Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MAP6_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Involved in microtubule stabilization in many cell types, including neuronal cells . Specifically has microtubule cold stabilizing activity . Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B (PubMed). Regulates KIF5A-mediated axonal cargo transport . Regulates axonal growth during neuron polarization . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in MAP6_HUMAN
GO:0043169 cation binding 48.2759 4 no
GO:0046872 metal ion binding 48.2759 5 no
GO:0019900 kinase binding 44.8276 4 no
GO:0019901 protein kinase binding 37.9310 5 no
GO:0030695 GTPase regulator activity 24.1379 4 no
GO:0000166 nucleotide binding 24.1379 4 no
GO:0017076 purine nucleotide binding 24.1379 5 no
GO:0032555 purine ribonucleotide binding 24.1379 4 no
GO:0043168 anion binding 24.1379 4 no
GO:0016301 kinase activity 20.6897 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 20.6897 4 no
GO:0030554 adenyl nucleotide binding 20.6897 6 no
GO:0032559 adenyl ribonucleotide binding 20.6897 5 no
GO:0035639 purine ribonucleoside triphosphate binding 20.6897 4 no
GO:0005509 calcium ion binding 20.6897 6 no
GO:0015631 tubulin binding 13.7931 4 yes
GO:0008017 microtubule binding 6.8966 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in MAP6_HUMAN
GO:0048522 positive regulation of cellular process 79.3103 4 yes
GO:0010646 regulation of cell communication 75.8621 4 no
GO:0060255 regulation of macromolecule metabolic process 68.9655 4 no
GO:0009966 regulation of signal transduction 65.5172 4 no
GO:0048523 negative regulation of cellular process 65.5172 4 no
GO:0031323 regulation of cellular metabolic process 65.5172 4 no
GO:0051128 regulation of cellular component organization 62.0690 4 yes
GO:0051049 regulation of transport 62.0690 4 no
GO:0080090 regulation of primary metabolic process 58.6207 4 no
GO:0022607 cellular component assembly 51.7241 4 no
GO:0009893 positive regulation of metabolic process 51.7241 4 no
GO:0051246 regulation of protein metabolic process 51.7241 5 no
GO:0006996 organelle organization 48.2759 4 yes
GO:0051050 positive regulation of transport 48.2759 4 no
GO:0010604 positive regulation of macromolecule metabolic process 48.2759 5 no
GO:0031325 positive regulation of cellular metabolic process 48.2759 5 no
GO:0031399 regulation of protein modification process 48.2759 6 no
GO:0019220 regulation of phosphate metabolic process 44.8276 6 no
GO:0042325 regulation of phosphorylation 44.8276 7 no
GO:0051174 regulation of phosphorus metabolic process 44.8276 5 no
GO:0042981 regulation of apoptotic process 41.3793 5 no
GO:0043067 regulation of programmed cell death 41.3793 4 no
GO:0001932 regulation of protein phosphorylation 41.3793 7 no
GO:0048584 positive regulation of response to stimulus 41.3793 4 no
GO:0051247 positive regulation of protein metabolic process 41.3793 6 no
GO:0008104 protein localization 37.9310 4 no
GO:1902531 regulation of intracellular signal transduction 37.9310 5 no
GO:0023056 positive regulation of signaling 37.9310 4 no
GO:0009889 regulation of biosynthetic process 37.9310 4 no
GO:0009892 negative regulation of metabolic process 37.9310 4 no
GO:0010556 regulation of macromolecule biosynthetic process 37.9310 5 no
GO:0010562 positive regulation of phosphorus metabolic process 37.9310 6 no
GO:0010605 negative regulation of macromolecule metabolic process 37.9310 5 no
GO:0031326 regulation of cellular biosynthetic process 37.9310 5 no
GO:0042327 positive regulation of phosphorylation 37.9310 8 no
GO:0045937 positive regulation of phosphate metabolic process 37.9310 7 no
GO:0031344 regulation of cell projection organization 34.4828 5 yes
GO:0033043 regulation of organelle organization 34.4828 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 34.4828 6 yes
GO:0048585 negative regulation of response to stimulus 34.4828 4 no
GO:0050804 modulation of chemical synaptic transmission 34.4828 5 no
GO:0099177 regulation of trans-synaptic signaling 34.4828 4 no
GO:0141124 intracellular signaling cassette 34.4828 4 no
GO:0010647 positive regulation of cell communication 34.4828 5 no
GO:0001934 positive regulation of protein phosphorylation 34.4828 8 no
GO:0010468 regulation of gene expression 34.4828 6 no
GO:0031324 negative regulation of cellular metabolic process 34.4828 5 no
GO:0031401 positive regulation of protein modification process 34.4828 7 no
GO:0034762 regulation of transmembrane transport 34.4828 4 no
GO:0043269 regulation of monoatomic ion transport 34.4828 5 no
GO:0022603 regulation of anatomical structure morphogenesis 31.0345 4 yes
GO:0051130 positive regulation of cellular component organization 31.0345 5 yes
GO:0051240 positive regulation of multicellular organismal process 31.0345 4 yes
GO:0043066 negative regulation of apoptotic process 31.0345 6 no
GO:0043069 negative regulation of programmed cell death 31.0345 5 no
GO:0050890 cognition 31.0345 4 no
GO:0051129 negative regulation of cellular component organization 31.0345 5 no
GO:0043933 protein-containing complex organization 31.0345 4 no
GO:0044087 regulation of cellular component biogenesis 31.0345 4 no
GO:0060341 regulation of cellular localization 31.0345 4 no
GO:0036211 protein modification process 31.0345 4 no
GO:0043085 positive regulation of catalytic activity 31.0345 4 no
GO:0043412 macromolecule modification 31.0345 4 no
GO:0051248 negative regulation of protein metabolic process 31.0345 6 no
GO:0051338 regulation of transferase activity 31.0345 4 no
GO:0060627 regulation of vesicle-mediated transport 31.0345 4 no
GO:0010959 regulation of metal ion transport 31.0345 6 no
GO:0034764 positive regulation of transmembrane transport 31.0345 5 no
GO:0034765 regulation of monoatomic ion transmembrane transport 31.0345 5 no
GO:0043270 positive regulation of monoatomic ion transport 31.0345 5 no
GO:0051924 regulation of calcium ion transport 31.0345 7 no
GO:0030030 cell projection organization 27.5862 4 yes
GO:0051094 positive regulation of developmental process 27.5862 4 yes
GO:2000026 regulation of multicellular organismal development 27.5862 4 yes
GO:0010038 response to metal ion 27.5862 4 no
GO:0009968 negative regulation of signal transduction 27.5862 5 no
GO:0010648 negative regulation of cell communication 27.5862 5 no
GO:0023057 negative regulation of signaling 27.5862 4 no
GO:0034330 cell junction organization 27.5862 4 no
GO:0032880 regulation of protein localization 27.5862 5 no
GO:0098657 import into cell 27.5862 4 no
GO:0006796 phosphate-containing compound metabolic process 27.5862 4 no
GO:0032101 regulation of response to external stimulus 27.5862 4 no
GO:0043549 regulation of kinase activity 27.5862 5 no
GO:0051336 regulation of hydrolase activity 27.5862 4 no
GO:0051347 positive regulation of transferase activity 27.5862 5 no
GO:0034767 positive regulation of monoatomic ion transmembrane transport 27.5862 6 no
GO:0051279 regulation of release of sequestered calcium ion into cytosol 27.5862 5 no
GO:0051282 regulation of sequestering of calcium ion 27.5862 4 no
GO:0051928 positive regulation of calcium ion transport 27.5862 6 no
GO:1903169 regulation of calcium ion transmembrane transport 27.5862 7 no
GO:1904062 regulation of monoatomic cation transmembrane transport 27.5862 6 no
GO:0010975 regulation of neuron projection development 24.1379 7 yes
GO:0045595 regulation of cell differentiation 24.1379 4 yes
GO:0043065 positive regulation of apoptotic process 24.1379 6 no
GO:0043068 positive regulation of programmed cell death 24.1379 5 no
GO:0065003 protein-containing complex assembly 24.1379 5 no
GO:0009890 negative regulation of biosynthetic process 24.1379 5 no
GO:0009967 positive regulation of signal transduction 24.1379 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 24.1379 6 no
GO:0031327 negative regulation of cellular biosynthetic process 24.1379 6 no
GO:0033674 positive regulation of kinase activity 24.1379 6 no
GO:0044057 regulation of system process 24.1379 4 no
GO:0045859 regulation of protein kinase activity 24.1379 6 no
GO:0071310 cellular response to organic substance 24.1379 4 no
GO:0080134 regulation of response to stress 24.1379 4 no
GO:0022898 regulation of transmembrane transporter activity 24.1379 4 no
GO:0031400 negative regulation of protein modification process 24.1379 7 no
GO:1904064 positive regulation of cation transmembrane transport 24.1379 7 no
GO:1904427 positive regulation of calcium ion transmembrane transport 24.1379 7 no
GO:0071702 organic substance transport 24.1379 4 no
GO:0071705 nitrogen compound transport 24.1379 4 no
GO:0009894 regulation of catabolic process 24.1379 4 no
GO:0050767 regulation of neurogenesis 20.6897 6 yes
GO:0051493 regulation of cytoskeleton organization 20.6897 6 yes
GO:0051960 regulation of nervous system development 20.6897 5 yes
GO:0060284 regulation of cell development 20.6897 5 yes
GO:0006811 monoatomic ion transport 20.6897 4 no
GO:0006812 monoatomic cation transport 20.6897 5 no
GO:0030001 metal ion transport 20.6897 6 no
GO:0006915 apoptotic process 20.6897 4 no
GO:0120036 plasma membrane bounded cell projection organization 20.6897 5 no
GO:0050807 regulation of synapse organization 20.6897 5 no
GO:0051046 regulation of secretion 20.6897 5 no
GO:0061024 membrane organization 20.6897 4 no
GO:1903829 positive regulation of protein localization 20.6897 5 no
GO:0009891 positive regulation of biosynthetic process 20.6897 5 no
GO:0010638 positive regulation of organelle organization 20.6897 6 no
GO:0016310 phosphorylation 20.6897 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 20.6897 5 no
GO:0030334 regulation of cell migration 20.6897 5 no
GO:0031328 positive regulation of cellular biosynthetic process 20.6897 6 no
GO:0034097 response to cytokine 20.6897 4 no
GO:0042127 regulation of cell population proliferation 20.6897 4 no
GO:0044089 positive regulation of cellular component biogenesis 20.6897 5 no
GO:0045860 positive regulation of protein kinase activity 20.6897 7 no
GO:0050776 regulation of immune response 20.6897 4 no
GO:0071900 regulation of protein serine/threonine kinase activity 20.6897 7 no
GO:1901701 cellular response to oxygen-containing compound 20.6897 4 no
GO:2000145 regulation of cell motility 20.6897 4 no
GO:0010563 negative regulation of phosphorus metabolic process 20.6897 6 no
GO:0019722 calcium-mediated signaling 20.6897 5 no
GO:0032411 positive regulation of transporter activity 20.6897 4 no
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 20.6897 5 no
GO:0032414 positive regulation of ion transmembrane transporter activity 20.6897 5 no
GO:0042326 negative regulation of phosphorylation 20.6897 8 no
GO:0045936 negative regulation of phosphate metabolic process 20.6897 7 no
GO:0051051 negative regulation of transport 20.6897 4 no
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 20.6897 6 no
GO:0015031 protein transport 20.6897 4 no
GO:0007010 cytoskeleton organization 17.2414 5 yes
GO:0031346 positive regulation of cell projection organization 17.2414 6 yes
GO:0048812 neuron projection morphogenesis 17.2414 5 yes
GO:0050770 regulation of axonogenesis 17.2414 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 17.2414 4 yes
GO:0010720 positive regulation of cell development 13.7931 6 yes
GO:0045597 positive regulation of cell differentiation 13.7931 5 yes
GO:0050769 positive regulation of neurogenesis 13.7931 6 yes
GO:0051962 positive regulation of nervous system development 13.7931 5 yes
GO:0030705 cytoskeleton-dependent intracellular transport 10.3448 4 yes
GO:0032886 regulation of microtubule-based process 10.3448 4 yes
GO:0050772 positive regulation of axonogenesis 10.3448 6 yes
GO:0070507 regulation of microtubule cytoskeleton organization 10.3448 5 yes
GO:0048813 dendrite morphogenesis 6.8966 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
T106B_HUMAN [view interactions] Low throughput no yes
RAB7A_HUMAN [view entry] [view interactions] Low throughput yes yes
ITSN1_HUMAN [view entry] [view interactions] Low throughput yes yes
P85A_HUMAN [view interactions] Low throughput no yes
PLCG1_HUMAN [view entry] [view interactions] Low throughput yes yes
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
KCMA1_HUMAN [view entry] [view interactions] High throughput yes no
PSN1_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
SNP25_HUMAN [view entry] [view interactions] High throughput yes yes
HERC2_HUMAN [view interactions] High throughput no yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
RIMS1_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
ANK2_HUMAN [view entry] [view interactions] High throughput yes yes
DYR1A_HUMAN [view interactions] High throughput no yes
SOX4_HUMAN [view interactions] High throughput no yes
RARB_HUMAN [view interactions] High throughput no yes
RARG_HUMAN [view interactions] High throughput no yes
GRSF1_HUMAN [view interactions] High throughput no yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
TIA1_HUMAN [view interactions] High throughput no no
ACK1_HUMAN [view entry] [view interactions] High throughput yes yes
SLX4I_HUMAN [view interactions] High throughput no yes
PLXD1_HUMAN [view interactions] High throughput no yes
NRP1_HUMAN [view entry] [view interactions] High throughput yes yes
VGFR2_HUMAN [view interactions] High throughput no no
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
TMM79_HUMAN [view interactions] High throughput no no
PEG10_HUMAN [view interactions] High throughput no no
ATG5_HUMAN [view entry] [view interactions] High throughput yes no
UBP48_HUMAN [view interactions] High throughput no yes
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
CDKA2_HUMAN [view interactions] High throughput no no
TBB5_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes