Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TTC7B_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, plays a central role in bridging PI4KA to EFR3B and FAM126A, via direct interactions (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in TTC7B_HUMAN
GO:0017076 purine nucleotide binding 28.5714 4 no
GO:0032555 purine ribonucleotide binding 28.5714 4 no
GO:0035639 purine ribonucleoside triphosphate binding 28.5714 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in TTC7B_HUMAN
GO:0006644 phospholipid metabolic process 57.1429 4 yes
GO:0006650 glycerophospholipid metabolic process 57.1429 5 yes
GO:0006661 phosphatidylinositol biosynthetic process 57.1429 6 yes
GO:0006796 phosphate-containing compound metabolic process 57.1429 4 yes
GO:0008104 protein localization 57.1429 4 yes
GO:0008610 lipid biosynthetic process 57.1429 4 yes
GO:0008654 phospholipid biosynthetic process 57.1429 4 yes
GO:0045017 glycerolipid biosynthetic process 57.1429 4 yes
GO:0046474 glycerophospholipid biosynthetic process 57.1429 5 yes
GO:0046486 glycerolipid metabolic process 57.1429 4 yes
GO:0046488 phosphatidylinositol metabolic process 57.1429 6 yes
GO:0046854 phosphatidylinositol phosphate biosynthetic process 57.1429 7 yes
GO:0090407 organophosphate biosynthetic process 57.1429 4 yes
GO:0072657 protein localization to membrane 42.8571 4 yes
GO:0072659 protein localization to plasma membrane 42.8571 5 yes
GO:1990778 protein localization to cell periphery 42.8571 5 yes
GO:0006915 apoptotic process 28.5714 4 no
GO:0006996 organelle organization 28.5714 4 no
GO:0007010 cytoskeleton organization 28.5714 5 no
GO:0007015 actin filament organization 28.5714 5 no
GO:0016192 vesicle-mediated transport 28.5714 4 no
GO:0033043 regulation of organelle organization 28.5714 5 no
GO:0048522 positive regulation of cellular process 28.5714 4 no
GO:0048523 negative regulation of cellular process 28.5714 4 no
GO:0051128 regulation of cellular component organization 28.5714 4 no
GO:0051726 regulation of cell cycle 28.5714 4 no
GO:0097435 supramolecular fiber organization 28.5714 4 no
GO:0000209 protein polyubiquitination 28.5714 8 no
GO:0016567 protein ubiquitination 28.5714 7 no
GO:0032446 protein modification by small protein conjugation 28.5714 6 no
GO:0036211 protein modification process 28.5714 4 no
GO:0043412 macromolecule modification 28.5714 4 no
GO:0070647 protein modification by small protein conjugation or removal 28.5714 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
HYCCI_HUMAN [view interactions] Low throughput no no
TTC7B_HUMAN [view entry] [view interactions] Low throughput yes yes
PI4KA_HUMAN [view entry] [view interactions] Low throughput yes yes
HDAC4_HUMAN [view interactions] High throughput no yes
F126B_HUMAN [view interactions] High throughput no yes
COG6_HUMAN [view interactions] High throughput no yes
R3GEF_HUMAN [view interactions] High throughput no yes
RUSC1_HUMAN [view entry] [view interactions] High throughput yes yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
CTDSL_HUMAN [view interactions] High throughput no no
RGS20_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
CD226_HUMAN [view interactions] High throughput no yes
PO3F1_HUMAN [view interactions] High throughput no no
IDD_HUMAN [view interactions] High throughput no no
CENPM_HUMAN [view interactions] High throughput no yes
CB050_HUMAN [view interactions] High throughput no no
BRD2_HUMAN [view interactions] High throughput no yes
RHOF_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
EFR3B_HUMAN [view entry] [view interactions] Computational yes no
T150A_HUMAN [view interactions] Computational no yes