Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KELL_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in KELL_HUMAN
GO:0043169 cation binding 50.0000 4 yes
GO:0046872 metal ion binding 50.0000 5 yes
GO:0031625 ubiquitin protein ligase binding 50.0000 5 no
GO:0044389 ubiquitin-like protein ligase binding 50.0000 4 no
GO:0000166 nucleotide binding 33.3333 4 no
GO:0017076 purine nucleotide binding 33.3333 5 no
GO:0032555 purine ribonucleotide binding 33.3333 4 no
GO:0035639 purine ribonucleoside triphosphate binding 33.3333 4 no
GO:0043168 anion binding 33.3333 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in KELL_HUMAN
GO:0048523 negative regulation of cellular process 66.6667 4 yes
GO:0051128 regulation of cellular component organization 66.6667 4 yes
GO:0030003 intracellular monoatomic cation homeostasis 50.0000 5 yes
GO:0055080 monoatomic cation homeostasis 50.0000 4 yes
GO:0036211 protein modification process 50.0000 4 no
GO:0043412 macromolecule modification 50.0000 4 no
GO:0009892 negative regulation of metabolic process 50.0000 4 no
GO:0009894 regulation of catabolic process 50.0000 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 50.0000 5 no
GO:0022607 cellular component assembly 50.0000 4 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0031324 negative regulation of cellular metabolic process 50.0000 5 no
GO:0043933 protein-containing complex organization 50.0000 4 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 50.0000 5 no
GO:0065003 protein-containing complex assembly 50.0000 5 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0008104 protein localization 50.0000 4 no
GO:0071702 organic substance transport 50.0000 4 no
GO:0006508 proteolysis 50.0000 4 yes
GO:0006873 intracellular monoatomic ion homeostasis 50.0000 4 yes
GO:0010959 regulation of metal ion transport 33.3333 6 yes
GO:0034762 regulation of transmembrane transport 33.3333 4 yes
GO:0034765 regulation of monoatomic ion transmembrane transport 33.3333 5 yes
GO:0043269 regulation of monoatomic ion transport 33.3333 5 yes
GO:0051049 regulation of transport 33.3333 4 yes
GO:0055074 calcium ion homeostasis 33.3333 4 yes
GO:1904062 regulation of monoatomic cation transmembrane transport 33.3333 6 yes
GO:0009057 macromolecule catabolic process 33.3333 4 no
GO:0016567 protein ubiquitination 33.3333 8 no
GO:0019941 modification-dependent protein catabolic process 33.3333 6 no
GO:0032446 protein modification by small protein conjugation 33.3333 7 no
GO:0043632 modification-dependent macromolecule catabolic process 33.3333 5 no
GO:0043687 post-translational protein modification 33.3333 5 no
GO:0051603 proteolysis involved in protein catabolic process 33.3333 5 no
GO:0070647 protein modification by small protein conjugation or removal 33.3333 6 no
GO:0006915 apoptotic process 33.3333 4 no
GO:0006996 organelle organization 33.3333 4 no
GO:0007010 cytoskeleton organization 33.3333 5 no
GO:0009059 macromolecule biosynthetic process 33.3333 4 no
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0009893 positive regulation of metabolic process 33.3333 4 no
GO:0009966 regulation of signal transduction 33.3333 4 no
GO:0009968 negative regulation of signal transduction 33.3333 5 no
GO:0010467 gene expression 33.3333 5 no
GO:0010468 regulation of gene expression 33.3333 6 no
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 no
GO:0010646 regulation of cell communication 33.3333 4 no
GO:0010647 positive regulation of cell communication 33.3333 5 no
GO:0010648 negative regulation of cell communication 33.3333 5 no
GO:0023056 positive regulation of signaling 33.3333 4 no
GO:0023057 negative regulation of signaling 33.3333 4 no
GO:0030030 cell projection organization 33.3333 4 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0032006 regulation of TOR signaling 33.3333 6 no
GO:0043200 response to amino acid 33.3333 4 no
GO:0048522 positive regulation of cellular process 33.3333 4 no
GO:0048585 negative regulation of response to stimulus 33.3333 4 no
GO:0051246 regulation of protein metabolic process 33.3333 5 no
GO:0051726 regulation of cell cycle 33.3333 4 no
GO:0060255 regulation of macromolecule metabolic process 33.3333 4 no
GO:0097435 supramolecular fiber organization 33.3333 4 no
GO:1902531 regulation of intracellular signal transduction 33.3333 5 no
GO:1902532 negative regulation of intracellular signal transduction 33.3333 6 no
GO:1903432 regulation of TORC1 signaling 33.3333 7 no
GO:0006109 regulation of carbohydrate metabolic process 33.3333 5 no
GO:0006110 regulation of glycolytic process 33.3333 6 no
GO:0006140 regulation of nucleotide metabolic process 33.3333 5 no
GO:0006886 intracellular protein transport 33.3333 4 no
GO:0009895 negative regulation of catabolic process 33.3333 5 no
GO:0010243 response to organonitrogen compound 33.3333 4 no
GO:0010563 negative regulation of phosphorus metabolic process 33.3333 6 no
GO:0015031 protein transport 33.3333 4 no
GO:0019220 regulation of phosphate metabolic process 33.3333 6 no
GO:0030811 regulation of nucleotide catabolic process 33.3333 5 no
GO:0030812 negative regulation of nucleotide catabolic process 33.3333 6 no
GO:0033121 regulation of purine nucleotide catabolic process 33.3333 6 no
GO:0033122 negative regulation of purine nucleotide catabolic process 33.3333 7 no
GO:0043467 regulation of generation of precursor metabolites and energy 33.3333 5 no
GO:0043470 regulation of carbohydrate catabolic process 33.3333 5 no
GO:0045820 negative regulation of glycolytic process 33.3333 6 no
GO:0045912 negative regulation of carbohydrate metabolic process 33.3333 5 no
GO:0045936 negative regulation of phosphate metabolic process 33.3333 7 no
GO:0045980 negative regulation of nucleotide metabolic process 33.3333 6 no
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 no
GO:0062012 regulation of small molecule metabolic process 33.3333 4 no
GO:0062014 negative regulation of small molecule metabolic process 33.3333 5 no
GO:0071705 nitrogen compound transport 33.3333 4 no
GO:1900542 regulation of purine nucleotide metabolic process 33.3333 6 no
GO:1900543 negative regulation of purine nucleotide metabolic process 33.3333 7 no
GO:1903578 regulation of ATP metabolic process 33.3333 7 no
GO:1903579 negative regulation of ATP metabolic process 33.3333 8 no
GO:1904538 regulation of glycolytic process through fructose-6-phosphate 33.3333 7 no
GO:1904539 negative regulation of glycolytic process through fructose-6-phosphate 33.3333 7 no
GO:0006811 monoatomic ion transport 33.3333 4 yes
GO:0006874 intracellular calcium ion homeostasis 33.3333 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
B3AT_HUMAN [view entry] [view interactions] High throughput yes no
P20D2_HUMAN [view interactions] High throughput no yes
ADIPO_HUMAN [view interactions] High throughput no no
CO5_HUMAN [view interactions] High throughput no no
TTMP_HUMAN [view interactions] High throughput no no
SERPH_HUMAN [view interactions] High throughput no no
KAPCA_HUMAN [view entry] [view interactions] High throughput yes yes
TGFR2_HUMAN [view interactions] High throughput no no
EWS_HUMAN [view interactions] High throughput no yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
CLD19_HUMAN [view interactions] High throughput no no
SELT_HUMAN [view interactions] High throughput no yes
FLVC1_HUMAN [view interactions] High throughput no yes
MOT10_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes