Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

OPRK_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in OPRK_HUMAN
GO:0003924 GTPase activity 44.4444 7 no
GO:0016462 pyrophosphatase activity 44.4444 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 44.4444 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 44.4444 6 no
GO:0000166 nucleotide binding 33.3333 4 no
GO:0001664 G protein-coupled receptor binding 33.3333 4 no
GO:0005525 GTP binding 33.3333 5 no
GO:0017076 purine nucleotide binding 33.3333 5 no
GO:0019001 guanyl nucleotide binding 33.3333 6 no
GO:0031821 G protein-coupled serotonin receptor binding 33.3333 5 no
GO:0032555 purine ribonucleotide binding 33.3333 4 no
GO:0032561 guanyl ribonucleotide binding 33.3333 5 no
GO:0035639 purine ribonucleoside triphosphate binding 33.3333 4 no
GO:0043168 anion binding 33.3333 4 no
GO:0043169 cation binding 33.3333 4 no
GO:0046872 metal ion binding 33.3333 5 no
GO:0008017 microtubule binding 22.2222 5 no
GO:0015631 tubulin binding 22.2222 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in OPRK_HUMAN
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 66.6667 4 yes
GO:0010646 regulation of cell communication 66.6667 4 yes
GO:0009966 regulation of signal transduction 55.5556 4 yes
GO:1902531 regulation of intracellular signal transduction 55.5556 5 yes
GO:0010243 response to organonitrogen compound 44.4444 4 yes
GO:0033993 response to lipid 44.4444 4 yes
GO:0048522 positive regulation of cellular process 44.4444 4 yes
GO:0071310 cellular response to organic substance 44.4444 4 yes
GO:0071396 cellular response to lipid 44.4444 5 yes
GO:0097305 response to alcohol 44.4444 4 yes
GO:1901701 cellular response to oxygen-containing compound 44.4444 4 yes
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 33.3333 5 yes
GO:0009967 positive regulation of signal transduction 33.3333 5 yes
GO:0010647 positive regulation of cell communication 33.3333 5 yes
GO:0023056 positive regulation of signaling 33.3333 4 yes
GO:0048584 positive regulation of response to stimulus 33.3333 4 yes
GO:0051046 regulation of secretion 33.3333 5 yes
GO:0051049 regulation of transport 33.3333 4 yes
GO:1902533 positive regulation of intracellular signal transduction 33.3333 6 yes
GO:1903530 regulation of secretion by cell 33.3333 4 yes
GO:0014070 response to organic cyclic compound 33.3333 4 no
GO:0032880 regulation of protein localization 33.3333 5 no
GO:0060341 regulation of cellular localization 33.3333 4 no
GO:0071407 cellular response to organic cyclic compound 33.3333 5 no
GO:0097306 cellular response to alcohol 33.3333 5 no
GO:1901654 response to ketone 33.3333 4 no
GO:1901655 cellular response to ketone 33.3333 5 no
GO:0008104 protein localization 33.3333 4 no
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 22.2222 4 yes
GO:0007268 chemical synaptic transmission 22.2222 7 yes
GO:0007600 sensory perception 22.2222 4 yes
GO:0010648 negative regulation of cell communication 22.2222 5 yes
GO:0023057 negative regulation of signaling 22.2222 4 yes
GO:0043434 response to peptide hormone 22.2222 4 yes
GO:0046883 regulation of hormone secretion 22.2222 4 yes
GO:0046888 negative regulation of hormone secretion 22.2222 5 yes
GO:0048523 negative regulation of cellular process 22.2222 4 yes
GO:0051047 positive regulation of secretion 22.2222 5 yes
GO:0051048 negative regulation of secretion 22.2222 5 yes
GO:0051050 positive regulation of transport 22.2222 4 yes
GO:0051051 negative regulation of transport 22.2222 4 yes
GO:0098916 anterograde trans-synaptic signaling 22.2222 6 yes
GO:0099536 synaptic signaling 22.2222 4 yes
GO:0099537 trans-synaptic signaling 22.2222 5 yes
GO:1903531 negative regulation of secretion by cell 22.2222 5 yes
GO:1903532 positive regulation of secretion by cell 22.2222 5 yes
GO:1903829 positive regulation of protein localization 22.2222 5 no
GO:0043122 regulation of canonical NF-kappaB signal transduction 22.2222 6 no
GO:0043123 positive regulation of canonical NF-kappaB signal transduction 22.2222 7 no
GO:0050708 regulation of protein secretion 22.2222 5 no
GO:0051223 regulation of protein transport 22.2222 5 no
GO:0070201 regulation of establishment of protein localization 22.2222 6 no
GO:0071702 organic substance transport 22.2222 4 no
GO:0071705 nitrogen compound transport 22.2222 4 no
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 22.2222 5 no
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway 22.2222 4 no
GO:0032870 cellular response to hormone stimulus 22.2222 4 no
GO:0034694 response to prostaglandin 22.2222 4 no
GO:0034695 response to prostaglandin E 22.2222 5 no
GO:0071379 cellular response to prostaglandin stimulus 22.2222 5 no
GO:0071380 cellular response to prostaglandin E stimulus 22.2222 6 no
GO:0071417 cellular response to organonitrogen compound 22.2222 4 no
GO:0071867 response to monoamine 22.2222 5 no
GO:0071868 cellular response to monoamine stimulus 22.2222 5 no
GO:0071869 response to catecholamine 22.2222 4 no
GO:0071870 cellular response to catecholamine stimulus 22.2222 5 no
GO:1901699 cellular response to nitrogen compound 22.2222 4 no
GO:0006996 organelle organization 22.2222 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GBRL1_HUMAN [view interactions] Low throughput no yes
GBRAP_HUMAN [view entry] [view interactions] Low throughput yes no
APJ_HUMAN [view interactions] Low throughput no yes
OX1R_HUMAN [view interactions] Low throughput no yes
NHRF1_HUMAN [view interactions] Low throughput no no
GBG2_HUMAN [view entry] [view interactions] Low throughput yes yes
GBB1_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAI1_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAO_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAZ_HUMAN [view entry] [view interactions] Low throughput yes yes
PDYN_HUMAN [view interactions] Low throughput no yes
CXA4_HUMAN [view interactions] High throughput no yes
AUP1_HUMAN [view interactions] High throughput no yes
VAPA_HUMAN [view entry] [view interactions] High throughput yes yes
WLS_HUMAN [view entry] [view interactions] High throughput yes no
SIAH1_HUMAN [view interactions] High throughput no yes
SIAH2_HUMAN [view interactions] High throughput no no
GASP1_HUMAN [view interactions] High throughput no yes
NKG7_HUMAN [view interactions] High throughput no no
DOK4_HUMAN [view interactions] High throughput no yes