PI51C_HUMAN
Evidence for PS localization
Functions
Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (PubMed, PubMed). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (Probable). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis . Together with PIP5K1A, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps . Promotes particle attachment by generating the pool of PtdIns(4,5)P2 that induces controlled actin depolymerization to facilitate Fc-gamma-R clustering. Mediates RAC1-dependent reorganization of actin filaments. Required for synaptic vesicle transport . Controls the plasma membrane pool of PtdIns(4,5)P2 implicated in synaptic vesicle endocytosis and exocytosis (PubMed). Plays a role in endocytosis mediated by clathrin and AP-2 (adaptor protein complex 2) (PubMed). Required for clathrin-coated pits assembly at the synapse (PubMed). Participates in cell junction assembly (PubMed). Modulates adherens junctions formation by facilitating CDH1/cadherin trafficking (PubMed). Required for focal adhesion dynamics. Modulates the targeting of talins (TLN1 and TLN2) to the plasma membrane and their efficient assembly into focal adhesions (PubMed). Regulates the interaction between talins (TLN1 and TLN2) and beta-integrins (PubMed). Required for uropodium formation and retraction of the cell rear during directed migration . Has a role in growth factor-stimulated directional cell migration and adhesion . Required for talin assembly into nascent adhesions forming at the leading edge toward the direction of the growth factor (PubMed). Negative regulator of T-cell activation and adhesion . Negatively regulates integrin alpha-L/beta-2 (LFA-1) polarization and adhesion induced by T-cell receptor . Together with PIP5K1A has a role during embryogenesis and together with PIP5K1B may have a role immediately after birth . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PI51C_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 40.0000 | 4 | no |
| GO:0019901 | protein kinase binding | 40.0000 | 5 | no |
| GO:0017076 | purine nucleotide binding | 38.1818 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 38.1818 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 38.1818 | 4 | yes |
| GO:0046872 | metal ion binding | 30.9091 | 4 | no |
| GO:0005524 | ATP binding | 29.0909 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 29.0909 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 29.0909 | 5 | yes |
| GO:0016301 | kinase activity | 27.2727 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 27.2727 | 4 | yes |
| GO:0045296 | cadherin binding | 25.4545 | 4 | no |
| GO:0016307 | phosphatidylinositol phosphate kinase activity | 9.0909 | 5 | yes |
| GO:0016308 | 1-phosphatidylinositol-4-phosphate 5-kinase activity | 7.2727 | 6 | yes |
| GO:0052812 | phosphatidylinositol-3,4-bisphosphate 5-kinase activity | 5.4545 | 6 | yes |
| GO:0052813 | phosphatidylinositol bisphosphate kinase activity | 5.4545 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PI51C_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 67.2727 | 4 | no |
| GO:0010646 | regulation of cell communication | 58.1818 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 58.1818 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 54.5455 | 4 | no |
| GO:0009966 | regulation of signal transduction | 50.9091 | 4 | yes |
| GO:0051049 | regulation of transport | 50.9091 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 49.0909 | 4 | no |
| GO:0022607 | cellular component assembly | 47.2727 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 47.2727 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 45.4545 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 43.6364 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 43.6364 | 5 | no |
| GO:0033043 | regulation of organelle organization | 43.6364 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 43.6364 | 4 | no |
| GO:0006996 | organelle organization | 41.8182 | 4 | yes |
| GO:0008104 | protein localization | 41.8182 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 41.8182 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.0000 | 5 | no |
| GO:2000145 | regulation of cell motility | 40.0000 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 40.0000 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 38.1818 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 38.1818 | 5 | yes |
| GO:0030334 | regulation of cell migration | 38.1818 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 38.1818 | 5 | no |
| GO:0010468 | regulation of gene expression | 36.3636 | 5 | no |
| GO:0051050 | positive regulation of transport | 36.3636 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 36.3636 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 36.3636 | 5 | no |
| GO:0023056 | positive regulation of signaling | 36.3636 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 34.5455 | 5 | no |
| GO:0034330 | cell junction organization | 32.7273 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 32.7273 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 32.7273 | 4 | no |
| GO:0060341 | regulation of cellular localization | 32.7273 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.9091 | 5 | no |
| GO:0010941 | regulation of cell death | 30.9091 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 30.9091 | 6 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.9091 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 30.9091 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 30.9091 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.9091 | 6 | no |
| GO:0071310 | cellular response to organic substance | 30.9091 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 30.9091 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 30.9091 | 4 | no |
| GO:0034329 | cell junction assembly | 29.0909 | 5 | yes |
| GO:0009894 | regulation of catabolic process | 29.0909 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 29.0909 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 29.0909 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 29.0909 | 5 | no |
| GO:0031399 | regulation of protein modification process | 29.0909 | 6 | no |
| GO:0032880 | regulation of protein localization | 29.0909 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 29.0909 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 29.0909 | 5 | no |
| GO:0006897 | endocytosis | 27.2727 | 5 | yes |
| GO:0007010 | cytoskeleton organization | 27.2727 | 5 | yes |
| GO:0030155 | regulation of cell adhesion | 27.2727 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 27.2727 | 7 | no |
| GO:0042127 | regulation of cell population proliferation | 27.2727 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 27.2727 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 27.2727 | 4 | no |
| GO:0010638 | positive regulation of organelle organization | 27.2727 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 27.2727 | 4 | no |
| GO:0045216 | cell-cell junction organization | 25.4545 | 5 | yes |
| GO:0061024 | membrane organization | 25.4545 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 25.4545 | 7 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 25.4545 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.4545 | 5 | no |
| GO:0031329 | regulation of cellular catabolic process | 25.4545 | 5 | no |
| GO:0036211 | protein modification process | 25.4545 | 4 | no |
| GO:0043412 | macromolecule modification | 25.4545 | 4 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 25.4545 | 7 | no |
| GO:0048585 | negative regulation of response to stimulus | 25.4545 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 25.4545 | 5 | no |
| GO:0060548 | negative regulation of cell death | 25.4545 | 5 | no |
| GO:0071702 | organic substance transport | 25.4545 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 25.4545 | 6 | no |
| GO:0030030 | cell projection organization | 25.4545 | 4 | no |
| GO:0006644 | phospholipid metabolic process | 23.6364 | 4 | yes |
| GO:0006650 | glycerophospholipid metabolic process | 23.6364 | 5 | yes |
| GO:0046486 | glycerolipid metabolic process | 23.6364 | 4 | yes |
| GO:0046488 | phosphatidylinositol metabolic process | 23.6364 | 6 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 23.6364 | 8 | no |
| GO:0009968 | negative regulation of signal transduction | 23.6364 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 23.6364 | 5 | no |
| GO:0015031 | protein transport | 23.6364 | 4 | no |
| GO:0023057 | negative regulation of signaling | 23.6364 | 4 | no |
| GO:0030335 | positive regulation of cell migration | 23.6364 | 6 | no |
| GO:0040017 | positive regulation of locomotion | 23.6364 | 4 | no |
| GO:0042327 | positive regulation of phosphorylation | 23.6364 | 8 | no |
| GO:0043269 | regulation of ion transport | 23.6364 | 5 | no |
| GO:0051338 | regulation of transferase activity | 23.6364 | 4 | no |
| GO:0051726 | regulation of cell cycle | 23.6364 | 4 | no |
| GO:0071705 | nitrogen compound transport | 23.6364 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 23.6364 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 23.6364 | 4 | no |
| GO:2000147 | positive regulation of cell motility | 23.6364 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 23.6364 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 23.6364 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 23.6364 | 5 | no |
| GO:0007043 | cell-cell junction assembly | 21.8182 | 6 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 21.8182 | 6 | no |
| GO:0006886 | intracellular protein transport | 21.8182 | 4 | no |
| GO:0016310 | phosphorylation | 21.8182 | 5 | no |
| GO:0043066 | negative regulation of apoptotic process | 21.8182 | 7 | no |
| GO:0043069 | negative regulation of programmed cell death | 21.8182 | 6 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 21.8182 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 21.8182 | 4 | no |
| GO:0051336 | regulation of hydrolase activity | 21.8182 | 4 | no |
| GO:0080134 | regulation of response to stress | 21.8182 | 4 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 21.8182 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 21.8182 | 6 | no |
| GO:0032970 | regulation of actin filament-based process | 21.8182 | 4 | no |
| GO:0010810 | regulation of cell-substrate adhesion | 21.8182 | 5 | no |
| GO:0006661 | phosphatidylinositol biosynthetic process | 16.3636 | 6 | yes |
| GO:0008610 | lipid biosynthetic process | 16.3636 | 4 | yes |
| GO:0008654 | phospholipid biosynthetic process | 16.3636 | 4 | yes |
| GO:0045017 | glycerolipid biosynthetic process | 16.3636 | 4 | yes |
| GO:0046474 | glycerophospholipid biosynthetic process | 16.3636 | 5 | yes |
| GO:0048488 | synaptic vesicle endocytosis | 16.3636 | 5 | yes |
| GO:0090407 | organophosphate biosynthetic process | 16.3636 | 4 | yes |
| GO:0099003 | vesicle-mediated transport in synapse | 16.3636 | 5 | yes |
| GO:0140238 | presynaptic endocytosis | 16.3636 | 4 | yes |
| GO:0006898 | receptor-mediated endocytosis | 14.5455 | 6 | yes |
| GO:0014066 | regulation of phosphatidylinositol 3-kinase signaling | 10.9091 | 6 | yes |
| GO:0034332 | adherens junction organization | 10.9091 | 6 | yes |
| GO:0072583 | clathrin-dependent endocytosis | 10.9091 | 7 | yes |
| GO:0006887 | exocytosis | 7.2727 | 4 | yes |
| GO:0006909 | phagocytosis | 7.2727 | 5 | yes |
| GO:0016079 | synaptic vesicle exocytosis | 7.2727 | 4 | yes |
| GO:0023061 | signal release | 7.2727 | 4 | yes |
| GO:0034333 | adherens junction assembly | 7.2727 | 7 | yes |
| GO:0045055 | regulated exocytosis | 7.2727 | 5 | yes |
| GO:0046903 | secretion | 7.2727 | 4 | yes |
| GO:0099643 | signal release from synapse | 7.2727 | 5 | yes |
| GO:0030593 | neutrophil chemotaxis | 3.6364 | 5 | yes |
| GO:0060326 | cell chemotaxis | 3.6364 | 4 | yes |
| GO:0071621 | granulocyte chemotaxis | 3.6364 | 4 | yes |
| GO:0097530 | granulocyte migration | 3.6364 | 4 | yes |
| GO:1990266 | neutrophil migration | 3.6364 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in PI51C_HUMAN |
|---|---|---|---|---|
| DOID:0050686 | organ system cancer | 3.6364 | 3 | no |
| DOID:6457 | Cowden syndrome | 3.6364 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| AP2M1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TLN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| AP2B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| AP2A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SNX5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PI5L1_HUMAN | [view interactions] | Low throughput | no | no |
| TLN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CADH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LAP4B_HUMAN | [view interactions] | Low throughput | no | yes |
| NEDD4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SMUF1_HUMAN | [view interactions] | Low throughput | no | yes |
| SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| BAKOR_HUMAN | [view interactions] | Low throughput | no | yes |
| ITB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| AKT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AKT2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PKD1_HUMAN | [view interactions] | Low throughput | no | yes |
| CDK5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CDK1_HUMAN | [view interactions] | Low throughput | no | no |
| CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PEX14_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| PGTB2_HUMAN | [view interactions] | High throughput | no | yes |
| COQ2_HUMAN | [view interactions] | High throughput | no | yes |
| SOAT1_HUMAN | [view interactions] | High throughput | no | no |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| PI51C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| PI51A_HUMAN | [view interactions] | High throughput | no | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| ARHG1_HUMAN | [view interactions] | High throughput | no | no |
| VAV_HUMAN | [view interactions] | High throughput | no | no |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PGBD5_HUMAN | [view interactions] | High throughput | no | no |
| SNX4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PI51B_HUMAN | [view interactions] | High throughput | no | yes |
| HDHD2_HUMAN | [view interactions] | High throughput | no | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P4K2B_HUMAN | [view interactions] | Computational | no | yes |
| PK3CG_HUMAN | [view interactions] | Computational | no | yes |
| ROCK2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP1M1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ROCK1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| P85A_HUMAN | [view interactions] | Computational | no | yes |
| RAC3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| P55G_HUMAN | [view interactions] | Computational | no | yes |
| CADH2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CTNA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CTND1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PK3CB_HUMAN | [view interactions] | Computational | no | yes |
| P4K2A_HUMAN | [view interactions] | Computational | no | yes |
| PI4KA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ACTG_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PTEN_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PP4P1_HUMAN | [view interactions] | Computational | no | yes |
| PP4P2_HUMAN | [view interactions] | Computational | no | yes |
| VINC_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PLCE1_HUMAN | [view interactions] | Computational | no | yes |
| PI42B_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RAC2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CHSTF_HUMAN | [view interactions] | Computational | no | yes |
| PI3R6_HUMAN | [view interactions] | Computational | no | yes |
| PLCB4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PLCG1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PLAK_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RHOA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PLCD4_HUMAN | [view interactions] | Computational | no | no |
| PI3R5_HUMAN | [view interactions] | Computational | no | no |
| FARP2_HUMAN | [view interactions] | Computational | no | yes |
| PI42A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PK3CA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PLCB2_HUMAN | [view interactions] | Computational | no | no |
| PLCB3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| OCRL_HUMAN | [view interactions] | Computational | no | yes |
| INP5E_HUMAN | [view interactions] | Computational | no | yes |
| I5P2_HUMAN | [view interactions] | Computational | no | yes |
| PLCG2_HUMAN | [view interactions] | Computational | no | yes |
| PLCZ1_HUMAN | [view interactions] | Computational | no | no |
| PK3CD_HUMAN | [view interactions] | Computational | no | no |
| PLCD3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PLCD1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PI42C_HUMAN | [view interactions] | Computational | no | yes |
| P85B_HUMAN | [view interactions] | Computational | no | yes |
| PLCB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SAC1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PLCH1_HUMAN | [view interactions] | Computational | no | no |
| PTPRM_HUMAN | [view interactions] | Computational | no | yes |
| SYNJ2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PLCH2_HUMAN | [view interactions] | Computational | no | yes |