R4RL2_HUMAN

Evidence for PS localization

GO

G2C

SynGO

SynaptomeDB

Functions

Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG . Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG . Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

No data found.

Biological process

No data found.

Disease

No data found.

All partners