SCD5_HUMAN
Evidence for PS localization
Functions
Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed, PubMed, PubMed). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed, PubMed). Involved in neuronal cell proliferation and differentiation through down-regulation of EGFR/AKT/MAPK and Wnt signaling pathways (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SCD5_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 47.0588 | 4 | yes |
| GO:0046872 | metal ion binding | 41.1765 | 5 | yes |
| GO:0017076 | purine nucleotide binding | 35.2941 | 5 | no |
| GO:0000166 | nucleotide binding | 35.2941 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 29.4118 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 29.4118 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 29.4118 | 6 | no |
| GO:0032555 | purine ribonucleotide binding | 29.4118 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 29.4118 | 4 | no |
| GO:0043168 | anion binding | 29.4118 | 4 | no |
| GO:0005525 | GTP binding | 23.5294 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 23.5294 | 6 | no |
| GO:0032561 | guanyl ribonucleotide binding | 23.5294 | 5 | no |
| GO:0003723 | RNA binding | 23.5294 | 4 | no |
| GO:0003924 | GTPase activity | 23.5294 | 7 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SCD5_HUMAN |
|---|---|---|---|---|
| GO:0006996 | organelle organization | 41.1765 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 35.2941 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 29.4118 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 29.4118 | 4 | no |
| GO:0071702 | organic substance transport | 29.4118 | 4 | no |
| GO:0006915 | apoptotic process | 23.5294 | 4 | no |
| GO:0022607 | cellular component assembly | 23.5294 | 4 | no |
| GO:0008104 | protein localization | 23.5294 | 4 | no |
| GO:0009966 | regulation of signal transduction | 23.5294 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 23.5294 | 5 | no |
| GO:0010646 | regulation of cell communication | 23.5294 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 23.5294 | 5 | no |
| GO:0023057 | negative regulation of signaling | 23.5294 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 23.5294 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 23.5294 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 23.5294 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TECT3_HUMAN | [view interactions] | High throughput | no | yes |
| TECT2_HUMAN | [view interactions] | High throughput | no | yes |
| KCNK3_HUMAN | [view interactions] | High throughput | no | no |
| T176A_HUMAN | [view interactions] | High throughput | no | yes |
| CNDP1_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| AT2A3_HUMAN | [view interactions] | High throughput | no | yes |
| KLRD1_HUMAN | [view interactions] | High throughput | no | no |
| GPIX_HUMAN | [view interactions] | High throughput | no | no |
| ACHA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VSIG4_HUMAN | [view interactions] | High throughput | no | no |
| S22A9_HUMAN | [view interactions] | High throughput | no | no |
| TNFL8_HUMAN | [view interactions] | High throughput | no | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OTULL_HUMAN | [view interactions] | High throughput | no | no |
| ST7_HUMAN | [view interactions] | High throughput | no | yes |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| DJC25_HUMAN | [view interactions] | High throughput | no | yes |
| SEC63_HUMAN | [view interactions] | High throughput | no | yes |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAP31_HUMAN | [view interactions] | High throughput | no | yes |
| CKAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DERL1_HUMAN | [view interactions] | High throughput | no | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI1_HUMAN | [view interactions] | High throughput | no | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| DHB11_HUMAN | [view interactions] | High throughput | no | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATG9A_HUMAN | [view interactions] | High throughput | no | yes |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESYT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |