LFG2_HUMAN
Evidence for PS localization
Functions
Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
No data found.
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in LFG2_HUMAN |
|---|---|---|---|---|
| GO:0009966 | regulation of signal transduction | 75.0000 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 75.0000 | 5 | yes |
| GO:0010646 | regulation of cell communication | 75.0000 | 4 | yes |
| GO:0010648 | negative regulation of cell communication | 75.0000 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 75.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 75.0000 | 4 | yes |
| GO:0048585 | negative regulation of response to stimulus | 75.0000 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 50.0000 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 50.0000 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 50.0000 | 4 | no |
| GO:0023056 | positive regulation of signaling | 50.0000 | 4 | no |
| GO:0030947 | regulation of vascular endothelial growth factor receptor signaling pathway | 50.0000 | 5 | no |
| GO:0030948 | negative regulation of vascular endothelial growth factor receptor signaling pathway | 50.0000 | 6 | no |
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 50.0000 | 4 | no |
| GO:0090287 | regulation of cellular response to growth factor stimulus | 50.0000 | 4 | no |
| GO:0090288 | negative regulation of cellular response to growth factor stimulus | 50.0000 | 5 | no |
| GO:0098657 | import into cell | 50.0000 | 4 | no |
| GO:0006508 | proteolysis | 50.0000 | 4 | no |
| GO:0009057 | macromolecule catabolic process | 50.0000 | 4 | no |
| GO:0016567 | protein ubiquitination | 50.0000 | 8 | no |
| GO:0019941 | modification-dependent protein catabolic process | 50.0000 | 6 | no |
| GO:0032446 | protein modification by small protein conjugation | 50.0000 | 7 | no |
| GO:0036211 | protein modification process | 50.0000 | 4 | no |
| GO:0043412 | macromolecule modification | 50.0000 | 4 | no |
| GO:0043632 | modification-dependent macromolecule catabolic process | 50.0000 | 5 | no |
| GO:0043687 | post-translational protein modification | 50.0000 | 5 | no |
| GO:0051603 | proteolysis involved in protein catabolic process | 50.0000 | 5 | no |
| GO:0070647 | protein modification by small protein conjugation or removal | 50.0000 | 6 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TNR6_HUMAN | [view interactions] | Low throughput | no | no |
| RO52_HUMAN | [view interactions] | Low throughput | no | yes |
| B2CL1_HUMAN | [view interactions] | Low throughput | no | yes |
| BCL2_HUMAN | [view interactions] | Low throughput | no | no |
| STK11_HUMAN | [view interactions] | High throughput | no | yes |
| GGT6_HUMAN | [view interactions] | High throughput | no | yes |
| EPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LEG7_HUMAN | [view interactions] | High throughput | no | no |
| NEDD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S22A2_HUMAN | [view interactions] | High throughput | no | no |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |