Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TLN2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in TLN2_HUMAN
GO:0003779 actin binding 34.7826 4 yes
GO:0046872 metal ion binding 34.7826 4 no
GO:0017076 purine nucleotide binding 30.4348 4 no
GO:0032555 purine ribonucleotide binding 30.4348 4 no
GO:0035639 purine ribonucleoside triphosphate binding 30.4348 4 no
GO:0019900 kinase binding 30.4348 4 no
GO:0019901 protein kinase binding 30.4348 5 no
GO:0005524 ATP binding 26.0870 5 no
GO:0030554 adenyl nucleotide binding 26.0870 5 no
GO:0032559 adenyl ribonucleotide binding 26.0870 5 no
GO:0045296 cadherin binding 26.0870 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in TLN2_HUMAN
GO:0022607 cellular component assembly 73.9130 4 yes
GO:0048523 negative regulation of cellular process 65.2174 4 no
GO:0031323 regulation of cellular metabolic process 60.8696 4 no
GO:0048522 positive regulation of cellular process 60.8696 4 no
GO:0006996 organelle organization 56.5217 4 no
GO:0051128 regulation of cellular component organization 56.5217 4 no
GO:0060255 regulation of macromolecule metabolic process 52.1739 4 no
GO:0051171 regulation of nitrogen compound metabolic process 47.8261 4 no
GO:0080090 regulation of primary metabolic process 47.8261 4 no
GO:0051049 regulation of transport 43.4783 4 no
GO:0009893 positive regulation of metabolic process 43.4783 4 no
GO:0010604 positive regulation of macromolecule metabolic process 43.4783 5 no
GO:0009966 regulation of signal transduction 43.4783 4 no
GO:0010646 regulation of cell communication 43.4783 4 no
GO:0051246 regulation of protein metabolic process 43.4783 5 no
GO:0009892 negative regulation of metabolic process 43.4783 4 no
GO:0008104 protein localization 39.1304 4 no
GO:0016192 vesicle-mediated transport 39.1304 4 no
GO:0007010 cytoskeleton organization 39.1304 5 no
GO:0030334 regulation of cell migration 39.1304 5 no
GO:0048584 positive regulation of response to stimulus 39.1304 4 no
GO:2000145 regulation of cell motility 39.1304 4 no
GO:0010941 regulation of cell death 39.1304 4 no
GO:0031325 positive regulation of cellular metabolic process 39.1304 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 39.1304 5 no
GO:0051247 positive regulation of protein metabolic process 39.1304 6 no
GO:0060548 negative regulation of cell death 39.1304 5 no
GO:0010605 negative regulation of macromolecule metabolic process 39.1304 5 no
GO:0031324 negative regulation of cellular metabolic process 39.1304 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 39.1304 5 no
GO:0034329 cell junction assembly 34.7826 5 yes
GO:0034330 cell junction organization 34.7826 4 yes
GO:0043933 protein-containing complex organization 34.7826 4 no
GO:0065003 protein-containing complex assembly 34.7826 5 no
GO:0009894 regulation of catabolic process 34.7826 4 no
GO:0030155 regulation of cell adhesion 34.7826 4 no
GO:0030335 positive regulation of cell migration 34.7826 6 no
GO:0033043 regulation of organelle organization 34.7826 5 no
GO:0040017 positive regulation of locomotion 34.7826 4 no
GO:0044087 regulation of cellular component biogenesis 34.7826 4 no
GO:2000147 positive regulation of cell motility 34.7826 5 no
GO:0030030 cell projection organization 34.7826 4 no
GO:0120036 plasma membrane bounded cell projection organization 34.7826 5 no
GO:0001932 regulation of protein phosphorylation 34.7826 7 no
GO:0019220 regulation of phosphate metabolic process 34.7826 6 no
GO:0031399 regulation of protein modification process 34.7826 6 no
GO:0042325 regulation of phosphorylation 34.7826 7 no
GO:0042981 regulation of apoptotic process 34.7826 6 no
GO:0043066 negative regulation of apoptotic process 34.7826 7 no
GO:0043067 regulation of programmed cell death 34.7826 5 no
GO:0043069 negative regulation of programmed cell death 34.7826 6 no
GO:0043085 positive regulation of catalytic activity 34.7826 4 no
GO:0051174 regulation of phosphorus metabolic process 34.7826 5 no
GO:0051248 negative regulation of protein metabolic process 34.7826 6 no
GO:0043269 regulation of ion transport 30.4348 5 no
GO:0010468 regulation of gene expression 30.4348 5 no
GO:0010810 regulation of cell-substrate adhesion 30.4348 5 no
GO:0009967 positive regulation of signal transduction 30.4348 5 no
GO:0010647 positive regulation of cell communication 30.4348 5 no
GO:0022603 regulation of anatomical structure morphogenesis 30.4348 4 no
GO:0023056 positive regulation of signaling 30.4348 4 no
GO:0045595 regulation of cell differentiation 30.4348 4 no
GO:0051050 positive regulation of transport 30.4348 4 no
GO:0001934 positive regulation of protein phosphorylation 30.4348 8 no
GO:0007229 integrin-mediated signaling pathway 30.4348 4 no
GO:0010562 positive regulation of phosphorus metabolic process 30.4348 6 no
GO:0031401 positive regulation of protein modification process 30.4348 7 no
GO:0042327 positive regulation of phosphorylation 30.4348 8 no
GO:0045937 positive regulation of phosphate metabolic process 30.4348 7 no
GO:0051338 regulation of transferase activity 30.4348 4 no
GO:0051347 positive regulation of transferase activity 30.4348 5 no
GO:1902531 regulation of intracellular signal transduction 30.4348 5 no
GO:0045216 cell-cell junction organization 26.0870 5 yes
GO:0034762 regulation of transmembrane transport 26.0870 4 no
GO:0034765 regulation of ion transmembrane transport 26.0870 5 no
GO:0031329 regulation of cellular catabolic process 26.0870 5 no
GO:0001894 tissue homeostasis 26.0870 5 no
GO:0051493 regulation of cytoskeleton organization 26.0870 6 no
GO:0060249 anatomical structure homeostasis 26.0870 4 no
GO:0071310 cellular response to organic substance 26.0870 4 no
GO:0031344 regulation of cell projection organization 26.0870 5 no
GO:0051094 positive regulation of developmental process 26.0870 4 no
GO:0051130 positive regulation of cellular component organization 26.0870 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 26.0870 6 no
GO:0033674 positive regulation of kinase activity 26.0870 6 no
GO:0042127 regulation of cell population proliferation 26.0870 4 no
GO:0043549 regulation of kinase activity 26.0870 5 no
GO:0045859 regulation of protein kinase activity 26.0870 6 no
GO:0045860 positive regulation of protein kinase activity 26.0870 7 no
GO:0009889 regulation of biosynthetic process 26.0870 4 no
GO:0010556 regulation of macromolecule biosynthetic process 26.0870 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 26.0870 5 no
GO:0031326 regulation of cellular biosynthetic process 26.0870 5 no
GO:0051252 regulation of RNA metabolic process 26.0870 5 no
GO:0032880 regulation of protein localization 26.0870 5 no
GO:0060341 regulation of cellular localization 26.0870 4 no
GO:0007043 cell-cell junction assembly 21.7391 6 yes
GO:0001952 regulation of cell-matrix adhesion 21.7391 6 no
GO:0010628 positive regulation of gene expression 21.7391 6 no
GO:0051893 regulation of focal adhesion assembly 21.7391 7 no
GO:0080134 regulation of response to stress 21.7391 4 no
GO:0090109 regulation of cell-substrate junction assembly 21.7391 6 no
GO:0150116 regulation of cell-substrate junction organization 21.7391 5 no
GO:1901888 regulation of cell junction assembly 21.7391 5 no
GO:0050804 modulation of chemical synaptic transmission 21.7391 5 no
GO:0050890 cognition 21.7391 4 no
GO:0051129 negative regulation of cellular component organization 21.7391 5 no
GO:0051240 positive regulation of multicellular organismal process 21.7391 4 no
GO:0099177 regulation of trans-synaptic signaling 21.7391 4 no
GO:1904062 regulation of cation transmembrane transport 21.7391 6 no
GO:2000026 regulation of multicellular organismal development 21.7391 4 no
GO:0006796 phosphate-containing compound metabolic process 21.7391 4 no
GO:0008284 positive regulation of cell population proliferation 21.7391 5 no
GO:0043412 macromolecule modification 21.7391 4 no
GO:0050776 regulation of immune response 21.7391 4 no
GO:0030031 cell projection assembly 21.7391 5 no
GO:0006355 regulation of DNA-templated transcription 21.7391 6 no
GO:0010243 response to organonitrogen compound 21.7391 4 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 21.7391 8 no
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 21.7391 9 no
GO:1903506 regulation of nucleic acid-templated transcription 21.7391 7 no
GO:2001141 regulation of RNA biosynthetic process 21.7391 6 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ITB5_HUMAN [view interactions] Low throughput no yes
ITB2_HUMAN [view interactions] Low throughput no no
ABL1_HUMAN [view entry] [view interactions] Low throughput yes yes
ITB3_HUMAN [view entry] [view interactions] Low throughput yes no
ITB1_HUMAN [view entry] [view interactions] Low throughput yes no
PI51C_HUMAN [view entry] [view interactions] Low throughput yes yes
HIF1N_HUMAN [view interactions] High throughput no yes
SKP1_HUMAN [view interactions] High throughput no yes
DGCR8_HUMAN [view entry] [view interactions] High throughput yes yes
TMEDA_HUMAN [view interactions] High throughput no yes
LMBL2_HUMAN [view interactions] High throughput no no
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
SGTB_HUMAN [view interactions] High throughput no yes
HNRPD_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPQ_HUMAN [view entry] [view interactions] High throughput yes yes
KANK4_HUMAN [view interactions] High throughput no no
RIN3_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
ALBU_HUMAN [view interactions] High throughput no no
CDC5L_HUMAN [view interactions] High throughput no yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
DMD_HUMAN [view entry] [view interactions] High throughput yes no
HDAC4_HUMAN [view interactions] High throughput no yes
CE350_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
FOS_HUMAN [view interactions] High throughput no yes
RGCC_HUMAN [view interactions] High throughput no yes
CCND2_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
ZCH18_HUMAN [view interactions] High throughput no yes
DX39A_HUMAN [view interactions] High throughput no yes
SOSD1_HUMAN [view interactions] High throughput no no
CL3L1_HUMAN [view interactions] High throughput no no
KCNA3_HUMAN [view entry] [view interactions] High throughput yes no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
CLK1_HUMAN [view interactions] High throughput no yes
TWF2_HUMAN [view interactions] High throughput no no
EXOC8_HUMAN [view entry] [view interactions] High throughput yes yes
NUP93_HUMAN [view interactions] High throughput no yes
DCNL5_HUMAN [view interactions] High throughput no yes
DDI2_HUMAN [view interactions] High throughput no no
DIAP1_HUMAN [view interactions] High throughput no yes
HAT1_HUMAN [view interactions] High throughput no yes
SNF8_HUMAN [view interactions] High throughput no yes
TRM6_HUMAN [view interactions] High throughput no yes
TRM61_HUMAN [view interactions] High throughput no no
TTC4_HUMAN [view interactions] High throughput no yes
UBL7_HUMAN [view interactions] High throughput no yes
ASPG_HUMAN [view interactions] High throughput no yes
CO4A_HUMAN [view interactions] High throughput no no
CO4B_HUMAN [view interactions] High throughput no no
ZYX_HUMAN [view interactions] High throughput no no
VINC_HUMAN [view entry] [view interactions] Computational yes no
SRC_HUMAN [view entry] [view interactions] Computational yes no
ACTG_HUMAN [view entry] [view interactions] Computational yes yes
ITA2B_HUMAN [view interactions] Computational no no
ITB8_HUMAN [view interactions] Computational no no
ITA5_HUMAN [view entry] [view interactions] Computational yes no
AB1IP_HUMAN [view interactions] Computational no no
TLN1_HUMAN [view entry] [view interactions] Computational yes no
CAN2_HUMAN [view interactions] Computational no no
FAK1_HUMAN [view entry] [view interactions] Computational yes yes