Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GNAS1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as GNAS isoforms . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GNAS1_HUMAN
GO:0000166 nucleotide binding 46.1538 4 yes
GO:0017076 purine nucleotide binding 46.1538 5 yes
GO:0032555 purine ribonucleotide binding 38.4615 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 38.4615 4 yes
GO:0043168 anion binding 38.4615 4 yes
GO:0003924 GTPase activity 30.7692 7 yes
GO:0016462 pyrophosphatase activity 30.7692 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 30.7692 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 30.7692 6 yes
GO:0001664 G protein-coupled receptor binding 23.0769 4 yes
GO:0005525 GTP binding 23.0769 5 yes
GO:0019001 guanyl nucleotide binding 23.0769 6 yes
GO:0032561 guanyl ribonucleotide binding 23.0769 5 yes
GO:0030554 adenyl nucleotide binding 23.0769 6 no
GO:0005159 insulin-like growth factor receptor binding 15.3846 4 yes
GO:0043169 cation binding 15.3846 4 yes
GO:0046872 metal ion binding 15.3846 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GNAS1_HUMAN
GO:0048522 positive regulation of cellular process 53.8462 4 no
GO:0010646 regulation of cell communication 46.1538 4 no
GO:0031323 regulation of cellular metabolic process 38.4615 4 no
GO:0141124 intracellular signaling cassette 38.4615 4 no
GO:0006996 organelle organization 38.4615 4 no
GO:0009966 regulation of signal transduction 38.4615 4 no
GO:0048523 negative regulation of cellular process 38.4615 4 no
GO:1902531 regulation of intracellular signal transduction 38.4615 5 no
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 30.7692 4 yes
GO:0009893 positive regulation of metabolic process 30.7692 4 yes
GO:0008104 protein localization 30.7692 4 no
GO:0009889 regulation of biosynthetic process 30.7692 4 no
GO:0010468 regulation of gene expression 30.7692 6 no
GO:0010556 regulation of macromolecule biosynthetic process 30.7692 5 no
GO:0022607 cellular component assembly 30.7692 4 no
GO:0031326 regulation of cellular biosynthetic process 30.7692 5 no
GO:0034330 cell junction organization 30.7692 4 no
GO:0060255 regulation of macromolecule metabolic process 30.7692 4 no
GO:0007264 small GTPase-mediated signal transduction 30.7692 5 no
GO:0007265 Ras protein signal transduction 30.7692 6 no
GO:0080090 regulation of primary metabolic process 30.7692 4 no
GO:0051128 regulation of cellular component organization 30.7692 4 no
GO:0009967 positive regulation of signal transduction 30.7692 5 no
GO:0010647 positive regulation of cell communication 30.7692 5 no
GO:0023056 positive regulation of signaling 30.7692 4 no
GO:0048584 positive regulation of response to stimulus 30.7692 4 no
GO:1902533 positive regulation of intracellular signal transduction 30.7692 6 no
GO:0042981 regulation of apoptotic process 30.7692 5 no
GO:0043066 negative regulation of apoptotic process 30.7692 6 no
GO:0043067 regulation of programmed cell death 30.7692 4 no
GO:0043069 negative regulation of programmed cell death 30.7692 5 no
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 23.0769 5 yes
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway 23.0769 4 yes
GO:0007600 sensory perception 23.0769 4 yes
GO:0051240 positive regulation of multicellular organismal process 23.0769 4 yes
GO:0009891 positive regulation of biosynthetic process 23.0769 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 23.0769 6 no
GO:0010604 positive regulation of macromolecule metabolic process 23.0769 5 no
GO:0031325 positive regulation of cellular metabolic process 23.0769 5 no
GO:0031328 positive regulation of cellular biosynthetic process 23.0769 6 no
GO:0032970 regulation of actin filament-based process 23.0769 4 no
GO:0051049 regulation of transport 23.0769 4 no
GO:0051050 positive regulation of transport 23.0769 4 no
GO:0072657 protein localization to membrane 23.0769 4 no
GO:0010243 response to organonitrogen compound 23.0769 4 no
GO:0014070 response to organic cyclic compound 23.0769 4 no
GO:0033993 response to lipid 23.0769 4 no
GO:0097305 response to alcohol 23.0769 4 no
GO:0009892 negative regulation of metabolic process 23.0769 4 no
GO:0050808 synapse organization 23.0769 5 no
GO:0051130 positive regulation of cellular component organization 23.0769 5 no
GO:0007010 cytoskeleton organization 23.0769 5 no
GO:0051056 regulation of small GTPase mediated signal transduction 23.0769 6 no
GO:0051246 regulation of protein metabolic process 23.0769 5 no
GO:0008284 positive regulation of cell population proliferation 23.0769 5 no
GO:0042127 regulation of cell population proliferation 23.0769 4 no
GO:0009416 response to light stimulus 23.0769 4 no
GO:0007606 sensory perception of chemical stimulus 15.3846 5 yes
GO:0034109 homotypic cell-cell adhesion 15.3846 4 yes
GO:0070527 platelet aggregation 15.3846 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ARRB1_HUMAN [view entry] [view interactions] Low throughput yes yes
AGRF1_HUMAN [view interactions] Low throughput no no
FZD6_HUMAN [view interactions] Low throughput no yes
GBG2_HUMAN [view entry] [view interactions] Low throughput yes yes
GBB1_HUMAN [view entry] [view interactions] Low throughput yes yes
FZD3_HUMAN [view interactions] Low throughput no yes
JAK3_HUMAN [view interactions] High throughput no no
THOC2_HUMAN [view interactions] High throughput no yes
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
MDEAS_HUMAN [view interactions] High throughput no yes
MAX_HUMAN [view interactions] High throughput no yes
SMC1A_HUMAN [view interactions] High throughput no yes
CATA_HUMAN [view entry] [view interactions] High throughput yes no
LRRK2_HUMAN [view interactions] High throughput no yes
MOT11_HUMAN [view interactions] High throughput no no
HMGA2_HUMAN [view interactions] High throughput no yes
MB212_HUMAN [view interactions] High throughput no no
VAMP5_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
BCKD_HUMAN [view entry] [view interactions] High throughput yes yes
STK3_HUMAN [view interactions] High throughput no yes
PIM3_HUMAN [view interactions] High throughput no no
TBCK_HUMAN [view interactions] High throughput no yes
HASP_HUMAN [view interactions] High throughput no yes
CDKL2_HUMAN [view entry] [view interactions] High throughput yes no
PAK5_HUMAN [view interactions] High throughput no yes
CD81_HUMAN [view interactions] High throughput no no
ANK2_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
NFKB1_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no