular metabolic process 57.1429 5 no
GO:0048522 positive regulation of cellular process 57.1429 4 no
GO:0060255 regulation of macromolecule metabolic process 57.1429 4 no
GO:0080090 regulation of primary metabolic process 57.1429 4 no
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 57.1429 4 no
GO:0009968 negative regulation of signal transduction 42.8571 5 yes
GO:0010648 negative regulation of cell communication 42.8571 5 yes
GO:0023057 negative regulation of signaling 42.8571 4 yes
GO:0043085 positive regulation of catalytic activity 42.8571 4 yes
GO:0048585 negative regulation of response to stimulus 42.8571 4 yes
GO:0009889 regulation of biosynthetic process 42.8571 4 no
GO:0009891 positive regulation of biosynthetic process 42.8571 5 no
GO:0009892 negative regulation of metabolic process 42.8571 4 no
GO:0009894 regulation of catabolic process 42.8571 4 no
GO:0010506 regulation of autophagy 42.8571 6 no
GO:0010556 regulation of macromolecule biosynthetic process 42.8571 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 42.8571 6 no
GO:0010604 positive regulation of macromolecule metabolic process 42.8571 5 no
GO:0031324 negative regulation of cellular metabolic process 42.8571 5 no
GO:0031326 regulation of cellular biosynthetic process 42.8571 5 no
GO:0031328 positive regulation of cellular biosynthetic process 42.8571 6 no
GO:0031329 regulation of cellular catabolic process 42.8571 5 no
GO:0031399 regulation of protein modification process 42.8571 6 no
GO:0051246 regulation of protein metabolic process 42.8571 5 no
GO:0019220 regulation of phosphate metabolic process 42.8571 6 no
GO:0051174 regulation of phosphorus metabolic process 42.8571 5 no
GO:0007213 G protein-coupled acetylcholine receptor signaling pathway 28.5714 4 yes
GO:0051336 regulation of hydrolase activity 28.5714 4 yes
GO:0051345 positive regulation of hydrolase activity 28.5714 5 yes
GO:0095500 acetylcholine receptor signaling pathway 28.5714 4 yes
GO:0006996 organelle organization 28.5714 4 no
GO:0008104 protein localization 28.5714 4 no
GO:0022607 cellular component assembly 28.5714 4 no
GO:0031401 positive regulation of protein modification process 28.5714 7 no
GO:0032091 negative regulation of protein binding 28.5714 5 no
GO:0036211 protein modification process 28.5714 4 no
GO:0043393 regulation of protein binding 28.5714 4 no
GO:0043412 macromolecule modification 28.5714 4 no
GO:0043933 protein-containing complex organization 28.5714 4 no
GO:0051100 negative regulation of binding 28.5714 4 no
GO:0051247 positive regulation of protein metabolic process 28.5714 6 no
GO:0065003 protein-containing complex assembly 28.5714 5 no
GO:0001932 regulation of protein phosphorylation 28.5714 7 no
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 28.5714 5 no
GO:0009416 response to light stimulus 28.5714 4 no
GO:0010563 negative regulation of phosphorus metabolic process 28.5714 6 no
GO:0010605 negative regulation of macromolecule metabolic process 28.5714 5 no
GO:0042325 regulation of phosphorylation 28.5714 7 no
GO:0043086 negative regulation of catalytic activity 28.5714 4 no
GO:0043549 regulation of kinase activity 28.5714 5 no
GO:0045859 regulation of protein kinase activity 28.5714 6 no
GO:0045936 negative regulation of phosphate metabolic process 28.5714 7 no
GO:0051338 regulation of transferase activity 28.5714 4 no
GO:0006163 purine nucleotide metabolic process 28.5714 5 no
GO:0006351 DNA-templated transcription 28.5714 6 no
GO:0006355 regulation of DNA-templated transcription 28.5714 7 no
GO:0006357 regulation of transcription by RNA polymerase II 28.5714 8 no
GO:0006366 transcription by RNA polymerase II 28.5714 7 no
GO:0006753 nucleoside phosphate metabolic process 28.5714 4 no
GO:0006796 phosphate-containing compound metabolic process 28.5714 4 no
GO:0009059 macromolecule biosynthetic process 28.5714 4 no
GO:0009117 nucleotide metabolic process 28.5714 5 no
GO:0009141 nucleoside triphosphate metabolic process 28.5714 5 no
GO:0009144 purine nucleoside triphosphate metabolic process 28.5714 6 no
GO:0009150 purine ribonucleotide metabolic process 28.5714 6 no
GO:0009199 ribonucleoside triphosphate metabolic process 28.5714 6 no
GO:0009205 purine ribonucleoside triphosphate metabolic process 28.5714 7 no
GO:0009259 ribonucleotide metabolic process 28.5714 5 no
GO:0009967 positive regulation of signal transduction 28.5714 5 no
GO:0010243 response to organonitrogen compound 28.5714 4 no
GO:0010468 regulation of gene expression 28.5714 6 no
GO:0010647 positive regulation of cell communication 28.5714 5 no
GO:0016070 RNA metabolic process 28.5714 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 28.5714 5 no
GO:0019693 ribose phosphate metabolic process 28.5714 4 no
GO:0023056 positive regulation of signaling 28.5714 4 no
GO:0032774 RNA biosynthetic process 28.5714 5 no
GO:0033043 regulation of organelle organization 28.5714 5 no
GO:0034654 nucleobase-containing compound biosynthetic process 28.5714 4 no
GO:0044057 regulation of system process 28.5714 4 no
GO:0045893 positive regulation of DNA-templated transcription 28.5714 8 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 28.5714 5 no
GO:0045944 positive regulation of transcription by RNA polymerase II 28.5714 9 no
GO:0048584 positive regulation of response to stimulus 28.5714 4 no
GO:0051093 negative regulation of developmental process 28.5714 4 no
GO:0051094 positive regulation of developmental process 28.5714 4 no
GO:0051128 regulation of cellular component organization 28.5714 4 no
GO:0051240 positive regulation of multicellular organismal process 28.5714 4 no
GO:0051241 negative regulation of multicellular organismal process 28.5714 4 no
GO:0051252 regulation of RNA metabolic process 28.5714 5 no
GO:0051254 positive regulation of RNA metabolic process 28.5714 6 no
GO:0071310 cellular response to organic substance 28.5714 4 no
GO:0071417 cellular response to organonitrogen compound 28.5714 4 no
GO:0072521 purine-containing compound metabolic process 28.5714 4 no
GO:0090257 regulation of muscle system process 28.5714 5 no
GO:0090304 nucleic acid metabolic process 28.5714 4 no
GO:0141187 nucleic acid biosynthetic process 28.5714 5 no
GO:1901362 organic cyclic compound biosynthetic process 28.5714 4 no
GO:1901699 cellular response to nitrogen compound 28.5714 4 no
GO:1901701 cellular response to oxygen-containing compound 28.5714 4 no
GO:1902531 regulation of intracellular signal transduction 28.5714 5 no
GO:1902533 positive regulation of intracellular signal transduction 28.5714 6 no
GO:1902680 positive regulation of RNA biosynthetic process 28.5714 7 no
GO:1904645 response to amyloid-beta 28.5714 4 no
GO:1904646 cellular response to amyloid-beta 28.5714 5 no
GO:2001141 regulation of RNA biosynthetic process 28.5714 6 no
GO:0006936 muscle contraction 28.5714 4 no
GO:0009896 positive regulation of catabolic process 28.5714 5 no
GO:0010508 positive regulation of autophagy 28.5714 7 no
GO:0016239 positive regulation of macroautophagy 28.5714 8 no
GO:0016241 regulation of macroautophagy 28.5714 7 no
GO:0031279 regulation of cyclase activity 28.5714 4 no
GO:0031331 positive regulation of cellular catabolic process 28.5714 6 no
GO:0045761 regulation of adenylate cyclase activity 28.5714 5 no
GO:0051339 regulation of lyase activity 28.5714 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GNAO_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAI3_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAQ_HUMAN [view entry] [view interactions] Low throughput yes yes
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
HOOK2_HUMAN [view interactions] High throughput no yes
UHMK1_HUMAN [view interactions] High throughput no no
CC85B_HUMAN [view interactions] High throughput no yes
PKHF2_HUMAN [view interactions] High throughput no yes
K1C40_HUMAN [view interactions] High throughput no no
NXT2_HUMAN [view interactions] High throughput no yes
UBR2_HUMAN [view interactions] High throughput no yes
K1C17_HUMAN [view interactions] High throughput no no
CSK_HUMAN [view interactions] High throughput no yes
ADRB2_HUMAN [view entry] [view interactions] High throughput yes no
CPNE9_HUMAN [view interactions] High throughput no no