Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ITAX_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

No data found.

Biological process

Term Name % Distance from top the of the tree Annotated in ITAX_HUMAN
GO:0009893 positive regulation of metabolic process 100.0000 4 yes
GO:0010468 regulation of gene expression 100.0000 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 100.0000 5 yes
GO:0010628 positive regulation of gene expression 100.0000 6 yes
GO:0022603 regulation of anatomical structure morphogenesis 100.0000 4 yes
GO:0045765 regulation of angiogenesis 100.0000 5 yes
GO:0045766 positive regulation of angiogenesis 100.0000 6 yes
GO:0048522 positive regulation of cellular process 100.0000 4 yes
GO:0051094 positive regulation of developmental process 100.0000 4 yes
GO:0051240 positive regulation of multicellular organismal process 100.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 100.0000 4 yes
GO:1901342 regulation of vasculature development 100.0000 5 yes
GO:1904018 positive regulation of vasculature development 100.0000 5 yes
GO:2000026 regulation of multicellular organismal development 100.0000 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ITB2_HUMAN [view interactions] Low throughput no no
TGO1_HUMAN [view interactions] Low throughput no yes
CO3_HUMAN [view entry] [view interactions] Low throughput yes no
NHLC2_HUMAN [view interactions] High throughput no yes