Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PI51C_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (PubMed, PubMed). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (Probable). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis . Together with PIP5K1A, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps . Promotes particle attachment by generating the pool of PtdIns(4,5)P2 that induces controlled actin depolymerization to facilitate Fc-gamma-R clustering. Mediates RAC1-dependent reorganization of actin filaments. Required for synaptic vesicle transport . Controls the plasma membrane pool of PtdIns(4,5)P2 implicated in synaptic vesicle endocytosis and exocytosis (PubMed). Plays a role in endocytosis mediated by clathrin and AP-2 (adaptor protein complex 2) (PubMed). Required for clathrin-coated pits assembly at the synapse (PubMed). Participates in cell junction assembly (PubMed). Modulates adherens junctions formation by facilitating CDH1/cadherin trafficking (PubMed). Required for focal adhesion dynamics. Modulates the targeting of talins (TLN1 and TLN2) to the plasma membrane and their efficient assembly into focal adhesions (PubMed). Regulates the interaction between talins (TLN1 and TLN2) and beta-integrins (PubMed). Required for uropodium formation and retraction of the cell rear during directed migration . Has a role in growth factor-stimulated directional cell migration and adhesion . Required for talin assembly into nascent adhesions forming at the leading edge toward the direction of the growth factor (PubMed). Negative regulator of T-cell activation and adhesion . Negatively regulates integrin alpha-L/beta-2 (LFA-1) polarization and adhesion induced by T-cell receptor . Together with PIP5K1A has a role during embryogenesis and together with PIP5K1B may have a role immediately after birth . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PI51C_HUMAN
GO:0043168 anion binding 45.1613 4 yes
GO:0019900 kinase binding 45.1613 4 no
GO:0019901 protein kinase binding 45.1613 5 no
GO:0000166 nucleotide binding 38.7097 4 yes
GO:0017076 purine nucleotide binding 38.7097 5 yes
GO:0032555 purine ribonucleotide binding 38.7097 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 38.7097 4 yes
GO:0005524 ATP binding 32.2581 5 yes
GO:0016301 kinase activity 32.2581 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 32.2581 4 yes
GO:0030554 adenyl nucleotide binding 32.2581 6 yes
GO:0032559 adenyl ribonucleotide binding 32.2581 5 yes
GO:0043169 cation binding 32.2581 4 no
GO:0046872 metal ion binding 29.0323 5 no
GO:0001727 lipid kinase activity 9.6774 5 yes
GO:0052742 phosphatidylinositol kinase activity 9.6774 5 yes
GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity 6.4516 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PI51C_HUMAN
GO:0048522 positive regulation of cellular process 74.1935 4 no
GO:0010646 regulation of cell communication 67.7419 4 yes
GO:0048523 negative regulation of cellular process 61.2903 4 no
GO:0031323 regulation of cellular metabolic process 61.2903 4 no
GO:0051049 regulation of transport 61.2903 4 no
GO:0051128 regulation of cellular component organization 58.0645 4 no
GO:0060255 regulation of macromolecule metabolic process 54.8387 4 no
GO:0080090 regulation of primary metabolic process 54.8387 4 no
GO:0009966 regulation of signal transduction 54.8387 4 yes
GO:0022607 cellular component assembly 48.3871 4 yes
GO:0098657 import into cell 48.3871 4 yes
GO:1902531 regulation of intracellular signal transduction 48.3871 5 yes
GO:0009893 positive regulation of metabolic process 48.3871 4 no
GO:0010647 positive regulation of cell communication 48.3871 5 no
GO:0023056 positive regulation of signaling 48.3871 4 no
GO:0048584 positive regulation of response to stimulus 48.3871 4 no
GO:0051050 positive regulation of transport 48.3871 4 no
GO:0051246 regulation of protein metabolic process 45.1613 5 no
GO:0009889 regulation of biosynthetic process 45.1613 4 no
GO:0010556 regulation of macromolecule biosynthetic process 45.1613 5 no
GO:0031326 regulation of cellular biosynthetic process 45.1613 5 no
GO:0006996 organelle organization 45.1613 4 yes
GO:0031325 positive regulation of cellular metabolic process 45.1613 5 no
GO:0008104 protein localization 41.9355 4 no
GO:0010604 positive regulation of macromolecule metabolic process 41.9355 5 no
GO:0009967 positive regulation of signal transduction 38.7097 5 no
GO:0010468 regulation of gene expression 38.7097 6 no
GO:0060341 regulation of cellular localization 38.7097 4 no
GO:0030334 regulation of cell migration 38.7097 5 no
GO:2000145 regulation of cell motility 38.7097 4 no
GO:0071702 organic substance transport 38.7097 4 no
GO:0009892 negative regulation of metabolic process 38.7097 4 no
GO:0031324 negative regulation of cellular metabolic process 38.7097 5 no
GO:0009894 regulation of catabolic process 35.4839 4 no
GO:0015031 protein transport 35.4839 4 no
GO:0033043 regulation of organelle organization 35.4839 5 no
GO:0071705 nitrogen compound transport 35.4839 4 no
GO:0031399 regulation of protein modification process 35.4839 6 no
GO:0042325 regulation of phosphorylation 32.2581 7 no
GO:0051051 negative regulation of transport 32.2581 4 no
GO:0051174 regulation of phosphorus metabolic process 32.2581 5 no
GO:0051247 positive regulation of protein metabolic process 32.2581 6 no
GO:0032880 regulation of protein localization 32.2581 5 no
GO:0042981 regulation of apoptotic process 32.2581 5 no
GO:0043067 regulation of programmed cell death 32.2581 4 no
GO:0071310 cellular response to organic substance 32.2581 4 no
GO:0006796 phosphate-containing compound metabolic process 32.2581 4 yes
GO:0016310 phosphorylation 32.2581 5 yes
GO:0034330 cell junction organization 32.2581 4 yes
GO:0051130 positive regulation of cellular component organization 32.2581 5 no
GO:0060627 regulation of vesicle-mediated transport 32.2581 4 no
GO:0006886 intracellular protein transport 32.2581 4 no
GO:0001932 regulation of protein phosphorylation 32.2581 7 no
GO:0010605 negative regulation of macromolecule metabolic process 32.2581 5 no
GO:0019220 regulation of phosphate metabolic process 32.2581 6 no
GO:0042327 positive regulation of phosphorylation 29.0323 8 no
GO:0043085 positive regulation of catalytic activity 29.0323 4 no
GO:0045937 positive regulation of phosphate metabolic process 29.0323 7 no
GO:0022603 regulation of anatomical structure morphogenesis 29.0323 4 no
GO:0031344 regulation of cell projection organization 29.0323 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 29.0323 6 no
GO:0007167 enzyme-linked receptor protein signaling pathway 29.0323 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 29.0323 5 no
GO:1902533 positive regulation of intracellular signal transduction 29.0323 6 no
GO:0030335 positive regulation of cell migration 29.0323 6 no
GO:0040017 positive regulation of locomotion 29.0323 4 no
GO:2000147 positive regulation of cell motility 29.0323 5 no
GO:0036211 protein modification process 29.0323 4 no
GO:0043412 macromolecule modification 29.0323 4 no
GO:0007010 cytoskeleton organization 29.0323 5 yes
GO:0001934 positive regulation of protein phosphorylation 29.0323 8 no
GO:0010562 positive regulation of phosphorus metabolic process 29.0323 6 no
GO:0031401 positive regulation of protein modification process 29.0323 7 no
GO:0034762 regulation of transmembrane transport 25.8065 4 no
GO:0043269 regulation of monoatomic ion transport 25.8065 5 no
GO:0051338 regulation of transferase activity 25.8065 4 no
GO:0051347 positive regulation of transferase activity 25.8065 5 no
GO:0008284 positive regulation of cell population proliferation 25.8065 5 no
GO:0010243 response to organonitrogen compound 25.8065 4 no
GO:0030155 regulation of cell adhesion 25.8065 4 no
GO:0042127 regulation of cell population proliferation 25.8065 4 no
GO:0043066 negative regulation of apoptotic process 25.8065 6 no
GO:0043069 negative regulation of programmed cell death 25.8065 5 no
GO:0051129 negative regulation of cellular component organization 25.8065 5 no
GO:1901701 cellular response to oxygen-containing compound 25.8065 4 no
GO:1903829 positive regulation of protein localization 25.8065 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.8065 5 no
GO:0006898 receptor-mediated endocytosis 25.8065 4 yes
GO:0034329 cell junction assembly 25.8065 5 yes
GO:0002684 positive regulation of immune system process 25.8065 4 no
GO:0031329 regulation of cellular catabolic process 25.8065 5 no
GO:0044087 regulation of cellular component biogenesis 25.8065 4 no
GO:0010038 response to metal ion 25.8065 4 no
GO:0010959 regulation of metal ion transport 25.8065 6 no
GO:0033674 positive regulation of kinase activity 22.5806 6 no
GO:0043549 regulation of kinase activity 22.5806 5 no
GO:0045859 regulation of protein kinase activity 22.5806 6 no
GO:0045860 positive regulation of protein kinase activity 22.5806 7 no
GO:0051336 regulation of hydrolase activity 22.5806 4 no
GO:0051726 regulation of cell cycle 22.5806 4 no
GO:0043933 protein-containing complex organization 22.5806 4 no
GO:0009890 negative regulation of biosynthetic process 22.5806 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 22.5806 6 no
GO:0031327 negative regulation of cellular biosynthetic process 22.5806 6 no
GO:0006915 apoptotic process 22.5806 4 no
GO:0071417 cellular response to organonitrogen compound 22.5806 4 no
GO:1901699 cellular response to nitrogen compound 22.5806 4 no
GO:1905475 regulation of protein localization to membrane 22.5806 6 no
GO:0030030 cell projection organization 22.5806 4 no
GO:0120036 plasma membrane bounded cell projection organization 22.5806 5 no
GO:0009891 positive regulation of biosynthetic process 22.5806 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 22.5806 6 no
GO:0031328 positive regulation of cellular biosynthetic process 22.5806 6 no
GO:0045595 regulation of cell differentiation 22.5806 4 no
GO:0048488 synaptic vesicle endocytosis 22.5806 5 yes
GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 22.5806 6 yes
GO:0061024 membrane organization 22.5806 4 yes
GO:0140238 presynaptic endocytosis 22.5806 4 yes
GO:0010506 regulation of autophagy 22.5806 6 no
GO:0010638 positive regulation of organelle organization 22.5806 6 no
GO:0016241 regulation of macroautophagy 22.5806 7 no
GO:0051240 positive regulation of multicellular organismal process 22.5806 4 no
GO:0080134 regulation of response to stress 22.5806 4 no
GO:0045216 cell-cell junction organization 19.3548 5 yes
GO:0072583 clathrin-dependent endocytosis 19.3548 5 yes
GO:0006909 phagocytosis 16.1290 4 yes
GO:0007043 cell-cell junction assembly 16.1290 6 yes
GO:0046903 secretion 16.1290 4 yes
GO:0016079 synaptic vesicle exocytosis 12.9032 4 yes
GO:0023061 signal release 12.9032 4 yes
GO:0034332 adherens junction organization 12.9032 6 yes
GO:0045055 regulated exocytosis 12.9032 4 yes
GO:0099643 signal release from synapse 12.9032 5 yes
GO:0006644 phospholipid metabolic process 9.6774 4 yes
GO:0006650 glycerophospholipid metabolic process 9.6774 5 yes
GO:0006661 phosphatidylinositol biosynthetic process 9.6774 6 yes
GO:0008610 lipid biosynthetic process 9.6774 4 yes
GO:0008654 phospholipid biosynthetic process 9.6774 5 yes
GO:0045017 glycerolipid biosynthetic process 9.6774 4 yes
GO:0046474 glycerophospholipid biosynthetic process 9.6774 5 yes
GO:0046486 glycerolipid metabolic process 9.6774 4 yes
GO:0046488 phosphatidylinositol metabolic process 9.6774 6 yes
GO:0046854 phosphatidylinositol phosphate biosynthetic process 9.6774 7 yes
GO:0060326 cell chemotaxis 9.6774 4 yes
GO:0090407 organophosphate biosynthetic process 9.6774 4 yes
GO:0030593 neutrophil chemotaxis 6.4516 5 yes
GO:0034333 adherens junction assembly 6.4516 7 yes
GO:0071621 granulocyte chemotaxis 6.4516 4 yes
GO:0097530 granulocyte migration 6.4516 4 yes
GO:1990266 neutrophil migration 6.4516 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TLN1_HUMAN [view entry] [view interactions] Low throughput yes no
AP2B1_HUMAN [view entry] [view interactions] Low throughput yes yes
ARF6_HUMAN [view entry] [view interactions] Low throughput yes yes
SYT1_HUMAN [view entry] [view interactions] Low throughput yes no
AP2A1_HUMAN [view entry] [view interactions] Low throughput yes yes
FAK1_HUMAN [view entry] [view interactions] Low throughput yes yes
SNX5_HUMAN [view entry] [view interactions] Low throughput yes yes
PI5L1_HUMAN [view interactions] Low throughput no no
TLN2_HUMAN [view entry] [view interactions] Low throughput yes yes
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
AP2A2_HUMAN [view entry] [view interactions] Low throughput yes yes
CADH1_HUMAN [view entry] [view interactions] Low throughput yes no
LAP4B_HUMAN [view interactions] Low throughput no yes
NEDD4_HUMAN [view entry] [view interactions] Low throughput yes yes
SMUF1_HUMAN [view interactions] Low throughput no yes
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
BAKOR_HUMAN [view interactions] Low throughput no yes
ITB1_HUMAN [view entry] [view interactions] Low throughput yes no
AKT1_HUMAN [view entry] [view interactions] Low throughput yes yes
AKT2_HUMAN [view entry] [view interactions] Low throughput yes yes
PKD1_HUMAN [view interactions] Low throughput no yes
CDK5_HUMAN [view entry] [view interactions] Low throughput yes yes
CDK1_HUMAN [view interactions] Low throughput no no
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
AP2M1_HUMAN [view entry] [view interactions] Low throughput yes yes
PGTB2_HUMAN [view interactions] High throughput no yes
PK3CA_HUMAN [view entry] [view interactions] High throughput yes yes
COQ2_HUMAN [view interactions] High throughput no yes
SOAT1_HUMAN [view interactions] High throughput no no
VDAC1_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC4_HUMAN [view interactions] High throughput no yes
PI51C_HUMAN [view entry] [view interactions] High throughput yes yes
TPTE_HUMAN [view interactions] High throughput no no
NYAP1_HUMAN [view interactions] High throughput no no
ITB3_HUMAN [view entry] [view interactions] High throughput yes no
BAP1_HUMAN [view interactions] High throughput no yes
MOV10_HUMAN [view interactions] High throughput no no
PI51A_HUMAN [view interactions] High throughput no yes
LARP7_HUMAN [view interactions] High throughput no yes
ARHG1_HUMAN [view interactions] High throughput no no
VAV_HUMAN [view interactions] High throughput no no
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
P53_HUMAN [view interactions] High throughput no no
RHOJ_HUMAN [view interactions] High throughput no yes
RHOF_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
PGBD5_HUMAN [view interactions] High throughput no no
SNX4_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
TOP3B_HUMAN [view interactions] High throughput no no
SPPL3_HUMAN [view interactions] High throughput no no
PI51B_HUMAN [view interactions] High throughput no yes
HDHD2_HUMAN [view interactions] High throughput no yes
IQGA1_HUMAN [view entry] [view interactions] High throughput yes no
AP1B1_HUMAN [view entry] [view interactions] High throughput yes yes
DPP4_HUMAN [view interactions] High throughput no no
MUC18_HUMAN [view interactions] High throughput no yes
SSR3_HUMAN [view interactions] High throughput no yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes