Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TLN2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in TLN2_HUMAN
GO:0043169 cation binding 52.6316 4 no
GO:0046872 metal ion binding 52.6316 5 no
GO:0003779 actin binding 36.8421 4 yes
GO:0046914 transition metal ion binding 31.5789 6 no
GO:0019900 kinase binding 31.5789 4 no
GO:0019901 protein kinase binding 31.5789 5 no
GO:0002020 protease binding 21.0526 4 no
GO:0008270 zinc ion binding 21.0526 7 no
GO:0000166 nucleotide binding 21.0526 4 no
GO:0017076 purine nucleotide binding 21.0526 5 no
GO:0032555 purine ribonucleotide binding 21.0526 4 no
GO:0035639 purine ribonucleoside triphosphate binding 21.0526 4 no
GO:0043168 anion binding 21.0526 4 no
GO:0003723 RNA binding 21.0526 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in TLN2_HUMAN
GO:0031323 regulation of cellular metabolic process 73.6842 4 no
GO:0022607 cellular component assembly 73.6842 4 yes
GO:0048522 positive regulation of cellular process 68.4211 4 no
GO:0051128 regulation of cellular component organization 63.1579 4 no
GO:0006996 organelle organization 63.1579 4 no
GO:0048523 negative regulation of cellular process 57.8947 4 no
GO:0060255 regulation of macromolecule metabolic process 57.8947 4 no
GO:0080090 regulation of primary metabolic process 57.8947 4 no
GO:0009892 negative regulation of metabolic process 52.6316 4 no
GO:0010605 negative regulation of macromolecule metabolic process 52.6316 5 no
GO:0031325 positive regulation of cellular metabolic process 47.3684 5 no
GO:0031326 regulation of cellular biosynthetic process 47.3684 5 no
GO:0051049 regulation of transport 47.3684 4 no
GO:0051246 regulation of protein metabolic process 47.3684 5 no
GO:0009894 regulation of catabolic process 47.3684 4 no
GO:0009889 regulation of biosynthetic process 47.3684 4 no
GO:0009893 positive regulation of metabolic process 47.3684 4 no
GO:0009966 regulation of signal transduction 47.3684 4 no
GO:0010468 regulation of gene expression 47.3684 6 no
GO:0010556 regulation of macromolecule biosynthetic process 47.3684 5 no
GO:0010604 positive regulation of macromolecule metabolic process 47.3684 5 no
GO:0010646 regulation of cell communication 47.3684 4 no
GO:0031324 negative regulation of cellular metabolic process 42.1053 5 no
GO:0042981 regulation of apoptotic process 42.1053 5 no
GO:0043066 negative regulation of apoptotic process 42.1053 6 no
GO:0043067 regulation of programmed cell death 42.1053 4 no
GO:0043069 negative regulation of programmed cell death 42.1053 5 no
GO:0051247 positive regulation of protein metabolic process 42.1053 6 no
GO:0051248 negative regulation of protein metabolic process 42.1053 6 no
GO:0051252 regulation of RNA metabolic process 42.1053 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 42.1053 5 no
GO:0031399 regulation of protein modification process 36.8421 6 no
GO:0032880 regulation of protein localization 36.8421 5 no
GO:0034762 regulation of transmembrane transport 36.8421 4 no
GO:0034765 regulation of monoatomic ion transmembrane transport 36.8421 5 no
GO:0042325 regulation of phosphorylation 36.8421 7 no
GO:0043085 positive regulation of catalytic activity 36.8421 4 no
GO:0043269 regulation of monoatomic ion transport 36.8421 5 no
GO:0043933 protein-containing complex organization 36.8421 4 no
GO:0051174 regulation of phosphorus metabolic process 36.8421 5 no
GO:0051338 regulation of transferase activity 36.8421 4 no
GO:0060341 regulation of cellular localization 36.8421 4 no
GO:0065003 protein-containing complex assembly 36.8421 5 no
GO:1902531 regulation of intracellular signal transduction 36.8421 5 no
GO:0008104 protein localization 36.8421 4 no
GO:0033043 regulation of organelle organization 36.8421 5 no
GO:0048584 positive regulation of response to stimulus 36.8421 4 no
GO:0051130 positive regulation of cellular component organization 36.8421 5 no
GO:0009891 positive regulation of biosynthetic process 36.8421 5 no
GO:0031328 positive regulation of cellular biosynthetic process 36.8421 6 no
GO:0001932 regulation of protein phosphorylation 36.8421 7 no
GO:0019220 regulation of phosphate metabolic process 36.8421 6 no
GO:0030030 cell projection organization 31.5789 4 no
GO:0031401 positive regulation of protein modification process 31.5789 7 no
GO:0042127 regulation of cell population proliferation 31.5789 4 no
GO:0043549 regulation of kinase activity 31.5789 5 no
GO:0048585 negative regulation of response to stimulus 31.5789 4 no
GO:0050804 modulation of chemical synaptic transmission 31.5789 5 no
GO:0050807 regulation of synapse organization 31.5789 5 no
GO:0051347 positive regulation of transferase activity 31.5789 5 no
GO:0071310 cellular response to organic substance 31.5789 4 no
GO:0099177 regulation of trans-synaptic signaling 31.5789 4 no
GO:1904062 regulation of monoatomic cation transmembrane transport 31.5789 6 no
GO:2001141 regulation of RNA biosynthetic process 31.5789 6 no
GO:0010647 positive regulation of cell communication 31.5789 5 no
GO:0023056 positive regulation of signaling 31.5789 4 no
GO:0044087 regulation of cellular component biogenesis 31.5789 4 no
GO:0051050 positive regulation of transport 31.5789 4 no
GO:0051094 positive regulation of developmental process 31.5789 4 no
GO:0051493 regulation of cytoskeleton organization 31.5789 6 no
GO:0010557 positive regulation of macromolecule biosynthetic process 31.5789 6 no
GO:0010628 positive regulation of gene expression 31.5789 7 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 31.5789 5 no
GO:0006355 regulation of DNA-templated transcription 31.5789 7 no
GO:0009968 negative regulation of signal transduction 31.5789 5 no
GO:0010243 response to organonitrogen compound 31.5789 4 no
GO:0010648 negative regulation of cell communication 31.5789 5 no
GO:0010959 regulation of metal ion transport 31.5789 6 no
GO:0023057 negative regulation of signaling 31.5789 4 no
GO:0031327 negative regulation of cellular biosynthetic process 26.3158 6 no
GO:0031344 regulation of cell projection organization 26.3158 5 no
GO:0031400 negative regulation of protein modification process 26.3158 7 no
GO:0033674 positive regulation of kinase activity 26.3158 6 no
GO:0042326 negative regulation of phosphorylation 26.3158 8 no
GO:0042327 positive regulation of phosphorylation 26.3158 8 no
GO:0043523 regulation of neuron apoptotic process 26.3158 6 no
GO:0045859 regulation of protein kinase activity 26.3158 6 no
GO:0045860 positive regulation of protein kinase activity 26.3158 7 no
GO:0045936 negative regulation of phosphate metabolic process 26.3158 7 no
GO:0045937 positive regulation of phosphate metabolic process 26.3158 7 no
GO:0050890 cognition 26.3158 4 no
GO:0051129 negative regulation of cellular component organization 26.3158 5 no
GO:0051924 regulation of calcium ion transport 26.3158 7 no
GO:0071417 cellular response to organonitrogen compound 26.3158 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 26.3158 6 no
GO:0120036 plasma membrane bounded cell projection organization 26.3158 5 no
GO:1901699 cellular response to nitrogen compound 26.3158 4 no
GO:1901701 cellular response to oxygen-containing compound 26.3158 4 no
GO:1902532 negative regulation of intracellular signal transduction 26.3158 6 no
GO:1903169 regulation of calcium ion transmembrane transport 26.3158 7 no
GO:1903829 positive regulation of protein localization 26.3158 5 no
GO:0009967 positive regulation of signal transduction 26.3158 5 no
GO:0022603 regulation of anatomical structure morphogenesis 26.3158 4 no
GO:0034764 positive regulation of transmembrane transport 26.3158 5 no
GO:0045595 regulation of cell differentiation 26.3158 4 no
GO:0098657 import into cell 26.3158 4 no
GO:0006357 regulation of transcription by RNA polymerase II 26.3158 8 no
GO:0010506 regulation of autophagy 26.3158 6 no
GO:0031329 regulation of cellular catabolic process 26.3158 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 26.3158 5 no
GO:0060627 regulation of vesicle-mediated transport 26.3158 4 no
GO:0080134 regulation of response to stress 26.3158 4 no
GO:0051253 negative regulation of RNA metabolic process 26.3158 6 no
GO:0034330 cell junction organization 26.3158 4 yes
GO:0001933 negative regulation of protein phosphorylation 26.3158 8 no
GO:0001934 positive regulation of protein phosphorylation 26.3158 8 no
GO:0009890 negative regulation of biosynthetic process 26.3158 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 26.3158 6 no
GO:0010562 positive regulation of phosphorus metabolic process 26.3158 6 no
GO:0010563 negative regulation of phosphorus metabolic process 26.3158 6 no
GO:0030155 regulation of cell adhesion 21.0526 4 no
GO:0043065 positive regulation of apoptotic process 21.0526 6 no
GO:0043068 positive regulation of programmed cell death 21.0526 5 no
GO:0050865 regulation of cell activation 21.0526 4 no
GO:0051726 regulation of cell cycle 21.0526 4 no
GO:0071241 cellular response to inorganic substance 21.0526 4 no
GO:0007612 learning 21.0526 4 no
GO:0022898 regulation of transmembrane transporter activity 21.0526 4 no
GO:0032956 regulation of actin cytoskeleton organization 21.0526 5 no
GO:0032970 regulation of actin filament-based process 21.0526 4 no
GO:0034767 positive regulation of monoatomic ion transmembrane transport 21.0526 6 no
GO:0043270 positive regulation of monoatomic ion transport 21.0526 5 no
GO:0044057 regulation of system process 21.0526 4 no
GO:0051240 positive regulation of multicellular organismal process 21.0526 4 no
GO:0141124 intracellular signaling cassette 21.0526 4 no
GO:1902903 regulation of supramolecular fiber organization 21.0526 5 no
GO:2000026 regulation of multicellular organismal development 21.0526 4 no
GO:0006796 phosphate-containing compound metabolic process 21.0526 4 no
GO:0007010 cytoskeleton organization 21.0526 5 no
GO:0061024 membrane organization 21.0526 4 no
GO:0008284 positive regulation of cell population proliferation 21.0526 5 no
GO:0010638 positive regulation of organelle organization 21.0526 6 no
GO:0030031 cell projection assembly 21.0526 5 no
GO:0030100 regulation of endocytosis 21.0526 5 no
GO:0030334 regulation of cell migration 21.0526 5 no
GO:0030335 positive regulation of cell migration 21.0526 6 no
GO:0040017 positive regulation of locomotion 21.0526 4 no
GO:0043408 regulation of MAPK cascade 21.0526 6 no
GO:0043412 macromolecule modification 21.0526 4 no
GO:0051254 positive regulation of RNA metabolic process 21.0526 6 no
GO:0051279 regulation of release of sequestered calcium ion into cytosol 21.0526 5 no
GO:0051282 regulation of sequestering of calcium ion 21.0526 4 no
GO:0090287 regulation of cellular response to growth factor stimulus 21.0526 4 no
GO:0090304 nucleic acid metabolic process 21.0526 4 no
GO:0097435 supramolecular fiber organization 21.0526 4 no
GO:1902533 positive regulation of intracellular signal transduction 21.0526 6 no
GO:2000145 regulation of cell motility 21.0526 4 no
GO:2000147 positive regulation of cell motility 21.0526 5 no
GO:0001894 tissue homeostasis 21.0526 4 no
GO:0022411 cellular component disassembly 21.0526 4 no
GO:0051580 regulation of neurotransmitter uptake 21.0526 6 no
GO:0051588 regulation of neurotransmitter transport 21.0526 5 no
GO:0071702 organic substance transport 21.0526 4 no
GO:0071705 nitrogen compound transport 21.0526 4 no
GO:0009895 negative regulation of catabolic process 21.0526 5 no
GO:0034329 cell junction assembly 21.0526 5 yes
GO:0002694 regulation of leukocyte activation 21.0526 4 no
GO:0010038 response to metal ion 21.0526 4 no
GO:0007043 cell-cell junction assembly 10.5263 6 yes
GO:0045216 cell-cell junction organization 10.5263 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ITB5_HUMAN [view interactions] Low throughput no yes
ITB2_HUMAN [view interactions] Low throughput no no
ABL1_HUMAN [view entry] [view interactions] Low throughput yes yes
ITB3_HUMAN [view entry] [view interactions] Low throughput yes no
ITB1_HUMAN [view entry] [view interactions] Low throughput yes no
PI51C_HUMAN [view entry] [view interactions] Low throughput yes yes
RGCC_HUMAN [view interactions] High throughput no yes
CCND2_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
ZCH18_HUMAN [view interactions] High throughput no yes
DX39A_HUMAN [view interactions] High throughput no yes
SOSD1_HUMAN [view interactions] High throughput no no
CL3L1_HUMAN [view interactions] High throughput no no
KCNA3_HUMAN [view entry] [view interactions] High throughput yes no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
TOP3B_HUMAN [view interactions] High throughput no no
CLK1_HUMAN [view interactions] High throughput no yes
TWF2_HUMAN [view interactions] High throughput no no
EXOC8_HUMAN [view entry] [view interactions] High throughput yes yes
NUP93_HUMAN [view interactions] High throughput no yes
DCNL5_HUMAN [view interactions] High throughput no yes
DDI2_HUMAN [view interactions] High throughput no no
DIAP1_HUMAN [view interactions] High throughput no yes
HAT1_HUMAN [view interactions] High throughput no yes
SNF8_HUMAN [view interactions] High throughput no yes
TRM6_HUMAN [view interactions] High throughput no yes
TRM61_HUMAN [view interactions] High throughput no no
TTC4_HUMAN [view interactions] High throughput no yes
UBL7_HUMAN [view interactions] High throughput no yes
ASPG_HUMAN [view interactions] High throughput no yes
CO4A_HUMAN [view interactions] High throughput no no
CO4B_HUMAN [view interactions] High throughput no no
ZYX_HUMAN [view interactions] High throughput no no
LNP_HUMAN [view interactions] High throughput no yes
KBTB4_HUMAN [view interactions] High throughput no yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
HIF1N_HUMAN [view interactions] High throughput no yes
SKP1_HUMAN [view interactions] High throughput no yes
DGCR8_HUMAN [view entry] [view interactions] High throughput yes yes
TMEDA_HUMAN [view interactions] High throughput no yes
LMBL2_HUMAN [view interactions] High throughput no no
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
SGTB_HUMAN [view interactions] High throughput no yes
HNRPD_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPQ_HUMAN [view entry] [view interactions] High throughput yes yes
KANK4_HUMAN [view interactions] High throughput no no
RIN3_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
ALBU_HUMAN [view interactions] High throughput no no
CDC5L_HUMAN [view interactions] High throughput no yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
DMD_HUMAN [view entry] [view interactions] High throughput yes no
HDAC4_HUMAN [view interactions] High throughput no yes
CE350_HUMAN [view interactions] High throughput no yes
HSP13_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
FOS_HUMAN [view interactions] High throughput no yes