Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SYT4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Synaptotagmin family member which does not bind Ca(2+) (PubMed) . Involved in neuronal dense core vesicles (DCVs) mobility through its interaction with KIF1A. Upon increased neuronal activity, phosphorylation by MAPK8/JNK1 destabilizes the interaction with KIF1A and captures DCVs to synapses . Plays a role in dendrite formation by melanocytes (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SYT4_HUMAN
GO:0043169 cation binding 62.5000 4 yes
GO:0046872 metal ion binding 62.5000 5 yes
GO:0005509 calcium ion binding 37.5000 6 yes
GO:0005544 calcium-dependent phospholipid binding 37.5000 4 yes
GO:0008324 monoatomic cation transmembrane transporter activity 25.0000 4 no
GO:0022890 inorganic cation transmembrane transporter activity 25.0000 4 no
GO:0043168 anion binding 25.0000 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in SYT4_HUMAN
GO:0048522 positive regulation of cellular process 62.5000 4 yes
GO:0051049 regulation of transport 62.5000 4 yes
GO:0071241 cellular response to inorganic substance 50.0000 4 yes
GO:0071248 cellular response to metal ion 50.0000 5 yes
GO:0099177 regulation of trans-synaptic signaling 50.0000 4 yes
GO:1903530 regulation of secretion by cell 50.0000 4 yes
GO:1903859 regulation of dendrite extension 50.0000 5 yes
GO:1903861 positive regulation of dendrite extension 50.0000 6 yes
GO:0001558 regulation of cell growth 50.0000 4 yes
GO:0010038 response to metal ion 50.0000 4 yes
GO:0010646 regulation of cell communication 50.0000 4 yes
GO:0014059 regulation of dopamine secretion 50.0000 6 yes
GO:0017157 regulation of exocytosis 50.0000 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 50.0000 4 yes
GO:0022604 regulation of cell morphogenesis 50.0000 5 yes
GO:0030307 positive regulation of cell growth 50.0000 5 yes
GO:0033043 regulation of organelle organization 50.0000 5 yes
GO:0045927 positive regulation of growth 50.0000 4 yes
GO:0046928 regulation of neurotransmitter secretion 50.0000 5 yes
GO:0048523 negative regulation of cellular process 50.0000 4 yes
GO:0048638 regulation of developmental growth 50.0000 4 yes
GO:0048639 positive regulation of developmental growth 50.0000 5 yes
GO:0050433 regulation of catecholamine secretion 50.0000 5 yes
GO:0050804 modulation of chemical synaptic transmission 50.0000 5 yes
GO:0051046 regulation of secretion 50.0000 5 yes
GO:0051050 positive regulation of transport 50.0000 4 yes
GO:0051094 positive regulation of developmental process 50.0000 4 yes
GO:0051128 regulation of cellular component organization 50.0000 4 yes
GO:0051588 regulation of neurotransmitter transport 50.0000 5 yes
GO:0051952 regulation of amine transport 50.0000 5 yes
GO:0060627 regulation of vesicle-mediated transport 50.0000 4 yes
GO:0070201 regulation of establishment of protein localization 37.5000 6 yes
GO:0071277 cellular response to calcium ion 37.5000 6 yes
GO:0099643 signal release from synapse 37.5000 5 yes
GO:1903305 regulation of regulated secretory pathway 37.5000 6 yes
GO:1903307 positive regulation of regulated secretory pathway 37.5000 7 yes
GO:1903531 negative regulation of secretion by cell 37.5000 5 yes
GO:1903532 positive regulation of secretion by cell 37.5000 5 yes
GO:1903828 negative regulation of protein localization 37.5000 5 yes
GO:1904950 negative regulation of establishment of protein localization 37.5000 6 yes
GO:2000300 regulation of synaptic vesicle exocytosis 37.5000 6 yes
GO:0098657 import into cell 37.5000 4 no
GO:0022607 cellular component assembly 37.5000 4 no
GO:0043412 macromolecule modification 37.5000 4 no
GO:0043933 protein-containing complex organization 37.5000 4 no
GO:0065003 protein-containing complex assembly 37.5000 5 no
GO:0006996 organelle organization 37.5000 4 yes
GO:0010648 negative regulation of cell communication 37.5000 5 yes
GO:0016079 synaptic vesicle exocytosis 37.5000 4 yes
GO:0017156 calcium-ion regulated exocytosis 37.5000 5 yes
GO:0017158 regulation of calcium ion-dependent exocytosis 37.5000 7 yes
GO:0023057 negative regulation of signaling 37.5000 4 yes
GO:0023061 signal release 37.5000 4 yes
GO:0030100 regulation of endocytosis 37.5000 5 yes
GO:0031338 regulation of vesicle fusion 37.5000 5 yes
GO:0032880 regulation of protein localization 37.5000 5 yes
GO:0045055 regulated exocytosis 37.5000 4 yes
GO:0045920 negative regulation of exocytosis 37.5000 6 yes
GO:0045921 positive regulation of exocytosis 37.5000 6 yes
GO:0045956 positive regulation of calcium ion-dependent exocytosis 37.5000 8 yes
GO:0046903 secretion 37.5000 4 yes
GO:0048791 calcium ion-regulated exocytosis of neurotransmitter 37.5000 5 yes
GO:0050708 regulation of protein secretion 37.5000 5 yes
GO:0050709 negative regulation of protein secretion 37.5000 6 yes
GO:0050890 cognition 37.5000 4 yes
GO:0051047 positive regulation of secretion 37.5000 5 yes
GO:0051048 negative regulation of secretion 37.5000 5 yes
GO:0051051 negative regulation of transport 37.5000 4 yes
GO:0051093 negative regulation of developmental process 37.5000 4 yes
GO:0051223 regulation of protein transport 37.5000 5 yes
GO:0051224 negative regulation of protein transport 37.5000 5 yes
GO:0051592 response to calcium ion 37.5000 5 yes
GO:0051954 positive regulation of amine transport 37.5000 5 yes
GO:0060341 regulation of cellular localization 37.5000 4 yes
GO:0061024 membrane organization 25.0000 4 yes
GO:0061025 membrane fusion 25.0000 5 yes
GO:0090174 organelle membrane fusion 25.0000 6 yes
GO:0099518 vesicle cytoskeletal trafficking 25.0000 5 yes
GO:0099519 dense core granule cytoskeletal transport 25.0000 6 yes
GO:0150035 regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission 25.0000 6 yes
GO:0150044 regulation of postsynaptic dense core vesicle exocytosis 25.0000 9 yes
GO:1901950 dense core granule transport 25.0000 5 yes
GO:1903306 negative regulation of regulated secretory pathway 25.0000 7 yes
GO:1905413 regulation of dense core granule exocytosis 25.0000 8 yes
GO:1905415 positive regulation of dense core granule exocytosis 25.0000 9 yes
GO:1905432 regulation of retrograde trans-synaptic signaling by neuropeptide 25.0000 5 yes
GO:1905433 negative regulation of retrograde trans-synaptic signaling by neuropeptide 25.0000 5 yes
GO:2000026 regulation of multicellular organismal development 25.0000 4 yes
GO:2000301 negative regulation of synaptic vesicle exocytosis 25.0000 7 yes
GO:0032970 regulation of actin filament-based process 25.0000 4 no
GO:0141124 intracellular signaling cassette 25.0000 4 no
GO:0006836 neurotransmitter transport 25.0000 4 no
GO:0007268 chemical synaptic transmission 25.0000 7 no
GO:0009889 regulation of biosynthetic process 25.0000 4 no
GO:0009890 negative regulation of biosynthetic process 25.0000 5 no
GO:0009891 positive regulation of biosynthetic process 25.0000 5 no
GO:0009892 negative regulation of metabolic process 25.0000 4 no
GO:0009893 positive regulation of metabolic process 25.0000 4 no
GO:0009894 regulation of catabolic process 25.0000 4 no
GO:0010468 regulation of gene expression 25.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0010558 negative regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0010604 positive regulation of macromolecule metabolic process 25.0000 5 no
GO:0010605 negative regulation of macromolecule metabolic process 25.0000 5 no
GO:0010628 positive regulation of gene expression 25.0000 7 no
GO:0010629 negative regulation of gene expression 25.0000 7 no
GO:0010638 positive regulation of organelle organization 25.0000 6 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0031323 regulation of cellular metabolic process 25.0000 4 no
GO:0031324 negative regulation of cellular metabolic process 25.0000 5 no
GO:0031325 positive regulation of cellular metabolic process 25.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0031327 negative regulation of cellular biosynthetic process 25.0000 6 no
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 no
GO:0036211 protein modification process 25.0000 4 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 no
GO:0051246 regulation of protein metabolic process 25.0000 5 no
GO:0051247 positive regulation of protein metabolic process 25.0000 6 no
GO:0051248 negative regulation of protein metabolic process 25.0000 6 no
GO:0051252 regulation of RNA metabolic process 25.0000 5 no
GO:0051253 negative regulation of RNA metabolic process 25.0000 6 no
GO:0051590 positive regulation of neurotransmitter transport 25.0000 5 no
GO:0060255 regulation of macromolecule metabolic process 25.0000 4 no
GO:0071310 cellular response to organic substance 25.0000 4 no
GO:0080090 regulation of primary metabolic process 25.0000 4 no
GO:0098916 anterograde trans-synaptic signaling 25.0000 6 no
GO:0099536 synaptic signaling 25.0000 4 no
GO:0099537 trans-synaptic signaling 25.0000 5 no
GO:0006796 phosphate-containing compound metabolic process 25.0000 4 no
GO:0006906 vesicle fusion 25.0000 6 yes
GO:0007613 memory 25.0000 4 yes
GO:0010721 negative regulation of cell development 25.0000 6 yes
GO:0014048 regulation of glutamate secretion 25.0000 5 yes
GO:0014049 positive regulation of glutamate secretion 25.0000 6 yes
GO:0016050 vesicle organization 25.0000 5 yes
GO:0016482 cytosolic transport 25.0000 4 yes
GO:0030705 cytoskeleton-dependent intracellular transport 25.0000 4 yes
GO:0032252 secretory granule localization 25.0000 4 yes
GO:0032253 dense core granule localization 25.0000 5 yes
GO:0032890 regulation of organic acid transport 25.0000 5 yes
GO:0032892 positive regulation of organic acid transport 25.0000 5 yes
GO:0033604 negative regulation of catecholamine secretion 25.0000 6 yes
GO:0045595 regulation of cell differentiation 25.0000 4 yes
GO:0045596 negative regulation of cell differentiation 25.0000 5 yes
GO:0045955 negative regulation of calcium ion-dependent exocytosis 25.0000 8 yes
GO:0048168 regulation of neuronal synaptic plasticity 25.0000 4 yes
GO:0048172 regulation of short-term neuronal synaptic plasticity 25.0000 5 yes
GO:0048174 negative regulation of short-term neuronal synaptic plasticity 25.0000 6 yes
GO:0048284 organelle fusion 25.0000 5 yes
GO:0050767 regulation of neurogenesis 25.0000 6 yes
GO:0050768 negative regulation of neurogenesis 25.0000 6 yes
GO:0051241 negative regulation of multicellular organismal process 25.0000 4 yes
GO:0051650 establishment of vesicle localization 25.0000 4 yes
GO:0051953 negative regulation of amine transport 25.0000 5 yes
GO:0051955 regulation of amino acid transport 25.0000 6 yes
GO:0051957 positive regulation of amino acid transport 25.0000 6 yes
GO:0051960 regulation of nervous system development 25.0000 5 yes
GO:0051961 negative regulation of nervous system development 25.0000 5 yes
GO:0060284 regulation of cell development 25.0000 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MK08_HUMAN [view interactions] Low throughput no yes
MK09_HUMAN [view interactions] Low throughput no yes
MK10_HUMAN [view entry] [view interactions] Low throughput yes yes
SYT1_HUMAN [view entry] [view interactions] Low throughput yes no
PRKN_HUMAN [view entry] [view interactions] Low throughput yes yes
HNRPQ_HUMAN [view entry] [view interactions] Low throughput yes yes
HNRPC_HUMAN [view interactions] High throughput no yes
CAC1B_HUMAN [view interactions] High throughput no yes
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
SGTA_HUMAN [view interactions] High throughput no yes
NBR1_HUMAN [view interactions] High throughput no yes
SGTB_HUMAN [view interactions] High throughput no yes
NDUAC_HUMAN [view entry] [view interactions] High throughput yes yes
BRWD1_HUMAN [view interactions] High throughput no yes
SYT4_HUMAN [view entry] [view interactions] High throughput yes yes
DMRTB_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
DOC2B_HUMAN [view interactions] High throughput no no