Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SPIR1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed, PubMed). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (PubMed). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed). Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SPIR1_HUMAN
GO:0019900 kinase binding 46.6667 4 no
GO:0019901 protein kinase binding 46.6667 5 no
GO:0000166 nucleotide binding 26.6667 4 no
GO:0005524 ATP binding 26.6667 5 no
GO:0017076 purine nucleotide binding 26.6667 5 no
GO:0030554 adenyl nucleotide binding 26.6667 6 no
GO:0032555 purine ribonucleotide binding 26.6667 4 no
GO:0032559 adenyl ribonucleotide binding 26.6667 5 no
GO:0035639 purine ribonucleoside triphosphate binding 26.6667 4 no
GO:0043168 anion binding 26.6667 4 no
GO:0004860 protein kinase inhibitor activity 26.6667 5 no
GO:0019210 kinase inhibitor activity 26.6667 4 no
GO:0019887 protein kinase regulator activity 26.6667 4 no
GO:0045296 cadherin binding 26.6667 4 no
GO:0045309 protein phosphorylated amino acid binding 26.6667 4 no
GO:0050815 phosphoserine residue binding 26.6667 5 no
GO:0003779 actin binding 20.0000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SPIR1_HUMAN
GO:0060255 regulation of macromolecule metabolic process 80.0000 4 yes
GO:0008104 protein localization 73.3333 4 yes
GO:0080090 regulation of primary metabolic process 73.3333 4 yes
GO:0048523 negative regulation of cellular process 73.3333 4 no
GO:0048522 positive regulation of cellular process 66.6667 4 yes
GO:0031323 regulation of cellular metabolic process 66.6667 4 no
GO:0006996 organelle organization 53.3333 4 yes
GO:0051128 regulation of cellular component organization 53.3333 4 yes
GO:0009892 negative regulation of metabolic process 53.3333 4 no
GO:0010605 negative regulation of macromolecule metabolic process 53.3333 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 46.6667 5 yes
GO:0051246 regulation of protein metabolic process 46.6667 5 no
GO:0031324 negative regulation of cellular metabolic process 46.6667 5 no
GO:0009893 positive regulation of metabolic process 40.0000 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 40.0000 5 yes
GO:0080134 regulation of response to stress 40.0000 4 yes
GO:0051248 negative regulation of protein metabolic process 40.0000 6 no
GO:0009889 regulation of biosynthetic process 40.0000 4 no
GO:0010468 regulation of gene expression 40.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 40.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 40.0000 5 no
GO:0051049 regulation of transport 40.0000 4 no
GO:0019220 regulation of phosphate metabolic process 40.0000 6 no
GO:0031399 regulation of protein modification process 40.0000 6 no
GO:0051174 regulation of phosphorus metabolic process 40.0000 5 no
GO:0007010 cytoskeleton organization 33.3333 5 yes
GO:0015031 protein transport 33.3333 4 yes
GO:0022607 cellular component assembly 33.3333 4 yes
GO:0048584 positive regulation of response to stimulus 33.3333 4 yes
GO:0071702 organic substance transport 33.3333 4 yes
GO:0071705 nitrogen compound transport 33.3333 4 yes
GO:0042981 regulation of apoptotic process 33.3333 5 no
GO:0043067 regulation of programmed cell death 33.3333 4 no
GO:0006355 regulation of DNA-templated transcription 33.3333 7 no
GO:0010646 regulation of cell communication 33.3333 4 no
GO:0045595 regulation of cell differentiation 33.3333 4 no
GO:0051252 regulation of RNA metabolic process 33.3333 5 no
GO:2001141 regulation of RNA biosynthetic process 33.3333 6 no
GO:0010563 negative regulation of phosphorus metabolic process 33.3333 6 no
GO:0031400 negative regulation of protein modification process 33.3333 7 no
GO:0045936 negative regulation of phosphate metabolic process 33.3333 7 no
GO:0022603 regulation of anatomical structure morphogenesis 26.6667 4 yes
GO:0033043 regulation of organelle organization 26.6667 5 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 26.6667 5 yes
GO:0051094 positive regulation of developmental process 26.6667 4 yes
GO:0071310 cellular response to organic substance 26.6667 4 no
GO:0021762 substantia nigra development 26.6667 4 no
GO:0031325 positive regulation of cellular metabolic process 26.6667 5 no
GO:0034762 regulation of transmembrane transport 26.6667 4 no
GO:0006605 protein targeting 26.6667 4 no
GO:0009966 regulation of signal transduction 26.6667 4 no
GO:0009968 negative regulation of signal transduction 26.6667 5 no
GO:0010648 negative regulation of cell communication 26.6667 5 no
GO:0023057 negative regulation of signaling 26.6667 4 no
GO:0048585 negative regulation of response to stimulus 26.6667 4 no
GO:0032880 regulation of protein localization 26.6667 5 no
GO:0051726 regulation of cell cycle 26.6667 4 no
GO:0060341 regulation of cellular localization 26.6667 4 no
GO:0001932 regulation of protein phosphorylation 26.6667 7 no
GO:0042325 regulation of phosphorylation 26.6667 7 no
GO:0043549 regulation of kinase activity 26.6667 5 no
GO:0045859 regulation of protein kinase activity 26.6667 6 no
GO:0051338 regulation of transferase activity 26.6667 4 no
GO:0006282 regulation of DNA repair 20.0000 5 yes
GO:0045739 positive regulation of DNA repair 20.0000 5 yes
GO:0051052 regulation of DNA metabolic process 20.0000 5 yes
GO:0051054 positive regulation of DNA metabolic process 20.0000 6 yes
GO:0061640 cytoskeleton-dependent cytokinesis 20.0000 4 yes
GO:0080135 regulation of cellular response to stress 20.0000 4 yes
GO:2000779 regulation of double-strand break repair 20.0000 6 yes
GO:2000781 positive regulation of double-strand break repair 20.0000 6 yes
GO:0007015 actin filament organization 13.3333 5 yes
GO:0010821 regulation of mitochondrion organization 13.3333 6 yes
GO:0030046 parallel actin filament bundle assembly 13.3333 6 yes
GO:0040038 polar body extrusion after meiotic divisions 13.3333 4 yes
GO:0043933 protein-containing complex organization 13.3333 4 yes
GO:0051017 actin filament bundle assembly 13.3333 5 yes
GO:0051293 establishment of spindle localization 13.3333 4 yes
GO:0061024 membrane organization 13.3333 4 yes
GO:0061572 actin filament bundle organization 13.3333 6 yes
GO:0070649 formin-nucleated actin cable assembly 13.3333 7 yes
GO:0097435 supramolecular fiber organization 13.3333 4 yes
GO:0110009 formin-nucleated actin cable organization 13.3333 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NPHP4_HUMAN [view interactions] Low throughput no yes
FMN2_HUMAN [view entry] [view interactions] Low throughput yes no
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
BCAR1_HUMAN [view interactions] High throughput no yes
BBS4_HUMAN [view interactions] High throughput no no
AT1A3_HUMAN [view entry] [view interactions] High throughput yes no
PECA1_HUMAN [view interactions] High throughput no no
PLD1_HUMAN [view interactions] High throughput no no
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
ESR1_HUMAN [view interactions] High throughput no no
CBY1_HUMAN [view interactions] High throughput no no
FBW1B_HUMAN [view interactions] High throughput no yes
BCL7A_HUMAN [view interactions] High throughput no yes
BCL7C_HUMAN [view interactions] High throughput no yes
TMOD3_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
ACTC_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
TOP3B_HUMAN [view interactions] High throughput no no
MTCH2_HUMAN [view entry] [view interactions] High throughput yes yes