KELL_HUMAN
Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in KELL_HUMAN |
---|---|---|---|---|
GO:0031625 | ubiquitin protein ligase binding | 50.0000 | 5 | no |
GO:0044389 | ubiquitin-like protein ligase binding | 50.0000 | 4 | no |
GO:0046872 | metal ion binding | 33.3333 | 4 | yes |
GO:0017076 | purine nucleotide binding | 33.3333 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 33.3333 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 33.3333 | 4 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in KELL_HUMAN |
---|---|---|---|---|
GO:0048523 | negative regulation of cellular process | 66.6667 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 66.6667 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 50.0000 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | no |
GO:0006508 | proteolysis | 50.0000 | 4 | yes |
GO:0006873 | cellular ion homeostasis | 50.0000 | 4 | yes |
GO:0030003 | cellular cation homeostasis | 50.0000 | 5 | yes |
GO:0048878 | chemical homeostasis | 50.0000 | 4 | yes |
GO:0050801 | ion homeostasis | 50.0000 | 5 | yes |
GO:0055080 | cation homeostasis | 50.0000 | 6 | yes |
GO:0098771 | inorganic ion homeostasis | 50.0000 | 6 | yes |
GO:0036211 | protein modification process | 50.0000 | 4 | no |
GO:0043412 | macromolecule modification | 50.0000 | 4 | no |
GO:0043632 | modification-dependent macromolecule catabolic process | 33.3333 | 5 | no |
GO:0044265 | cellular macromolecule catabolic process | 33.3333 | 4 | no |
GO:0051603 | proteolysis involved in protein catabolic process | 33.3333 | 5 | no |
GO:0070647 | protein modification by small protein conjugation or removal | 33.3333 | 5 | no |
GO:0009892 | negative regulation of metabolic process | 33.3333 | 4 | no |
GO:0009966 | regulation of signal transduction | 33.3333 | 4 | no |
GO:0009968 | negative regulation of signal transduction | 33.3333 | 5 | no |
GO:0010468 | regulation of gene expression | 33.3333 | 5 | no |
GO:0010646 | regulation of cell communication | 33.3333 | 4 | no |
GO:0010648 | negative regulation of cell communication | 33.3333 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 33.3333 | 5 | no |
GO:0022607 | cellular component assembly | 33.3333 | 4 | no |
GO:0023057 | negative regulation of signaling | 33.3333 | 4 | no |
GO:0031324 | negative regulation of cellular metabolic process | 33.3333 | 5 | no |
GO:0043933 | protein-containing complex organization | 33.3333 | 4 | no |
GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 33.3333 | 6 | no |
GO:0048522 | positive regulation of cellular process | 33.3333 | 4 | no |
GO:0048585 | negative regulation of response to stimulus | 33.3333 | 4 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 33.3333 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 33.3333 | 5 | no |
GO:0051726 | regulation of cell cycle | 33.3333 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 33.3333 | 4 | no |
GO:0065003 | protein-containing complex assembly | 33.3333 | 5 | no |
GO:0008104 | protein localization | 33.3333 | 4 | no |
GO:0009894 | regulation of catabolic process | 33.3333 | 4 | no |
GO:0006874 | cellular calcium ion homeostasis | 33.3333 | 7 | yes |
GO:0006875 | cellular metal ion homeostasis | 33.3333 | 6 | yes |
GO:0010959 | regulation of metal ion transport | 33.3333 | 6 | yes |
GO:0034762 | regulation of transmembrane transport | 33.3333 | 4 | yes |
GO:0034765 | regulation of ion transmembrane transport | 33.3333 | 5 | yes |
GO:0043269 | regulation of ion transport | 33.3333 | 5 | yes |
GO:0051049 | regulation of transport | 33.3333 | 4 | yes |
GO:0055065 | metal ion homeostasis | 33.3333 | 7 | yes |
GO:0055074 | calcium ion homeostasis | 33.3333 | 8 | yes |
GO:0072503 | cellular divalent inorganic cation homeostasis | 33.3333 | 6 | yes |
GO:0072507 | divalent inorganic cation homeostasis | 33.3333 | 7 | yes |
GO:1904062 | regulation of cation transmembrane transport | 33.3333 | 6 | yes |
GO:0006996 | organelle organization | 33.3333 | 4 | no |
GO:0007010 | cytoskeleton organization | 33.3333 | 5 | no |
GO:0009057 | macromolecule catabolic process | 33.3333 | 4 | no |
GO:0016567 | protein ubiquitination | 33.3333 | 7 | no |
GO:0019941 | modification-dependent protein catabolic process | 33.3333 | 6 | no |
GO:0032446 | protein modification by small protein conjugation | 33.3333 | 6 | no |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
B3AT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
P20D2_HUMAN | [view interactions] | High throughput | no | yes |
ADIPO_HUMAN | [view interactions] | High throughput | no | no |
CO5_HUMAN | [view interactions] | High throughput | no | no |
TTMP_HUMAN | [view interactions] | High throughput | no | no |
SERPH_HUMAN | [view interactions] | High throughput | no | no |
KAPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TGFR2_HUMAN | [view interactions] | High throughput | no | no |
EWS_HUMAN | [view interactions] | High throughput | no | yes |
CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CLD19_HUMAN | [view interactions] | High throughput | no | no |
SELT_HUMAN | [view interactions] | High throughput | no | yes |
FLVC1_HUMAN | [view interactions] | High throughput | no | yes |
MOT10_HUMAN | [view interactions] | High throughput | no | yes |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
XKR3_HUMAN | [view interactions] | Computational | no | no |
XKR2_HUMAN | [view interactions] | Computational | no | no |
XK_HUMAN | [view interactions] | Computational | no | yes |
EDN3_HUMAN | [view interactions] | Computational | no | no |