Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MAP6_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Involved in microtubule stabilization in many cell types, including neuronal cells . Specifically has microtubule cold stabilizing activity . Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B (PubMed). Regulates KIF5A-mediated axonal cargo transport . Regulates axonal growth during neuron polarization . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in MAP6_HUMAN
GO:0019900 kinase binding 52.3810 4 no
GO:0046872 metal ion binding 47.6190 4 no
GO:0019901 protein kinase binding 42.8571 5 no
GO:0005509 calcium ion binding 28.5714 5 no
GO:0019887 protein kinase regulator activity 23.8095 4 no
GO:0016301 kinase activity 23.8095 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 23.8095 4 no
GO:0017076 purine nucleotide binding 23.8095 4 no
GO:0032555 purine ribonucleotide binding 23.8095 4 no
GO:0035639 purine ribonucleoside triphosphate binding 23.8095 4 no
GO:0015631 tubulin binding 19.0476 4 yes
GO:0008017 microtubule binding 9.5238 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in MAP6_HUMAN
GO:0048522 positive regulation of cellular process 85.7143 4 yes
GO:0010646 regulation of cell communication 76.1905 4 no
GO:0060255 regulation of macromolecule metabolic process 71.4286 4 no
GO:0080090 regulation of primary metabolic process 71.4286 4 no
GO:0009966 regulation of signal transduction 71.4286 4 no
GO:0051171 regulation of nitrogen compound metabolic process 71.4286 4 no
GO:0051049 regulation of transport 66.6667 4 no
GO:0031323 regulation of cellular metabolic process 66.6667 4 no
GO:0048523 negative regulation of cellular process 66.6667 4 no
GO:0051246 regulation of protein metabolic process 61.9048 5 no
GO:0006996 organelle organization 61.9048 4 yes
GO:0051128 regulation of cellular component organization 61.9048 4 yes
GO:0051174 regulation of phosphorus metabolic process 57.1429 5 no
GO:0009893 positive regulation of metabolic process 57.1429 4 no
GO:0010941 regulation of cell death 57.1429 4 no
GO:0019220 regulation of phosphate metabolic process 57.1429 6 no
GO:0031399 regulation of protein modification process 57.1429 6 no
GO:0042325 regulation of phosphorylation 57.1429 7 no
GO:0051173 positive regulation of nitrogen compound metabolic process 52.3810 5 no
GO:0051247 positive regulation of protein metabolic process 52.3810 6 no
GO:1902531 regulation of intracellular signal transduction 52.3810 5 no
GO:0042981 regulation of apoptotic process 52.3810 6 no
GO:0043067 regulation of programmed cell death 52.3810 5 no
GO:0001932 regulation of protein phosphorylation 52.3810 7 no
GO:0010604 positive regulation of macromolecule metabolic process 52.3810 5 no
GO:0031325 positive regulation of cellular metabolic process 52.3810 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 47.6190 5 no
GO:0051338 regulation of transferase activity 47.6190 4 no
GO:0051050 positive regulation of transport 47.6190 4 no
GO:0009892 negative regulation of metabolic process 47.6190 4 no
GO:0010562 positive regulation of phosphorus metabolic process 47.6190 6 no
GO:0010605 negative regulation of macromolecule metabolic process 47.6190 5 no
GO:0042327 positive regulation of phosphorylation 47.6190 8 no
GO:0045937 positive regulation of phosphate metabolic process 47.6190 7 no
GO:0051248 negative regulation of protein metabolic process 42.8571 6 no
GO:0051336 regulation of hydrolase activity 42.8571 4 no
GO:0051347 positive regulation of transferase activity 42.8571 5 no
GO:0043269 regulation of ion transport 42.8571 5 no
GO:0001934 positive regulation of protein phosphorylation 42.8571 8 no
GO:0031401 positive regulation of protein modification process 42.8571 7 no
GO:0022607 cellular component assembly 42.8571 4 no
GO:0050804 modulation of chemical synaptic transmission 42.8571 5 no
GO:0099177 regulation of trans-synaptic signaling 42.8571 4 no
GO:0010942 positive regulation of cell death 42.8571 5 no
GO:0031324 negative regulation of cellular metabolic process 42.8571 5 no
GO:0043085 positive regulation of catalytic activity 42.8571 4 no
GO:0043549 regulation of kinase activity 42.8571 5 no
GO:0071310 cellular response to organic substance 38.0952 4 no
GO:0034762 regulation of transmembrane transport 38.0952 4 no
GO:0034765 regulation of ion transmembrane transport 38.0952 5 no
GO:0043065 positive regulation of apoptotic process 38.0952 7 no
GO:0043068 positive regulation of programmed cell death 38.0952 6 no
GO:0043270 positive regulation of ion transport 38.0952 5 no
GO:0045859 regulation of protein kinase activity 38.0952 6 no
GO:0008104 protein localization 38.0952 4 no
GO:0033043 regulation of organelle organization 38.0952 5 yes
GO:0051130 positive regulation of cellular component organization 38.0952 5 yes
GO:0016192 vesicle-mediated transport 38.0952 4 no
GO:0033674 positive regulation of kinase activity 38.0952 6 no
GO:0036211 protein modification process 38.0952 4 no
GO:0043412 macromolecule modification 38.0952 4 no
GO:0006796 phosphate-containing compound metabolic process 33.3333 4 no
GO:0010959 regulation of metal ion transport 33.3333 6 no
GO:0034764 positive regulation of transmembrane transport 33.3333 5 no
GO:0034767 positive regulation of ion transmembrane transport 33.3333 6 no
GO:0048584 positive regulation of response to stimulus 33.3333 4 no
GO:0048585 negative regulation of response to stimulus 33.3333 4 no
GO:0051924 regulation of calcium ion transport 33.3333 7 no
GO:0051928 positive regulation of calcium ion transport 33.3333 6 no
GO:0045860 positive regulation of protein kinase activity 33.3333 7 no
GO:0071900 regulation of protein serine/threonine kinase activity 33.3333 7 no
GO:0043066 negative regulation of apoptotic process 33.3333 7 no
GO:0043069 negative regulation of programmed cell death 33.3333 6 no
GO:0060548 negative regulation of cell death 33.3333 5 no
GO:0031344 regulation of cell projection organization 33.3333 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 33.3333 6 yes
GO:0010647 positive regulation of cell communication 33.3333 5 no
GO:0023056 positive regulation of signaling 33.3333 4 no
GO:0010038 response to metal ion 33.3333 4 no
GO:0010468 regulation of gene expression 33.3333 5 no
GO:0010563 negative regulation of phosphorus metabolic process 33.3333 6 no
GO:0031400 negative regulation of protein modification process 33.3333 7 no
GO:0045936 negative regulation of phosphate metabolic process 33.3333 7 no
GO:0070848 response to growth factor 28.5714 4 no
GO:1901701 cellular response to oxygen-containing compound 28.5714 4 no
GO:0051279 regulation of release of sequestered calcium ion into cytosol 28.5714 5 no
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 28.5714 6 no
GO:0051282 regulation of sequestering of calcium ion 28.5714 4 no
GO:1903169 regulation of calcium ion transmembrane transport 28.5714 7 no
GO:1904062 regulation of cation transmembrane transport 28.5714 6 no
GO:1904064 positive regulation of cation transmembrane transport 28.5714 7 no
GO:1904427 positive regulation of calcium ion transmembrane transport 28.5714 7 no
GO:0035303 regulation of dephosphorylation 28.5714 7 no
GO:0071902 positive regulation of protein serine/threonine kinase activity 28.5714 8 no
GO:0009968 negative regulation of signal transduction 28.5714 5 no
GO:0010648 negative regulation of cell communication 28.5714 5 no
GO:0023057 negative regulation of signaling 28.5714 4 no
GO:0009889 regulation of biosynthetic process 28.5714 4 no
GO:0010243 response to organonitrogen compound 28.5714 4 no
GO:0010556 regulation of macromolecule biosynthetic process 28.5714 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 28.5714 5 no
GO:0031326 regulation of cellular biosynthetic process 28.5714 5 no
GO:0071702 organic substance transport 28.5714 4 no
GO:0071705 nitrogen compound transport 28.5714 4 no
GO:0060627 regulation of vesicle-mediated transport 28.5714 4 no
GO:0007010 cytoskeleton organization 28.5714 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 28.5714 4 yes
GO:0051094 positive regulation of developmental process 28.5714 4 yes
GO:0051240 positive regulation of multicellular organismal process 28.5714 4 yes
GO:0050890 cognition 28.5714 4 no
GO:0060341 regulation of cellular localization 28.5714 4 no
GO:0009894 regulation of catabolic process 28.5714 4 no
GO:0010638 positive regulation of organelle organization 28.5714 6 no
GO:0042326 negative regulation of phosphorylation 28.5714 8 no
GO:0043086 negative regulation of catalytic activity 28.5714 4 no
GO:0044087 regulation of cellular component biogenesis 28.5714 4 no
GO:0044089 positive regulation of cellular component biogenesis 28.5714 5 no
GO:0051129 negative regulation of cellular component organization 28.5714 5 no
GO:0051345 positive regulation of hydrolase activity 23.8095 5 no
GO:0071363 cellular response to growth factor stimulus 23.8095 5 no
GO:0080134 regulation of response to stress 23.8095 4 no
GO:1901214 regulation of neuron death 23.8095 5 no
GO:0019722 calcium-mediated signaling 23.8095 5 no
GO:0019932 second-messenger-mediated signaling 23.8095 4 no
GO:0030334 regulation of cell migration 23.8095 5 no
GO:0032101 regulation of response to external stimulus 23.8095 4 no
GO:2000145 regulation of cell motility 23.8095 4 no
GO:0001933 negative regulation of protein phosphorylation 23.8095 8 no
GO:0010921 regulation of phosphatase activity 23.8095 5 no
GO:0022898 regulation of transmembrane transporter activity 23.8095 4 no
GO:0035304 regulation of protein dephosphorylation 23.8095 7 no
GO:0043666 regulation of phosphoprotein phosphatase activity 23.8095 6 no
GO:0044057 regulation of system process 23.8095 4 no
GO:0051051 negative regulation of transport 23.8095 4 no
GO:0051099 positive regulation of binding 23.8095 4 no
GO:0051726 regulation of cell cycle 23.8095 4 no
GO:0006811 ion transport 23.8095 4 no
GO:0006812 cation transport 23.8095 5 no
GO:0006355 regulation of DNA-templated transcription 23.8095 6 no
GO:0015031 protein transport 23.8095 4 no
GO:0043408 regulation of MAPK cascade 23.8095 6 no
GO:0051252 regulation of RNA metabolic process 23.8095 5 no
GO:0071417 cellular response to organonitrogen compound 23.8095 4 no
GO:1901699 cellular response to nitrogen compound 23.8095 4 no
GO:1903506 regulation of nucleic acid-templated transcription 23.8095 7 no
GO:2001141 regulation of RNA biosynthetic process 23.8095 6 no
GO:0006468 protein phosphorylation 23.8095 5 no
GO:0014070 response to organic cyclic compound 23.8095 4 no
GO:0016310 phosphorylation 23.8095 5 no
GO:0010975 regulation of neuron projection development 23.8095 7 yes
GO:0030030 cell projection organization 23.8095 4 yes
GO:0031346 positive regulation of cell projection organization 23.8095 6 yes
GO:0045595 regulation of cell differentiation 23.8095 4 yes
GO:0051493 regulation of cytoskeleton organization 23.8095 6 yes
GO:2000026 regulation of multicellular organismal development 23.8095 4 yes
GO:0006897 endocytosis 23.8095 5 no
GO:0032880 regulation of protein localization 23.8095 5 no
GO:0043933 protein-containing complex organization 23.8095 4 no
GO:0051046 regulation of secretion 23.8095 5 no
GO:0061024 membrane organization 23.8095 4 no
GO:1903530 regulation of secretion by cell 23.8095 4 no
GO:0050848 regulation of calcium-mediated signaling 23.8095 6 no
GO:0050767 regulation of neurogenesis 19.0476 6 yes
GO:0050770 regulation of axonogenesis 19.0476 5 yes
GO:0051960 regulation of nervous system development 19.0476 5 yes
GO:0060284 regulation of cell development 19.0476 5 yes
GO:0010720 positive regulation of cell development 14.2857 6 yes
GO:0030705 cytoskeleton-dependent intracellular transport 14.2857 4 yes
GO:0032886 regulation of microtubule-based process 14.2857 4 yes
GO:0045597 positive regulation of cell differentiation 14.2857 5 yes
GO:0050769 positive regulation of neurogenesis 14.2857 6 yes
GO:0050772 positive regulation of axonogenesis 14.2857 6 yes
GO:0051962 positive regulation of nervous system development 14.2857 5 yes
GO:0070507 regulation of microtubule cytoskeleton organization 14.2857 5 yes
GO:0032990 cell part morphogenesis 9.5238 4 yes
GO:0048812 neuron projection morphogenesis 9.5238 7 yes
GO:0048813 dendrite morphogenesis 9.5238 8 yes
GO:0048858 cell projection morphogenesis 9.5238 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 9.5238 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in MAP6_HUMAN
DOID:0050700 cardiomyopathy 9.5238 4 no
DOID:0060036 intrinsic cardiomyopathy 9.5238 5 no
DOID:114 heart disease 9.5238 3 no
DOID:2843 long QT syndrome 9.5238 6 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
T106B_HUMAN [view interactions] Low throughput no yes
RAB7A_HUMAN [view entry] [view interactions] Low throughput yes yes
ITSN1_HUMAN [view entry] [view interactions] Low throughput yes yes
P85A_HUMAN [view interactions] Low throughput no yes
PLCG1_HUMAN [view entry] [view interactions] Low throughput yes yes
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
KCMA1_HUMAN [view entry] [view interactions] High throughput yes no
PSN1_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
SNP25_HUMAN [view entry] [view interactions] High throughput yes yes
HERC2_HUMAN [view interactions] High throughput no yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
RARB_HUMAN [view interactions] High throughput no yes
RARG_HUMAN [view interactions] High throughput no yes
GRSF1_HUMAN [view interactions] High throughput no yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
TIA1_HUMAN [view interactions] High throughput no no
ACK1_HUMAN [view interactions] High throughput no yes
SLX4I_HUMAN [view interactions] High throughput no yes
PLXD1_HUMAN [view interactions] High throughput no yes
NRP1_HUMAN [view entry] [view interactions] High throughput yes yes
VGFR2_HUMAN [view interactions] High throughput no no
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
TMM79_HUMAN [view interactions] High throughput no no
PEG10_HUMAN [view interactions] High throughput no no
TBB5_HUMAN [view interactions] High throughput no yes