GNAS1_HUMAN
Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as GNAS isoforms . [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in GNAS1_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 44.7368 | 4 | yes |
GO:0032555 | purine ribonucleotide binding | 44.7368 | 4 | yes |
GO:0030554 | adenyl nucleotide binding | 31.5789 | 5 | no |
GO:0032559 | adenyl ribonucleotide binding | 31.5789 | 5 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 31.5789 | 4 | yes |
GO:0004930 | G protein-coupled receptor activity | 26.3158 | 4 | no |
GO:0046872 | metal ion binding | 23.6842 | 4 | yes |
GO:0003924 | GTPase activity | 21.0526 | 7 | yes |
GO:0016462 | pyrophosphatase activity | 21.0526 | 5 | yes |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 21.0526 | 4 | yes |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 21.0526 | 6 | yes |
GO:0001664 | G protein-coupled receptor binding | 18.4211 | 4 | yes |
GO:0005525 | GTP binding | 13.1579 | 5 | yes |
GO:0019001 | guanyl nucleotide binding | 13.1579 | 5 | yes |
GO:0032561 | guanyl ribonucleotide binding | 13.1579 | 5 | yes |
GO:0005159 | insulin-like growth factor receptor binding | 5.2632 | 4 | yes |
GO:0031690 | adrenergic receptor binding | 5.2632 | 5 | yes |
GO:0035254 | glutamate receptor binding | 5.2632 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in GNAS1_HUMAN |
---|---|---|---|---|
GO:0048523 | negative regulation of cellular process | 52.6316 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 52.6316 | 4 | no |
GO:0010646 | regulation of cell communication | 52.6316 | 4 | no |
GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 50.0000 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | no |
GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 47.3684 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 39.4737 | 5 | no |
GO:0051049 | regulation of transport | 39.4737 | 4 | no |
GO:0009966 | regulation of signal transduction | 36.8421 | 4 | no |
GO:0010468 | regulation of gene expression | 36.8421 | 5 | no |
GO:0010647 | positive regulation of cell communication | 36.8421 | 5 | no |
GO:0023056 | positive regulation of signaling | 36.8421 | 4 | no |
GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway | 34.2105 | 5 | yes |
GO:0010243 | response to organonitrogen compound | 34.2105 | 4 | no |
GO:0014070 | response to organic cyclic compound | 34.2105 | 4 | no |
GO:0001932 | regulation of protein phosphorylation | 34.2105 | 7 | no |
GO:0019220 | regulation of phosphate metabolic process | 34.2105 | 6 | no |
GO:0031399 | regulation of protein modification process | 34.2105 | 6 | no |
GO:0042325 | regulation of phosphorylation | 34.2105 | 7 | no |
GO:0051174 | regulation of phosphorus metabolic process | 34.2105 | 5 | no |
GO:0009892 | negative regulation of metabolic process | 31.5789 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 31.5789 | 4 | no |
GO:0050804 | modulation of chemical synaptic transmission | 31.5789 | 5 | no |
GO:0099177 | regulation of trans-synaptic signaling | 31.5789 | 4 | no |
GO:0071310 | cellular response to organic substance | 28.9474 | 4 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 28.9474 | 5 | no |
GO:0009889 | regulation of biosynthetic process | 28.9474 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 28.9474 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 28.9474 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 28.9474 | 5 | no |
GO:0051252 | regulation of RNA metabolic process | 28.9474 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 28.9474 | 5 | no |
GO:0009893 | positive regulation of metabolic process | 26.3158 | 4 | yes |
GO:1901701 | cellular response to oxygen-containing compound | 26.3158 | 4 | no |
GO:0031324 | negative regulation of cellular metabolic process | 26.3158 | 5 | no |
GO:0006355 | regulation of DNA-templated transcription | 26.3158 | 6 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 26.3158 | 5 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 26.3158 | 5 | no |
GO:0051050 | positive regulation of transport | 26.3158 | 4 | no |
GO:1902533 | positive regulation of intracellular signal transduction | 26.3158 | 6 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 26.3158 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 26.3158 | 6 | no |
GO:0033993 | response to lipid | 23.6842 | 4 | no |
GO:0071407 | cellular response to organic cyclic compound | 23.6842 | 5 | no |
GO:0050890 | cognition | 23.6842 | 4 | no |
GO:0006796 | phosphate-containing compound metabolic process | 23.6842 | 4 | no |
GO:0022607 | cellular component assembly | 23.6842 | 4 | no |
GO:0043269 | regulation of ion transport | 23.6842 | 5 | no |
GO:0051248 | negative regulation of protein metabolic process | 23.6842 | 6 | no |
GO:0043085 | positive regulation of catalytic activity | 23.6842 | 4 | no |
GO:0043549 | regulation of kinase activity | 23.6842 | 5 | no |
GO:0045859 | regulation of protein kinase activity | 23.6842 | 6 | no |
GO:0051338 | regulation of transferase activity | 23.6842 | 4 | no |
GO:0042127 | regulation of cell population proliferation | 23.6842 | 4 | no |
GO:0051240 | positive regulation of multicellular organismal process | 21.0526 | 4 | yes |
GO:0071417 | cellular response to organonitrogen compound | 21.0526 | 4 | no |
GO:1901699 | cellular response to nitrogen compound | 21.0526 | 4 | no |
GO:0036211 | protein modification process | 21.0526 | 4 | no |
GO:0043412 | macromolecule modification | 21.0526 | 4 | no |
GO:0010648 | negative regulation of cell communication | 21.0526 | 5 | no |
GO:0023057 | negative regulation of signaling | 21.0526 | 4 | no |
GO:0048585 | negative regulation of response to stimulus | 21.0526 | 4 | no |
GO:0032880 | regulation of protein localization | 21.0526 | 5 | no |
GO:0060341 | regulation of cellular localization | 21.0526 | 4 | no |
GO:0003018 | vascular process in circulatory system | 21.0526 | 4 | no |
GO:0044057 | regulation of system process | 21.0526 | 4 | no |
GO:0051046 | regulation of secretion | 21.0526 | 5 | no |
GO:1903530 | regulation of secretion by cell | 21.0526 | 4 | no |
GO:0043086 | negative regulation of catalytic activity | 21.0526 | 4 | no |
GO:0007191 | adenylate cyclase-activating dopamine receptor signaling pathway | 13.1579 | 4 | yes |
GO:0007600 | sensory perception | 13.1579 | 4 | yes |
GO:0120162 | positive regulation of cold-induced thermogenesis | 7.8947 | 4 | yes |
GO:0007606 | sensory perception of chemical stimulus | 5.2632 | 5 | yes |
GO:0034109 | homotypic cell-cell adhesion | 5.2632 | 4 | yes |
GO:0070527 | platelet aggregation | 5.2632 | 5 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
ARRB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
JAK3_HUMAN | [view interactions] | High throughput | no | no |
THOC2_HUMAN | [view interactions] | High throughput | no | yes |
FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MDEAS_HUMAN | [view interactions] | High throughput | no | yes |
MAX_HUMAN | [view interactions] | High throughput | no | yes |
SMC1A_HUMAN | [view interactions] | High throughput | no | yes |
CATA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
MOT11_HUMAN | [view interactions] | High throughput | no | no |
HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
MB212_HUMAN | [view interactions] | High throughput | no | no |
VAMP5_HUMAN | [view interactions] | High throughput | no | no |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
BCKD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STK3_HUMAN | [view interactions] | High throughput | no | yes |
PIM3_HUMAN | [view interactions] | High throughput | no | no |
TBCK_HUMAN | [view interactions] | High throughput | no | yes |
HASP_HUMAN | [view interactions] | High throughput | no | yes |
CDKL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PAK5_HUMAN | [view interactions] | High throughput | no | yes |
CD81_HUMAN | [view interactions] | High throughput | no | no |
NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FPR1_HUMAN | [view interactions] | Computational | no | no |
ADCY8_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ESR1_HUMAN | [view interactions] | Computational | no | no |
P2RY2_HUMAN | [view interactions] | Computational | no | no |
KPCA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ADRB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GBG4_HUMAN | [view interactions] | Computational | no | no |
GNAQ_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
KAP2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GBG1_HUMAN | [view interactions] | Computational | no | no |
PA24C_HUMAN | [view interactions] | Computational | no | yes |
ADCY1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
PA24E_HUMAN | [view interactions] | Computational | no | no |
CXCR4_HUMAN | [view interactions] | Computational | no | no |
VIPR2_HUMAN | [view interactions] | Computational | no | no |
FSHB_HUMAN | [view interactions] | Computational | no | no |
GNRHR_HUMAN | [view interactions] | Computational | no | no |
RPGF3_HUMAN | [view interactions] | Computational | no | yes |
KAPCB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ACM1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GBB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PE2R2_HUMAN | [view interactions] | Computational | no | no |
SECR_HUMAN | [view interactions] | Computational | no | no |
GBB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CRFR1_HUMAN | [view interactions] | Computational | no | yes |
GLR_HUMAN | [view interactions] | Computational | no | no |
GHRHR_HUMAN | [view interactions] | Computational | no | no |
MSHR_HUMAN | [view interactions] | Computational | no | no |
SCTR_HUMAN | [view interactions] | Computational | no | no |
5HT6R_HUMAN | [view interactions] | Computational | no | yes |
CALC_HUMAN | [view interactions] | Computational | no | no |
KAP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CRFR2_HUMAN | [view interactions] | Computational | no | no |
RAMP2_HUMAN | [view interactions] | Computational | no | no |
PA24D_HUMAN | [view interactions] | Computational | no | no |
5HT2C_HUMAN | [view interactions] | Computational | no | no |
OXYR_HUMAN | [view interactions] | Computational | no | no |
OPRM_HUMAN | [view entry] [view interactions] | Computational | yes | no |
ADCY2_HUMAN | [view interactions] | Computational | no | yes |
RIC8B_HUMAN | [view interactions] | Computational | no | yes |
ADA1B_HUMAN | [view interactions] | Computational | no | no |
THRB_HUMAN | [view interactions] | Computational | no | no |
ADCY4_HUMAN | [view interactions] | Computational | no | yes |
AGTR2_HUMAN | [view interactions] | Computational | no | no |
RAMP3_HUMAN | [view interactions] | Computational | no | no |
HRH2_HUMAN | [view interactions] | Computational | no | no |
GBG5_HUMAN | [view interactions] | Computational | no | no |
RAMP1_HUMAN | [view interactions] | Computational | no | no |
PACR_HUMAN | [view interactions] | Computational | no | no |
ADCY3_HUMAN | [view interactions] | Computational | no | yes |
CCL11_HUMAN | [view interactions] | Computational | no | no |
GRM1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ADML_HUMAN | [view interactions] | Computational | no | no |
PA24B_HUMAN | [view interactions] | Computational | no | no |
PI2R_HUMAN | [view interactions] | Computational | no | no |
GNAI1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
LSHR_HUMAN | [view interactions] | Computational | no | no |
AXIN1_HUMAN | [view interactions] | Computational | no | yes |
PTH1R_HUMAN | [view interactions] | Computational | no | no |
CRF_HUMAN | [view interactions] | Computational | no | no |
CALRL_HUMAN | [view interactions] | Computational | no | yes |
RXFP2_HUMAN | [view interactions] | Computational | no | no |
KAPCG_HUMAN | [view interactions] | Computational | no | no |
KAP3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PA24A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
EDN1_HUMAN | [view interactions] | Computational | no | no |
PACA_HUMAN | [view interactions] | Computational | no | no |
GRK4_HUMAN | [view interactions] | Computational | no | yes |
RPGF4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PE2R1_HUMAN | [view interactions] | Computational | no | no |
ADCY9_HUMAN | [view interactions] | Computational | no | yes |
CCR5_HUMAN | [view interactions] | Computational | no | no |
CCR3_HUMAN | [view interactions] | Computational | no | yes |
GBG2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GLP1R_HUMAN | [view interactions] | Computational | no | no |
SDF1_HUMAN | [view interactions] | Computational | no | no |
ESR2_HUMAN | [view interactions] | Computational | no | no |
AA2AR_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
5HT7R_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
IL1A_HUMAN | [view interactions] | Computational | no | no |
CCL4_HUMAN | [view interactions] | Computational | no | no |
ADCY5_HUMAN | [view interactions] | Computational | no | no |
MTG1_HUMAN | [view interactions] | Computational | no | yes |
GNB5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ADRB3_HUMAN | [view interactions] | Computational | no | no |
PAQR5_HUMAN | [view interactions] | Computational | no | no |
PE2R4_HUMAN | [view interactions] | Computational | no | yes |
ADM2_HUMAN | [view interactions] | Computational | no | no |
ANGT_HUMAN | [view interactions] | Computational | no | no |
GLUC_HUMAN | [view interactions] | Computational | no | no |
ADCY7_HUMAN | [view interactions] | Computational | no | yes |
ADCY6_HUMAN | [view interactions] | Computational | no | yes |
MAGD2_HUMAN | [view interactions] | Computational | no | yes |
EDNRA_HUMAN | [view interactions] | Computational | no | yes |
DRD1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
ADRB2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
SRC_HUMAN | [view entry] [view interactions] | Computational | yes | no |
AA2BR_HUMAN | [view interactions] | Computational | no | no |
LPAR4_HUMAN | [view interactions] | Computational | no | no |
GNAL_HUMAN | [view interactions] | Computational | no | yes |
RIC8A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
KAP0_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GP119_HUMAN | [view interactions] | Computational | no | no |
GBB3_HUMAN | [view interactions] | Computational | no | yes |
PE2R3_HUMAN | [view interactions] | Computational | no | no |
PA24F_HUMAN | [view interactions] | Computational | no | no |
GPER1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
DRD5_HUMAN | [view entry] [view interactions] | Computational | yes | no |
GBB4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ACTHR_HUMAN | [view interactions] | Computational | no | no |