R4RL2_HUMAN
Evidence for PS localization
Functions
Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG . Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG . Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in R4RL2_HUMAN |
|---|---|---|---|---|
| GO:0042803 | protein homodimerization activity | 60.0000 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in R4RL2_HUMAN |
|---|---|---|---|---|
| GO:0030030 | cell projection organization | 80.0000 | 4 | yes |
| GO:0031175 | neuron projection development | 80.0000 | 6 | yes |
| GO:0031344 | regulation of cell projection organization | 80.0000 | 5 | yes |
| GO:0031345 | negative regulation of cell projection organization | 80.0000 | 6 | yes |
| GO:0048523 | negative regulation of cellular process | 80.0000 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 80.0000 | 4 | yes |
| GO:0051129 | negative regulation of cellular component organization | 80.0000 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 80.0000 | 6 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 80.0000 | 5 | yes |
| GO:0010975 | regulation of neuron projection development | 60.0000 | 7 | yes |
| GO:0010977 | negative regulation of neuron projection development | 60.0000 | 7 | yes |
| GO:0010941 | regulation of cell death | 60.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 60.0000 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 60.0000 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 60.0000 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 60.0000 | 4 | no |
| GO:0045596 | negative regulation of cell differentiation | 60.0000 | 5 | no |
| GO:0048522 | positive regulation of cellular process | 60.0000 | 4 | no |
| GO:0048638 | regulation of developmental growth | 60.0000 | 4 | no |
| GO:0051093 | negative regulation of developmental process | 60.0000 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 60.0000 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 60.0000 | 4 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 60.0000 | 4 | no |
| GO:0031102 | neuron projection regeneration | 40.0000 | 4 | yes |
| GO:0031103 | axon regeneration | 40.0000 | 5 | yes |
| GO:0048678 | response to axon injury | 40.0000 | 4 | yes |
| GO:0061564 | axon development | 40.0000 | 7 | yes |
| GO:0001558 | regulation of cell growth | 40.0000 | 4 | no |
| GO:0010721 | negative regulation of cell development | 40.0000 | 6 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 40.0000 | 4 | no |
| GO:0030308 | negative regulation of cell growth | 40.0000 | 5 | no |
| GO:0030516 | regulation of axon extension | 40.0000 | 5 | no |
| GO:0030517 | negative regulation of axon extension | 40.0000 | 6 | no |
| GO:0031644 | regulation of nervous system process | 40.0000 | 5 | no |
| GO:0043523 | regulation of neuron apoptotic process | 40.0000 | 6 | no |
| GO:0044057 | regulation of system process | 40.0000 | 4 | no |
| GO:0045597 | positive regulation of cell differentiation | 40.0000 | 5 | no |
| GO:0045664 | regulation of neuron differentiation | 40.0000 | 5 | no |
| GO:0045665 | negative regulation of neuron differentiation | 40.0000 | 6 | no |
| GO:0045926 | negative regulation of growth | 40.0000 | 4 | no |
| GO:0048640 | negative regulation of developmental growth | 40.0000 | 5 | no |
| GO:0050767 | regulation of neurogenesis | 40.0000 | 6 | no |
| GO:0050768 | negative regulation of neurogenesis | 40.0000 | 6 | no |
| GO:0050770 | regulation of axonogenesis | 40.0000 | 5 | no |
| GO:0050771 | negative regulation of axonogenesis | 40.0000 | 6 | no |
| GO:0051960 | regulation of nervous system development | 40.0000 | 5 | no |
| GO:0051961 | negative regulation of nervous system development | 40.0000 | 5 | no |
| GO:0060284 | regulation of cell development | 40.0000 | 5 | no |
| GO:0060548 | negative regulation of cell death | 40.0000 | 5 | no |
| GO:0061387 | regulation of extent of cell growth | 40.0000 | 5 | no |
| GO:1901214 | regulation of neuron death | 40.0000 | 5 | no |
| GO:1901215 | negative regulation of neuron death | 40.0000 | 6 | no |
| GO:2000026 | regulation of multicellular organismal development | 40.0000 | 4 | no |
| GO:0001817 | regulation of cytokine production | 40.0000 | 4 | no |
| GO:0001819 | positive regulation of cytokine production | 40.0000 | 5 | no |
| GO:0002684 | positive regulation of immune system process | 40.0000 | 4 | no |
| GO:0002685 | regulation of leukocyte migration | 40.0000 | 4 | no |
| GO:0002687 | positive regulation of leukocyte migration | 40.0000 | 5 | no |
| GO:0006915 | apoptotic process | 40.0000 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 40.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 40.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 40.0000 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 40.0000 | 5 | no |
| GO:0010468 | regulation of gene expression | 40.0000 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.0000 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 40.0000 | 5 | no |
| GO:0010628 | positive regulation of gene expression | 40.0000 | 6 | no |
| GO:0010646 | regulation of cell communication | 40.0000 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 40.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 40.0000 | 4 | no |
| GO:0030334 | regulation of cell migration | 40.0000 | 5 | no |
| GO:0030335 | positive regulation of cell migration | 40.0000 | 6 | no |
| GO:0031323 | regulation of cellular metabolic process | 40.0000 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 40.0000 | 5 | no |
| GO:0032880 | regulation of protein localization | 40.0000 | 5 | no |
| GO:0034121 | regulation of toll-like receptor signaling pathway | 40.0000 | 6 | no |
| GO:0034248 | regulation of cellular amide metabolic process | 40.0000 | 5 | no |
| GO:0040017 | positive regulation of locomotion | 40.0000 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 40.0000 | 4 | no |
| GO:0043933 | protein-containing complex organization | 40.0000 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 40.0000 | 4 | no |
| GO:0048878 | chemical homeostasis | 40.0000 | 4 | no |
| GO:0050776 | regulation of immune response | 40.0000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 40.0000 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 40.0000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 40.0000 | 5 | no |
| GO:0051896 | regulation of protein kinase B signaling | 40.0000 | 6 | no |
| GO:0051897 | positive regulation of protein kinase B signaling | 40.0000 | 7 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 40.0000 | 4 | no |
| GO:0060341 | regulation of cellular localization | 40.0000 | 4 | no |
| GO:0062207 | regulation of pattern recognition receptor signaling pathway | 40.0000 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 40.0000 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 40.0000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 40.0000 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 40.0000 | 6 | no |
| GO:1902991 | regulation of amyloid precursor protein catabolic process | 40.0000 | 6 | no |
| GO:1903829 | positive regulation of protein localization | 40.0000 | 5 | no |
| GO:2000145 | regulation of cell motility | 40.0000 | 4 | no |
| GO:2000147 | positive regulation of cell motility | 40.0000 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| LEG3_HUMAN | [view interactions] | High throughput | no | yes |
| LRC33_HUMAN | [view interactions] | High throughput | no | yes |
| CBX1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI69_HUMAN | [view interactions] | High throughput | no | no |
| NUDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| IL20_HUMAN | [view interactions] | High throughput | no | no |
| LCN6_HUMAN | [view interactions] | High throughput | no | no |
| CL12B_HUMAN | [view interactions] | High throughput | no | no |
| T106A_HUMAN | [view interactions] | High throughput | no | no |
| RTN4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MAG_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |