SCD5_HUMAN
Evidence for PS localization
Functions
Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed, PubMed, PubMed). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed, PubMed). Involved in neuronal cell proliferation and differentiation through down-regulation of EGFR/AKT/MAPK and Wnt signaling pathways (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SCD5_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 33.3333 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 26.6667 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 26.6667 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.6667 | 4 | no |
| GO:0004768 | stearoyl-CoA 9-desaturase activity | 13.3333 | 6 | yes |
| GO:0005506 | iron ion binding | 13.3333 | 6 | yes |
| GO:0016215 | acyl-CoA desaturase activity | 13.3333 | 5 | yes |
| GO:0016717 | oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water | 13.3333 | 4 | yes |
| GO:0046914 | transition metal ion binding | 13.3333 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SCD5_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 46.6667 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 33.3333 | 4 | no |
| GO:0022607 | cellular component assembly | 26.6667 | 4 | no |
| GO:0006996 | organelle organization | 26.6667 | 4 | no |
| GO:0009966 | regulation of signal transduction | 26.6667 | 4 | no |
| GO:0010646 | regulation of cell communication | 26.6667 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 26.6667 | 4 | no |
| GO:0051049 | regulation of transport | 26.6667 | 4 | no |
| GO:0006631 | fatty acid metabolic process | 20.0000 | 4 | yes |
| GO:0006633 | fatty acid biosynthetic process | 20.0000 | 5 | yes |
| GO:0008610 | lipid biosynthetic process | 20.0000 | 4 | yes |
| GO:0016053 | organic acid biosynthetic process | 20.0000 | 4 | yes |
| GO:0019752 | carboxylic acid metabolic process | 20.0000 | 5 | yes |
| GO:0032787 | monocarboxylic acid metabolic process | 20.0000 | 6 | yes |
| GO:0043436 | oxoacid metabolic process | 20.0000 | 4 | yes |
| GO:0046394 | carboxylic acid biosynthetic process | 20.0000 | 5 | yes |
| GO:0072330 | monocarboxylic acid biosynthetic process | 20.0000 | 6 | yes |
| GO:0006636 | unsaturated fatty acid biosynthetic process | 13.3333 | 6 | yes |
| GO:0033559 | unsaturated fatty acid metabolic process | 13.3333 | 5 | yes |
| GO:1903964 | monounsaturated fatty acid metabolic process | 13.3333 | 4 | yes |
| GO:1903966 | monounsaturated fatty acid biosynthetic process | 13.3333 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TECT3_HUMAN | [view interactions] | High throughput | no | yes |
| TECT2_HUMAN | [view interactions] | High throughput | no | yes |
| T176A_HUMAN | [view interactions] | High throughput | no | yes |
| CNDP1_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| AT2A3_HUMAN | [view interactions] | High throughput | no | yes |
| KLRD1_HUMAN | [view interactions] | High throughput | no | no |
| GPIX_HUMAN | [view interactions] | High throughput | no | no |
| ACHA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VSIG4_HUMAN | [view interactions] | High throughput | no | no |
| S22A9_HUMAN | [view interactions] | High throughput | no | no |
| TNFL8_HUMAN | [view interactions] | High throughput | no | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OTULL_HUMAN | [view interactions] | High throughput | no | no |
| ST7_HUMAN | [view interactions] | High throughput | no | yes |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| DJC25_HUMAN | [view interactions] | High throughput | no | yes |
| SEC63_HUMAN | [view interactions] | High throughput | no | yes |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAP31_HUMAN | [view interactions] | High throughput | no | yes |
| CKAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DERL1_HUMAN | [view interactions] | High throughput | no | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI1_HUMAN | [view interactions] | High throughput | no | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| DHB11_HUMAN | [view interactions] | High throughput | no | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCR5_HUMAN | [view interactions] | Computational | no | no |
| ACOT2_HUMAN | [view interactions] | Computational | no | yes |
| ACOT4_HUMAN | [view interactions] | Computational | no | yes |
| ACOT1_HUMAN | [view interactions] | Computational | no | yes |
| SCD_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DHB12_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CD4_HUMAN | [view interactions] | Computational | no | no |
| HACD3_HUMAN | [view interactions] | Computational | no | yes |
| ITIH4_HUMAN | [view interactions] | Computational | no | no |
| SRBP2_HUMAN | [view interactions] | Computational | no | yes |
| EGR2_HUMAN | [view interactions] | Computational | no | no |
| TECR_HUMAN | [view interactions] | Computational | no | yes |
| ELOV6_HUMAN | [view interactions] | Computational | no | yes |
| HACD1_HUMAN | [view interactions] | Computational | no | no |
| HACD2_HUMAN | [view interactions] | Computational | no | yes |
| HACD4_HUMAN | [view interactions] | Computational | no | no |