OPRK_HUMAN
G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
No data found.
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in OPRK_HUMAN |
---|---|---|---|---|
GO:0009966 | regulation of signal transduction | 100.0000 | 4 | yes |
GO:0009967 | positive regulation of signal transduction | 100.0000 | 5 | yes |
GO:0010646 | regulation of cell communication | 100.0000 | 4 | yes |
GO:0010647 | positive regulation of cell communication | 100.0000 | 5 | yes |
GO:0023056 | positive regulation of signaling | 100.0000 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 100.0000 | 4 | yes |
GO:0048584 | positive regulation of response to stimulus | 100.0000 | 4 | yes |
GO:1902531 | regulation of intracellular signal transduction | 100.0000 | 5 | yes |
GO:1902533 | positive regulation of intracellular signal transduction | 100.0000 | 6 | yes |
GO:0051046 | regulation of secretion | 66.6667 | 5 | yes |
GO:0051047 | positive regulation of secretion | 66.6667 | 5 | yes |
GO:0051049 | regulation of transport | 66.6667 | 4 | yes |
GO:0051050 | positive regulation of transport | 66.6667 | 4 | yes |
GO:1903530 | regulation of secretion by cell | 66.6667 | 4 | yes |
GO:1903532 | positive regulation of secretion by cell | 66.6667 | 5 | yes |
GO:0008104 | protein localization | 66.6667 | 4 | no |
GO:0043122 | regulation of I-kappaB kinase/NF-kappaB signaling | 66.6667 | 6 | no |
GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 66.6667 | 7 | no |
GO:0071702 | organic substance transport | 66.6667 | 4 | no |
GO:0071705 | nitrogen compound transport | 66.6667 | 4 | no |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
GBRL1_HUMAN | [view interactions] | Low throughput | no | yes |
GBRAP_HUMAN | [view interactions] | Low throughput | no | no |
APJ_HUMAN | [view interactions] | Low throughput | no | yes |
NHRF1_HUMAN | [view interactions] | Low throughput | no | no |
AUP1_HUMAN | [view interactions] | High throughput | no | yes |
CXA4_HUMAN | [view interactions] | High throughput | no | yes |
VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
WLS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SIAH2_HUMAN | [view interactions] | High throughput | no | no |
SIAH1_HUMAN | [view interactions] | High throughput | no | yes |
GASP1_HUMAN | [view interactions] | High throughput | no | yes |
NKG7_HUMAN | [view interactions] | High throughput | no | no |
DOK4_HUMAN | [view interactions] | High throughput | no | yes |
COLI_HUMAN | [view interactions] | Computational | no | no |
PENK_HUMAN | [view interactions] | Computational | no | yes |
MECP2_HUMAN | [view interactions] | Computational | no | yes |
PDYN_HUMAN | [view interactions] | Computational | no | yes |