SYT4_HUMAN
Evidence for PS localization
Functions
Synaptotagmin family member which does not bind Ca(2+) (PubMed) . Involved in neuronal dense core vesicles (DCVs) mobility through its interaction with KIF1A. Upon increased neuronal activity, phosphorylation by MAPK8/JNK1 destabilizes the interaction with KIF1A and captures DCVs to synapses . Plays a role in dendrite formation by melanocytes (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SYT4_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 44.4444 | 4 | yes |
| GO:0005509 | calcium ion binding | 33.3333 | 5 | yes |
| GO:0005544 | calcium-dependent phospholipid binding | 33.3333 | 4 | yes |
| GO:0019905 | syntaxin binding | 33.3333 | 4 | no |
| GO:0017075 | syntaxin-1 binding | 22.2222 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SYT4_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 66.6667 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 66.6667 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 66.6667 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 66.6667 | 5 | yes |
| GO:0051046 | regulation of secretion | 66.6667 | 5 | yes |
| GO:0051049 | regulation of transport | 66.6667 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 66.6667 | 4 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 66.6667 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 66.6667 | 4 | yes |
| GO:1903530 | regulation of secretion by cell | 66.6667 | 4 | yes |
| GO:0006836 | neurotransmitter transport | 55.5556 | 4 | yes |
| GO:0006887 | exocytosis | 55.5556 | 4 | yes |
| GO:0017157 | regulation of exocytosis | 55.5556 | 5 | yes |
| GO:0023061 | signal release | 55.5556 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 55.5556 | 5 | yes |
| GO:0045055 | regulated exocytosis | 55.5556 | 5 | yes |
| GO:0046903 | secretion | 55.5556 | 4 | yes |
| GO:0046928 | regulation of neurotransmitter secretion | 55.5556 | 4 | yes |
| GO:0051588 | regulation of neurotransmitter transport | 55.5556 | 5 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 55.5556 | 4 | yes |
| GO:0099643 | signal release from synapse | 55.5556 | 5 | yes |
| GO:0001558 | regulation of cell growth | 44.4444 | 4 | yes |
| GO:0006996 | organelle organization | 44.4444 | 4 | yes |
| GO:0010038 | response to metal ion | 44.4444 | 4 | yes |
| GO:0014059 | regulation of dopamine secretion | 44.4444 | 6 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 44.4444 | 4 | yes |
| GO:0022604 | regulation of cell morphogenesis | 44.4444 | 5 | yes |
| GO:0030307 | positive regulation of cell growth | 44.4444 | 5 | yes |
| GO:0031338 | regulation of vesicle fusion | 44.4444 | 5 | yes |
| GO:0032880 | regulation of protein localization | 44.4444 | 5 | yes |
| GO:0043269 | regulation of ion transport | 44.4444 | 5 | yes |
| GO:0045927 | positive regulation of growth | 44.4444 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 44.4444 | 4 | yes |
| GO:0048638 | regulation of developmental growth | 44.4444 | 4 | yes |
| GO:0048639 | positive regulation of developmental growth | 44.4444 | 5 | yes |
| GO:0050433 | regulation of catecholamine secretion | 44.4444 | 5 | yes |
| GO:0050708 | regulation of protein secretion | 44.4444 | 5 | yes |
| GO:0050890 | cognition | 44.4444 | 4 | yes |
| GO:0051050 | positive regulation of transport | 44.4444 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 44.4444 | 4 | yes |
| GO:0051223 | regulation of protein transport | 44.4444 | 5 | yes |
| GO:0051952 | regulation of amine transport | 44.4444 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 44.4444 | 4 | yes |
| GO:0070201 | regulation of establishment of protein localization | 44.4444 | 6 | yes |
| GO:0071241 | cellular response to inorganic substance | 44.4444 | 4 | yes |
| GO:0071248 | cellular response to metal ion | 44.4444 | 5 | yes |
| GO:1903859 | regulation of dendrite extension | 44.4444 | 5 | yes |
| GO:1903861 | positive regulation of dendrite extension | 44.4444 | 6 | yes |
| GO:0007268 | chemical synaptic transmission | 44.4444 | 6 | no |
| GO:0022607 | cellular component assembly | 44.4444 | 4 | no |
| GO:0043933 | protein-containing complex organization | 44.4444 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 44.4444 | 5 | no |
| GO:0098916 | anterograde trans-synaptic signaling | 44.4444 | 5 | no |
| GO:0006906 | vesicle fusion | 33.3333 | 6 | yes |
| GO:0007269 | neurotransmitter secretion | 33.3333 | 4 | yes |
| GO:0010648 | negative regulation of cell communication | 33.3333 | 5 | yes |
| GO:0016050 | vesicle organization | 33.3333 | 5 | yes |
| GO:0017156 | calcium-ion regulated exocytosis | 33.3333 | 6 | yes |
| GO:0017158 | regulation of calcium ion-dependent exocytosis | 33.3333 | 7 | yes |
| GO:0023057 | negative regulation of signaling | 33.3333 | 4 | yes |
| GO:0043270 | positive regulation of ion transport | 33.3333 | 5 | yes |
| GO:0045920 | negative regulation of exocytosis | 33.3333 | 6 | yes |
| GO:0045921 | positive regulation of exocytosis | 33.3333 | 6 | yes |
| GO:0045956 | positive regulation of calcium ion-dependent exocytosis | 33.3333 | 8 | yes |
| GO:0046929 | negative regulation of neurotransmitter secretion | 33.3333 | 5 | yes |
| GO:0048284 | organelle fusion | 33.3333 | 5 | yes |
| GO:0050709 | negative regulation of protein secretion | 33.3333 | 6 | yes |
| GO:0050805 | negative regulation of synaptic transmission | 33.3333 | 5 | yes |
| GO:0051047 | positive regulation of secretion | 33.3333 | 5 | yes |
| GO:0051048 | negative regulation of secretion | 33.3333 | 5 | yes |
| GO:0051051 | negative regulation of transport | 33.3333 | 4 | yes |
| GO:0051093 | negative regulation of developmental process | 33.3333 | 4 | yes |
| GO:0051224 | negative regulation of protein transport | 33.3333 | 5 | yes |
| GO:0051589 | negative regulation of neurotransmitter transport | 33.3333 | 5 | yes |
| GO:0051592 | response to calcium ion | 33.3333 | 5 | yes |
| GO:0051954 | positive regulation of amine transport | 33.3333 | 5 | yes |
| GO:0061024 | membrane organization | 33.3333 | 4 | yes |
| GO:0061025 | membrane fusion | 33.3333 | 5 | yes |
| GO:0071277 | cellular response to calcium ion | 33.3333 | 6 | yes |
| GO:0090174 | organelle membrane fusion | 33.3333 | 6 | yes |
| GO:1903233 | regulation of calcium ion-dependent exocytosis of neurotransmitter | 33.3333 | 6 | yes |
| GO:1903305 | regulation of regulated secretory pathway | 33.3333 | 6 | yes |
| GO:1903307 | positive regulation of regulated secretory pathway | 33.3333 | 7 | yes |
| GO:1903531 | negative regulation of secretion by cell | 33.3333 | 5 | yes |
| GO:1903532 | positive regulation of secretion by cell | 33.3333 | 5 | yes |
| GO:1903828 | negative regulation of protein localization | 33.3333 | 5 | yes |
| GO:1904950 | negative regulation of establishment of protein localization | 33.3333 | 6 | yes |
| GO:2000300 | regulation of synaptic vesicle exocytosis | 33.3333 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 33.3333 | 4 | no |
| GO:0010468 | regulation of gene expression | 33.3333 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 33.3333 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 33.3333 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 33.3333 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 33.3333 | 5 | no |
| GO:0043412 | macromolecule modification | 33.3333 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 33.3333 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 33.3333 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 33.3333 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 33.3333 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 33.3333 | 5 | no |
| GO:0016079 | synaptic vesicle exocytosis | 33.3333 | 4 | no |
| GO:0023056 | positive regulation of signaling | 33.3333 | 4 | no |
| GO:0099003 | vesicle-mediated transport in synapse | 33.3333 | 5 | no |
| GO:0007613 | memory | 22.2222 | 4 | yes |
| GO:0010721 | negative regulation of cell development | 22.2222 | 6 | yes |
| GO:0014048 | regulation of glutamate secretion | 22.2222 | 5 | yes |
| GO:0014049 | positive regulation of glutamate secretion | 22.2222 | 6 | yes |
| GO:0016482 | cytosolic transport | 22.2222 | 4 | yes |
| GO:0030100 | regulation of endocytosis | 22.2222 | 5 | yes |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 22.2222 | 4 | yes |
| GO:0032252 | secretory granule localization | 22.2222 | 4 | yes |
| GO:0032253 | dense core granule localization | 22.2222 | 5 | yes |
| GO:0032890 | regulation of organic acid transport | 22.2222 | 5 | yes |
| GO:0032892 | positive regulation of organic acid transport | 22.2222 | 5 | yes |
| GO:0033604 | negative regulation of catecholamine secretion | 22.2222 | 6 | yes |
| GO:0044070 | regulation of anion transport | 22.2222 | 6 | yes |
| GO:0045595 | regulation of cell differentiation | 22.2222 | 4 | yes |
| GO:0045596 | negative regulation of cell differentiation | 22.2222 | 5 | yes |
| GO:0045955 | negative regulation of calcium ion-dependent exocytosis | 22.2222 | 8 | yes |
| GO:0048168 | regulation of neuronal synaptic plasticity | 22.2222 | 4 | yes |
| GO:0048172 | regulation of short-term neuronal synaptic plasticity | 22.2222 | 5 | yes |
| GO:0048174 | negative regulation of short-term neuronal synaptic plasticity | 22.2222 | 6 | yes |
| GO:0050767 | regulation of neurogenesis | 22.2222 | 6 | yes |
| GO:0050768 | negative regulation of neurogenesis | 22.2222 | 6 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 22.2222 | 4 | yes |
| GO:0051650 | establishment of vesicle localization | 22.2222 | 4 | yes |
| GO:0051953 | negative regulation of amine transport | 22.2222 | 5 | yes |
| GO:0051955 | regulation of amino acid transport | 22.2222 | 6 | yes |
| GO:0051957 | positive regulation of amino acid transport | 22.2222 | 6 | yes |
| GO:0051960 | regulation of nervous system development | 22.2222 | 5 | yes |
| GO:0051961 | negative regulation of nervous system development | 22.2222 | 5 | yes |
| GO:0060284 | regulation of cell development | 22.2222 | 5 | yes |
| GO:0099161 | regulation of presynaptic dense core granule exocytosis | 22.2222 | 7 | yes |
| GO:0099171 | presynaptic modulation of chemical synaptic transmission | 22.2222 | 6 | yes |
| GO:0099183 | trans-synaptic signaling by BDNF, modulating synaptic transmission | 22.2222 | 6 | yes |
| GO:0099191 | trans-synaptic signaling by BDNF | 22.2222 | 5 | yes |
| GO:0099518 | vesicle cytoskeletal trafficking | 22.2222 | 5 | yes |
| GO:0099519 | dense core granule cytoskeletal transport | 22.2222 | 6 | yes |
| GO:0099550 | trans-synaptic signaling, modulating synaptic transmission | 22.2222 | 5 | yes |
| GO:1901950 | dense core granule transport | 22.2222 | 5 | yes |
| GO:1903306 | negative regulation of regulated secretory pathway | 22.2222 | 7 | yes |
| GO:1903793 | positive regulation of anion transport | 22.2222 | 6 | yes |
| GO:1905413 | regulation of dense core granule exocytosis | 22.2222 | 8 | yes |
| GO:1905415 | positive regulation of dense core granule exocytosis | 22.2222 | 9 | yes |
| GO:1905432 | regulation of retrograde trans-synaptic signaling by neuropeptide | 22.2222 | 5 | yes |
| GO:1905433 | negative regulation of retrograde trans-synaptic signaling by neuropeptide | 22.2222 | 5 | yes |
| GO:2000026 | regulation of multicellular organismal development | 22.2222 | 4 | yes |
| GO:2000301 | negative regulation of synaptic vesicle exocytosis | 22.2222 | 6 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 22.2222 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 22.2222 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 22.2222 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 22.2222 | 4 | no |
| GO:0009894 | regulation of catabolic process | 22.2222 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 22.2222 | 6 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 22.2222 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 22.2222 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.2222 | 5 | no |
| GO:0010628 | positive regulation of gene expression | 22.2222 | 6 | no |
| GO:0010629 | negative regulation of gene expression | 22.2222 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 22.2222 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 22.2222 | 5 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 22.2222 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 22.2222 | 6 | no |
| GO:0031329 | regulation of cellular catabolic process | 22.2222 | 5 | no |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 22.2222 | 6 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 22.2222 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 22.2222 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 22.2222 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.2222 | 6 | no |
| GO:0051248 | negative regulation of protein metabolic process | 22.2222 | 6 | no |
| GO:0051253 | negative regulation of RNA metabolic process | 22.2222 | 6 | no |
| GO:0071310 | cellular response to organic substance | 22.2222 | 4 | no |
| GO:0001504 | neurotransmitter uptake | 22.2222 | 4 | no |
| GO:0002791 | regulation of peptide secretion | 22.2222 | 6 | no |
| GO:0006897 | endocytosis | 22.2222 | 5 | no |
| GO:0007612 | learning | 22.2222 | 4 | no |
| GO:0046883 | regulation of hormone secretion | 22.2222 | 4 | no |
| GO:0048278 | vesicle docking | 22.2222 | 4 | no |
| GO:0050796 | regulation of insulin secretion | 22.2222 | 6 | no |
| GO:0050806 | positive regulation of synaptic transmission | 22.2222 | 5 | no |
| GO:0090087 | regulation of peptide transport | 22.2222 | 5 | no |
| GO:0090276 | regulation of peptide hormone secretion | 22.2222 | 5 | no |
| GO:0098657 | import into cell | 22.2222 | 4 | no |
| GO:0098967 | exocytic insertion of neurotransmitter receptor to postsynaptic membrane | 22.2222 | 4 | no |
| GO:0008104 | protein localization | 22.2222 | 4 | no |
| GO:0031630 | regulation of synaptic vesicle fusion to presynaptic active zone membrane | 22.2222 | 6 | no |
| GO:0071702 | organic substance transport | 22.2222 | 4 | no |
| GO:0071705 | nitrogen compound transport | 22.2222 | 4 | no |
| GO:1901632 | regulation of synaptic vesicle membrane organization | 22.2222 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 22.2222 | 6 | no |
| GO:0010638 | positive regulation of organelle organization | 22.2222 | 6 | no |
| GO:0036211 | protein modification process | 22.2222 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 22.2222 | 5 | no |
| GO:0051590 | positive regulation of neurotransmitter transport | 22.2222 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 22.2222 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 22.2222 | 6 | no |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in SYT4_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 22.2222 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MK08_HUMAN | [view interactions] | Low throughput | no | yes |
| MK09_HUMAN | [view interactions] | Low throughput | no | yes |
| MK10_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PRKN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HNRPQ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HNRPC_HUMAN | [view interactions] | High throughput | no | yes |
| CAC1B_HUMAN | [view interactions] | High throughput | no | yes |
| SGTA_HUMAN | [view interactions] | High throughput | no | yes |
| NBR1_HUMAN | [view interactions] | High throughput | no | yes |
| SGTB_HUMAN | [view interactions] | High throughput | no | yes |
| NDUAC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYT4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DMRTB_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| DOC2B_HUMAN | [view interactions] | High throughput | no | no |
| SNP25_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CPLX1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NEC2_HUMAN | [view interactions] | Computational | no | no |